Patrick Humbert

The polarity protein Scrib limits atherosclerosis development in mice

Christoph Schuermann, Franziska L Dienst, Katalin Palfi, Andrea E Vasconez, James A Oo, ShengPeng Wang, Giulia K Buchmann, Stefan Offermanns, Bart van de Sluis, Matthias S Leisegang, Stefan Guenther, Patrick O Humbert, Eunjee Lee, Jun Zhu, Andreas Weigert, Praveen Mathoor, Ilka Wittig, Christoph Kruse, Ralf P Brandes

Journal article  |  2019  |  Cardiovascular Research

AIMS: The protein Scrib (Scribble 1) is known to control apico-basal polarity in epithelial cells. The role of polarity proteins i..

Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains

Sofia Caria, Bryce Z Stewart, Ruitao Jin, Brian J Smith, Patrick O Humbert, Marc Kvansakul

Journal article  |  2019  |  The FEBS Journal

Scribble is a crucial adaptor protein that plays a pivotal role during establishment and control of cell polarity, impacting many ..

VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland

Prestina Smith, Nathan Godde, Stefany Rubio, Melawit Tekeste, Eszter K Vladar, Jeffrey D Axelrod, Deborah J Henderson, Michal Milgrom-Hoffman, Patrick O Humbert, Lindsay Hinck

Journal article  |  2019  |  Scientific Reports

Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC

Jing Yuan How, Sofia Caria, Patrick O Humbert, Marc Kvansakul

Journal article  |  2019  |  FEBS Letters

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Cuiping Xia, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane JF Cronin, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger

Journal article  |  2018  |  PLOS Genetics

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Rebecca Stephens, Krystle Lim, Marta Portela, Marc Kvansakul, Patrick O Humbert, Helena E Richardson

Journal article  |  2018  |  Journal of Molecular Biology

Cell Polarity Regulation-From Atomic to Macroscopic Scale

Marc Kvansakul, Patrick Orson Humbert

Journal article  |  2018  |  Journal of Molecular Biology

Regulation of cellular and PCP signalling by the Scribble polarity module

Michal Milgrom-Hoffman, Patrick O Humbert

Journal article  |  2018  |  Seminars in Cell & Developmental Biology

Intermittent hypoxia induces a metastatic phenotype in breast cancer

Anna Chen, Jaclyn Sceneay, Nathan Godde, Tanja Kinwel, Sunyoung Ham, Erik W Thompson, Patrick O Humbert, Andreas Moller

Journal article  |  2018  |  Oncogene

Investigating the role of polarity protein, SCRIB, in hematopoiesis

Novita Novita, Alysha Dew, Chad Johnson, Carl R Walkley, Louise E Purton, Patrick O Humbert, Phillip K Darcy, Sarah L Ellis

Conference Proceedings  |  2018  |  Molecular and Cellular Biology / Genetics

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth

Helen B Pearson, Jason Li, Valerie S Meniel, Christina M Fennell, Paul Waring, Karen G Montgomery, Richard J Rebello, Arthi A Macpherson, Sarah Koushyar, Luc Furic, Carleen Cullinane, Richard W Clarkson, Matthew J Smalley, Kaylene J Simpson, Toby J Phesse, Peter R Shepherd, Patrick O Humbert, Owen J Sansom, Wayne A Phillips

Journal article  |  2018  |  Cancer Discovery

Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large

Sofia Caria, Charlene M Magtoto, Tinaz Samiei, Marta Portela, Krystle YB Lim, Jing Yuan How, Bryce Z Stewart, Patrick O Humbert, Helena E Richardson, Marc Kvansakul

Journal article  |  2018  |  Journal of Biological Chemistry

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor -PIX

Krystle YB Lim, Nathan J Goedde, Patrick O Humbert, Marc Kvansakul

Journal article  |  2017  |  Journal of Biological Chemistry

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species

J Manent, S Banerjee, R de Matos Simoes, T Zoranovic, C Mitsiades, JM Penninger, KJ Simpson, PO Humbert, HE Richardson

Journal article  |  2017  |  Oncogene

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation

Christina B Wolwer, Nathan Godde, Luke B Pase, Imogen A Elsum, Krystle YB Lim, Faruk Sacirbegovic, Carl R Walkley, Sarah Ellis, Shigeo Ohno, Fumio Matsuzaki, Sarah M Russell, Patrick O Humbert

Journal article  |  2017  |  PLOS ONE

How to expel a bad tenant: Linking cyclin A2, enucleation and cell size

Christina B Woelwer, Patrick O Humbert

Journal article  |  2017  |  Cell Cycle

A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization

Lorey K Smith, Daniel W Thomas, Kaylene J Simpson, Patrick O Humbert

Journal article  |  2016  |  ASSAY and Drug Development Technologies

Association between targeted somatic mutation (TSM) signatures and HGS-OvCa progression

Robyn A Lindley, Patrick Humbert, Cliff Larner, Eric H Akmeemana, Christopher RR Pendlebury

Journal article  |  2016  |  Cancer Medicine

Scribble acts as an oncogene in E mu-myc-driven lymphoma

ED Hawkins, J Oliaro, KM Ramsbottom, A Newbold, PO Humbert, RW Johnstone, SM Russell

Journal article  |  2016  |  Oncogene

Lethal giant larvae-1 deficiency enhances the CD8( ) effector T-cell response to antigen challenge in vivo

Kelly M Ramsbottom, Faruk Sacirbegovic, Edwin D Hawkins, Axel Kallies, Gabrielle T Belz, Vanessa Van Ham, Nicole M Haynes, Michael J Durrant, Patrick O Humbert, Sarah M Russell, Jane Oliaro

Journal article  |  2016  |  Immunology & Cell Biology

Calcium Signaling Is Required for Erythroid Enucleation

Christina B Woelwer, Luke B Pase, Sarah M Russell, Patrick O Humbert

Journal article  |  2016  |  PLOS ONE

A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation

Christina B Woelwer, Luke B Pase, Helen B Pearson, Nathan J Goedde, Kurt Lackovic, David CS Huang, Sarah M Russell, Patrick O Humbert

Journal article  |  2015  |  PLOS ONE

The polarity protein Scrib mediates epidermal development and exerts a tumor suppressive function during skin carcinogenesis

Helen B Pearson, Edwina McGlinn, Toby J Phesse, Holger Schlueter, Anuratha Srikumar, Nathan J Goedde, Christina B Woelwer, Andrew Ryan, Wayne A Phillips, Matthias Ernst, Pritinder Kaur, Patrick Humbert

Journal article  |  2015  |  MOLECULAR CANCER

Asymmetric cell division during T cell development controls downstream fate

Pham Kim, Raz Shimoni, Mirren Charnley, Mandy J Ludford-Menting, Edwin D Hawkins, Kelly Ramsbottom, Jane Oliaro, David Izon, Stephen B Ting, Joseph Reynolds, Grant Lythe, Carmen Molina-Paris, Heather Melichar, Ellen Robey, Patrick O Humbert, Min Gu, Sarah M Russell

Journal article  |  2015  |  Journal of Cell Biology

Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling

Christoph Kruse, Angela RM Kurz, Katalin Palfi, Patrick O Humbert, Markus Sperandio, Ralf P Brandes, Christian Fork, U Ruth Michaelis

Journal article  |  2015  |  Arteriosclerosis, Thrombosis, and Vascular Biology

Mitotic Spindle Orientation: Semaphorin-Plexin Signaling Flags the Way

Patrick O Humbert, Nathan J Goedde

Journal article  |  2015  |  Developmental Cell

The Polarity Protein Scribble Regulates Myelination and Remyelination in the Central Nervous System

Andrew A Jarjour, Amanda Boyd, Lukas E Dow, Rebecca K Holloway, Sandra Goebbels, Patrick O Humbert, Anna Williams, Charles Ffrench-Constant

Journal article  |  2015  |  PLOS Biology

Muscle Stem Cell Fate Is Controlled by the Cell-Polarity Protein Scrib

Yusuke Ono, Yoshishige Urata, Shinji Goto, Shunsuke Nakagawa, Patrick O Humbert, Tao-Sheng Li, Peter S Zammit

Journal article  |  2015  |  Cell Reports

Estrogen receptor alpha drives proliferation in PTEN-deficient prostate carcinoma by stimulating survival signaling, MYC expression and altering glucose sensitivity

Itsuhiro Takizawa, Mitchell G Lawrence, Preetika Balanathan, Richard Rebello, Helen B Pearson, Elika Garg, John Pedersen, Normand Pouliot, Robert Nadon, Matthew J Watt, Renea A Taylor, Patrick Humbert, Ivan Topisirovic, Ola Larsson, Gail P Risbridger, Luc Furic

Journal article  |  2015  |  Oncotarget

The Scribble-Dlg-Lgl Module in Cell Polarity Regulation

Patrick O Humbert, Sarah M Russell, Lorey Smith, Helena E Richardson

Book Chapter  |  2015

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo

IA Elsum, LL Yates, HB Pearson, TJ Phesse, F Long, R O'Donoghue, M Ernst, C Cullinane, PO Humbert

Journal article  |  2014  |  Oncogene

Dissecting the role of polarity regulators in cancer through the use of mouse models

Nathan J Goedde, Helen B Pearson, Lorey K Smith, Patrick O Humbert

Journal article  |  2014  |  Experimental Cell Research

Keratin 76 Is Required for Tight Junction Function and Maintenance of the Skin Barrier

Tia DiTommaso, Denny L Cottle, Helen B Pearson, Holger Schlueter, Pritinder Kaur, Patrick O Humbert, Ian M Smyth

Journal article  |  2014  |  PLoS Genetics

Scrib:Rac1 interactions are required for the morphogenesis of the ventricular myocardium

Veronika Boczonadi, Rachel Gillespie, Iain Keenan, Simon A Ramsbottom, Charlotte Donald-Wilson, Mariana Al Nazer, Patrick Humbert, Robert J Schwarz, Bill Chaudhry, Deborah J Henderson

Journal article  |  2014  |  Cardiovascular Research

Scribble Modulates the MAPK/Fra1 Pathway to Disrupt Luminal and Ductal Integrity and Suppress Tumour Formation in the Mammary Gland

Nathan J Godde, Julie M Sheridan, Lorey K Smith, Helen B Pearson, Kara L Britt, Ryan C Galea, Laura L Yates, Jane E Visvader, Patrick O Humbert

Journal article  |  2014  |  PLOS GENETICS

Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia

Edwin D Hawkins, Jane Oliaro, Kelly M Ramsbottom, Stephen B Ting, Faruk Sacirbegovic, Michael Harvey, Tanja Kinwell, Jacques Ghysdael, Ricky W Johnstone, Patrick O Humbert, Sarah M Russell

Journal article  |  2014  |  PLoS ONE

Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation

Imogen A Elsum, Claire Martin, Patrick O Humbert

Journal article  |  2013  |  Journal of Cell Science

Increasing Intracellular Bioavailable Copper Selectively Targets Prostate Cancer Cells

Michael A Cater, Helen B Pearson, Kamil Wolyniec, Paul Klaver, Maree Bilandzic, Brett M Paterson, Ashley I Bush, Patrick O Humbert, Sharon La Fontaine, Paul S Donnelly, Ygal Haupt

Journal article  |  2013  |  ACS CHEMICAL BIOLOGY

Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers

Benjamin Namdarian, Edwin Wong, Ryan Galea, John Pedersen, Xiaowen Chin, Robert Speirs, Patrick O Humbert, Anthony J Costello, Niall M Corcoran, Christopher M Hovens

Journal article  |  2013  |  Urologic Oncology - Seminars and Original Investigations

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity

Edwin D Hawkins, Jane Oliaro, Axel Kallies, Gabrielle T Belz, Andrew Filby, Thea Hogan, Nicole Haynes, Kelly M Ramsbottom, Vanessa Van Ham, Tanja Kinwell, Benedict Seddon, Derek Davies, David Tarlinton, Andrew M Lew, Patrick O Humbert, Sarah M Russell

Journal article  |  2013  |  Nature Communications

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery

Lee F Willoughby, Tanja Schlosser, Samuel A Manning, John P Parisot, Ian P Street, Helena E Richardson, Patrick O Humbert, Anthony M Brumby

Journal article  |  2013  |  DISEASE MODELS & MECHANISMS

Discovery and analysis of consistent active subnetworks in cancers

Raj K Gaire, Lorey Smith, Patrick Humbert, James Bailey, Peter J Stuckey, Izhak Haviv

Journal article  |  2013  |  BMC Bioinformatics

Localization, Not Important in All Tumor-Suppressing Properties: A Lesson Learnt from Scribble

Imogen A Elsum, Patrick O Humbert

Journal article  |  2013  |  Cells Tissues Organs

Characterization of In Vivo Dlg1 Deletion on T Cell Development and Function

Lisa A Humphries, Meredith H Shaffer, Faruk Sacirbegovic, Tamar Tomassian, Kerrie-Ann McMahon, Patrick O Humbert, Oscar Silva, June L Round, Kogo Takamiya, Richard L Huganir, Janis K Burkhardt, Sarah M Russell, M Carrie Miceli

Journal article  |  2012  |  PLOS ONE

Physiological Levels of Pik3ca(H1047R) Mutation in the Mouse Mammary Gland Results in Ductal Hyperplasia and Formation of ER alpha-Positive Tumors

Anjali Tikoo, Vincent Roh, Karen G Montgomery, Ivan Ivetac, Paul Waring, Rebecca Pelzer, Lauren Hare, Mark Shackleton, Patrick Humbert, Wayne A Phillips

Journal article  |  2012  |  PLOS ONE

Conditional deletion of Scrib gene in the developing myocardium leads to congenital heart defects

DJ Henderson, V Boczonadi, P Humbert, B Chaudhry

Journal article  |  2012  |  Cardiovascular Research

The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man

Imogen Elsum, Laura Yates, Patrick O Humbert, Helena E Richardson

Journal article  |  2012  |  Essays in Biochemistry

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia

Helen B Pearson, Pedro A Perez-Mancera, Lukas E Dow, Andrew Ryan, Pierre Tennstedt, Debora Bogani, Imogen Elsum, Andy Greenfield, David A Tuveson, Ronald Simon, Patrick O Humbert

Journal article  |  2011  |  Journal of Clinical Investigation

Identification of Novel Ras-Cooperating Oncogenes in Drosophila melanogaster: A RhoGEF/Rho-Family/JNK Pathway Is a Central Driver of Tumorigenesis

Anthony M Brumby, Karen R Goulding, Tanja Schlosser, Sherene Loi, Ryan Galea, Peytee Khoo, Jessica E Bolden, Toshiro Aigaki, Patrick O Humbert, Helena E Richardson

Journal article  |  2011  |  Genetics

RNAi-Mediated Knock-Down of Arylamine N-acetyltransferase-1 Expression Induces E-cadherin Up-Regulation and Cell-Cell Contact Growth Inhibition

Jacky M Tiang, Neville J Butcher, Carleen Cullinane, Patrick O Humbert, Rodney F Minchin

Journal article  |  2011  |  PLoS One

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway (vol 19, pg 138, 2010)

Jacinta Caddy, Tomasz Wilanowski, Charbel Darido, Sebastian Dworkin, Stephen B Ting, Quan Zhao, Gerhard Rank, Alana Auden, Seema Srivastava, Tony A Papenfuss, Jennifer N Murdoch, Patrick O Humbert, Vishwas Parekh, Nidal Boulos, Thomas Weber, Jian Zuo, John M Cunningham, Stephen M Jane

Journal article  |  2010  |  Developmental Cell

Epidermal Wound Repair Is Regulated by the Planar Cell Polarity Signaling Pathway

Jacinta Caddy, Tomasz Wilanowski, Charbel Darido, Sebastian Dworkin, Stephen B Ting, Quan Zhao, Gerhard Rank, Alana Auden, Seema Srivastava, Tony A Papenfuss, Jennifer N Murdoch, Patrick O Humbert, Nidal Boulos, Thomas Weber, Jian Zuo, John M Cunningham, Stephen M Jane

Journal article  |  2010  |  Developmental Cell

Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms

Jane Oliaro, Vanessa Van Ham, Faruk Sacirbegovic, Anupama Pasam, Ze'ev Bomzon, Kim Pham, Mandy J Ludford-Menting, Nigel J Waterhouse, Michael Bots, Edwin D Hawkins, Sally V Watt, Leonie A Cluse, Chris JP Clarke, David J Izon, John T Chang, Natalie Thompson, Min Gu, Ricky W Johnstone, Mark J Smyth, Patrick O Humbert, et al.

Journal article  |  2010  |  Journal of Immunology

Cell Polarity in Motion: Redefining Mammary Tissue Organization Through EMT and Cell Polarity Transitions

Nathan J Godde, Ryan C Galea, Imogen A Elsum, Patrick O Humbert

Journal article  |  2010  |  Journal of Mammary Gland Biology and Neoplasia

Functional delineation of structural domains in Yorkie/Yes-associated protein

Xiaomeng Zhang, Claire C Miton, Patrick O Humbert, Kieran F Harvey

Conference Proceedings  |  2010  |  Cellular and Molecular Biology

Tumor Suppressor Scribble Regulates Assembly of Tight Junctions in the Intestinal Epithelium

Andrei I Ivanov, Cheryl Young, Kyle Den Beste, Christopher T Capaldo, Patrick O Humbert, Patrick Brennwald, Charles A Parkos, Asma Nusrat

Journal article  |  2010  |  American Journal of Pathology

Transcriptional Output of the Salvador/Warts/Hippo Pathway Is Controlled in Distinct Fashions in Drosophila melanogaster and Mammalian Cell Lines

Xiaomeng Zhang, Claire C Milton, Patrick O Humbert, Kieran F Harvey

Journal article  |  2009  |  Cancer Research

EKLF/KLF1 Controls Cell Cycle Entry via Direct Regulation of E2f2

Michael R Tallack, Janelle R Keys, Patrick O Humbert, Andrew C Perkins

Journal article  |  2009  |  Journal of Biological Chemistry

Scribble Interacts with beta-Catenin to Localize Synaptic Vesicles to Synapses

Yu Sun, Mytyl Aiga, Eileen Yoshida, Patrick O Humbert, Shernaz X Bamji

Journal article  |  2009  |  Molecular Biology of the Cell

Vimentin Regulates Scribble Activity by Protecting It from Proteasomal Degradation

Dominic CY Phua, Patrick O Humbert, Walter Hunziker

Journal article  |  2009  |  Molecular Biology of the Cell

Multiscale Modeling of Form and Function

Adam J Engler, Patrick O Humbert, Bernhard Wehrle-Haller, Valerie M Weaver

Journal article  |  2009  |  Science

Guest editors

L Banks, PO Humbert

Journal article  |  2008  |  Oncogene

Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module

PO Humbert, NA Grzeschik, AM Brumby, R Galea, I Elsum, HE Richardson

Journal article  |  2008  |  Oncogene

On the guardians of polarity and the disorientation of cancer INTRODUCTION

L Banks, PO Humbert

Journal article  |  2008  |  Oncogene

Loss of human Scribble cooperates with H-Ras to promote cell invasion through deregulation of MAPK signalling

LE Dow, IA Elsum, CL King, KM Kinross, HE Richardson, PO Humbert

Journal article  |  2008  |  Oncogene

The polarity regulator scribble in epithelial migration and cancer

Lukas E Dow, Jeffrey S Kauffman, Jacinta Caddy, Andrew S Peterson, Stephen M Jane, Sarah M Russell, Patrick O Humbert

Conference Proceedings  |  2007  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

T cell shape and function is orchestrated by a network of T polarity proteins

SM Russell, MJ Ludford-Menting, Oliaro J Jane, F Sacirbegovic, ETY Cheah, N Pedersen, S Thomas, A Pasam, R Iazzolino, LE Dow, NE Waterhouse, A Murphy, S Ellis, MJ Smyth, MH Kershaw, PK Darcy, PO Humbert

Conference Proceedings  |  2007  |  JOURNAL OF INVESTIGATIVE DERMATOLOGY

The tumour-suppressor scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge (vol 26, pg 2272, 2007)

LE Dow, JS Kauffman, J Caddy, K Zarbalis, AS Peterson, SM Jane, SM Russell, PO Humbert

Journal article  |  2007  |  Oncogene

The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge

LE Dow, JS Kauffman, J Caddy, AS Peterson, SM Jane, SM Russell, PO Humbert

Journal article  |  2007  |  Oncogene

Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis

Lukas E Dow, Patrick O Humbert

Book Chapter  |  2007  |  International review of cytology

The Scribble and Par complexes in polarity and migration: friends or foes?

Patrick O Humbert, Lukas E Dow, Sarah M Russell

Journal article  |  2006  |  Trends in Cell Biology

E2f4 regulates fetal erythropoiesis through the promotion of cellular proliferation

Kathryn M Kinross, Allison J Clark, Rosa M Iazzolino, Patrick Orson Humbert

Journal article  |  2006  |  Blood

The role of polarity determinants in T cell polarity and function

F Sacirbegovic, R Iazzolino, PO Humbert, SM Russell

Conference Proceedings  |  2005  |  TISSUE ANTIGENS

T cell shape is orchestrated by PDZ-containing proteins: Parallels with epithelial polarity

SM Russell, MJ Ludford-Menting, Jane J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, S Thomas, A Pasam, R Iazzolino, LE Dow, NE Waterhouse, A Murphy, S Ellis, MJ Smyth, MH Kershaw, PK Darcy, PO Humbert

Conference Proceedings  |  2005  |  MECHANISMS OF DEVELOPMENT

E2f4 promotes cell cycle progression and cellular proliferation in foetal erythropoiesis

PO Humbert, KM Kinross, AJ Clark, RM Iazzolino

Conference Proceedings  |  2005  |  MECHANISMS OF DEVELOPMENT

A network of PDZ-containing proteins regulates T cell polarity and morphology during migration and immunological synapse formation

MJ Ludford-Menting, J Oliaro, F Sacirbegovic, ETY Cheah, N Pedersen, SJ Thomas, A Pasam, R Iazzolino, LE Dow, NJ Waterhouse, A Murphy, S Ellis, MJ Smyth, MH Kershaw, PK Darcy, PO Humbert, SM Russell

Journal article  |  2005  |  Immunity

New tricks for old dogs: unexpected roles for cell cycle regulators revealed using animal models

P Humbert, AM Brumby, LM Quinn, HE Richardson

Journal article  |  2004  |  Current Opinion in Cell Biology

Cell-intrinsic requirement for pRb in erythropoiesis

AJ Clark, KM Doyle, PO Humbert

Journal article  |  2004  |  Blood

All known in vivo functions of the Oct-2 transcription factor require the C-terminal protein domain

LM Corcoran, F Koentgen, W Dietrich, M Veale, PO Humbert

Journal article  |  2004  |  Journal of Immunology

hScrib is a functional homologue of the Drosophila tumour suppressor Scribble

LE Dow, AM Brumby, R Muratore, ML Coombe, KA Sedelies, JA Trapani, SM Russell, HE Richardson, PO Humbert

Journal article  |  2003  |  Oncogene

Dlg, Scribble and Lgl in cell polarity, cell proliferation and cancer

P Humbert, S Russell, H Richardson

Journal article  |  2003  |  Bioessays

In vivo analysis of E2F4 function in erythropoiesis.

KM Doyle, AJ Clark, R Muratore, PO Humbert

Conference Proceedings  |  2002  |  BLOOD

E2F4 is essential for normal erythrocyte maturation and neonatal viability

PO Humbert, C Rogers, S Ganiatsas, RL Landsberg, JM Trimarchi, S Dandapani, C Brugnara, S Erdman, M Schrenzel, RT Bronson, JA Lees

Journal article  |  2000  |  Molecular Cell

E2f3 is critical for normal cellular proliferation

PO Humbert, R Verona, JM Trimarchi, C Rogers, S Dandapani, JA Lees

Journal article  |  2000  |  Genes and Development

Oct-2 gene disruption eliminates the peritoneal B-1 lymphocyte lineage and attenuates B-2 cell maturation and function

PO Humbert, LM Corcoran

Journal article  |  1997  |  Journal of Immunology