Wilson Wong

Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein

Brad E Sleebs, Kate E Jarman, Sonja Frolich, Wilson Wong, Julie Healer, Weiwen Dai, Isabelle S Lucet, Danny W Wilson, Alan F Cowman

Journal article  |  2020  |  International Journal for Parasitology: Drugs and Drug Resistance

The P. falciparum parasite, responsible for the disease in humans known as malaria, must invade erythrocytes to provide an environ..

The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis

Stanley C Xie, Riley D Metcalfe, Eric Hanssen, Tuo Yang, David L Gillett, Andrew P Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley

Journal article  |  2019  |  Nature Microbiology

The activity of the proteasome 20S catalytic core is regulated by protein complexes that bind to one or both ends. The PA28 regula..

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex

Wilson Wong, Rick Huang, Sebastien Menant, Chuan Hong, Jarrod J Sandow, Richard W Birkinshaw, Julie Healer, Anthony N Hodder, Usheer Kanjee, Christopher J Tonkin, Denise Heckmann, Vladislav Soroka, Teit Max Moscote Sogaard, Thomas Jorgensen, Manoj T Duraisingh, Peter E Czabotar, Willem A de Jongh, Wai-Hong Tham, Andrew I Webb, Zhiheng Yu, et al.

Journal article  |  2019  |  Nature

The structure of the Plasmodium falciparum 20S proteasome in complex with the PA28 activator

Riley D Metcalfe, Stanley C Xie, Eric Hanssen, Tuo Yang, David L Gillett, Andrew Leis, Craig J Morton, Michael J Kuiper, Michael W Parker, Natalie J Spillman, Wilson Wong, Christopher Tsu, Lawrence R Dick, Michael DW Griffin, Leann Tilley

Conference Proceedings  |  2019  |  Acta Crystallographica Section A: Foundations and advances

Cryo-EM structure of an essential Plasmodium vivax invasion complex

Jakub Gruszczyk, Rick K Huang, Li-Jin Chan, Sebastien Menant, Chuan Hong, James M Murphy, Yee-Foong Mok, Michael DW Griffin, Richard D Pearson, Wilson Wong, Alan F Cowman, Zhiheng Yu, Tham Wai-Hong

Journal article  |  2018  |  Nature

A Weak Spot in Multiple Protozoan Parasites

Wilson Wong

Journal article  |  2017  |  Structure

Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis

Wilson Wong, Xiao-Chen Bai, Brad E Sleebs, Tony Triglia, Alan Brown, Jennifer K Thompson, Katherine E Jackson, Eric Hanssen, Danushka S Marapana, Israel S Fernandez, Stuart A Ralph, Alan F Cowman, Sjors HW Scheres, Jake Baum

Journal article  |  2017  |  Nature Microbiology

Structural basis for inhibition of erythrocyte invasion by antibodies to Plasmodium falciparum protein CyRPA

Lin Chen, Yibin Xu, Wilson Wong, Jennifer K Thompson, Julie Healer, Ethan D Goddard-Borger, Michael C Lawrence, Alan F Cowman

Journal article  |  2017  |  eLife

Disassembly activity of actin-depolymerizing factor (ADF) is associated with distinct cellular processes in apicomplexan parasites

Silvia Haase, Dennis Zimmermann, Maya A Olshina, Mark Wilkinson, Fabio Fisher, Yan Hong Tan, Rebecca J Stewart, Christopher J Tonkin, Wilson Wong, David R Kovar, Jake Baum

Journal article  |  2015  |  Molecular Biology of the Cell

Plasmodium falciparum coronin organizes arrays of parallel actin filaments potentially guiding directional motility in invasive malaria parasites

Maya A Olshina, Fiona Angrisano, Danushka S Marapana, David T Riglar, Kartik Bane, Wilson Wong, Bruno Catimel, Meng-Xin Yin, Andrew B Holmes, Friedrich Frischknecht, David R Kovar, Jake Baum

Journal article  |  2015  |  Malaria Journal