Vijay Rajagopal

EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism

Juliana Gomez, Zammam Areeb, Sarah F Stuart, Hong PT Nguyen, Lucia Paradiso, Ahmad Zulkifli, Sonakshi Madan, Vijay Rajagopal, Magdalene K Montgomery, Hui K Gan, Andrew M Scott, Jordan Jones, Andrew H Kaye, Andrew P Morokoff, Rodney B Luwor

Journal article  |  2021  |  Cancers

Reticulocalbin 1 (RCN1) is an endoplasmic reticulum (ER)-residing protein, involved in promoting cell survival during pathophysiol..

Cortical Tension Initiates the Positive Feedback Loop Between E-cadherin and F-actin

Qilin Yu, William Holmes, Jean Thiery, Rodney Luwor, Vijay Rajagopal

Journal article  |  2021

Adherens junctions (AJs) physically link two cells at their contact interface via extracellular homophilic interactions between ca..

EM-stellar: benchmarking deep learning for electron microscopy image segmentation.

Afshin Khadangi, Thomas Boudier, Vijay Rajagopal

Journal article  |  2021  |  Bioinformatics

MOTIVATION: The inherent low contrast of electron microscopy (EM) datasets presents a significant challenge for rapid segmentation..

Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells

Cole Zmurchok, Jared Collette, Vijay Rajagopal, William R Holmes

Journal article  |  2020  |  Biophysical Journal

Migratory cells are known to adapt to environments that contain wide-ranging levels of chemoattractant. Although biochemical model..

Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels.

Arman Namvar, Adam J Blanch, Matthew W Dixon, Olivia MS Carmo, Boyin Liu, Snigdha Tiash, Oliver Looker, Dean Andrew, Li-Jin Chan, Wai-Hong Tham, Peter VS Lee, Vijay Rajagopal, Leann Tilley

Journal article  |  2020  |  Cellular Microbiology

The remarkable deformability of red blood cells (RBCs) depends on the viscoelasticity of the plasma membrane and cell contents and..

An in-silico study to determine whether changes to mitochondria organization through engineered mitochondrial dynamics can enhance bioenergetics in cardiomyocytes

Adarsh Kumbhari, Shouryadipta Ghosh, Peter Kim, Vijay Rajagopal

Journal article  |  2020

SUMMARY Mitochondria are the powerhouse of the cell and owing to their unique energetic demands, heart muscles contain a high dens..

Ca2 Release via IP3 Receptors Shapes the Cardiac Ca2 Transient for Hypertrophic Signaling.

Hilary Hunt, Agnė Tilūnaitė, Greg Bass, Christian Soeller, H Llewelyn Roderick, Vijay Rajagopal, Edmund J Crampin

Journal article  |  2020  |  Biophysical Journal

Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocyte..

Ca2 release via IP3Rs increases RyR mediated Ca2 spark frequency in ventricular cardiomyocytes without altering spark amplitude and duration

Agnė Tilūnaitė, David Ladd, Hilary Hunt, Christian Soeller, Llewelyn Roderick, Edmund Crampin, Vijay Rajagopal

Journal article  |  2020

Abstract Calcium plays critical roles in cardiac cells, coupling electrical excitation to mechanical contraction with each heartbe..

EM-stellar: benchmarking deep learning for electron microscopy image segmentation

Afshin Khadangi, Thomas Boudier, Vijay Rajagopal

Journal article  |  2020

The inherent low contrast of electron microscopy (EM) datasets presents a significant challenge for rapid segmentation of cellular..

Membrane tension can enhance adaptation to maintain polarity of migrating cells

C Zmurchok, J Collette, V Rajagopal, WR Holmes

Journal article  |  2020

Abstract Migratory cells are known to adapt to environments that contain wide-ranging levels of chemoattractant. While biochemical..