Sandra Nicholson

Large-scale survey and database of high affinity ligands for peptide recognition modules

Joan Teyra, Abdellali Kelil, Shobhit Jain, Mohamed Helmy, Raghav Jajodia, Yogesh Hooda, Jun Gu, Akshay A D'Cruz, Sandra E Nicholson, Jinrong Min, Marius Sudol, Philip M Kim, Gary D Bader, Sachdev S Sidhu

Journal article  |  2020  |  MOLECULAR SYSTEMS BIOLOGY

Many proteins involved in signal transduction contain peptide recognition modules (PRMs) that recognize short linear motifs (SLiMs..

CD155 on Tumor Cells Drives Resistance to Immunotherapy by Inducing the Degradation of the Activating Receptor CD226 in CD8( ) T Cells

Matthias Braun, Amelia Roman Aguilera, Ashmitha Sundarrajan, Dillon Corvino, Kimberley Stannard, Sophie Krumeich, Indrajit Das, Luize G Lima, Lizeth G Meza Guzman, Kunlun Li, Rui Li, Nazhifah Salim, Maria Villancanas Jorge, Sunyoung Ham, Gabrielle Kelly, Frank Vari, Ailin Lepletier, Ashwini Raghavendra, Sally Pearson, Jason Madore, et al.

Journal article  |  2020  |  IMMUNITY

The activating receptor CD226 is expressed on lymphocytes, monocytes, and platelets and promotes anti-tumor immunity in pre-clinic..

Natural Killer Cells: Tumor Surveillance and Signaling

Lizeth G Meza Guzman, Narelle Keating, Sandra E Nicholson

Journal article  |  2020  |  CANCERS

Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate ability to detect and kill tumorigenic c..

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses

Thomas J Hayman, Alan C Hsu, Tatiana B Kolesnik, Laura F Dagley, Joschka Willemsen, Michelle D Tate, Paul J Baker, Nadia J Kershaw, Lukasz Kedzierski, Andrew Webb, Peter A Wark, Katherine Kedzierska, Seth L Masters, Gabrielle T Belz, Marco Binder, Philip M Hansbro, Nicos A Nicola, Sandra E Nicholson

Journal article  |  2019  |  IMMUNOLOGY AND CELL BIOLOGY

The innate immune system is our first line of defense against viral pathogens. Host cell pattern recognition receptors sense viral..

Introduction to the Special Issue: The tumor microenvironment and molecular regulation of innate immune cells

Sandra E Nicholson, Stephanie S Watowich

Journal article  |  2019  |  MOLECULAR IMMUNOLOGY

SOCS-mediated immunomodulation of natural killer cells

Narelle Keating, Sandra E Nicholson

Journal article  |  2019  |  CYTOKINE

Natural killer (NK) cells are innate immune cells with an intrinsic ability to detect and kill infected and cancerous cells. The s..

Natural killer cells and anti-tumor immunity

Sandra E Nicholson, Narelle Keating, Gabrielle T Belz

Journal article  |  2019  |  MOLECULAR IMMUNOLOGY

Immune checkpoint inhibitors harness the power of the immune system to fight cancer. The clinical success achieved with antibodies..

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

Maiada M Sadek, Nicholas Barlow, Eleanor WW Leung, Billy Williams-Noonan, Beow Keat Yap, Fairolniza Mohd Shariff, Tom T Caradoc-Davies, Sandra E Nicholson, David K Chalmers, Philip E Thompson, Ruby HP Law, Raymond S Norton

Journal article  |  2018  |  ACS CHEMICAL BIOLOGY

SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4 interact with inducible nitric oxide synthase (iNOS), causin..

Identification of a second binding site on the TRIM25 B30.2 domain

Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael DW Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson

Journal article  |  2018  |  BIOCHEMICAL JOURNAL

The retinoic acid-inducible gene-I (RIG-I) receptor recognizes short 5'-di- and triphosphate base-paired viral RNA and is a critic..

Understanding SOCS protein specificity

Edmond M Linossi, Dale J Calleja, Sandra E Nicholson

Journal article  |  2018  |  GROWTH FACTORS

The development and activity of our immune system are largely controlled by the action of pleiotropic cytokines and growth factors..