Ruslan Pustovit

Dopamine and ghrelin receptor co-expression and interaction in the spinal defecation centers

John B Furness, Ruslan Pustovit, Andrew J Syder, Mitchell T Ringuet, Eun Ji Yoo, Andrea Fanjul, Jill Wykosky, Linda J Fothergill, Emily A Whitfield, Sebastian GB Furness

Journal article  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Dopamine receptor 2 (DRD2) and ghrelin receptor (GHSR1a) agonists both stimulate defecation by actions at the lumbosac..

Squalamine Restores the Function of the Enteric Nervous System in Mouse Models of Parkinson's Disease

Christine L West, Yu-Kang Mao, Thilini Delungahawatta, Jessica Y Amin, Sohana Farhin, Rachel M McQuade, Shanti Diwakarla, Ruslan Pustovit, Andrew M Stanisz, John Bienenstock, Denise Barbut, Michael Zasloff, John B Furness, Wolfgang A Kunze

Journal article  |  2020  |  JOURNAL OF PARKINSONS DISEASE

Background: Parkinson’s disease (PD) is a progressive neurodegenerative disorder thought to be caused by accumulation of α-synucle..

Investigation of nerve pathways mediating colorectal dysfunction in Parkinson's disease model produced by lesion of nigrostriatal dopaminergic neurons

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Journal article  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Gastrointestinal (GI) dysfunction, including constipation, is a common non-motor symptom of Parkinson's disease (PD). ..

Effects and sites of action of a M1 receptor positive allosteric modulator on colonic motility in rats and dogs compared with 5-HT4 agonism and cholinesterase inhibition

Yasuhiro Tsukimi, Ruslan V Pustovit, Andrea M Harrington, Sonia Garcia-Caraballo, Stuart M Brierley, Madeleine Di Natale, Juan C Molero, John B Furness

Journal article  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Muscarinic receptor 1 positive allosteric modulators (M1PAMs) enhance colonic propulsive contractions and defecation t..

Evidence that Dopamine is the Physiological Agonist of Spinal Gherlin Receptors and Acts Through Heteromeric Dopamine D2/ Ghrelin Receptors

Sebastian Furness, Ruslan Pustovit, Mitchell Ringuet, Juan Molero, Linda Fothergill, John Furness

Conference Proceedings  |  2020  |  FASEB JOURNAL

Effects of M1 receptor positive allosteric modulators on colorectal function

Ruslan Pustovit, Yasuhiro Tsukimi, Yasuo Itomi, Mitchell Ringuet, Madeleine Di Natale, Juan C Molero, JB Furness

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

Distant effects on the colon following 6-hydroxydopamine lesioning of the medial forebrain bundle

Xin-yi Chai, Shanti Diwakarla, Ruslan V Pustovit, Rachel M McQuade, Madeleine Di Natale, Charlotte M Ermine, Clare L Parish, David I Finkelstein, John B Furness

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

Dopamine/ghrelin receptor heteromers and their roles in lumbo-sacral defecation centres

Mitchell T Ringuet, Ruslan V Pustovit, Andrea Fanjul, Andrew Syder, Jie Huang, Lindsay Yoo, Sebastian GB Furness, Linda J Fothergill, Wendy Winchester, Paul Wade, Jill Wykosky, John B Furness

Conference Proceedings  |  2020  |  NEUROGASTROENTEROLOGY AND MOTILITY

Muscarinic receptor 1 allosteric modulators stimulate colorectal emptying in dog, mouse and rat and resolve constipation

Ruslan V Pustovit, Yasuo Itomi, Mitchell Ringuet, Shanti Diwakarla, Xin-yi Chai, Rachel M McQuade, Yasuhiro Tsukimi, John B Furness

Journal article  |  2019  |  NEUROGASTROENTEROLOGY AND MOTILITY

BACKGROUND: Because M1 muscarinic receptors are expressed by enteric neurons, we investigated whether positive allosteric modulato..

The involvement of dopamine, but not ghrelin, in physiological control of defecation through ghrelin receptors

J Furness, R Pustovit

Conference Proceedings  |  2018  |  NEUROGASTROENTEROLOGY AND MOTILITY