Fiona Angrisano

Plasmodium vivax-How hidden reservoirs hinder global malaria elimination

Fiona Angrisano, Leanne J Robinson

Journal article  |  2022  |  PARASITOLOGY INTERNATIONAL

Plasmodium vivax is the most geographically widespread human malaria parasite. Global malaria efforts have been less successful at..

Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Katarzyna A Sala, Andrew M Blagborough, Chafen Lu, Timothy A Springer

Journal article  |  2021  |  ELIFE

HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fuso..

SARS-CoV-2 Multi-Antigen Serology Assay

Ramin Mazhari, Shazia Ruybal-Pesantez, Fiona Angrisano, Nicholas Kiernan-Walker, Stephanie Hyslop, Rhea J Longley, Caitlin Bourke, Catherine Chen, Deborah A Williamson, Leanne J Robinson, Ivo Mueller, Emily M Eriksson

Journal article  |  2021  |  METHODS AND PROTOCOLS

Serology tests are extremely useful for assessing whether a person has been infected with a pathogen. Since the onset of the COVID..

The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957

Celia Miguel-Blanco, James M Murithi, Ernest Diez Benavente, Fiona Angrisano, Katarzyna A Sala, Donelly A van Schalkwyk, Manu Vanaerschot, Frank Schwach, Matthew J Fuchter, Oliver Billker, Colin J Sutherland, Susana G Campino, Taane G Clark, Andrew M Blagborough, David A Fidock, Esperanza Herreros, Francisco Javier Gamo, Jake Baum, Michael J Delves

Journal article  |  2021  |  SCIENTIFIC REPORTS

New antimalarial therapeutics are needed to ensure that malaria cases continue to be driven down, as both emerging parasite resist..

PIMMS43 is required for malaria parasite immune evasion and sporogonic development in the mosquito vector

Chiamaka V Ukegbu, Maria Giorgalli, Sofia Tapanelli, Luisa DP Rona, Amie Jaye, Claudia Wyer, Fiona Angrisano, Andrew M Blagborough, George K Christophides, Dina Vlachou

Journal article  |  2020  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

After being ingested by a female Anopheles mosquito during a bloodmeal on an infected host, and before they can reach the mosquito..

Male-Specific Protein Disulphide Isomerase Function is Essential for Plasmodium Transmission and a Vulnerable Target for Intervention

Fiona Angrisano, Katarzyna A Sala, Sofia Tapanelli, George K Christophides, Andrew M Blagborough

Journal article  |  2019  |  SCIENTIFIC REPORTS

Inhibiting transmission of Plasmodium is an essential strategy in malaria eradication, and the biological process of gamete fusion..

The effects of dyslipidaemia and cholesterol modulation on erythrocyte susceptibility to malaria parasite infection

Marion Koch, Jaimini Cegla, Ben Jones, Yuning Lu, Ziad Mallat, Andrew M Blagborough, Fiona Angrisano, Jake Baum

Journal article  |  2019  |  MALARIA JOURNAL

BACKGROUND: Malaria disease commences when blood-stage parasites, called merozoites, invade human erythrocytes. Whilst the process..

Epistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites

Hanwei Fang, Ana Rita Gomes, Natacha Klages, Paco Pino, Bohumil Maco, Eloise M Walker, Zenon A Zenonos, Fiona Angrisano, Jake Baum, Christian Doerig, David A Baker, Oliver Billker, Mathieu Brochet

Journal article  |  2018  |  NATURE COMMUNICATIONS

In malaria parasites, evolution of parasitism has been linked to functional optimisation. Despite this optimisation, most members ..

Antimalarial Transmission-Blocking Interventions: Past, Present, and Future

MJ Delves, F Angrisano, M Blagborough

Journal article  |  2018  |  TRENDS IN PARASITOLOGY

Malaria remains a major global health challenge. Appropriate use of current antimalarial tools has reduced the disease burden, but..

Understanding Human-Derived Antibodies Generated by Polymorphic Malaria Vaccine Against Merozoite Surface Protein 2

Fiona Angrisano, Andrew M Blagborough

Journal article  |  2018  |  JOURNAL OF INFECTIOUS DISEASES