Dr. Jess Nithianantharajah is an Australian Research Council Future Fellow and heads the Synapse Biology and Cognition laboratory within the Division of Behavioural Neuroscience. She completed her doctoral thesis in behavioural neuroscience at the University of Melbourne examining synaptic changes following learning and experience, and commenced postdoctoral training at the Howard Florey Institute to further investigate gene-environment interactions modulating experience-dependent synaptic plasticity.
Dr. Nithianantharajah was recruited as a postdoctoral fellow by Prof. Seth Grant at the Wellcome Trust Sanger Institute in Cambridge, UK. During this time, she held a joint appointment at the University of Cambridge working with Prof. Tim Bussey and Dr. Lisa Saksida on the development of the novel rodent touchscreen cognitive tests - an innovative behavioural tool for mice that has advanced how we model complex learning and mental processes in animals. Employing the rodent touchscreen assays to probe distinct cognitive components, Dr. Nithianantharajah’s recent work has provided the first evidence of dissecting the cognitive repertoire in mice to show that these cognitive components are differentially regulated by a family of postsynaptic scaffold proteins, providing novel insights into the evolution of cognition. Moreover, her research has been the first to showcase the translational capacity of the touchscreens in assessing cognition in mice and humans carrying mutations in the same gene, highlighting the clinical relevance of this innovative method. She relocated to the University of Edinburgh and in 2014, was recruited back to the Florey Institute of Neuroscience and Mental Heath as an Independent group leader. Dr. Nithianantharajah’s research interests lie in understanding the role of synaptic genes in cognition and disease.
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Jess Nithianantharajah's selected work
Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfuncti..
Gene-Environment Interactions Modulating Cognition And Dementia In Huntington’S Disease
Bridging the translational divide: identical cognitive touchscreen testing in mice and hum..
Displaying the 4 most recent projects by Jess Nithianantharajah.
Displaying the 42 most recent scholarly works by Jess Nithianantharajah.
Cognition in Stroke Rehabilitation and Recovery Research: Consensus-Based Core Recommendations From the Second Stroke Recovery and Rehabilitation Roundtable
Matthew W McDonald, Sandra E Black, David A Copland, Dale Corbett, Rick M Dijkhuizen, Tracy D Farr, Matthew S Jeffers, Rajesh N Kaaria, Frini Karayanidis, Alexander P Leff, Jess Nithianantharajah, Sarah Pendlebury, Terence J Quinn, Andrew N Clarkson, Michael J O'Sullivan
Journal article | 2019 | Neurorehabilitation and Neural Repair
Cognitive impairment is an important target for rehabilitation as it is common following stroke, is associated with reduced qualit..
Cognition in stroke rehabilitation and recovery research: Consensus-based core recommendations from the second Stroke Recovery and Rehabilitation Roundtable
Matthew W McDonald, Sandra E Black, David A Copland, Dale Corbett, Rick M Dijkhuizen, Tracy D Farr, Matthew S Jeffers, Rajesh N Kalaria, Frini Karayanidis, Alexander P Leff, Jess Nithianantharajah, Sarah Pendlebury, Terence J Quinn, Andrew N Clarkson, Michael J O'Sullivan
Journal article | 2019 | International Journal of Stroke
Evolution of brain volume and hippocampal neurogenesis over 12 months after focal ischemia in adult rats
Charlotte Ermine, Warda Syeda, David Wright, Jessica Kauhausen, Stefano Frausin, Vanessa Brait, Katrina O'Brien, Jessica Nithianantharajah, Emilio Werden, Leigh Johnston, Amy Brodtmann, Lachlan Thompson
Conference Proceedings | 2019 | INTERNATIONAL JOURNAL OF STROKE
Cognitive deficits in a rat model of temporal lobe epilepsy using touchscreen-based translational tools
Simone Carron, Gabi Dersi, Ezgi Ozturk, Jess Nithianantharajah, Nigel C Jones
Journal article | 2019 | EPILEPSIA
OBJECTIVE: Cognitive deficits are commonly observed in people with epilepsy, but the biologic causation of these is challenging to..
Paradoxical effects of exercise on hippocampal plasticity and cognition in mice with a heterozygous null mutation in the serotonin transporter gene
Jake Rogers, Feng Chen, Davor Stanic, Farheen Farzana, Shanshan Li, Ariel M Zeleznikow-Johnston, Jess Nithianantharajah, I Leonid Churilov, Paul A Adlard, Laurence Lanfumey, Anthony J Hannan, Thibault Renoir
Journal article | 2019 | British Journal of Pharmacology
Colonic dilation and altered ex vivo gastrointestinal motility in the neuroligin-3 knockout mouse.
Anita JL Leembruggen, Gayathri K Balasuriya, Jinghong Zhang, Shana Schokman, Kristy Swiderski, Joel C Bornstein, Jess Nithianantharajah, Elisa L Hill-Yardin
Journal article | 2019 | Autism Research
Gastrointestinal (GI) dysfunction is commonly reported by people diagnosed with autism spectrum disorder (ASD; autism) but the cau..
Hypoxia-Induced MicroRNA-210 Targets Neurodegenerative Pathways.
Michelle E Watts, Sarah M Williams, Jess Nithianantharajah, Charles Claudianos
Journal article | 2018 | Non-Coding RNA
Hypoxia-regulated microRNA-210 (miR-210) is a highly conserved microRNA, known to regulate various processes under hypoxic conditi..
Arc Requires PSD95 for Assembly into Postsynaptic Complexes Involved with Neural Dysfunction and Intelligence
Esperanza Fernandez, Mark O Collins, Rene AW Frank, Fei Zhu, Maksym V Kopanitsa, Jess Nithianantharajah, Sarah A Lempriere, David Fricker, Kathryn A Elsegood, Catherine L McLaughlin, Mike DR Croning, Colin Mclean, J Douglas Armstrong, W David Hill, Ian J Deary, Giulia Cencelli, Claudia Bagni, Menachem Fromer, Shaun M Purcell, Andrew J Pocklington, et al.
Journal article | 2017 | Cell Reports
Using Animal Models to Study the Role of the Gut-Brain Axis in Autism.
Jess Nithianantharajah, Gayathri K Balasuriya, Ashley E Franks, Elisa L Hill-Yardin
Journal article | 2017 | Current Developmental Disorders Reports
PURPOSE OF REVIEW: Individuals with autism spectrum disorders (ASD) commonly also suffer from gastrointestinal (GI) dysfunction; h..
Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene
J Nithianantharajah, AG McKechanie, TJ Stewart, M Johnstone, DH Blackwood, D St Clair, SGN Grant, TJ Bussey, LM Saksida
Journal article | 2015 | Scientific Reports
Synaptic scaffold evolution generated components of vertebrate cognitive complexity
Jess Nithianantharajah, Noboru H Komiyama, Andrew McKechanie, Mandy Johnstone, Douglas H Blackwood, David St Clair, Richard D Emes, Louie N van de Lagemaat, Lisa M Saksida, Timothy J Bussey, Seth GN Grant
Journal article | 2013 | Nature Neuroscience
TNiK Is Required for Postsynaptic and Nuclear Signaling Pathways and Cognitive Function
Marcelo P Coba, Noboru H Komiyama, Jess Nithianantharajah, Maksym V Kopanitsa, Tim Indersmitten, Nathan G Skene, Ellie J Tuck, David G Fricker, Kathryn A Elsegood, Lianne E Stanford, Nurudeen O Afinowi, Lisa M Saksida, Timothy J Bussey, Thomas J O'Dell, Seth GN Grant
Journal article | 2012 | Journal of Neuroscience
Retinal dysfunction, photoreceptor protein dysregulation and neuronal remodelling in the R6/1 mouse model of Huntington's disease
Abrez Hussain Batcha, Una Greferath, Andrew I Jobling, Kirstan A Vessey, Michelle M Ward, Jess Nithianantharajah, Anthony J Hannan, Michael Kalloniatis, Erica L Fletcher
Journal article | 2012 | Neurobiology of Disease
MOLECULAR MEDIATORS, ENVIRONMENTAL MODULATORS AND EXPERIENCE-DEPENDENT PLASTICITY IN MOUSE MODELS OF BRAIN DISORDERS
TYC Pang, T Renoir, MS Zajac, EL Burrows, X Du, M Ransome, G Chan, A Argyropoulos, C Mo, E Manning, CE McOmish, L Gray, J Nithianantharajah, AJ Hannan
Journal article | 2010 | JOURNAL OF NEUROCHEMISTRY
Arc Future Fellow
Florey Department Of Neuroscience And Mental Health
Bachelor of Science (Honours)
University of Melbourne
PhD Behavioural Neuroscience
University of Melbourne