Sandra Nicholson

Natural Killer Cells: Tumor Surveillance and Signaling

Lizeth G Meza Guzman, Narelle Keating, Sandra E Nicholson

Journal article  |  2020  |  Cancers

Natural killer (NK) cells play a pivotal role in cancer immunotherapy due to their innate ability to detect and kill tumorigenic c..

RIPLET, and not TRIM25, is required for endogenous RIG-I-dependent antiviral responses

Thomas J Hayman, Alan C Hsu, Tatiana B Kolesnik, Laura F Dagley, Joschka Willemsen, Michelle D Tate, Paul J Baker, Nadia J Kershaw, Lukasz Kedzierski, Andrew Webb, Peter A Wark, Katherine Kedzierska, Seth L Masters, Gabrielle T Belz, Marco Binder, Philip M Hansbro, Nicos A Nicola, Sandra E Nicholson

Journal article  |  2019  |  Immunology & Cell Biology

The innate immune system is our first line of defence against viral pathogens. Host cell pattern recognition receptors (PRRs) sens..

Introduction to the Special Issue: The tumor microenvironment and molecular regulation of innate immune cells

Sandra E Nicholson, Stephanie S Watowich

Journal article  |  2019  |  Molecular Immunology

SOCS-mediated immunomodulation of natural killer cells

Narelle Keating, Sandra E Nicholson

Journal article  |  2019  |  Cytokine

Natural killer cells and anti-tumor immunity

Sandra E Nicholson, Narelle Keating, Gabrielle T Belz

Journal article  |  2019  |  Molecular Immunology

A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent

Maiada M Sadek, Nicholas Barlow, Eleanor WW Leung, Billy Williams-Noonan, Beow Keat Yap, Fairolniza Mohd Shariff, Tom T Caradoc-Davies, Sandra E Nicholson, David K Chalmers, Philip E Thompson, Ruby HP Law, Raymond S Norton

Journal article  |  2018  |  ACS Chemical Biology

Identification of a second binding site on the TRIM25 B30.2 domain

Akshay A D'Cruz, Nadia J Kershaw, Thomas J Hayman, Edmond M Linossi, Jessica J Chiang, May K Wang, Laura F Dagley, Tatiana B Kolesnik, Jian-Guo Zhang, Seth L Masters, Michael DW Griffin, Michaela U Gack, James M Murphy, Nicos A Nicola, Jeffrey J Babon, Sandra E Nicholson

Journal article  |  2018  |  Biochemical Journal

Understanding SOCS protein specificity

Edmond M Linossi, Dale J Calleja, Sandra E Nicholson

Journal article  |  2018  |  Growth Factors

Characterisation of a novel coumarin-based fluorescent probe for monitoring nitric oxide production in macrophages

Maiada M Sadek, Mina Barzegar Amiri Olia, Cameron J Nowell, Nicholas Barlow, Carl H Schiesser, Sandra E Nicholson, Raymond S Norton

Journal article  |  2017  |  Bioorganic & Medicinal Chemistry

Suppressor of cytokine signaling (SOCS)5 ameliorates influenza infection via inhibition of EGFR signaling

Lukasz Kedzierski, Michelle D Tate, Alan C Hsu, Tatiana B Kolesnik, Edmond M Linossi, Laura Dagley, Zhaoguang Dong, Sarah Freeman, Giuseppe Infusini, Malcolm R Starkey, Nicola L Bird, Simon M Chatfield, Jeffrey J Babon, Nicholas Huntington, Gabrielle Belz, Andrew webb, Peter AB Wark, Nicos A Nicola, Jianqing Xu, Katherine Kedzierska, et al.

Journal article  |  2017  |  eLife

Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7

Isobel D Lawrenson, Danielle L Krebs, Edmond M Linossi, Jian-Guo Zhang, Tamara J McLennan, Caitlin Collin, Helen M Mcrae, Tatiana B Kolesnik, Katrina Koh, Joanne M Britto, Andrew J Kueh, Bilal N Sheikh, Farrah El-Saafin, Nicos A Nicola, Seong-Seng Tan, Jeffrey J Babon, Sandra E Nicholson, Warren S Alexander, Tim Thomas, Anne K Voss

Journal article  |  2017  |  Cerebral Cortex

Targeting cytokine signaling checkpoint CIS activates NK cells to protect from tumor initiation and metastasis

Eva M Putz, Camille Guillerey, Kevin Kos, Kimberley Stannard, Kim Miles, Rebecca B Delconte, Kazuyoshi Takeda, Sandra E Nicholson, Nicholas D Huntington, Mark J Smyth

Journal article  |  2017  |  OncoImmunology

Molecular Insights into the Interaction Between the SPRY Domain-Containing SOCS Box Protein SPSB2 and Peptides Based on the Binding Motif from iNOS

Eleanor WW Leung, Mark D Mulcair, Beow Keat Yap, Sandra E Nicholson, Martin J Scanlon, Raymond S Norton

Journal article  |  2017  |  Australian Journal of Chemistry

CIS is a potent checkpoint in NK cell-mediated tumor immunity

Rebecca B Delconte, Tatiana B Kolesnik, Laura F Dagley, Jai Rautela, Wei Shi, Eva M Putz, Kimberley Stannard, Jian-Guo Zhang, Charis Teh, Matt Firth, Takashi Ushiki, Christopher E Andoniou, Mariapia A Degli-Esposti, Phillip P Sharp, Caroline E Sanvitale, Giuseppe Infusini, Nicholas PD Liau, Edmond M Linossi, Christopher J Burns, Sebastian Carotta, et al.

Journal article  |  2016  |  Nature Immunology

Design, Synthesis, and Characterization of Cyclic Peptidomimetics of the Inducible Nitric Oxide Synthase Binding Epitope That Disrupt the Protein-Protein Interaction Involving SPRY Domain-Containing Suppressor of Cytokine Signaling Box Protein (SPSB) 2 and Inducible Nitric Oxide Synthase

Jitendra R Harjani, Beow Keat Yap, Eleanor WW Leung, Andrew Lucke, Sandra E Nicholson, Martin J Scanlon, David K Chalmers, Philip E Thompson, Raymond S Norton, Jonathan B Baell

Journal article  |  2016  |  Journal of Medicinal Chemistry

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

Seth L Masters, Vasiliki Lagou, Isabelle Jeru, Paul J Baker, Lien Van Eyck, David A Parry, Dylan Lawless, Dominic De Nardo, Josselyn E Garcia-Perez, Laura F Dagley, Caroline L Holley, James Dooley, Fiona Moghaddas, Emanuela Pasciuto, Pierre-Yves Jeandel, Raf Sciot, Dena Lyras, Andrew I Webb, Sandra E Nicholson, Lien De Somer, et al.

Journal article  |  2016  |  Science Translational Medicine

Redox-stable cyclic peptide inhibitors of the SPSB2-iNOS interaction

Beow Keat Yap, Jitendra R Harjani, Eleanor WW Leung, Sandra E Nicholson, Martin J Scanlon, David K Chalmers, Philip E Thompson, Jonathan B Baell, Raymond S Norton

Journal article  |  2016  |  FEBS Letters

The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15

Rebecca B Delconte, Wei Shi, Priyanka Sathe, Takashi Ushiki, Cyril Seillet, Martina Minnich, Tatiana B Kolesnik, Lucille C Rankin, Lisa A Mielke, Jian-Guo Zhang, Meinrad Busslinger, Mark J Smyth, Dana S Hutchinson, Stephen L Nutt, Sandra E Nicholson, Warren S Alexander, Lynn M Corcoran, Eric Vivier, Gabrielle T Belz, Sebastian Carotta, et al.

Journal article  |  2016  |  Immunity

The JAK-STAT-SOCS Signaling Cascade

JM Murphy, JJ Babon, NA Nicola, SE Nicholson

Book Chapter  |  2016

SOCS4 is dispensable for an efficient recall response to influenza despite being required for primary immunity

Lukasz Kedzierski, E Bridie Clemens, Nicola L Bird, Benjamin T Kile, Gabrielle T Belz, Nicos A Nicola, Katherine Kedzierska, Sandra E Nicholson

Journal article  |  2015  |  Immunology & Cell Biology

Structure and Functional Characterization of the Conserved JAK Interaction Region in the Intrinsically Disordered N-Terminus of SOCS5

Indu R Chandrashekaran, Biswaranjan Mohanty, Edmond M Linossi, Laura F Dagley, Eleanor WW Leung, James M Murphy, Jeffrey J Babon, Sandra E Nicholson, Raymond S Norton

Journal article  |  2015  |  Biochemistry

SPSB1, a Novel Negative Regulator of the Transforming Growth Factor-beta Signaling Pathway Targeting the Type II Receptor

Sheng Liu, Thao Nheu, Rodney Luwor, Sandra E Nicholson, Hong-Jian Zhu

Journal article  |  2015  |  Journal of Biological Chemistry

Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons

Vera Gielen, Annemarie Sykes, Jie Zhu, Brian Chan, Jonathan Macintyre, Nicolas Regamey, Elisabeth Kieninger, Atul Gupta, Amelia Shoemark, Cara Bossley, Jane Davies, Sejal Saglani, Patrick Walker, Sandra E Nicholson, Alexander H Dalpke, Onn-Min Kon, Andrew Bush, Sebastian L Johnston, Michael R Edwards

Journal article  |  2015  |  Journal of Allergy and Clinical Immunology

Kinase inhibition, competitive binding and proteasomal degradation: resolving the molecular function of the suppressor of cytokine signaling (SOCS) proteins

Edmond M Linossi, Sandra E Nicholson

Journal article  |  2015  |  Immunological Reviews

Correction: The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation (Proceedings of the National Academy of Sciences of the United States of America (1999) 96, 5 (2071-2076) DOI: 10.1073/pnas.96.5.2071)

JG Zhang, A Farley, SE Nicholson, TA Willson, LM Zugaro, RJ Simpson, RL Moritz, D Cary, R Richardson, G Hausmann, BT Kile, SBH Kent, WS Alexander, D Metcalf, DJ Hilton, NA Nicola, M Baca

Journal article  |  2015  |  Proceedings of the National Academy of Sciences

DNAM-1 Expression Marks an Alternative Program of NK Cell Maturation

Ludovic Martinet, Lucas Ferrari De Andrade, Camille Guillerey, Jason S Lee, Jing Liu, Fernando Souza-Fonseca-Guimaraes, Dana S Hutchinson, Tatiana B Kolesnik, Sandra E Nicholson, Nicholas D Huntington, Mark J Smyth

Journal article  |  2015  |  Cell Reports

SOCS6 and SOCS7 Synergistically Regulate DAB1 Protein Levels and Cortical Neuron Migration.

ID Lawrenson, DL Krebs, EL Linossi, JG Zhang, TJ McLennan, C Collin, JM Britto, AJ Kueh, BN Sheikh, F El-Saafin, NA Nicola, S-S Tan, JJ babon, SE NICHOLSON, WS Alexander, T Thomas, AK voss

Journal article  |  2015  |  Cerebral Cortex

Key Role of Suppressor of Cytokine Signaling 3 in Regulating gp130 Cytokine-Induced Signaling and Limiting Chondrocyte Responses During Murine Inflammatory Arthritis

Xiao Liu, Ben A Croker, Ian K Campbell, Stephanie J Gauci, Warren S Alexander, Brett A Tonkin, Nicole C Walsh, Edmond M Linossi, Sandra E Nicholson, Kate E Lawlor, Ian P Wicks

Journal article  |  2014  |  Arthritis & Rheumatology

A Potent Cyclic Peptide Targeting SPSB2 Protein as a Potential Anti-infective Agent

Beow Keat Yap, Eleanor WW Leung, Hiromasa Yagi, Charles A Galea, Sandeep Chhabra, David K Chalmers, Sandra E Nicholson, Philip E Thompson, Raymond S Norton

Journal article  |  2014  |  Journal of Medicinal Chemistry

Innate immunodeficiency following genetic ablation of Mcl1 in natural killer cells

Priyanka Sathe, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Cyril Seillet, Michael Chopin, Cassandra J Vandenberg, Lucille C Rankin, Lisa A Mielke, Ingela Vikstrom, Tatiana B Kolesnik, Sandra E Nicholson, Eric Vivier, Mark J Smyth, Stephen L Nutt, Stefan P Glaser, Andreas Strasser, Gabrielle T Belz, Sebastian Carotta, Nicholas D Huntington

Journal article  |  2014  |  Nature Communications

Regulation of macrophage polarization by the STAT-SOCS signaling axis

SE Nicholson, PJ Murray

Book Chapter  |  2014

Suppressor of Cytokine Signaling 4 (SOCS4) Protects against Severe Cytokine Storm and Enhances Viral Clearance during Influenza Infection

Lukasz Kedzierski, Edmond M Linossi, Tatiana B Kolesnik, E Bridie Day, Nicola L Bird, Benjamin T Kile, Gabrielle T Belz, Donald Metcalf, Nicos A Nicola, Katherine Kedzierska, Sandra E Nicholson

Journal article  |  2014  |  PLOS PATHOGENS

Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling

Akshay A D'Cruz, Nadia J Kershaw, Jessica J Chiang, May K Wang, Nicos A Nicola, Jeffrey J Babon, Michaela U Gack, Sandra E Nicholson

Journal article  |  2013  |  Biochemical Journal

Suppressor of Cytokine Signaling (SOCS) 5 Utilises Distinct Domains for Regulation of JAK1 and Interaction with the Adaptor Protein Shc-1

Edmond M Linossi, Indu R Chandrashekaran, Tatiana B Kolesnik, James M Murphy, Andrew I Webb, Tracy A Willson, Lukasz Kedzierski, Alex N Bullock, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson

Journal article  |  2013  |  PLOS ONE

Suppression of cytokine signaling: The SOCS perspective

Edmond M Linossi, Jeffrey J Babon, Douglas J Hilton, Sandra E Nicholson

Journal article  |  2013  |  Cytokine & Growth Factor Reviews

Detection of endogenous SOCS1 and SOCS3 proteins by immunoprecipitation and Western blot analysis.

Jian-Guo Zhang, Sandra E Nicholson

Journal article  |  2013  |  Methods in molecular biology (Clifton, N.J.)

The suppressors of cytokine signalling (SOCS) protein family consist of eight members (SOCS 1-7, and CIS). SOCS1 and SOCS3 are the..

Analysis of Suppressor of Cytokine Signalling (SOCS) gene expression by real-time quantitative PCR.

Tatiana B Kolesnik, Sandra E Nicholson

Journal article  |  2013  |  Methods in molecular biology (Clifton, N.J.)

The Suppressor of Cytokine Signalling (SOCS) proteins are a family of negative regulators characterized by a central SH2 domain an..

Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity

Akshay A D'Cruz, Jeffrey J Babon, Raymond S Norton, Nicos A Nicola, Sandra E Nicholson

Journal article  |  2013  |  Protein Science

Preface

SE Nicholson, NA Nicola

Book  |  2013  |  Methods in Molecular Biology

The anti-inflammatory actions of IL-4 in human monocytes are not mediated by IL-10, RP105 or the kinase activity of RIPK2

Eleanor A Woodward, Tatiana B Kolesnik, Sandra E Nicholson, Cecilia M Prele, Prue H Hart

Journal article  |  2012  |  Cytokine

The SOCS boxuAdapting proteins for ubiquitination and proteasomal degradation

Edmond M Linossi, Sandra E Nicholson

Journal article  |  2012  |  IUBMB Life

Biology and significance of the JAK/STAT signalling pathways

Hiu Kiu, Sandra E Nicholson

Journal article  |  2012  |  Growth Factors

The N-terminal domains of SOCS proteins: A conserved region in the disordered N-termini of SOCS4 and 5

Zhi-Ping Feng, Indu R Chandrashekaran, Andrew Low, Terence P Speed, Sandra E Nicholson, Raymond S Norton

Journal article  |  2012  |  Proteins - Structure, Function, and Bioinformatics

TLR Regulation of SPSB1 Controls Inducible Nitric Oxide Synthase Induction

Rowena S Lewis, Tatiana B Kolesnik, Zhihe Kuang, Akshay A D'Cruz, Marnie E Blewitt, Seth L Masters, Andrew Low, Tracy Willson, Raymond S Norton, Sandra E Nicholson

Journal article  |  2011  |  Journal of Immunology

Suppressor of Cytokine Signaling (SOCS) 1 Inhibits Type I Interferon (IFN) Signaling via the Interferon alpha Receptor (IFNAR1)-associated Tyrosine Kinase Tyk2

Rebecca AR Piganis, Nicole A De Weerd, Jodee A Gould, Christian W Schindler, Ashley Mansell, Sandra E Nicholson, Paul J Hertzog

Journal article  |  2011  |  Journal of Biological Chemistry

Suppressor of Cytokine Signaling 1 Regulates Embryonic Myelopoiesis Independently of Its Effects on T Cell Development

Lynda A O'Sullivan, Suzita M Noor, Monique C Trengove, Rowena S Lewis, Clifford Liongue, Naomi S Sprigg, Sandra E Nicholson, Alister C Ward

Journal article  |  2011  |  The Journal of Immunology

The anti-inflammatory effects of interleukin-4 are not mediated by suppressor of cytokine signalling-1 (SOCS1)

Eleanor A Woodward, Cecilia M Prele, Sandra E Nicholson, Tatiana B Kolesnik, Prue H Hart

Journal article  |  2010  |  Immunology

Structural Basis for Par-4 Recognition by the SPRY Domain- and SOCS Box-Containing Proteins SPSB1, SPSB2, and SPSB4

Panagis Filippakopoulos, Andrew Low, Timothy D Sharpe, Jonas Uppenberg, Shenggen Yao, Zhihe Kuang, Pavel Savitsky, Rowena S Lewis, Sandra E Nicholson, Raymond S Norton, Alex N Bullock

Journal article  |  2010  |  Journal of Molecular Biology

The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation

Zhihe Kuang, Rowena S Lewis, Joan M Curtis, Yifan Zhan, Bernadette M Saunders, Jeffrey J Babon, Tatiana B Kolesnik, Andrew Low, Seth L Masters, Tracy A Willson, Lukasz Kedzierski, Shenggen Yao, Emanuela Handman, Raymond S Norton, Sandra E Nicholson

Journal article  |  2010  |  The Journal of Cell Biology

Suppressor of cytokine signalling 1 (SOCS1) is a physiological regulator of the asthma response

C Lee, TB Kolesnik, I Caminschi, A Chakravorty, W Carter, WS Alexander, J Jones, GP Anderson, SE Nicholson

Journal article  |  2009  |  Clinical and Experimental Allergy

Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

Kristy Boyle, Jian-Guo Zhang, Sandra E Nicholson, Evelyn Trounson, Jeffery J Babon, Edward J McManus, Nicos A Nicola, Lorraine Robb

Journal article  |  2009  |  Cellular Signalling

SPRY Domain-Containing SOCS Box Protein 2: Crystal Structure and Residues Critical for Protein Binding

Z Kuang, S Yao, Y Xu, RS Lewis, A Low, SL Masters, TA Willson, TB Kolesnik, SE Nicholson, TJP Garrett, RS Norton

Journal article  |  2009  |  Journal of Molecular Biology

The four mammalian SPRY (a sequence repeat in dual-specificity kinase splA and ryanodine receptors) domain-containing suppressor o..

SOCS1 Regulates the IFN but Not NF kappa B Pathway in TLR-Stimulated Human Monocytes and Macrophages

Cecilia M Prele, Eleanor A Woodward, Jacqueline Bisley, April Keith-Magee, Sandra E Nicholson, Prue H Hart

Journal article  |  2008  |  The Journal of Immunology

SOCS regulation of the JAK/STAT signalling pathway

Ben A Croker, Hiu Kiu, Sandra E Nicholson

Journal article  |  2008  |  Semin. Cell. Dev. Biol.

The IL-4/IL-13/Stat6 signalling pathway promotes luminal mammary epithelial cell development

Walid T Khaled, Eliot KC Read, Sandra E Nicholson, Fiona O Baxter, Amelia J Brennan, Paul J Came, Naomi Sprigg, Andrew NJ McKenzie, Christine J Watson

Journal article  |  2007  |  Development

Dynamics of the SPRY domain-containing SOCS box protein 2: Flexibility of key functional loops

Shenggen Yao, Ming S Liu, Seth L Masters, Jian-Guo Zhang, Jeffrey J Babon, Nicos A Nicola, Sandra E Nicholson, Raymond S Norton

Journal article  |  2006  |  Protein Science

The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability

JJ Babon, EJ McManus, SG Yao, DP DeSouza, LA Mielke, NS Sprigg, TA Willson, DJ Hilton, NA Nicola, M Baca, SE Nicholson, RS Norton

Journal article  |  2006  |  Molecular Cell

Suppressor of cytokine signaling 1 negatively regulates Toll-like receptor signaling by mediating Mal degradation

A Mansell, R Smith, SL Doyle, P Gray, JE Fenner, PJ Crack, SE Nicholson, DJ Hilton, LAJ O'Neill, PJ Hertzog

Journal article  |  2006  |  Nature Immunology

The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues

SL Masters, SG Yao, TA Willson, JG Zhang, KR Palmer, BJ Smith, JJ Babon, NA Nicola, RS Norton, SE Nicholson

Journal article  |  2006  |  Nature Structural & Molecular Biology

Genetic deletion of murine SPRY domain-containing SOCS box protein 2 (SSB-2) results in very mild thrombocytopenia

SL Masters, KR Palmer, WS Stevenson, D Metcalf, EM Viney, NS Sprigg, WS Alexander, NA Nicola, SE Nicholson

Journal article  |  2005  |  Molecular and Cellular Biology

Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling

SE Nicholson, D Metcalf, NS Sprigg, R Columbus, F Walker, A Silva, D Cary, TA Willson, JG Zhang, DJ Hilton, WS Alexander, NA Nicola

Journal article  |  2005  |  Proceedings of the National Academy of Sciences of the United States of America

Backbone H-1, C-13 and N-15 assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2)

SG Yao, S Masters, JG Zhang, K Palmer, J Babon, N Nicola, S Nicholson, R Norton

Journal article  |  2005  |  Journal of Biomolecular NMR

SOCS5 is expressed in primary B and T lymphoid cells but is dispensable for lymphocyte production and function

C Brender, R Columbus, D Metcalf, E Handman, R Starr, N Huntington, D Tarlinton, N Odum, SE Nicholson, NA Nicola, DJ Hilton, WS Alexander

Journal article  |  2004  |  Molecular and Cellular Biology

Contribution of the membrane-distal tyrosine in intracellular signaling by the granulocyte colony-stimulating factor receptor

TS Kendrick, RJ Lipscombe, O Rausch, SE Nicholson, JE Layton, LC Goldie-Cregan, MA Bogoyevitch

Journal article  |  2004  |  Journal of Biological Chemistry

SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation

DL Krebs, RT Uren, D Metcalf, S Rakar, JG Zhang, R Starr, DP De Souza, K Hanzinikolas, J Eyles, LM Connolly, RJ Simpson, NA Nicola, SE Nicholson, M Baca, DJ Hilton, WS Alexander

Journal article  |  2002  |  Molecular and Cellular Biology

The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo

JG Zhang, D Metcalf, S Rakar, M Asimakis, CJ Greenhalgh, TA Willson, R Starr, SE Nicholson, W Carter, WS Alexander, DJ Hilton, NA Nicola

Journal article  |  2001  |  Proceedings of the National Academy of Sciences

Preconditions for spontaneous agroforestry in hilly regions of Vietnam - implications for extension

PV WOODS, RJ PETHERAM

Conference Proceedings  |  2001  |  Assisting forest owners, farmers and stakeholder decision-making

Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130

SE Nicholson, D De Souza, LJ Fabri, J Corbin, TA Willson, JG Zhang, A Silva, M Asimakis, A Farley, AD Nash, D Metcalf, DJ Hilton, NA Nicola, M Baca

Journal article  |  2000  |  Proceedings of the National Academy of Sciences

Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction

WS Alexander, R Starr, D Metcalf, SE Nicholson, A Farley, AG Elefanty, M Brysha, BT Kile, R Richardson, M Baca, JG Zhang, TA Willson, EM Viney, NS Sprigg, S Rakar, J Corbin, S Mifsud, L DiRago, D Cary, NA Nicola, et al.

Journal article  |  1999  |  Journal of Leukocyte Biology

The carboxyl-terminal domains of gp130-related cytokine receptors are necessary for suppressing embryonic stem cell differentiation - Involvement of STAT3

M Ernst, U Novak, SE Nicholson, JE Layton, AR Dunn

Journal article  |  1999  |  Journal of Biological Chemistry

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

JG Zhang, A Farley, SE Nicholson, TA Willson, LM Zugaro, RJ Simpson, RL Moritz, D Cary, R Richardson, G Hausmann, BJ Kile, SBH Kent, WS Alexander, D Metcalf, DJ Hilton, NA Nicola, M Baca

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction

SE Nicholson, TA Willson, A Farley, R Starr, JG Zhang, M Baca, WS Alexander, D Metcalf, DJ Hilton, NA Nicola

Journal article  |  1999  |  The EMBO Journal

Differential ability of SOCS proteins to regulate IL-6 and CSF-1 induced macrophage differentiation

U Novak, D Marks, SE Nicholson, D Hilton, L Paradiso

Journal article  |  1999  |  Growth Factors

Negative regulation of cytokine signaling by the SOCS proteins

NA Nicola, SE Nicholson, D Metcalf, JG Zhang, M Baca, A Farley, TA Willson, R Starr, W Alexander, DJ Hilton

Conference Proceedings  |  1999  |  Cold Spring Harbor Symposia on Quantitative Biology

The SOCS proteins: a new family of negative regulators of signal transduction

SE Nicholson, DJ Hilton

Conference Proceedings  |  1998  |  Journal of Leukocyte Biology

Twenty proteins containing a C-terminal SOCS box form five structural classes

DJ Hilton, RT Richardson, WS Alexander, EM Viney, TA Willson, NS Sprigg, R Starr, SE Nicholson, D Metcalf, NA Nicola

Journal article  |  1998  |  Proceedings of the National Academy of Sciences

CSF-1 and interferon-gamma act synergistically to promote differentiation of FDC-P1 cells into macrophages.

U Novak, S Nicholson, RP Bourette, LR Rohrschneider, W Alexander, L Paradiso

Journal article  |  1998  |  Growth Factors

FDC-P1 cells expressing the wildtype CSF-1 receptor, FDwtfms, differentiate into macrophages during incubation with CSF-1. This re..

Cytokines. Granulocyte colony-stimulating factor

JE Layton, S Nicholson, R Basser, J Cebon

Book  |  1997  |  Growth Factors and Cytokines in Health and Disease

Neutralising antibodies to the granulocyte colony-stimulating factor receptor recognise both the immunoglobulin-like domain and the cytokine receptor homologous domain.

JE Layton, J Iaria, SE Nicholson

Journal article  |  1997  |  Growth Factors

To define regions of the granulocyte colony-stimulating factor (G-CSF) receptor that are important for ligand binding, neutralisin..

Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF induced differentiation of murine myeloid leukemic (M1) cells

SE Nicholson, R Starr, U Novak, DJ Hilton, JE Layton

Journal article  |  1996  |  Journal of Biological Chemistry

DISTINCT REGIONS OF THE GRANULOCYTE-COLONY-STIMULATING FACTOR-RECEPTOR ARE REQUIRED FOR TYROSINE PHOSPHORYLATION OF THE SIGNALING MOLECULES JAK2, STAT3, AND P42, P44(MAPK)

SE NICHOLSON, U NOVAK, SF ZIEGLER, LE LAYTON

Journal article  |  1995  |  Blood

Tyrosine kinase JAK1 is associated with the granulocyte-colony-stimulating factor receptor and both become tyrosine-phosphorylated after receptor activation.

SE Nicholson, AC Oates, AG Harpur, A Ziemiecki, AF Wilks, JE Layton

Journal article  |  1994  |  Proceedings of the National Academy of Sciences

Granulocyte-colony-stimulating factor (G-CSF) stimulates the proliferation and differentiation of cells of the neutrophil lineage ..

Taxotere inhibits in-vitro growth of human colonic cancer cell lines

E Karantanis, S NICHOLSON, DL Morris

Journal article  |  1994  |  EJSO - European Journal of Surgical Oncology

The growth of carcinogen-induced colon cancer in rats is inhibited by cimetidine

W Adams, J Lawson, S Nicholson, DL Morris

Journal article  |  1992  |  Regulatory Peptides

Glucose repression of pigment production in atypical isolates of Aeromonas salmonicida

K Altmann, M Marshall, S NICHOLSON, PJ Hanna, N Gudkovs

Journal article  |  1992  |  Australian Journal of Chemistry