Stuart Ralph

Conservation, abundance, glycosylation profile, and localization of the TSP protein family in Cryptosporidium parvum.

Alan John, Stefanie M Bader, Niccolay Madiedo Soler, Kharizta Wiradiputri, Swapnil Tichkule, Sean T Smyth, Stuart A Ralph, Aaron R Jex, Nichollas E Scott, Christopher J Tonkin, Ethan D Goddard-Borger

Journal article  |  2023  |  J Biol Chem

Cryptosporidium parvum is a zoonotic apicomplexan parasite and a common cause of diarrheal disease worldwide. The development of v..

The AAA ATPase p97 as a novel parasite and tuberculosis drug target

George Kobakhidze, Ashish Sethi, Sepideh Valimehr, Stuart A Ralph, Isabelle Rouiller

Journal article  |  2022  |  TRENDS IN PARASITOLOGY

The multifunctional AAA+ ATPase p97 is an unfoldase/segregase involved in various cellular processes and present in all kingdoms o..

3, 2, 1, go! Cryptosporidium counts down to sex

Aaron R Jex, Christopher J Tonkin, Stuart A Ralph

Journal article  |  2022  |  PLOS BIOLOGY

Cryptosporidium is a leading cause of death from childhood diarrhea, but its biology is poorly understood. A recent study in PLOS ..

Is the AT-rich DNA of malaria parasites a drug target?

Michaela S Bulloch, Stuart A Ralph

Journal article  |  2022  |  TRENDS IN PHARMACOLOGICAL SCIENCES

A recent antimalarial screen by Alder and colleagues has uncovered a natural product, PDE-I2, with DNA-binding and schizonticidal ..

Chromosome-level genome of Schistosoma haematobium underpins genome-wide explorations of molecular variation

Andreas J Stroehlein, Pasi K Korhonen, V Vern Lee, Stuart A Ralph, Margaret Mentink-Kane, Hong You, Donald P McManus, Louis-Albert Tchuem Tchuente, J Russell Stothard, Parwinder Kaur, Olga Dudchenko, Erez Lieberman Aiden, Bicheng Yang, Huanming Yang, Aidan M Emery, Bonnie L Webster, Paul J Brindley, David Rollinson, Bill CH Chang, Robin B Gasser, et al.

Journal article  |  2022  |  PLOS PATHOGENS

Urogenital schistosomiasis is caused by the blood fluke Schistosoma haematobium and is one of the most neglected tropical diseases..

The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite

Katherine M Ellis, Leonardo Lucantoni, Marina Chavchich, Matthew Abraham, Amanda De Paoli, Madeline R Luth, Anne-Marie Zeeman, Michael J Delves, Fernando Sanchez-Roman Teran, Ursula Straschil, Jake Baum, Clemens HM Kocken, Stuart A Ralph, Elizabeth A Winzeler, Vicky M Avery, Michael D Edstein, Jonathan B Baell, Darren J Creek

Journal article  |  2021  |  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel bis-1,2,4-triazine compounds with potent in vitro activity against Plasmodium falciparum parasites were recently identified...

Functional Characterization of the m6A-Dependent Translational Modulator PfYTH.2 in the Human Malaria Parasite.

Ameya Sinha, Sebastian Baumgarten, Amy Distiller, Emma McHugh, Patty Chen, Meetali Singh, Jessica M Bryant, Jiaqi Liang, Germano Cecere, Peter C Dedon, Peter R Preiser, Stuart A Ralph, Artur Scherf

Journal article  |  2021  |  mBio

Posttranscriptional regulation of gene expression is central to the development and replication of the malaria parasite, Plasmodiu..

Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics

Simon A Cobbold, Madel Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler, Darren J Creek, Audrey Odom John, Leann Tilley, Stuart A Ralph, Malcolm J McConville

Journal article  |  2021  |  MOLECULAR SYSTEMS BIOLOGY

The malaria parasite, Plasmodium falciparum, proliferates rapidly in human erythrocytes by actively scavenging multiple carbon sou..

Direct Nanopore Sequencing of mRNA Reveals Landscape of Transcript Isoforms in Apicomplexan Parasites.

V Vern Lee, Louise M Judd, Aaron R Jex, Kathryn E Holt, Christopher J Tonkin, Stuart A Ralph

Journal article  |  2021  |  mSystems

Alternative splicing is a widespread phenomenon in metazoans by which single genes are able to produce multiple isoforms of the ge..

Parasitravaganza 2020: Insights into a Virtual Parasitology Conference

Coralie Boulet, Siobhon L Egan, Lisa Jones, Thorey K Jonsdottir, Michelle L Power, Stuart A Ralph, Lily Tran, Mae AF White

Journal article  |  2020  |  TRENDS IN PARASITOLOGY