Ed Stanley

Mimicry of embryonic circulation enhances the hoxa hemogenic niche and human blood development.

Jingjing Li, Osmond Lao, Freya F Bruveris, Liyuan Wang, Kajal Chaudry, Ziqi Yang, Nona Farbehi, Elizabeth S Ng, Edouard G Stanley, Richard P Harvey, Andrew G Elefanty, Robert E Nordon

Journal article  |  2022  |  Cell Rep

Precursors of the adult hematopoietic system arise from the aorta-gonad-mesonephros (AGM) region shortly after the embryonic circu..

Human pluripotent stem cell-derived macrophages host Mycobacterium abscessus infection.

Shicheng Sun, Michael See, Hieu T Nim, Kathleen Strumila, Elizabeth S Ng, Alejandro Hidalgo, Mirana Ramialison, Philip Sutton, Andrew G Elefanty, Sohinee Sarkar, Edouard G Stanley

Journal article  |  2022  |  Stem Cell Reports

Human macrophages are a natural host of many mycobacterium species, including Mycobacterium abscessus (M. abscessus), an emerging ..

Mapping human haematopoietic stem cells from haemogenic endothelium to birth.

Vincenzo Calvanese, Sandra Capellera-Garcia, Feiyang Ma, Iman Fares, Simone Liebscher, Elizabeth S Ng, Sophia Ekstrand, Júlia Aguadé-Gorgorió, Anastasia Vavilina, Diane Lefaudeux, Brian Nadel, Jacky Y Li, Yanling Wang, Lydia K Lee, Reza Ardehali, M Luisa Iruela-Arispe, Matteo Pellegrini, Ed G Stanley, Andrew G Elefanty, Katja Schenke-Layland, et al.

Journal article  |  2022  |  Nature

The ontogeny of human haematopoietic stem cells (HSCs) is poorly defined owing to the inability to identify HSCs as they emerge an..

CD90 Marks a Mesenchymal Program in Human Thymic Epithelial Cells In Vitro and In Vivo

Shicheng Sun, Jacky Y Li, Hieu T Nim, Adam Piers, Mirana Ramialison, Enzo R Porrello, Igor E Konstantinov, Andrew G Elefanty, Edouard G Stanley

Journal article  |  2022  |  FRONTIERS IN IMMUNOLOGY

Thymic epithelium is critical for the structural integrity of the thymus and for T cell development. Within the fully formed thymu..

Adult mouse fibroblasts retain organ-specific transcriptomic identity.

Elvira Forte, Mirana Ramialison, Hieu T Nim, Madison Mara, Jacky Y Li, Rachel Cohn, Sandra L Daigle, Sarah Boyd, Edouard G Stanley, Andrew G Elefanty, John Travis Hinson, Mauro W Costa, Nadia A Rosenthal, Milena B Furtado

Journal article  |  2022  |  Elife

Organ fibroblasts are essential components of homeostatic and diseased tissues. They participate in sculpting the extracellular ma..

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal

Tina M Schnoeder, Adrian Schwarzer, Ashok Kumar Jayavelu, Chen-Jen Hsu, Joanna Kirkpatrick, Konstanze Doehner, Florian Perner, Theresa Eifert, Nicolas Huber, Patricia Arreba-Tutusaus, Anna Dolnik, Salam A Assi, Monica Nafria, Lu Jiang, Yu-Ting Dai, Zhu Chen, Sai-Juan Chen, Sophie G Kellaway, Anetta Ptasinska, Elizabeth S Ng, et al.

Journal article  |  2022  |  BLOOD

In an effort to identify novel drugs targeting fusion-oncogene-induced acute myeloid leukemia (AML), we performed high-resolution ..

Creation of GMP-Compliant iPSCs From Banked Umbilical Cord Blood.

Pei Tian, Andrew Elefanty, Edouard G Stanley, Jennifer C Durnall, Lachlan H Thompson, Ngaire J Elwood

Journal article  |  2022  |  Front Cell Dev Biol

Many clinical trials are in progress using cells derived from induced pluripotent stem cells (iPSC) for immunotherapies and regene..

3121 – BENCHMARKING OF IN VITRO DIFFERENTIATED INDUCED HEMATOPOIETIC STEM CELLS (IHSCS) AGAINST HUMAN EMBRYONIC HSCS

Jacky Li, Andrew Elefanty, Elizabeth Ng, Hieu Nim, Edouard Stanley

Journal article  |  2022  |  Experimental Hematology

Effect and application of cryopreserved three-dimensional microcardiac spheroids in myocardial infarction therapy.

Soon-Jung Park, Hyeok Kim, Sunghun Lee, Jongsoo Kim, Taek-Hee Jung, Seong Woo Choi, Bong-Woo Park, Sun-Woong Kang, David A Elliott, Edouard G Stanley, Andrew G Elefanty, Kiwon Ban, Hun-Jun Park, Sung-Hwan Moon

Journal article  |  2022  |  Clin Transl Med

A Pro-Endocrine Pancreatic Islet Transcriptional Program Established During Development Is Retained in Human Gallbladder Epithelial Cells.

Mugdha V Joglekar, Subhshri Sahu, Wilson KM Wong, Sarang N Satoor, Charlotte X Dong, Ryan J Farr, Michael D Williams, Prapti Pandya, Gaurang Jhala, Sundy NY Yang, Yi Vee Chew, Nicola Hetherington, Dhan Thiruchevlam, Sasikala Mitnala, Guduru V Rao, Duvvuru Nageshwar Reddy, Thomas Loudovaris, Wayne J Hawthorne, Andrew G Elefanty, Vinay M Joglekar, et al.

Journal article  |  2022  |  Cell Mol Gastroenterol Hepatol

BACKGROUND & AIMS: Pancreatic islet β-cells are factories for insulin production; however, ectopic expression of insulin also is w..