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Dr

Patrick Humbert

Honorary
Biochemistry and Pharmacology
science & technology
life sciences & biomedicine
animals
humans
mice
cell polarity
cell biology
membrane proteins
oncology
Patrick Humbert's Profile Picture
Dr

Patrick Humbert

 
Division
Medicine, Dentistry and Health Sciences
 
Primary Interest
Molecular control of cellular proliferation
Patrick Humbert's Profile Picture
Dr

Patrick Humbert

 
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Projects

Displaying the 10 most recent projects from 18 for Patrick Humbert.

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ESTABLISHMENT OF ACRF ADVANCED CENTRE FOR CANCER CELL ISOLATION AND IMAGING

2013 - 2020
Completed
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DECIPHERING THE ROLE OF SCRIBBLE IN DEVELOPMENT AND DISEASE

Scribble is a protein that controls the orientation and organization of all cells within our body. Mutations in the Scribble gene are found ..

2016 - 2016
Completed
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INVESTIGATING THE ROLE OF PLANAR CELL POLARITY IN PROSTATE CANCER

2012 - 2015
Completed
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Understanding tumour formation driven by the signalling protein Ras

Cancer is a cooperative process, involving mutations in several genes. Activation of the signaling protein, Ras, contributes to ~30% of huma..

2012 - 2014
Completed
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THE ROLE OF CELL POLARITY REGULATORS IN MAMMARY GLAND DEVELOPMENT AND BREAST CANCER

2012 - 2014
Completed
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Molecular Regulation of tumourigenesis by Scribble and associated proteins

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have shown that Scribble, a key regulator of cell o..

2011 - 2013
Completed
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The role of cell orientation in Prostate Cancer

Every cell in our body has an intrinsic orientation that is controlled by a universal set of genes known as polarity genes. Loss of this ori..

2010 - 2012
Completed
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Understanding cell orientation in development and cancer

Cell polarity is the property of cells to be spatially oriented in a tissue or organ. We have now shown that the gene Scribble, a key regula..

2009 - 2012
Completed
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How do red blood cells lose their nucleus?

Removal of the nucleus from red blood cells (enucleation) is essential for proper circulation of red blood cells through the microvasculatur..

2009 - 2011
Completed
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DROSOPHILA AS A NOVEL TOOL FOR ANTI-CANCER DRUG DISCOVERY

2007 - 2011
Completed

18

Projects

Project Types

18

Research Grant

Scholarly Works

Displaying the 10 most recent scholarly works from 87 for Patrick Humbert.

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Structural basis of coronavirus E protein interactions with human PALS1 PDZ domain

Airah Javorsky, Patrick O Humbert, Marc Kvansakul

Journal article  |  2021  |  COMMUNICATIONS BIOLOGY

SARS-CoV-2 infection leads to coronavirus disease 2019 (COVID-19), which is associated with severe and life-threatening pneumonia ..

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Crystallographic Studies of PDZ Domain-Peptide Interactions of the Scribble Polarity Module.

Janesha C Maddumage, Bryce Z Stewart, Patrick O Humbert, Marc Kvansakul

Book Chapter  |  2021  |  Methods in Molecular Biology

The determination of high-resolution crystal structures of cell polarity regulatory proteins bound to their functional interactors..

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Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis

Nikolay Popgeorgiev, Jaison D Sa, Lea Jabbour, Suresh Banjara, Thi Minh Nguyen Trang, Aida Akhavan-E-Sabet, Rudy Gadet, Nikola Ralchev, Stephen Manon, Mark G Hinds, Hans-Jurgen Osigus, Bernd Schierwater, Patrick O Humbert, Ruth Rimokh, Germain Gillet, Marc Kvansakul

Journal article  |  2020  |  SCIENCE ADVANCES

In metazoans, Bcl-2 family proteins are major regulators of mitochondrially mediated apoptosis; however, their evolution remains p..

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The polarity protein Scrib limits atherosclerosis development in mice

Christoph Schuermann, Franziska L Dienst, Katalin Palfi, Andrea E Vasconez, James A Oo, ShengPeng Wang, Giulia K Buchmann, Stefan Offermanns, Bart van de Sluis, Matthias S Leisegang, Stefan Guenther, Patrick O Humbert, Eunjee Lee, Jun Zhu, Andreas Weigert, Praveen Mathoor, Ilka Wittig, Christoph Kruse, Ralf P Brandes

Journal article  |  2019  |  CARDIOVASCULAR RESEARCH

AIMS: The protein Scrib (Scribble 1) is known to control apico-basal polarity in epithelial cells. The role of polarity proteins i..

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Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains

Sofia Caria, Bryce Z Stewart, Ruitao Jin, Brian J Smith, Patrick O Humbert, Marc Kvansakul

Journal article  |  2019  |  FEBS JOURNAL

Scribble is a crucial adaptor protein that plays a pivotal role during establishment and control of cell polarity, impacting many ..

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VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland

Prestina Smith, Nathan Godde, Stefany Rubio, Melawit Tekeste, Eszter K Vladar, Jeffrey D Axelrod, Deborah J Henderson, Michal Milgrom-Hoffman, Patrick O Humbert, Lindsay Hinck

Journal article  |  2019  |  SCIENTIFIC REPORTS

The VANGL family of planar cell polarity proteins is implicated in breast cancer however its function in mammary gland biology is ..

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Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC

Jing Yuan How, Sofia Caria, Patrick O Humbert, Marc Kvansakul

Journal article  |  2019  |  FEBS LETTERS

Scribble (SCRIB) is an important adaptor protein that controls the establishment and maintenance of apico-basal cell polarity. To ..

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A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer

Tamara Zoranovic, Jan Manent, Lee Willoughby, Ricardo Matos de Simoes, John E La Marca, Sofya Golenkina, Cuiping Xia, Susanne Gruber, Belinda Angjeli, Elisabeth Eva Kanitz, Shane JF Cronin, G Gregory Neely, Andreas Wernitznig, Patrick O Humbert, Kaylene J Simpson, Constantine S Mitsiades, Helena E Richardson, Josef M Penninger

Journal article  |  2018  |  PLOS GENETICS

Oncogenic mutations in the small GTPase Ras contribute to ~30% of human cancers. However, Ras mutations alone are insufficient for..

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The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis

Rebecca Stephens, Krystle Lim, Marta Portela, Marc Kvansakul, Patrick O Humbert, Helena E Richardson

Journal article  |  2018  |  JOURNAL OF MOLECULAR BIOLOGY

The Scribble cell polarity module, comprising Scribbled (Scrib), Discs-large (Dlg) and Lethal-2-giant larvae (Lgl), has a tumor su..

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Cell Polarity Regulation-From Atomic to Macroscopic Scale

Marc Kvansakul, Patrick Orson Humbert

Journal article  |  2018  |  JOURNAL OF MOLECULAR BIOLOGY

87

Scholarly Works

Keyword Analysis

Expanding Knowledge
Clinical Health
Biochemistry and Cell Biology
Oncology and Carcinogenesis
Genetics
Immunology
Cardiovascular Medicine and Haematology
Zoology
Agricultural Biotechnology
Clinical Sciences

Honours, Awards and Fellowships

1999

Merck/MIT Postdoctoral Fellowship
1997

Anna Fuller Fellowship for Research in Molecular Oncology
1995

Australian Post-graduate Research Award University of Melbourne, Australia
1990

Mary F. Lockett Prize in Pharmacology University of Western Australia, Australia
1990

Lady James Prize in Natural Sciences University of Western Australia, Australia

5

Awards

Credentials

Positions

Honorary

Biochemistry and Pharmacology

Honorary

Clinical Pathology

Education

Post-Doctoral Fellow

Massachusetts Institute of Technology

PhD

University of Melbourne

Bachelor of Science

The University of Western Australia

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