Vijay Rajagopal

Surface area-to-volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels.

Arman Namvar, Adam J Blanch, Matthew W Dixon, Olivia MS Carmo, Boyin Liu, Snigdha Tiash, Oliver Looker, Dean Andrew, Li-Jin Chan, Wai-Hong Tham, Peter VS Lee, Vijay Rajagopal, Leann Tilley

Journal article  |  2020  |  Cellular Microbiology

The remarkable deformability of red blood cells (RBCs) depends on the viscoelasticity of the plasma membrane and cell contents and..

Ca2 Release via IP3 Receptors Shapes the Cardiac Ca2 Transient for Hypertrophic Signaling.

Hilary Hunt, Agnė Tilūnaitė, Greg Bass, Christian Soeller, H Llewelyn Roderick, Vijay Rajagopal, Edmund J Crampin

Journal article  |  2020  |  Biophysical Journal

Calcium (Ca2+) plays a central role in mediating both contractile function and hypertrophic signaling in ventricular cardiomyocyte..

Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells.

Cole Zmurchok, Jared Collette, Vijay Rajagopal, William R Holmes

Journal article  |  2020  |  Biophysical Journal

Migratory cells are known to adapt to environments that contain wide-ranging levels of chemoattractant. Although biochemical model..

Ca2 release via IP3Rs increases RyR mediated Ca2 spark frequency in ventricular cardiomyocytes without altering spark amplitude and duration

Agnė Tilūnaitė, David Ladd, Hilary Hunt, Christian Soeller, Llewelyn Roderick, Edmund Crampin, Vijay Rajagopal

Journal article  |  2020

Abstract Calcium plays critical roles in cardiac cells, coupling electrical excitation to mechanical contraction with each heartbe..

EM-stellar: benchmarking deep learning for electron microscopy image segmentation

Afshin Khadangi, Thomas Boudier, Vijay Rajagopal

Journal article  |  2020

Abstract The inherent low contrast of electron microscopy (EM) datasets presents a significant challenge for rapid segmentation of..

Membrane tension can enhance adaptation to maintain polarity of migrating cells

C Zmurchok, J Collette, V Rajagopal, WR Holmes

Journal article  |  2020

Abstract Migratory cells are known to adapt to environments that contain wide-ranging levels of chemoattractant. While biochemical..

Efficient estimation of load-free left ventricular geometry and passive myocardial properties using principal component analysis

Zhinuo J Wang, Vicky Y Wang, Thiranja P Babarenda Gamage, Vijayaraghavan Rajagopal, J Jane Cao, Poul MF Nielsen, Chris P Bradley, Alistair A Young, Martyn P Nash

Journal article  |  2020  |  International Journal for Numerical Methods in Biomedical Engineering

Models of cardiac mechanics require a well‐defined reference geometry from which deformations and hence myocardial strain and stre..

EM-net: Deep learning for electron microscopy image segmentation

Afshin Khadangi, Thomas Boudier, Vijay Rajagopal

Journal article  |  2020

Abstract Recent high-throughput electron microscopy techniques such as focused ion-beam scanning electron microscopy (FIB-SEM) pro..

Automated segmentation of cardiomyocyte Z-disks from high-throughput scanning electron microscopy data.

Afshin Khadangi, Eric Hanssen, Vijay Rajagopal

Journal article  |  2019  |  BMC Medical Informatics and Decision Making

BACKGROUND: With the advent of new high-throughput electron microscopy techniques such as serial block-face scanning electron micr..

Assessing Cardiomyocyte Excitation-Contraction Coupling Site Detection From Live Cell Imaging Using a Structurally-Realistic Computational Model of Calcium Release

David Ladd, Agne Tilunaite, H Llewelyn Roderick, Christian Soeller, Edmund J Crampin, Vijay Rajagopal

Journal article  |  2019  |  Frontiers in Physiology

Calcium signaling plays a pivotal role in cardiomyocytes, coupling electrical excitation to mechanical contraction of the heart. D..