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A/Prof

Sandra Nicholson

Honorary
science & technology
life sciences & biomedicine
animals
mice
suppressor of cytokine signaling proteins
humans
signal transduction
biochemistry & molecular biology
cell biology
Sandra Nicholson's Profile Picture
A/Prof

Sandra Nicholson

 
Division
Medicine, Dentistry And Health Sciences
 
Primary Interest
Cytokine signalling and innate immunity
Sandra Nicholson's Profile Picture
A/Prof

Sandra Nicholson

 

Research interest:
I am interested in how the body initiates an innate immune response to infectious pathogens and then maintains ‘helpful’, rather than ‘damaging’ inflammatory responses.
The SOCS proteins are classic negative regulators that act as a handbrake to limit the damage associated with excessive pro-inflammatory cytokine signalling. TRIM proteins are another important class of intracellular proteins which both positively and negatively regulate innate immune signalling.

Our research program aims to understand the molecular detail of SOCS and TRIM protein complexes and how these signalling complexes are regulated in inflammatory and infectious disease. We are taking an integrated multi-disciplinary approach, which utilises in vivo model systems, quantitative proteomics and structural biology.Ultimately, I am interested in the connection between the deregulation of intracellular signalling and disease. Within this context, my research is focused on understanding how these protein families regulate innate immunity.
www.wehi.edu.au/people/sandra-nicholson

Scholarly Works

Displaying the 84 most recent scholarly works by Sandra Nicholson.

Credentials

Positions


Honorary

Medical Biology (W.E.H.I.)

Education


Master of Science

University of New South Wales

Bachelor of Science

Monash University

PhD

University of Melbourne