Dr Vijay Rajagopal is a Senior Lecturer at the Department of Biomedical Engineering at the University of Melbourne. Dr. Rajagopal's main research interests are in understanding biological remodelling: how cells integrate chemical and mechanical signals to adapt and maintain organ function and how these adaptation mechanisms are affected in disease.
He develops anatomically and functionally detailed computer models of cells and tissues that are closely tied to clinical data and experimental measurements. These models can be used to study fundamental biophysical mechanisms underlying biological remodelling. They can also be used for hypothesis testing in drug-discovery research and for disease modelling.
Dr. Rajagopal has a broad range of expertise in bioengineering spanning image analysis, biomechanics and mechanobiology, and systems and computational biology. Dr. Rajagopal received a PhD in Bioengineering from the University of Auckland, Auckland Bioengineering Institute. His PhD research pioneered the development of patient-specific and anatomically accurate models of the breast for breast cancer image analysis applications. This work was recognised in the New Zealand Young Scientist of the Year and MICCAI Young Scientist of the Year awards. He was then awarded a prestigious Early Career Researcher grant from the Royal Society of New Zealand to conduct pioneering studies to understand the sub-cellular mechanisms of heart disease. Subsequently, Dr. Rajagopal conducted research in cancer metastasis using microfluidics approaches at the Singapore-MIT Alliance for Research and Technology.
At the University of Melbourne Dr. Rajagopal combines these areas of expertise to discover sub-cellular mechanisms of heart disease. He is also leveraging this expertise to study sub-cellular mechanisms of cancer metastasis and red blood cell related diseases.
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Could Stem-Cell Derived Tissue Cultures Replace Animal Models For Drug Screening In Primar..
Mammogramic Density (Md) And Breast Cancer (The Project) With Peter Maccallum Cancer Insti..
Displaying the 5 most recent projects by Vijay Rajagopal.
Internal Research Grant
Displaying the 48 most recent scholarly works by Vijay Rajagopal.
Efficient estimation of load-free left ventricular geometry and passive myocardial properties using principal component analysis
Zhinuo J Wang, Vicky Y Wang, Thiranja P Babarenda Gamage, Vijayaraghavan Rajagopal, J Jane Cao, Poul MF Nielsen, Chris P Bradley, Alistair A Young, Martyn P Nash
Journal article | 2020 | International Journal for Numerical Methods in Biomedical Engineering
Models of cardiac mechanics require a well‐defined reference geometry from which deformations and hence myocardial strain and stre..
Automated segmentation of cardiomyocyte Z-disks from high-throughput scanning electron microscopy data.
Afshin Khadangi, Eric Hanssen, Vijay Rajagopal
Journal article | 2019 | BMC Medical Informatics and Decision Making
BACKGROUND: With the advent of new high-throughput electron microscopy techniques such as serial block-face scanning electron micr..
Assessing Cardiomyocyte Excitation-Contraction Coupling Site Detection From Live Cell Imaging Using a Structurally-Realistic Computational Model of Calcium Release
David Ladd, Agne Tilunaite, H Llewelyn Roderick, Christian Soeller, Edmund J Crampin, Vijay Rajagopal
Journal article | 2019 | Frontiers in Physiology
Calcium signaling plays a pivotal role in cardiomyocytes, coupling electrical excitation to mechanical contraction of the heart. D..
Multimodal analysis of Plasmodium knowlesi-infected erythrocytes reveals large invaginations, swelling of the host cell, and rheological defects
Boyin Liu, Adam J Blanch, Arman Namvar, Olivia Carmo, Snigdha Tiash, Dean Andrew, Eric Hanssen, Vijay Rajagopal, Matthew WA Dixon, Leann Tilley
Journal article | 2019 | CELLULAR MICROBIOLOGY
Assessment of single beat end-systolic elastance methods for quantifying ventricular contractility
Naomi Wo, Vijay Rajagopal, Michael MH Cheung, Joseph J Smolich, Jonathan P Mynard
Journal article | 2019 | Heart and Vessels
Multi-beat end-systolic elastance (EMB) is considered a gold-standard index of ventricular contractility. However, it is difficult..
Detecting RyR clusters with CaCLEAN: influence of spatial distribution and structural heterogeneity
David Ladd, Agne Tilunaite, Christian Soeller, Llewelyn Roderick, Edmund Crampin, Vijay Rajagopal
Journal article | 2019
Abstract In cardiomyocytes, the coordinated release of calcium ions from intracellular stores through ryanodine receptor (RyR) clu..
Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture
Shouryadipta Ghosh, Kenneth Tran, Lea MD Delbridge, Anthony JR Hickey, Eric Hanssen, Edmund J Crampin, Vijay Rajagopal
Journal article | 2018 | PLOS COMPUTATIONAL BIOLOGY
An automated workflow for segmenting single adult cardiac cells from large-volume serial block-face scanning electron microscopy data
Akter Hussain, Shouryadipta Ghosh, Siavash Beikoghli Kalkhoran, Derek J Hausenloy, Eric Hanssen, Vijay Rajagopal
Journal article | 2018 | Journal of Structural Biology
Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology
Vijay Rajagopal, Gregory Bass, Shouryadipta Ghosh, Hilary Hunt, Cameron Walkers, Eric Hanssen, Edmund Crampin, Christian Soeller
Journal article | 2018 | Journal of Visualized Experiments
Automated framework to reconstruct 3D model of cardiac Z-disk: an image processing approach
Eric Hanssen, V Rajagopal, Afshin Khadankishandi
Conference Proceedings | 2018 | PROCEEDINGS 2018 IEEE INTERNATIONAL CONFERENCE ON BIOINFORMATICS AND BIOMEDICINE (BIBM)
The Z-disk or Z-line is located at the lateral borders of sarcomere, the fundamental unit of striated muscle. They provide mechani..
Erythrocyte beta spectrin can be genetically targeted to protect mice from malaria
Patrick M Lelliott, Hong Ming Huang, Matthew W Dixon, Arman Namvar, Adam J Blanch, Vijay Rajagopal, Leann Tilley, Cevayir Coban, Brendan J McMorran, Simon J Foote, Gaetan Burgio
Journal article | 2017 | Blood Advances
Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy
Jan Jarosz, Shouryadipta Ghosh, Lea MD Delbridge, Amorita Petzer, Anthony JR Hickey, Edmund J Crampin, Eric Hanssen, Vijay Rajagopal
Journal article | 2017 | American Journal of Physiology-Cell Physiology
Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2 Release Patterns in Cardiomyocytes
Vijay Rajagopal, Gregory Bass, Cameron G Walker, David J Crossman, Amorita Petzer, Anthony Hickey, Ivo Siekmann, Masahiko Hoshijima, Mark H Ellisman, Edmund J Crampin, Christian Soeller
Journal article | 2015 | PLOS COMPUTATIONAL BIOLOGY
Super-resolution fluorescence imaging to study cardiac biophysics: alpha-actinin distribution and Z-disk topologies in optically thick cardiac tissue slices
Yufeng Hou, David J Crossman, Vijay Rajagopal, David Baddeley, Isuru Jayasinghe, Christian Soeller
Journal article | 2014 | Progress in Biophysics and Molecular Biology
OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project
Chris Bradley, Andy Bowery, Randall Britten, Vincent Budelmann, Oscar Camara, Richard Christie, Andrew Cookson, Alejandro F Frangi, Thiranja Babarenda Gamage, Thomas Heidlauf, Sebastian Krittian, David Ladd, Caton Little, Kumar Mithraratne, Martyn Nash, David Nickerson, Poul Nielsen, Oyvind Nordbo, Stig Omholt, Ali Pashaei, et al.
Journal article | 2011 | Progress in Biophysics & Molecular Biology
Identification of mechanical properties of heterogeneous soft bodies using gravity loading (vol 27, pg 371, 2011)
Thiranja P Babarenda Gamage, Vijayaraghavan Rajagopal, Matthias Ehrgott, Martyn P Nash, Poul MF Nielsen
Journal article | 2011 | INTERNATIONAL JOURNAL FOR NUMERICAL METHODS IN BIOMEDICAL ENGINEERING
Snr Lecturer, Computational Cellular Biomechanics
Australian Physiological Society
Australian Society of Biophysics
Australia NZ Society of Biomechanics
Australian Mathematical Society
Australia NZ Industrial and Applied Mathematics
Graduate Certificate in University Teaching
University of Melbourne
University of Auckland
University of Auckland