I am interested in how the body initiates an innate immune response to infectious pathogens and then maintains ‘helpful’, rather than ‘damaging’ inflammatory responses.
The SOCS proteins are classic negative regulators that act as a handbrake to limit the damage associated with excessive pro-inflammatory cytokine signalling. TRIM proteins are another important class of intracellular proteins which both positively and negatively regulate innate immune signalling.
Our research program aims to understand the molecular detail of SOCS and TRIM protein complexes and how these signalling complexes are regulated in inflammatory and infectious disease. We are taking an integrated multi-disciplinary approach, which utilises in vivo model systems, quantitative proteomics and structural biology.Ultimately, I am interested in the connection between the deregulation of intracellular signalling and disease. Within this context, my research is focused on understanding how these protein families regulate innate immunity.
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Sandra Nicholson's highlights
FEATURED Journal article
Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylationRead more
Sandra Nicholson's selected work
RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses
Introduction to the Special Issue: The tumor microenvironment and molecular regulation of ..
Displaying the 85 most recent scholarly works by Sandra Nicholson.
RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses
Thomas J Hayman, Alan C Hsu, Tatiana B Kolesnik, Laura F Dagley, Joschka Willemsen, Michelle D Tate, Paul J Baker, Nadia J Kershaw, Lukasz Kedzierski, Andrew Webb, Peter A Wark, Katherine Kedzierska, Seth L Masters, Gabrielle T Belz, Marco Binder, Philip M Hansbro, Nicos A Nicola, Sandra E Nicholson
Journal article | 2019 | Immunology & Cell Biology
The innate immune system is our first line of defence against viral pathogens. Host cell pattern recognition receptors (PRRs) sens..
A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent
Maiada M Sadek, Nicholas Barlow, Eleanor WW Leung, Billy Williams-Noonan, Beow Keat Yap, Fairolniza Mohd Shariff, Tom T Caradoc-Davies, Sandra E Nicholson, David K Chalmers, Philip E Thompson, Ruby HP Law, Raymond S Norton
Journal article | 2018 | ACS Chemical Biology
Identification of a second binding site on the TRIM25 B30.2 domain
Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael DW Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson
Journal article | 2018 | Biochemical Journal
Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages
Maiada M Sadek, Mina Barzegar Amiri Olia, Cameron J Nowell, Nicholas Barlow, Carl H Schiesser, Sandra E Nicholson, Raymond S Norton
Journal article | 2017 | Bioorganic & Medicinal Chemistry
Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling
Lukasz Kedzierski, Michelle D Tate, Alan C Hsu, Tatiana B Kolesnik, Edmond M Linossi, Laura Dagley, Zhaoguang Dong, Sarah Freeman, Giuseppe Infusini, Malcolm R Starkey, Nicola L Bird, Simon M Chatfield, Jeffrey J Babon, Nicholas Huntington, Gabrielle Belz, Andrew webb, Peter AB Wark, Nicos A Nicola, Jianqing Xu, Katherine Kedzierska, et al.
Journal article | 2017 | eLife
Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7
Isobel D Lawrenson, Danielle L Krebs, Edmond M Linossi, Jian-Guo Zhang, Tamara J McLennan, Caitlin Collin, Helen M Mcrae, Tatiana B Kolesnik, Katrina Koh, Joanne M Britto, Andrew J Kueh, Bilal N Sheikh, Farrah El-Saafin, Nicos A Nicola, Seong-Seng Tan, Jeffrey J Babon, Sandra E Nicholson, Warren S Alexander, Tim Thomas, Anne K Voss
Journal article | 2017 | Cerebral Cortex
Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis
Eva M Putz, Camille Guillerey, Kevin Kos, Kimberley Stannard, Kim Miles, Rebecca B Delconte, Kazuyoshi Takeda, Sandra E Nicholson, Nicholas D Huntington, Mark J Smyth
Journal article | 2017 | OncoImmunology
Molecular Insights into the Interaction Between the SPRY Domain-Containing SOCS Box Protein SPSB2 and Peptides Based on the Binding Motif from iNOS
Eleanor WW Leung, Mark D Mulcair, Beow Keat Yap, Sandra E Nicholson, Martin J Scanlon, Raymond S Norton
Journal article | 2017 | Australian Journal of Chemistry
CIS is a potent checkpoint in NK cell-mediated tumor immunity
Rebecca B Delconte, Tatiana B Kolesnik, Laura F Dagley, Jai Rautela, Wei Shi, Eva M Putz, Kimberley Stannard, Jian-Guo Zhang, Charis Teh, Matt Firth, Takashi Ushiki, Christopher E Andoniou, Mariapia A Degli-Esposti, Phillip P Sharp, Caroline E Sanvitale, Giuseppe Infusini, Nicholas PD Liau, Edmond M Linossi, Christopher J Burns, Sebastian Carotta, et al.
Journal article | 2016 | Nature Immunology
Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase
Jitendra R Harjani, Beow Keat Yap, Eleanor WW Leung, Andrew Lucke, Sandra E Nicholson, Martin J Scanlon, David K Chalmers, Philip E Thompson, Raymond S Norton, Jonathan B Baell
Journal article | 2016 | Journal of Medicinal Chemistry
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
Seth L Masters, Vasiliki Lagou, Isabelle Jeru, Paul J Baker, Lien Van Eyck, David A Parry, Dylan Lawless, Dominic De Nardo, Josselyn E Garcia-Perez, Laura F Dagley, Caroline L Holley, James Dooley, Fiona Moghaddas, Emanuela Pasciuto, Pierre-Yves Jeandel, Raf Sciot, Dena Lyras, Andrew I Webb, Sandra E Nicholson, Lien De Somer, et al.
Journal article | 2016 | Science Translational Medicine
The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15
Rebecca B Delconte, Wei Shi, Priyanka Sathe, Takashi Ushiki, Cyril Seillet, Martina Minnich, Tatiana B Kolesnik, Lucille C Rankin, Lisa A Mielke, Jian-Guo Zhang, Meinrad Busslinger, Mark J Smyth, Dana S Hutchinson, Stephen L Nutt, Sandra E Nicholson, Warren S Alexander, Lynn M Corcoran, Eric Vivier, Gabrielle T Belz, Sebastian Carotta, et al.
Journal article | 2016 | Immunity
SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity
Lukasz Kedzierski, E Bridie Clemens, Nicola L Bird, Benjamin T Kile, Gabrielle T Belz, Nicos A Nicola, Katherine Kedzierska, Sandra E Nicholson
Journal article | 2015 | Immunology & Cell Biology
Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5
Indu R Chandrashekaran, Biswaranjan Mohanty, Edmond M Linossi, Laura F Dagley, Eleanor WW Leung, James M Murphy, Jeffrey J Babon, Sandra E Nicholson, Raymond S Norton
Journal article | 2015 | Biochemistry
Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons
Vera Gielen, Annemarie Sykes, Jie Zhu, Brian Chan, Jonathan Macintyre, Nicolas Regamey, Elisabeth Kieninger, Atul Gupta, Amelia Shoemark, Cara Bossley, Jane Davies, Sejal Saglani, Patrick Walker, Sandra E Nicholson, Alexander H Dalpke, Onn-Min Kon, Andrew Bush, Sebastian L Johnston, Michael R Edwards
Journal article | 2015 | Journal of Allergy and Clinical Immunology
Correction: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation (Proceedings of the National Academy of Sciences of the United States of America (1999) 96, 5 (2071-2076) DOI: 10.1073/pnas.96.5.2071)
JG Zhang, A Farley, SE Nicholson, TA Willson, LM Zugaro, RJ Simpson, RL Moritz, D Cary, R Richardson, G Hausmann, BT Kile, SBH Kent, WS Alexander, D Metcalf, DJ Hilton, NA Nicola, M Baca
Journal article | 2015 | Proceedings of the National Academy of Sciences
DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation
Ludovic Martinet, Lucas Ferrari De Andrade, Camille Guillerey, Jason S Lee, Jing Liu, Fernando Souza-Fonseca-Guimaraes, Dana S Hutchinson, Tatiana B Kolesnik, Sandra E Nicholson, Nicholas D Huntington, Mark J Smyth
Journal article | 2015 | Cell Reports
SOCS6 and SOCS7 Synergistically Regulate DAB1 Protein Levels and Cortical Neuron Migration.
ID Lawrenson, DL Krebs, EL Linossi, JG Zhang, TJ McLennan, C Collin, JM Britto, AJ Kueh, BN Sheikh, F El-Saafin, NA Nicola, S-S Tan, JJ babon, SE NICHOLSON, WS Alexander, T Thomas, AK voss
Journal article | 2015 | Cerebral Cortex
Key Role of Suppressor of Cytokine Signaling 3 in Regulating gp130 Cytokine-Induced Signaling and Limiting Chondrocyte Responses During Murine Inflammatory Arthritis
Xiao Liu, Ben A Croker, Ian K Campbell, Stephanie J Gauci, Warren S Alexander, Brett A Tonkin, Nicole C Walsh, Edmond M Linossi, Sandra E Nicholson, Kate E Lawlor, Ian P Wicks
Journal article | 2014 | Arthritis & Rheumatology
Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells
Priyanka Sathe, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Cyril Seillet, Michael Chopin, Cassandra J Vandenberg, Lucille C Rankin, Lisa A Mielke, Ingela Vikstrom, Tatiana B Kolesnik, Sandra E Nicholson, Eric Vivier, Mark J Smyth, Stephen L Nutt, Stefan P Glaser, Andreas Strasser, Gabrielle T Belz, Sebastian Carotta, Nicholas D Huntington
Journal article | 2014 | Nature Communications
Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection
Lukasz Kedzierski, Edmond M Linossi, Tatiana B Kolesnik, E Bridie Day, Nicola L Bird, Benjamin T Kile, Gabrielle T Belz, Donald Metcalf, Nicos A Nicola, Katherine Kedzierska, Sandra E Nicholson
Journal article | 2014 | PLOS PATHOGENS
Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1
Edmond M Linossi, Indu R Chandrashekaran, Tatiana B Kolesnik, James M Murphy, Andrew I Webb, Tracy A Willson, Lukasz Kedzierski, Alex N Bullock, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson
Journal article | 2013 | PLOS ONE
Detection of endogenous SOCS1 and SOCS3 proteins by immunoprecipitation and Western blot analysis.
Jian-Guo Zhang, Sandra E Nicholson
Journal article | 2013 | Methods in molecular biology (Clifton, N.J.)
The suppressors of cytokine signalling (SOCS) protein family consist of eight members (SOCS 1-7, and CIS). SOCS1 and SOCS3 are the..
Analysis of Suppressor of Cytokine Signalling (SOCS) gene expression by real-time quantitative PCR.
Tatiana B Kolesnik, Sandra E Nicholson
Journal article | 2013 | Methods in molecular biology (Clifton, N.J.)
The Suppressor of Cytokine Signalling (SOCS) proteins are a family of negative regulators characterized by a central SH2 domain an..
Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon alpha Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2
Rebecca AR Piganis, Nicole A De Weerd, Jodee A Gould, Christian W Schindler, Ashley Mansell, Sandra E Nicholson, Paul J Hertzog
Journal article | 2011 | Journal of Biological Chemistry
Suppressor of Cytokine Signaling 1 Regulates Embryonic Myelopoiesis Independently of Its Effects on T Cell Development
Lynda A O'Sullivan, Suzita M Noor, Monique C Trengove, Rowena S Lewis, Clifford Liongue, Naomi S Sprigg, Sandra E Nicholson, Alister C Ward
Journal article | 2011 | The Journal of Immunology
Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4
Panagis Filippakopoulos, Andrew Low, Timothy D Sharpe, Jonas Uppenberg, Shenggen Yao, Zhihe Kuang, Pavel Savitsky, Rowena S Lewis, Sandra E Nicholson, Raymond S Norton, Alex N Bullock
Journal article | 2010 | Journal of Molecular Biology
The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation
Zhihe Kuang, Rowena S Lewis, Joan M Curtis, Yifan Zhan, Bernadette M Saunders, Jeffrey J Babon, Tatiana B Kolesnik, Andrew Low, Seth L Masters, Tracy A Willson, Lukasz Kedzierski, Shenggen Yao, Emanuela Handman, Raymond S Norton, Sandra E Nicholson
Journal article | 2010 | The Journal of Cell Biology
Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation
Kristy Boyle, Jian-Guo Zhang, Sandra E Nicholson, Evelyn Trounson, Jeffery J Babon, Edward J McManus, Nicos A Nicola, Lorraine Robb
Journal article | 2009 | Cellular Signalling
SPRY Domain-Containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding
Z Kuang, S Yao, Y Xu, RS Lewis, A Low, SL Masters, TA Willson, TB Kolesnik, SE Nicholson, TJP Garrett, RS Norton
Journal article | 2009 | Journal of Molecular Biology
The four mammalian SPRY (a sequence repeat in dual-specificity kinase splA and ryanodine receptors) domain-containing suppressor o..
The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability
JJ Babon, EJ McManus, SG Yao, DP DeSouza, LA Mielke, NS Sprigg, TA Willson, DJ Hilton, NA Nicola, M Baca, SE Nicholson, RS Norton
Journal article | 2006 | Molecular Cell
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling
SE Nicholson, D Metcalf, NS Sprigg, R Columbus, F Walker, A Silva, D Cary, TA Willson, JG Zhang, DJ Hilton, WS Alexander, NA Nicola
Journal article | 2005 | Proceedings of the National Academy of Sciences of the United States of America
SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function
C Brender, R Columbus, D Metcalf, E Handman, R Starr, N Huntington, D Tarlinton, N Odum, SE Nicholson, NA Nicola, DJ Hilton, WS Alexander
Journal article | 2004 | Molecular and Cellular Biology
SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation
DL Krebs, RT Uren, D Metcalf, S Rakar, JG Zhang, R Starr, DP De Souza, K Hanzinikolas, J Eyles, LM Connolly, RJ Simpson, NA Nicola, SE Nicholson, M Baca, DJ Hilton, WS Alexander
Journal article | 2002 | Molecular and Cellular Biology
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
JG Zhang, D Metcalf, S Rakar, M Asimakis, CJ Greenhalgh, TA Willson, R Starr, SE Nicholson, W Carter, WS Alexander, DJ Hilton, NA Nicola
Journal article | 2001 | Proceedings of the National Academy of Sciences
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
SE Nicholson, D De Souza, LJ Fabri, J Corbin, TA Willson, JG Zhang, A Silva, M Asimakis, A Farley, AD Nash, D Metcalf, DJ Hilton, NA Nicola, M Baca
Journal article | 2000 | Proceedings of the National Academy of Sciences
Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction
WS Alexander, R Starr, D Metcalf, SE Nicholson, A Farley, AG Elefanty, M Brysha, BT Kile, R Richardson, M Baca, JG Zhang, TA Willson, EM Viney, NS Sprigg, S Rakar, J Corbin, S Mifsud, L DiRago, D Cary, NA Nicola, et al.
Journal article | 1999 | Journal of Leukocyte Biology
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
JG Zhang, A Farley, SE Nicholson, TA Willson, LM Zugaro, RJ Simpson, RL Moritz, D Cary, R Richardson, G Hausmann, BJ Kile, SBH Kent, WS Alexander, D Metcalf, DJ Hilton, NA Nicola, M Baca
Journal article | 1999 | Proceedings of the National Academy of Sciences
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
SE Nicholson, TA Willson, A Farley, R Starr, JG Zhang, M Baca, WS Alexander, D Metcalf, DJ Hilton, NA Nicola
Journal article | 1999 | The EMBO Journal
CSF-1 and interferon-gamma act synergistically to promote differentiation of FDC-P1 cells into macrophages.
U Novak, S Nicholson, RP Bourette, LR Rohrschneider, W Alexander, L Paradiso
Journal article | 1998 | Growth Factors
FDC-P1 cells expressing the wildtype CSF-1 receptor, FDwtfms, differentiate into macrophages during incubation with CSF-1. This re..
Neutralising antibodies to the granulocyte colony-stimulating factor receptor recognise both the immunoglobulin-like domain and the cytokine receptor homologous domain.
JE Layton, J Iaria, SE Nicholson
Journal article | 1997 | Growth Factors
To define regions of the granulocyte colony-stimulating factor (G-CSF) receptor that are important for ligand binding, neutralisin..
Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.
SE Nicholson, AC Oates, AG Harpur, A Ziemiecki, AF Wilks, JE Layton
Journal article | 1994 | Proceedings of the National Academy of Sciences
Granulocyte-colony-stimulating factor (G-CSF) stimulates the proliferation and differentiation of cells of the neutrophil lineage ..