Sandra Nicholson

In Semliki Forest virus encephalitis, suppressor of cytokine signaling 4 (SOCS4) is an essential modulator of immune responses that mediates the balance between immunopathology and virus clearance

Lukasz Kedzierski, Abigail Er Qi Tan, Isabelle Jia Hui Foo, Divya Narayanan, Nagaraj Moily, Hayley A McQuilten, Sandra E Nicholson, John K Fazakerley

Journal article  |  2023  |  IMMUNOLOGY AND CELL BIOLOGY

Central nervous system virus infections are a major cause of morbidity and mortality worldwide and a significant global public hea..

SOCS2 regulation of growth hormone signaling requires a canonical interaction with phosphotyrosine.

Kunlun Li, Lizeth G Meza Guzman, Lachlan Whitehead, Evelyn Leong, Andrew Kueh, Warren S Alexander, Nadia J Kershaw, Jeffrey J Babon, Karen Doggett, Sandra E Nicholson

Journal article  |  2022  |  Biosci Rep

Suppressor of cytokine signaling (SOCS) 2 is the critical negative regulator of growth hormone (GH) and prolactin signaling. Mice ..

CIS controls the functional polarization of GM-CSF-derived macrophages

Shengbo Zhang, Jai Rautela, Naiara G Bediaga, Tatiana B Kolesnik, Yue You, Junli Nie, Laura F Dagley, Justin Bedo, Hanqing Wang, Li Sun, Robyn Sutherland, Elliot Surgenor, Nadia Iannarella, Rhys Allan, Fernando Souza-Fonseca-Guimaraes, Yi Xie, Qike Wang, Yuxia Zhang, Yuekang Xu, Stephen L Nutt, et al.

Journal article  |  2022  |  CELLULAR & MOLECULAR IMMUNOLOGY

The cytokine granulocyte-macrophage-colony stimulating factor (GM-CSF) possesses the capacity to differentiate monocytes into macr..

Suppressor of Cytokine Signalling 5 (SOCS5) Modulates Inflammatory Responses during Alphavirus Infection

Lukasz Kedzierski, Abigail Er Qi Tan, Isabelle Jia Hui Foo, Sandra E Nicholson, John K Fazakerley

Journal article  |  2022  |  VIRUSES-BASEL

CNS viral infections are one of the major causes of morbidity and mortality worldwide and a significant global public health conce..

Enhanced nitric oxide production by macrophages treated with a cell-penetrating peptide conjugate.

Arfatur Rahman, Macgregor A Matthews, Cameron J Nowell, David K Chalmers, Philip E Thompson, Sandra E Nicholson, Nicholas Barlow, Raymond S Norton

Journal article  |  2022  |  Bioorg Chem

The SPRY domain-containing SOCS box protein-2 (SPSB2) plays a critical role in the degradation of inducible nitric oxide synthase ..

Interferon-g primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

Daniel S Simpson, Jiyi Pang, Ashley Weir, Isabella Y Kong, Melanie Fritsch, Maryam Rashidi, James P Cooney, Kathryn C Davidson, Mary Speir, Tirta M Djajawi, Sebastian Hughes, Liana Mackiewicz, Merle Dayton, Holly Anderton, Marcel Doerflinger, Yexuan Deng, Allan Shuai Huang, Stephanie A Conos, Hazel Tye, Seong H Chow, et al.

Journal article  |  2022  |  IMMUNITY

Cell death plays an important role during pathogen infections. Here, we report that interferon-γ (IFNγ) sensitizes macrophages to ..

Optimization of Phosphotyrosine Peptides that Target the SH2 Domain of SOCS1 and Block Substrate Ubiquitination

Hao Chen, Yuntong Wu, Kunlun Li, Iain Currie, Narelle Keating, Farhad Dehkhoda, Christoph Grohmann, Jeffrey J Babon, Sandra E Nicholson, Brad E Sleebs

Journal article  |  2022  |  ACS CHEMICAL BIOLOGY

Suppressor of cytokine signaling 1 (SOCS1) has emerged as a potential therapeutic target in inflammatory and viral diseases. SOCS1..

Determining Activation Status of Natural Killer Cells Following Stimulation via Cytokines and Surface Receptors.

Lizeth G Meza Guzman, Sandra E Nicholson

Book Chapter  |  2022  |  Methods in Molecular Biology

Stimulation of Natural Killer (NK) cells with cytokines, target cell interaction, or antibody mediated activation of receptors on ..

Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands

Edmond M Linossi, Kunlun Li, Gianluca Veggiani, Cyrus Tan, Farhad Dehkhoda, Colin Hockings, Dale J Calleja, Narelle Keating, Rebecca Feltham, Andrew J Brooks, Shawn S Li, Sachdev S Sidhu, Jeffrey J Babon, Nadia J Kershaw, Sandra E Nicholson

Journal article  |  2021  |  NATURE COMMUNICATIONS

Suppressor of cytokine signaling (SOCS)2 protein is a key negative regulator of the growth hormone (GH) and Janus kinase (JAK)-Sig..

Large-scale survey and database of high affinity ligands for peptide recognition modules

Joan Teyra, Abdellali Kelil, Shobhit Jain, Mohamed Helmy, Raghav Jajodia, Yogesh Hooda, Jun Gu, Akshay A D'Cruz, Sandra E Nicholson, Jinrong Min, Marius Sudol, Philip M Kim, Gary D Bader, Sachdev S Sidhu

Journal article  |  2020  |  MOLECULAR SYSTEMS BIOLOGY

Many proteins involved in signal transduction contain peptide recognition modules (PRMs) that recognize short linear motifs (SLiMs..