Milica Ng

Cellular Microenvironment Stiffness Regulates Eicosanoid Production and Signaling Pathways

Asres Berhan, Trudi Harris, Jade Jaffar, Fernando Jativa, Shenna Langenbach, Ingrid Loennstedt, Monther Alhamdoosh, Milica Ng, Peter Lee, Glen Westall, Nick Wilson, Michael Wilson, Alastair G Stewart

Journal article  |  2020  |  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pathological changes in the biomechanical environment are implicated in the progression of idiopathic pulmonary fibrosis (IPF). St..

Blockade of the G-CSF Receptor Is Protective in a Mouse Model of Renal Ischemia-Reperfusion Injury

Jennifer L McRae, Ingela B Vikstrom, Anjan K Bongoni, Evelyn J Salvaris, Nella Fisicaro, Milica Ng, Monther Alhamdoosh, Adriana Baz Morelli, Peter J Cowan, Martin J Pearse

Journal article  |  2020  |  JOURNAL OF IMMUNOLOGY

Ischemia-reperfusion injury (IRI) is a complex inflammatory process that detrimentally affects the function of transplanted organs..

Topical application of human-derived Ig isotypes for the control of acute respiratory infection evaluated in a human CD89-expressing mouse model

Sandra Koernig, Ian K Campbell, Charley Mackenzie-Kludas, Alexander Schaub, Marius Loetscher, Wy Ching Ng, Roland Zehnder, Pawel Pelczar, Ildem Sanli, Monther Alhamdoosh, Milica Ng, Lorena E Brown, Fabian Kasermann, Cedric Vonarburg, Adrian W Zuercher

Journal article  |  2019  |  MUCOSAL IMMUNOLOGY

Recurrent and persistent airway infections remain prevalent in patients with primary immunodeficiency (PID), despite restoration o..

A potential association between IL-3 and type I and III interferons in systemic lupus erythematosus

Shereen Oon, Katherine Monaghan, Milica Ng, Alberta Hoi, Eric Morand, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Plasmacytoid dendritic cells (pDCs), through the production of type 1 interferons (IFNs) and other cytokines, are majo..

Machine learning applied to whole-blood RNA-sequencing data uncovers distinct subsets of patients with systemic lupus erythematosus

William A Figgett, Katherine Monaghan, Milica Ng, Monther Alhamdoosh, Eugene Maraskovsky, Nicholas J Wilson, Alberta Y Hoi, Eric F Morand, Fabienne Mackay

Journal article  |  2019  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease that is difficult to treat. There is currentl..

Therapeutic Targeting of the G-CSF Receptor Reduces Neutrophil Trafficking and Joint Inflammation in Antibody-Mediated Inflammatory Arthritis

Ian K Campbell, David Leong, Kirsten M Edwards, Veronika Rayzman, Milica Ng, Gabrielle L Goldberg, Nicholas J Wilson, Karen Scalzo-Inguanti, Charley Mackenzie-Kludas, Kate E Lawlor, Ian P Wicks, Lorena E Brown, Adriana Baz Morelli, Con Panousis, Michael J Wilson, Andrew D Nash, Brent S McKenzie, Arna E Andrews

Journal article  |  2016  |  JOURNAL OF IMMUNOLOGY

G-CSF is a hemopoietic growth factor that has a role in steady state granulopoiesis, as well as in mature neutrophil activation an..

A cytotoxic anti-IL-3R alpha antibody targets key cells and cytokines implicated in systemic lupus erythematosus

Shereen Oon, Huy Huynh, Tsin Yee Tai, Milica Ng, Katherine Monaghan, Mark Biondo, Gino Vairo, Eugene Maraskovsky, Andrew D Nash, Ian P Wicks, Nicholas J Wilson

Journal article  |  2016  |  JCI INSIGHT

To date, the major target of biologic therapeutics in systemic lupus erythematosus (SLE) has been the B cell, which produces patho..

Use of C-13 Stable Isotope Labelling for Pathway and Metabolic Flux Analysis in Leishmania Parasites

Eleanor C Saunders, David R de Souza, Jennifer M Chambers, Milica Ng, James Pyke, Malcolm J McConville

Journal article  |  2015  |  PARASITE GENOMICS PROTOCOLS, SECOND EDITION

This protocol describes the combined use of metabolite profiling and stable isotope labelling to define pathways of central carbon..

Induction of a Stringent Metabolic Response in Intracellular Stages of Leishmania mexicana Leads to Increased Dependence on Mitochondrial Metabolism

Eleanor C Saunders, William W Ng, Joachim Kloehn, Jennifer M Chambers, Milica Ng, Malcolm J McConville

Journal article  |  2014  |  PLOS PATHOGENS

Leishmania parasites alternate between extracellular promastigote stages in the insect vector and an obligate intracellular amasti..