Nigel Bunnett

Bile acids inhibit cholinergic constriction in proximal and peripheral airways from humans and rodents.

Andreacarola Urso, Frank D'Ovidio, Dingbang Xu, Charles W Emala, Nigel W Bunnett, Jose F Perez-Zoghbi

Journal article  |  2020  |  American Journal of Physiology-Lung Cellular and Molecular Physiology

Duodenogastroesophageal reflux (DGER) is associated with chronic lung disease. Bile acids (BAs) are established markers of DGER as..

Schwann cells expressing nociceptive channel TRPA1 orchestrate ethanol-evoked neuropathic pain in mice.

Francesco De Logu, Simone Li Puma, Lorenzo Landini, Francesca Portelli, Alessandro Innocenti, Daniel Souza Monteiro de Araujo, Malvin N Janal, Riccardo Patacchini, Nigel W Bunnett, Pierangelo Geppetti, Romina Nassini

Journal article  |  2019  |  Journal of Clinical Investigation

Excessive alcohol consumption is associated with spontaneous burning pain, hyperalgesia, and allodynia. Although acetaldehyde has ..

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain

Paulina D Ramirez-Garcia, Jeffri S Retamal, Priyank Shenoy, Wendy Imlach, Matthew Sykes, Nghia Truong, Luis Constandil, Teresa Pelissier, Cameron J Nowell, Song Y Khor, Louis M Layani, Chris Lumb, Daniel P Poole, TinaMarie Lieu, Gregory D Stewart, Quynh N Mai, Dane D Jensen, Rocco Latorre, Nicole N Scheff, Brian L Schmidt, et al.

Journal article  |  2019  |  Nature Nanotechnology

Nanoparticle-mediated drug delivery is especially useful for targets within endosomes because of the endosomal transport mechanism..

Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity

Joel Castro, Andrea M Harrington, TinaMarie Lieu, Sonia Garcia-Caraballo, Jessica Maddern, Gudrun Schober, Tracey O'Donnell, Luke Grundy, Amanda L Lumsden, Paul Miller, Andre Ghetti, Martin S Steinhoff, Daniel P Poole, Xinzhong Dong, Lin Chang, Nigel W Bunnett, Stuart M Brierley

Journal article  |  2019  |  JCI Insight

Itch induces scratching that removes irritants from the skin, whereas pain initiates withdrawal or avoidance of tissue damage. Whi..

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease

Bethany M Anderson, Daniel P Poole, Luigi Aurelio, Garrett Z Ng, Markus Fleischmann, Paulina Kasperkiewicz, Celine Morissette, Marcin Drag, Ian R van Driel, Brian L Schmidt, Stephen J Vanner, Nigel W Bunnett, Laura E Edgington-Mitchell

Journal article  |  2019  |  Scientific Reports

Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression.

Narek Israelyan, Andrew Del Colle, Zhishan Li, Yeji Park, Albert Xing, Jacob PR Jacobsen, Ruth Ann Luna, Dane D Jensen, Moneek Madra, Virginia Saurman, Ray Rahim, Rocco Latorre, Kimberly Law, William Carson, Nigel W Bunnett, Marc G Caron, Kara G Margolis

Journal article  |  2019  |  Gastroenterology

BACKGROUND & AIMS: Mood disorders and constipation are often comorbid, yet their shared etiologies have rarely been explored. The ..

Protein kinase D and G beta gamma mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

Peishen Zhao, Luke A Pattison, Dane D Jensen, Nestor N Jimenez-Vargas, Rocco Latorre, TinaMarie Lieu, Josue O Jaramillo, Cintya Lopez-Lopez, Daniel P Poole, Stephen J Vanner, Brian L Schmidt, Nigel W Bunnett

Journal article  |  2019  |  Journal of Biological Chemistry

Proteases sustain hyperexcitability and pain by cleaving protease-activated receptor-2 (PAR2) on nociceptors through distinct mech..

G-Protein-Coupled Receptors Are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Meritxell Canals, Daniel P Poole, Nicholas A Veldhuis, Brian L Schmidt, Nigel W Bunnett

Journal article  |  2019  |  Gastroenterology

Revised guidelines to enhance the rigor and reproducibility of research published in American Physiological Society journals.

Gina LC Yosten, Josephine C Adams, Christina N Bennett, Nigel W Bunnett, Rita Scheman, Curt D Sigmund, Bill J Yates, Irving H Zucker, Willis K Samson

Journal article  |  2018  |  American Journal of Physiology-Regulatory, Integrative and Comparative Physiology

Inflammation-associated changes in DOR expression and function in the mouse colon

Jesse J DiCello, Ayame Saito, Pradeep Rajasekhar, Emily M Eriksson, Rachel M McQuade, Cameron J Nowell, Benjamin W Sebastian, Jakub Fichna, Nicholas A Veldhuis, Meritxell Canals, Nigel W Bunnett, Simona E Carbone, Daniel P Poole

Journal article  |  2018  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Therapeutic Targeting of Endosomal G-Protein-Coupled Receptors.

Alex RB Thomsen, Dane D Jensen, Gareth A Hicks, Nigel W Bunnett

Journal article  |  2018  |  Trends in Pharmacological Sciences

G-protein-coupled receptors (GPCRs) are conventionally considered to function at the plasma membrane, where they detect extracellu..

TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice.

Ilaria Maddalena Marone, Francesco De Logu, Romina Nassini, Muryel De Carvalho Goncalves, Silvia Benemei, Juliano Ferreira, Piyush Jain, Simone Li Puma, Nigel W Bunnett, Pierangelo Geppetti, Serena Materazzi

Journal article  |  2018  |  Brain

Glyceryl trinitrate is administered as a provocative test for migraine pain. Glyceryl trinitrate causes prolonged mechanical allod..

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome

Nestor N Jimenez-Vargas, Luke A Pattison, Peishen Zhao, TinaMarie Lieu, Rocco Latorre, Dane D Jensen, Joel Castro, Luigi Aurelio, Giang T Le, Bernard Flynn, Carmen Klein Herenbrink, Holly R Yeatman, Laura Edgington-Mitchell, Christopher JH Porter, Michelle L Halls, Meritxell Canals, Nicholas A Veldhuis, Daniel P Poole, Peter McLean, Gareth A Hicks, et al.

Journal article  |  2018  |  Proceedings of the National Academy of Sciences

Co-expression of mu and delta opioid receptors by mouse colonic nociceptors

Raquel Guerrero-Alba, Eduardo Emmanuel Valdez-Morales, Nestor Nivardo Jimenez-Vargas, Romke Bron, Daniel Poole, David Reed, Joel Castro, Melissa Campaniello, Patrick A Hughes, Stuart M Brierley, Nigel Bunnett, Alan E Lomax, Stephen Vanner

Journal article  |  2018  |  British Journal of Pharmacology

Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice.

Francesco De Logu, Romina Nassini, Serena Materazzi, Muryel Carvalho Gonçalves, Daniele Nosi, Duccio Rossi Degl'Innocenti, Ilaria M Marone, Juliano Ferreira, Simone Li Puma, Silvia Benemei, Gabriela Trevisan, Daniel Souza Monteiro de Araújo, Riccardo Patacchini, Nigel W Bunnett, Pierangelo Geppetti

Journal article  |  2017  |  Nature Communications

It is known that transient receptor potential ankyrin 1 (TRPA1) channels, expressed by nociceptors, contribute to neuropathic pain..

Stress activates pronociceptive endogenous opioid signalling in DRG neurons during chronic colitis

Raquel Guerrero-Alba, Eduardo E Valdez-Morales, Nestor N Jimenez-Vargas, Cintya Lopez-Lopez, Josue Jaramillo-Polanco, Takanobu Okamoto, Yasmin Nasser, Nigel W Bunnett, Alan E Lomax, Stephen J Vanner

Journal article  |  2017  |  Gut

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

Rebecca E Yarwood, Wendy L Imlach, TinaMarie Lieu, Nicholas A Veldhuis, Dane D Jensen, Carmen Klein Herenbrink, Luigi Aurelio, Zhijian Cai, MacDonald J Christie, Daniel P Poole, Christopher JH Porter, Peter McLean, Gareth A Hicks, Pierangelo Geppetti, Michelle L Halls, Meritxell Canals, Nigel W Bunnett

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Sensitisation of TRPV4 by PAR(2) is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase (vol 467, pg 687, 2015)

Silvia Sostegni, Alexei Diakov, Peter McIntyre, Nigel Bunnett, Christoph Korbmacher, Silke Haerteis

Journal article  |  2017  |  Pflügers Archiv - European Journal of Physiology

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Dane D Jensen, TinaMarie Lieu, Michelle L Halls, Nicholas A Veldhuis, Wendy L Imlach, Quynh N Mai, Daniel P Poole, Tim Quach, Luigi Aurelio, Joshua Conner, Carmen Klein Herenbrink, Nicholas Barlow, Jamie S Simpson, Martin J Scanlon, Bimbil Graham, Adam McCluskey, Phillip J Robinson, Virginie Escriou, Romina Nassini, Serena Materazzi, et al.

Journal article  |  2017  |  Science Translational Medicine

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease

Ming-Chin Lee, James A McCubbin, Anne D Christensen, Daniel P Poole, Pradeep Rajasekhar, TinaMarie Lieu, Nigel W Bunnett, Sonia Garcia-Caraballo, Andelain Erickson, Stuart M Brierley, Reem Saleh, Adrian Achuthan, Andrew J Fleetwood, Robin L Anderson, John A Hamilton, Andrew D Cook

Journal article  |  2017  |  The Journal of Immunology

Fluorescent diphenylphosphonate-based probes for detection of serine protease activity during inflammation

Laura E Edgington-Mitchell, Nicholas Barlow, Luigi Aurelio, Aminath Samha, Monika Szabo, Bim Graham, Nigel Bunnett

Journal article  |  2017  |  Bioorganic & Medicinal Chemistry Letters

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2

T Lieu, E Savage, P Zhao, L Edgington-Mitchell, N Barlow, R Bron, DP Poole, P McLean, R-J Lohman, DP Fairlie, NW Bunnett

Journal article  |  2016  |  British Journal of Pharmacology

Legumain is activated in macrophages during pancreatitis

Laura E Edgington-Mitchell, Thomas Wartmann, Alicia K Fleming, Vasilena Gocheva, Wouter A van der Linden, Nimali P Withana, Martijn Verdoes, Luigi Aurelio, Daniel Edgington-Mitchell, TinaMarie Lieu, Belinda S Parker, Bim Graham, Thomas Reinheckel, John B Furness, Johanna A Joyce, Peter Storz, Walter Halangk, Matthew Bogyo, Nigel W Bunnett

Journal article  |  2016  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Distribution and trafficking of the mu-opioid receptor in enteric neurons of the guinea pig

Joslyn Lay, Simona E Carbone, Jesse J DiCello, Nigel W Bunnett, Meritxell Canals, Daniel P Poole

Journal article  |  2016  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Protein Kinase D and G Subunits Mediate Agonist-evoked Translocation of Protease-activated Receptor-2 from the Golgi Apparatus to the Plasma Membrane

Dane D Jensen, Peishen Zhao, Nestor N Jimenez-Vargas, TinaMarie Lieu, Marina Gerges, Holly R Yeatman, Meritxell Canals, Stephen J Vanner, Daniel P Poole, Nigel W Bunnett

Journal article  |  2016  |  Journal of Biological Chemistry

REGENERATION Not everything is scary about a glial scar

Shane A Liddelow, Ben A Barres

Journal article  |  2016  |  Nature

Prognostic and Mechanistic Potential of Progesterone Sulfates in Intrahepatic Cholestasis of Pregnancy and Pruritus Gravidarum

Shadi Abu-Hayyeh, Caroline Ovadia, TinaMarie Lieu, Dane D Jensen, Jenny Chambers, Peter H Dixon, Anita Lovgren-Sandblom, Ruth Bolier, Dagmar Tolenaars, Andreas E Kremer, Argyro Syngelaki, Muna Noori, David Williams, Jose JG Marin, Maria J Monte, Kypros H Nicolaides, Ulrich Beuers, Ronald Oude-Elferink, Paul T Seed, Lucy Chappell, et al.

Journal article  |  2016  |  Hepatology

Plasma membrane localization of the mu-opioid receptor controls spatiotemporal signaling

Michelle L Halls, Holly R Yeatman, Cameron J Nowell, Georgina L Thompson, Arisbel Batista Gondin, Srgjan Civciristov, Nigel W Bunnett, Nevin A Lambert, Daniel P Poole, Meritxell Canals

Journal article  |  2016  |  Science Signaling

G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future

Daniel P Poole, Nigel W Bunnett

Journal article  |  2016  |  Advances in experimental medicine and biology

Neurotensin-induced miR-133α expression regulates neurotensin receptor 1 recycling through its downstream target aftiphilin

N BUNNETT, IK Law, D Jensen, C Pothoulakis

Journal article  |  2016  |  Scientific Reports

Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission

J Fichna, DP Poole, N Veldhuis, SJ MacEachern, D Saur, PK Zakrzewski, AI Cygankiewicz, A Mokrowiecka, E Malecka-Panas, WM Krajewska, W Liedtke, MS Steinhoff, J-P Timmermans, NW Bunnett, KA Sharkey, MA Storr

Journal article  |  2015  |  Journal of Molecular Medicine

P2Y(1) Receptor Activation of the TRPV4 Ion Channel Enhances Purinergic Signaling in Satellite Glial Cells

Pradeep Rajasekhar, Daniel P Poole, Wolfgang Liedtke, Nigel W Bunnett, Nicholas A Veldhuis

Journal article  |  2015  |  Journal of Biological Chemistry

G Protein-Coupled Receptors: Dynamic Machines for Signaling Pain and Itch

Pierangelo Geppetti, Nicholas A Veldhuis, TinaMarie Lieu, Nigel W Bunnett

Journal article  |  2015  |  Neuron

Antibodies: friend or foe?

Romke Bron, Nigel W Bunnett

Journal article  |  2015  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Demonstration of elevated levels of active cathepsin S in dextran sulfate sodium colitis using a new activatable probe

N Barlow, Y Nasser, P Zhao, N Sharma, R Guerrero-Alba, LE Edgington-Mitchell, T Lieu, NA Veldhuis, DP Poole, JW Conner, E Lindstrom, AW Craig, B Graham, SJ Vanner, NW Bunnett

Journal article  |  2015  |  Neurogastroenterology & Motility

Inflammation-induced abnormalities in the subcellular localization and trafficking of the neurokinin 1 receptor in the enteric nervous system

Daniel P Poole, TinaMarie Lieu, Juan Carlos Pelayo, Emily M Eriksson, Nicholas A Veldhuis, Nigel W Bunnett

Journal article  |  2015  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome

Nicolas Cenac, Tereza Bautzova, Pauline Le Faouder, Nicholas A Veldhuis, Daniel P Poole, Corinne Rolland, Jessica Bertrand, Wolfgang Liedtke, Marc Dubourdeau, Justine Bertrand-Michel, Lisa Zecchi, Vincenzo Stanghellini, Nigel W Bunnett, Giovanni Barbara, Nathalie Vergnolle

Journal article  |  2015  |  Gastroenterology

The New Editorial Team

Nigel W Bunnett

Journal article  |  2015  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR(2)) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain

Peishen Zhao, TinaMarie Lieu, Nicholas Barlow, Silvia Sostegni, Silke Haerteis, Christoph Korbmacher, Wolfgang Liedtke, Nestor N Jimenez-Vargas, Stephen J Vanner, Nigel W Bunnett

Journal article  |  2015  |  Journal of Biological Chemistry

Fatty Acid-binding Proteins 1 and 2 Differentially Modulate the Activation of Peroxisome Proliferator-activated Receptor alpha in a Ligand-selective Manner

Maria LR Hughes, Bonan Liu, Michelle L Halls, Kylie M Wagstaff, Rahul Patil, Tony Velkov, David A Jans, Nigel W Bunnett, Martin J Scanlon, Christopher JH Porter

Journal article  |  2015  |  Journal of Biological Chemistry

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature

Mahmoud Saifeddine, Mahmoud El-Daly, Koichiro Mihara, Nigel W Bunnett, Peter McIntyre, Christophe Altier, Morley D Hollenberg, Rithwik Ramachandran

Journal article  |  2015  |  British Journal of Pharmacology

Targeting of Transient Receptor Potential Channels in Digestive Disease

DP Poole, TM Lieu, NA Veldhuis, P Rajasekhar, NW Bunnett

Book Chapter  |  2015

Sensitisation of TRPV4 by PAR(2) is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase

Silvia Sostegni, Alexei Diakov, Peter McIntyre, Nigel Bunnett, Christoph Korbmacher, Silke Haerteis

Journal article  |  2015  |  Pflügers Archiv - European Journal of Physiology

Biased signaling of protease-activated receptors (vol 5, 67, 2014)

Peishen Zhao, Matthew Metcalf, Nigel W Bunnett

Journal article  |  2015  |  Frontiers in Endocrinology

Corrigendum: CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice

W Xie, JT Fisher, TJ Lynch, M Luo, TIA Evans, TL Neff, W Zhou, Y Zhang, Y Ou, NW Bunnett, AF Russo, MJ Goodheart, KR Parekh, X Liu, JF Engelhardt

Journal article  |  2015  |  Journal of Clinical Investigation

Bunnett named editor of AJP–GI

N Bunnett

Journal article  |  2015  |  Physiologist

The G Protein-Coupled Receptor-Transient Receptor Potential Channel Axis: Molecular Insights for Targeting Disorders of Sensation and Inflammation

Nicholas A Veldhuis, Daniel P Poole, Megan Grace, Peter McIntyre, Nigel W Bunnett

Journal article  |  2015  |  Pharmacological Reviews

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

TinaMarie Lieu, Gihan Jayaweera, Peishen Zhao, Daniel P Poole, Dane Jensen, Megan Grace, Peter McIntyre, Romke Bron, Yvette M Wilson, Matteus Krappitz, Silke Haerteis, Christoph Korbmacher, Martin S Steinhoff, Romina Nassini, Serena Materazzi, Pierangelo Geppetti, Carlos U Corvera, Nigel W Bunnett

Journal article  |  2014  |  Gastroenterology

Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR(2) and TRPV4

Peishen Zhao, TinaMarie Lieu, Nicholas Barlow, Matthew Metcalf, Nicholas A Veldhuis, Dane D Jensen, Martina Kocan, Silvia Sostegni, Silke Haerteis, Vera Baraznenok, Ian Henderson, Erik Lindstrom, Raquel Guerrero-Alba, Eduardo E Valdez-Morales, Wolfgang Liedtke, Peter McIntyre, Stephen J Vanner, Christoph Korbmacher, Nigel W Bunnett

Journal article  |  2014  |  Journal of Biological Chemistry

The tyrosine kinase inhibitor bafetinib inhibits PAR2-induced activation of TRPV4 channels in vitro and pain in vivo

MS Grace, T Lieu, B Darby, FC Abogadie, N Veldhuis, NW Bunnett, P McIntyre

Journal article  |  2014  |  British Journal of Pharmacology

Serine proteases and protease-activated receptor 2 mediate the proinflammatory and algesic actions of diverse stimulants

F Cattaruzza, S Amadesi, JF Carlsson, JE Murphy, V Lyo, K Kirkwood, GS Cottrell, M Bogyo, W Knecht, NW Bunnett

Journal article  |  2014  |  British Journal of Pharmacology

Endothelin-converting Enzyme 1 and beta-Arrestins Exert Spatiotemporal Control of Substance P-induced Inflammatory Signals

Dane D Jensen, Michelle L Halls, Jane E Murphy, Meritxell Canals, Fiore Cattaruzza, Daniel P Poole, TinaMarie Lieu, Hon-Wai Koon, Charalabos Pothoulakis, Nigel W Bunnett

Journal article  |  2014  |  Journal of Biological Chemistry

Neuro-humoral signalling by bile acids and the TGR5 receptor in the gastrointestinal tract

Nigel W Bunnett

Journal article  |  2014  |  The Journal of Physiology

Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites

Silke Haerteis, Annabel Krappitz, Matteus Krappitz, Jane E Murphy, Marko Bertog, Bettina Krueger, Regina Nacken, Hyunjae Chung, Morley D Hollenberg, Wolfgang Knecht, Nigel W Bunnett, Christoph Korbmacher

Journal article  |  2014  |  Journal of Biological Chemistry

Neural peptidase endothelin-converting enzyme 1-regulates endothelin induced pruritus

Makiko Kido-Nakahara, Joerg Buddenkotte, Cordula Kempkes, Akihiko Ikoma, Ferda Cevikbas, Tasuku Akiyama, Frank Nunes, Stephan Seeliger, Burcu Hasdemir, Christian Mess, Timo Buhl, Mathias Sulk, Frank-Ulrich Mueller, Dieter Metze, Nigel W Bunnett, Aditi Bhargava, Earl Carstens, Masutaka Furue, Martin Steinhoff

Journal article  |  2014  |  Journal of Clinical Investigation

Localisation and activation of the neurokinin 1 receptor in the enteric nervous system of the mouse distal colon

Juan-Carlos Pelayo, Nicholas A Veldhuis, Emily M Eriksson, Nigel W Bunnett, Daniel P Poole

Journal article  |  2014  |  Cell and Tissue Research

Activation of Mu Opioid Receptors Sensitizes Transient Receptor Potential Vanilloid Type 1 (TRPV1) via beta-Arrestin-2-Mediated Cross-Talk

Matthew P Rowan, Sonya M Bierbower, Michael A Eskander, Kalina Szteyn, Elaine D Por, Ruben Gomez, Nicholas Veldhuis, Nigel W Bunnett, Nathaniel A Jeske

Journal article  |  2014  |  PLoS ONE

Feeding-dependent activation of enteric cells and sensory neurons by lymphatic fluid: evidence for a neurolymphocrine system

Daniel P Poole, Mike Lee, Patrick Tso, Nigel W Bunnett, Sek Jin Yo, TinaMarie Lieu, Amy Shiu, Jen-Chywan Wang, Daniel K Nomura, Gregory W Aponte

Journal article  |  2014  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

Localization of receptors for calcitonin-gene-related peptide to intraganglionic laminar endings of the mouse esophagus: peripheral interaction between vagal and spinal afferents?

L Horling, NW Bunnett, K Messlinger, WL Neuhuber, M Raab

Journal article  |  2014  |  Histochemistry and Cell Biology

GPBA: a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation

T Lieu, G Jayaweera, NW Bunnett

Journal article  |  2014  |  British Journal of Pharmacology

Biased signaling of protease-activated receptors

Peishen Zhao, Matthew Metcalf, Nigel W Bunnett

Journal article  |  2014  |  Frontiers in Endocrinology

TACHYKININS AND THEIR RECEPTORS: CONTRIBUTIONS TO PHYSIOLOGICAL CONTROL AND THE MECHANISMS OF DISEASE

Martin S Steinhoff, Bengt von Mentzer, Pierangelo Geppetti, Charalabos Pothoulakis, Nigel W Bunnett

Journal article  |  2014  |  Physiological Reviews

Sensitization of Peripheral Sensory Nerves by Mediators From Colonic Biopsies of Diarrhea-Predominant Irritable Bowel Syndrome Patients: A Role for PAR2

Eduardo E Valdez-Morales, Jeff Overington, Raquel Guerrero-Alba, Fernando Ochoa-Cortes, Charles O Ibeakanma, Ian Spreadbury, Nigel W Bunnett, Michael Beyak, Stephen J Vanner

Journal article  |  2013  |  American Journal of Gastroenterology

Agonist-biased Trafficking of Somatostatin Receptor 2A in Enteric Neurons

Peishen Zhao, Meritxell Canals, Jane E Murphy, Diana Klingler, Emily M Eriksson, Juan-Carlos Pelayo, Markus Hardt, Nigel W Bunnett, Daniel P Poole

Journal article  |  2013  |  Journal of Biological Chemistry

The Bile Acid Receptor TGR5 Does Not Interact with beta-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts

Dane D Jensen, Cody B Godfrey, Christian Niklas, Meritxell Canals, Martina Kocan, Daniel P Poole, Jane E Murphy, Farzad Alemi, Graeme S Cottrell, Christoph Korbmacher, Nevin A Lambert, Nigel W Bunnett, Carlos U Corvera

Journal article  |  2013  |  Journal of Biological Chemistry

Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice

Fiore Cattaruzza, Cali Johnson, Alan Leggit, Eileen Grady, A Katrin Schenk, Ferda Cevikbas, Wendy Cedron, Sandhya Bondada, Rebekah Kirkwood, Brian Malone, Martin Steinhoff, Nigel Bunnett, Kimberly S Kirkwood

Journal article  |  2013  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway

Senthilkumar Rajagopal, Divya P Kumar, Sunila Mahavadi, Sayak Bhattacharya, Ruizhe Zhou, Carlos U Corvera, Nigel W Bunnett, John R Grider, Karnam S Murthy

Journal article  |  2013  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Arresting inflammation: contributions of plasma membrane and endosomal signalling to neuropeptide-driven inflammatory disease

Fiore Cattaruzza, Daniel P Poole, Nigel W Bunnett

Journal article  |  2013  |  Biochemical Society Transactions

Preface to the series-historical and conceptual perspective of the autonomic nervous system book series

G Burnstock

Book Chapter  |  2013

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

Silke Haerteis, Matteus Krappitz, Marko Bertog, Annabel Krappitz, Vera Baraznenok, Ian Henderson, Erik Lindstrom, Jane E Murphy, Nigel W Bunnett, Christoph Korbmacher

Journal article  |  2012  |  Pflügers Archiv - European Journal of Physiology

Active cathepsins B, L, and S in murine and human pancreatitis

Victoria Lyo, Fiore Cattaruzza, Tyson N Kim, Austin W Walker, Margot Paulick, Daniel Cox, Jordan Cloyd, James Buxbaum, James Ostroff, Matthew Bogyo, Eileen F Grady, Nigel W Bunnett, Kimberly S Kirkwood

Journal article  |  2012  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Neurotensin-induced Proinflammatory Signaling in Human Colonocytes Is Regulated by beta-Arrestins and Endothelin-converting Enzyme-1-dependent Endocytosis and Resensitization of Neurotensin Receptor 1

Ivy Ka Man Law, Jane E Murphy, Kyriaki Bakirtzi, Nigel W Bunnett, Charalabos Pothoulakis

Journal article  |  2012  |  Journal of Biological Chemistry

Endothelin-Converting Enzyme-1 Actions Determine Differential Trafficking and Signaling of Corticotropin-Releasing Factor Receptor 1 at High Agonist Concentrations

Burcu Hasdemir, Shilpi Mahajan, Nigel W Bunnett, Min Liao, Aditi Bhargava

Journal article  |  2012  |  Molecular Endocrinology

Brain-Gut Interactions Increase Peripheral Nociceptive Signaling in Mice With Postinfectious Irritable Bowel Syndrome

Charles Ibeakanma, Fernando Ochoa-Cortes, Marcela Miranda-Morales, Todd Mcdonald, Ian Spreadbury, Nicolas Cenac, Fiore Cattaruzza, David Hurlbut, Stephanie Vanner, Nigel Bunnett, Nathalie Vergnolle, Stephen Vanner

Journal article  |  2011  |  Gastroenterology

Cathepsin S Is Activated During Colitis and Causes Visceral Hyperalgesia by a PAR(2)-Dependent Mechanism in Mice

Fiore Cattaruzza, Victoria Lyo, Ella Jones, David Pham, James Hawkins, Kimberley Kirkwood, Eduardo Valdez-Morales, Charles Ibeakanma, Stephen J Vanner, Matthew Bogyo, Nigel W Bunnett

Journal article  |  2011  |  Gastroenterology

Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones

Juan-Carlos Pelayo, Daniel P Poole, Martin Steinhoff, Graeme S Cottrell, Nigel W Bunnett

Journal article  |  2011  |  Journal of Physiology

Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor

Jane E Murphy, Dirk Roosterman, Graeme S Cottrell, Benjamin E Padilla, Micha Feld, Eva Brand, Wendy J Cedron, Nigel W Bunnett, Martin Steinhoff

Journal article  |  2011  |  American Journal of Physiology-Cell Physiology

Localization and Regulation of Fluorescently Labeled Delta Opioid Receptor, Expressed in Enteric Neurons of Mice

Daniel P Poole, Juan-Carlos Pelayo, Gregory Scherrer, Christopher J Evans, Brigitte L Kieffer, Nigel W Bunnett

Journal article  |  2011  |  Gastroenterology

CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice

Weiliang Xie, John T Fisher, Thomas J Lynch, Meihui Luo, Turan IA Evans, Traci L Neff, Weihong Zhou, Long Zhang, Yi Ou, Nigel W Bunnett, Andrew F Russo, Michael J Goodheart, Kalpaj R Parekh, Xiaoming Liu, John F Engelhardt

Journal article  |  2011  |  Journal of Clinical Investigation

Serine proteases mediate inflammatory pain in acute pancreatitis

Eugene P Ceppa, Victoria Lyo, Eileen F Grady, Wolfgang Knecht, Sarah Grahn, Anders Peterson, Nigel W Bunnett, Kimberly S Kirkwood, Fiore Cattaruzza

Journal article  |  2011  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Trafficking and Signaling of G Protein-Coupled Receptors in the Nervous System: Implications for Disease and Therapy

Nigel W Bunnett, Graeme S Cottrell

Journal article  |  2010  |  CNS & Neurological Disorders - Drug Targets

Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice

Eugene Ceppa, Fiore Cattaruzza, Victoria Lyo, Silvia Amadesi, Juan-Carlos Pelayo, Daniel P Poole, Natalya Vaksman, Wolfgang Liedtke, David M Cohen, Eileen F Grady, Nigel W Bunnett, Kimberly S Kirkwood

Journal article  |  2010  |  American Journal of Physiology - Gastrointestinal and Liver Physiology

Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system

DP Poole, C Godfrey, F Cattaruzza, GS Cottrell, JG Kirkland, JC Pelayo, NW Bunnett, CU Corvera

Journal article  |  2010  |  Neurogastroenterology and Motility

Pungent General Anesthetics Activate Transient Receptor Potential-A1 to Produce Hyperalgesia and Neurogenic Bronchoconstriction

Helge Eilers, Fiore Cattaruzza, Romina Nassini, Serena Materazzi, Eunice Andre, Catherine Chu, Graeme S Cottrell, Mark Schumacher, Pierangelo Geppetti, Nigel W Bunnett

Journal article  |  2010  |  Anesthesiology

A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation

N Vergnolle, N Cenac, C Altier, L Cellars, K Chapman, GW Zamponi, S Materazzi, R Nassini, W Liedtke, F Cattaruzza, EF Grady, P Geppetti, NW Bunnett

Journal article  |  2010  |  British Journal of Pharmacology

Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice

Fiore Cattaruzza, Ian Spreadbury, Marcela Miranda-Morales, Eileen F Grady, Stephen Vanner, Nigel W Bunnett

Journal article  |  2010  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Endosomes: A legitimate platform for the signaling train

Jane E Murphy, Benjamin E Padilla, Burcu Hasdemir, Graeme S Cottrell, Nigel W Bunnett

Journal article  |  2009  |  Proceedings of the National Academy of Sciences

Endosomal Deubiquitinating Enzymes Control Ubiquitination and Down-regulation of Protease-activated Receptor 2

Burcu Hasdemir, Jane E Murphy, Graeme S Cottrell, Nigel W Bunnett

Journal article  |  2009  |  Journal of Biological Chemistry

Protein Kinase D Isoforms Are Expressed in Rat and Mouse Primary Sensory Neurons and Are Activated by Agonists of Protease-Activated Receptor 2

Silvia Amadesi, Andrew D Grant, Graeme S Cottrell, Natalya Vaksman, Daniel P Poole, Enrique Rengurt, Nigel W Bunnett

Journal article  |  2009  |  Journal of Comparative Neurology

Endosomal Endothelin-converting Enzyme-1 A REGULATOR OF beta-ARRESTIN-DEPENDENT ERK SIGNALING

Graeme S Cottrell, Benjamin E Padilla, Silvia Amadesi, Daniel P Poole, Jane E Murphy, Markus Hardt, Dirk Roosterman, Martin Steinhoff, Nigel W Bunnett

Journal article  |  2009  |  Journal of Biological Chemistry

Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation

F Cattaruzza, GS Cottrell, N Vaksman, NW Bunnett

Journal article  |  2009  |  British Journal of Pharmacology

Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Serena Materazzi, Rornina Nassini, Eunice Andre, Barbara Campi, Silvia Amadesi, Marcello Trevisani, Nigel W Bunnett, Riccardo Patacchini, Pierangelo Geppetti

Journal article  |  2008  |  Proceedings of the National Academy of Sciences

Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents

Eunice Andre, Barbara Campi, Serena Materazzi, Marcello Trevisani, Silvia Amadesi, Daniela Massi, Christophe Creminon, Natalya Vaksman, Romina Nassini, Maurizio Civelli, Pier Giovanni Baraldi, Daniel P Poole, Nigel W Bunnett, Pierangelo Geppetti, Riccardo Patacchini

Journal article  |  2008  |  Journal of Clinical Investigation

Endothelin-converting enzyme-1 degrades internalized somatostatin-14

Dirk Roosterman, Cordula Kempkes, Graeme S Cottrell, Benjamin E Padilla, Nigel W Bunnett, Christoph W Turck, Martin Steinhoff

Journal article  |  2008  |  Endocrinology

Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia

Walter EB Sipe, Stuart M Brierley, Christopher M Martin, Benjamin D Phillis, Francisco Bautista Cruz, Eileen F Grady, Wolfgang Liedtke, David M Cohen, Stephen Vanner, L Ashley Blackshaw, Nigel W Bunnett

Journal article  |  2008  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactlivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution

Jochen K Lennerz, Victor Ruehle, Eugene P Ceppa, Winfried L Neuhuber, Nigel W Bunnett, Eileen F Grady, Karl Messlinger

Journal article  |  2008  |  The Journal of Comparative Neurology

Proteinase-activated receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP-response element-binding protein

Hongying Wang, Shoubin Wen, Nigel W Bunnett, Richard Leduc, Morley D Hollenberg, Wallace K MacNaughton

Journal article  |  2008  |  Journal of Biological Chemistry

Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury (vol 43, pg 581, 2007)

David Gazzieri, Marcello Trevisani, Jochen Spriinger, Selena Harrison, Graeme S Cottrell, Eunice Andre, Paola Nicoletti, Daniela Massi, Sandra Zecchi, Daniele Nosi, Marco Santucci, Norma P Gerard, Monica Lucattelli, Giuseppe Lungarella, Axel Fischer, Eileen F Grady, Nigel W Bunnett, Pierangelo Geppetti

Journal article  |  2007  |  Free Radical Biology and Medicine

Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins

Benjamin E Padilla, Graeme S Cottrell, Dirk Roosterman, Stella Pikios, Laurent Muller, Martin Steinhoff, Nigel W Bunnett

Journal article  |  2007  |  The Journal of Cell Biology

Protease-activated receptors: novel PARtners in innate immunity

V Shpacovitch, M Feld, NW Bunnett, M Steinhoff

Journal article  |  2007  |  Trends in Immunology

Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor

Burcu Hasdemir, Nigel W Bunnett, Graeme S Cottrell

Journal article  |  2007  |  Journal of Biological Chemistry

Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia

Wolfgang Knecht, Graeme S Cottrell, Silvia Amadesi, Johanna Mohlin, Anita Skaregarde, Karin Gedda, Anders Peterson, Kevin Chapman, Morley D Hollenberg, Nathalie Vergnolle, Nigel W Bunnett

Journal article  |  2007  |  Journal of Biological Chemistry

Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury

David Gazzieri, Marcello Trevisani, Jochen Springer, Selena Harrison, Graeme S Cottrell, Eunice Andre, Paola Nicoletti, Daniela Massi, Sandra Zecchi, Daniele Nosi, Marco Santucci, Norma P Gerard, Monica Lucattelli, Giuseppe Lungarella, Axel Fischer, Eileen F Grady, Nigel W Bunnett, Pierangelo Geppetti

Journal article  |  2007  |  Free Radical Biology and Medicine

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

Marcello Trevisani, Jan Siemens, Serena Materazzi, Diana M Bautista, Romina Nassini, Barbara Campi, Noritaka Imamachi, Eunice Andre, Riccardo Patacchini, Graeme S Cottrell, Raffaele Gatti, Allan I Basbaum, Nigel W Bunnett, David Julius, Pierangelo Geppetti

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

Calcitonin receptor-like and receptor activity modifying protein 1 in the rat dorsal horn localization in glutamatergic presynaptic terminal containing opioids and adrenergic alpha(2c) receptor

JCG Marvizon, OA Perez, B Song, W Chen, NW Bunnett, EF Grady, AJ Todd

Journal article  |  2007  |  Neuroscience

Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling

Dirk Roosterman, Graeme S Cottrell, Benjamin E Padilla, Laurent Muller, Christopher B Eckman, Nigel W Bunnett, Martin Steinhoff

Journal article  |  2007  |  Proceedings of the National Academy of Sciences

Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder

Jacob G Kirkland, Graeme S Cottrell, Nigel W Bunnett, Carlos U Corvera

Journal article  |  2007  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Protease-activated receptor 2, dipeptidyl peptidase 1, and proteases mediate Clostridium difficile toxin A enteritis

Graeme S Cottrell, Silvia Amadesi, Stella Pikios, Eric Camerer, J Adam Willardsen, Brett R Murphy, George H Caughey, Paul J Wolters, Shaun R Coughlin, Anders Peterson, Wolfgang Knecht, Charalabos Pothoulakis, Nigel W Bunnett, Eileen F Grady

Journal article  |  2007  |  Gastroenterology

Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon

Ahmed Kayssi, Silvia Amadesi, Francisco Bautista, Nigel W Bunnett, Stephen Vanner

Journal article  |  2007  |  The Journal of Physiology

Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1

Graeme S Cottrell, Benjamin Padilla, Stella Pikios, Dirk Roosterman, Martin Steinhoff, Eileen F Grady, Nigel W Bunnett

Journal article  |  2007  |  Journal of Biological Chemistry

Agonist-induced endocytosis of rat somatostatin receptor 1.

Dirk Roosterman, Oliver J Kreuzer, Nicole Brune, Graeme S Cottrell, Nigel W Bunnett, Wolfgang Meyerhof, Martin Steinhoff

Journal article  |  2007  |  Endocrinology

Somatostatin-receptor 1 (sst1) is an autoreceptor in the central nervous system that regulates the release of somatostatin. Sst1 i..

Role for protease activity in visceral pain in irritable bowel syndrome

Nicolas Cenac, Christopher N Andrews, Marinella Holzhausen, Kevin Chapman, Graeme Cottrell, Patricia Andrade-Gordon, Martin Steinhoff, Giovanni Barbara, Paul Beck, Nigel W Bunnett, Keith A Sharkey, Jose Geraldo P Ferraz, Eldon Shaffer, Nathalie Vergnolle

Journal article  |  2007  |  Journal of Clinical Investigation

Predominant surface distribution of neurokinin-3 receptors in non-dopaminergic dendrites in the rat substantia nigra and ventral tegmental area.

A Lessard, EF Grady, NW Bunnett, VM Pickel

Journal article  |  2007  |  Neuroscience

Neurokinin-3 (NK(3)) receptors are prevalent within the substantia nigra (SN) and ventral tegmental area (VTA), where their activa..

Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice

Andrew D Grant, Graeme S Cottrell, Silvia Amadesi, Marcello Trevisani, Paola Nicoletti, Serena Materazzi, Christophe Altier, Nicolas Cenac, GeraldW Zamponi, Francisco Bautista-Cruz, Carlos Barajas Lopez, Elizabeth K Joseph, Jon D Levine, Wolfgang Liedtke, Stephen Vanner, Nathalie Vergnolle, Pierangelo Geppetti, Nigel W Bunnett

Journal article  |  2007  |  The Journal of Physiology

Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome

Giovanni Barbara, Bingxian Wang, Vincenzo Stanghellini, Roberto De Giorgio, Cesare Cremon, Giovanni Di Nardo, Marcello Trevisani, Barbara Campi, Pierangelo Geppetti, Marcello Tonini, Nigel W Bunnett, David Grundy, Roberto Corinaldesi

Journal article  |  2007  |  Gastroenterology

Protease-activated receptors: novel PARtners in innate immunity

V Shpacovitch, M Feld, NW Bunnett, M Steinhoff

Journal article  |  2007  |  Trends in Immunology

Impaired pain sensation in mice lacking prokineticin 2

Wang-Ping Hu, Chengkang Zhang, Jia-Da Li, Z David Luo, Silvia Amadesi, Nigel Bunnett, Qun-Yong Zhou

Journal article  |  2006  |  Molecular Pain

Proteinase-activated receptors, targets for kallikrein signaling

Katerina Oikonomopoulou, Kristina K Hansen, Mahmoud Saifeddine, Illa Tea, Michael Blaber, Sachiko I Blaber, Isobel Scarisbrick, Patricia Andrade-Gordon, Graeme S Cottrell, Nigel W Bunnett, Eleftherios P Diamandis, Morley D Hollenberg

Journal article  |  2006  |  Journal of Biological Chemistry

Neuronal control of skin function: The skin as a neuroimmunoendocrine organ

Dirk Roosterman, Tobias Goerge, Stefan W Schneider, Nigel W Bunnett, Martin Steinhoff

Journal article  |  2006  |  Physiological Reviews

Tachykinins 2005 Meeting

N Bunnett

Journal article  |  2006  |  Vascular Pharmacology

Ubiquitin-dependent down-regulation of the neurokinin-1 receptor

Graeme S Cottrell, Benjamin Padilla, Stella Pikios, Dirk Roosterman, Martin Steinhoff, Daphne Gehringer, Eileen F Grady, Nigel W Bunnett

Journal article  |  2006  |  Journal of Biological Chemistry

Protease-activated receptor 2 sensitizes TRPV1 by protein kinase C epsilon- and A-dependent mechanisms in rats and mice

Silvia Amadesi, Graeme S Cottrell, Lorna Divino, Kevin Chapman, Eileen F Grady, Francisco Bautista, Rustum Karanjia, Carlos Barajas-Lopez, Stephen Vanner, Nathalie Vergnolle, Nigel W Bunnett

Journal article  |  2006  |  The Journal of Physiology

Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs

Raffaele Gatti, Eunice Andre, Silvia Amadesi, Thai Q Dinh, Axel Fischer, Nigel W Bunnett, Selena Harrison, Pierangelo Geppetti, Marcello Trevisani

Journal article  |  2006  |  Journal of Applied Physiology

A role for proteinase-activated receptor-1 in inflammatory bowel diseases.

Nathalie Vergnolle, Laurie Cellars, Andrea Mencarelli, Giovanni Rizzo, Sunita Swaminathan, Paul Beck, Martin Steinhoff, Patricia Andrade-Gordon, Nigel W Bunnett, Morley D Hollenberg, John L Wallace, Giuseppe Cirino, Stefano Fiorucci

Journal article  |  2006  |  Journal of Clinical Investigation

Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis

EC Wick, SG Hoge, SW Grahn, E Kim, LA Divino, EF Grady, NW Bunnett, KS Kirkwood

Journal article  |  2006  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Protease-activated receptors: How proteases signal to cells to cause inflammation and pain

Nigel W Bunnett

Journal article  |  2006  |  Seminars in Thrombosis and Hemostasis

Expression of the neurokinin type 1 receptor in the human colon

H Boutaghou-Cherid, C Porcher, M Liberge, Y Jule, NW Bunnett, MO Christen

Journal article  |  2006  |  Autonomic Neuroscience

Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat

GS Cottrell, D Roosterman, J Marvizon, B Song, E Wick, S Pikios, H Wong, C Berthelier, Y Tang, C Sternini, NW Bunnett, EF Grady

Journal article  |  2005  |  The Journal of Comparative Neurology

Mast cell tryptase controls paracellular permeability of the intestine - Role of protease-activated receptor 2 and beta-arrestins

C Jacob, PC Yang, D Darmoul, S Amadesi, T Saito, GS Cottrell, AM Coelho, P Singh, EF Grady, M Perdue, NW Bunnett

Journal article  |  2005  |  Journal of Biological Chemistry

Neutral endopeptidase determines the severity of pancreatitis-associated lung injury

AL Day, E Wick, TH Jordan, CE Jaffray, NW Bunnett, EF Grady, KS Kirkwood

Journal article  |  2005  |  Journal of Surgical Research

The stressed gut: Contributions of intestinal stress peptides to inflammation and motility

NW Bunnett

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells.

Sophie Dulon, Dominique Leduc, Graeme S Cottrell, Jacques D'Alayer, Kristina K Hansen, Nigel W Bunnett, Morley D Hollenberg, Dominique Pidard, Michel Chignard

Journal article  |  2005  |  American Journal of Respiratory Cell and Molecular Biology

Pseudomonas aeruginosa, a major lung pathogen in cystic fibrosis (CF) patients, secretes an elastolytic metalloproteinase (EPa) co..

c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2

C Jacob, GS Cottrell, D Gehringer, F Schmidlin, EF Grady, NW Bunnett

Journal article  |  2005  |  Journal of Biological Chemistry

Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R)

MM Hutter, EC Wick, AL Day, J Maa, EC Zerega, AC Richmond, TH Jordan, EF Grady, SJ Mulvihill, NW Bunnett, KS Kirkwood

Journal article  |  2005  |  Pancreas

Protease-activated receptors: regulation of neuronal function.

Toshiyuki Saito, Nigel W Bunnett

Journal article  |  2005  |  NeuroMolecular Medicine

Certain serine proteases from the circulation (e.g., coagulation factors), inflammatory cells (e.g., mast-cell tryptase, neutrophi..

Protease-activated receptors: protease signaling in the gastrointestinal tract.

Silvia Amadesi, Nigel Bunnett

Journal article  |  2004  |  Current Opinion in Pharmacology

Serine proteases from the circulation, inflammatory cells, digestive glands and microorganisms can signal to cells by cleaving pro..

A role for proteinase-activated receptor-1 in inflammatory bowel diseases (Retracted article. See vol 116, pg 2056, 2006)

N Vergnolle, L Cellars, A Mencarelli, G Rizzo, S Swaminathan, P Beck, M Steinhoff, P Andrade-Gordon, NW Bunnett, MD Hollenberg, JL Wallace, G Cirino, S Fiorucci

Journal article  |  2004  |  Journal of Clinical Investigation

Recycling and resensitization of the neurokinin 1 receptor - Influence of agonist concentration and Rab GTPases

D Roosterman, GS Cottrell, F Schmidlin, M Steinhoff, NW Bunnett

Journal article  |  2004  |  Journal of Biological Chemistry

Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia

S Amadesi, JJ Nie, N Vergnolle, GS Cottrell, EF Grady, M Trevisani, C Manni, P Geppetti, JA McRoberts, H Ennes, B Davis, EA Mayer, NW Bunnett

Journal article  |  2004  |  Journal of Neuroscience

Trypsin IV, a novel agonist of protease-activated receptors 2 and 4

GS Cottrell, S Amadesi, EF Grady, NW Bunnett

Journal article  |  2004  |  Journal of Biological Chemistry

Protease-activated receptors: Contribution to physiology and disease

VS Ossovskaya, NW Bunnett

Journal article  |  2004  |  Physiological Reviews

Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage

TE Scholzen, M Steinhoff, A Sindrilaru, A Schwarz, NW Bunnett, TA Luger, CA Armstrong, JC Ansel

Journal article  |  2004  |  The FASEB Journal

Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome

G Barbara, V Stanghellini, R De Giorgio, C Cremon, GS Cottrell, D Santini, G Pasquinelli, AM Morselli-Labate, EF Grady, NW Bunnett, SM Collins, R Corinalidesi

Journal article  |  2004  |  Gastroenterology

Protease-activated receptor 2: activation, signalling and function.

GS Cottrell, S Amadesi, F Schmidlin, N Bunnett

Conference Proceedings  |  2003  |  Biochemical Society Transactions

PARs (protease-activated receptors) are a family of four G-protein-coupled receptors for proteases from the circulation, inflammat..

Stimulation of proteinase-activated receptor 2 excites jejunal afferent nerves in anaesthetised rats

AJ Kirkup, W Jiang, NW Bunnett, D Grundy

Journal article  |  2003  |  The Journal of Physiology

Proinflammatory role of proteinase-activated receptor-2 in humans and mice during cutaneous inflammation in vivo

S Seeliger, CK Derian, N Vergnolle, NW Bunnett, R Nawroth, M Schmelz, PY von der Weid, J Buddenkotte, C Sunderkotter, D Metze, P Andrade-Gordon, E Harms, D Vestweber, TA Luger, M Steinhoff

Journal article  |  2003  |  The FASEB Journal

The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins

F Schmidlin, D Roosterman, NW Bunnett

Journal article  |  2003  |  American Journal of Physiology-Cell Physiology

Substance P regulates Th1-type colitis in IL-10 knockout mice.

Joel V Weinstock, Arthur Blum, Ahmed Metwali, David Elliott, Nigel Bunnett, Razvan Arsenescu

Journal article  |  2003  |  The Journal of Immunology

Substance P (SP) is a proinflammatory molecule that interacts with a neurokinin 1 receptor (NK-1R), which is on T cells and helps ..

Neutral endopeptidase (EC 3.4.24.11) downregulates the onset of intestinal inflammation in the nematode infected mouse

G Barbara, R De Giorgio, V Stanghellini, R Corinaldesi, C Cremon, N Gerard, C Gerard, EF Grady, NW Bunnett, PA Blennerhassett, SM Collins

Journal article  |  2003  |  Gut

Colitis induced by proteinase-activated receptor-2 agonists is mediated by a neurogenic mechanism

C Nguyen, AM Coelho, E Grady, SJ Compton, JL Wallace, MD Hollenberg, N Cenac, R Garcia-Villar, L Bueno, M Steinhoff, NW Bunnett, N Vergnolle

Journal article  |  2003  |  Canadian Journal of Physiology and Pharmacology

Bradykinin B-2 receptors mediate contraction in the normal and inflamed human gallbladder in vitro

M Trevisani, S Amadesi, F Schmidlin, MT Poblete, E Bardella, B Maggiore, S Harrison, CD Figueroa, M Tognetto, G Navarra, A Turini, NW Bunnett, P Geppetti, R De Giorgio

Journal article  |  2003  |  Gastroenterology

Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2

D Roosterman, F Schmidlin, NW Bunnett

Journal article  |  2003  |  American Journal of Physiology-Cell Physiology

Proteinase-activated receptor-2-induced colonic inflammation in mice: Possible involvement of afferent neurons, nitric oxide, and paracellular permeability

N Cenac, R Garcia-Villar, L Ferrier, M Larauche, N Vergnolle, NW Bunnett, AM Coelho, J Fioramonti, L Bueno

Journal article  |  2003  |  The Journal of Immunology

Proteinase-activated receptor-2: physiological and pathophysiological roles.

Anne-Marie Coelho, Valeria Ossovskaya, Nigel W Bunnett

Journal article  |  2003  |  Current Medicinal Chemistry-Cardiovascular & Hematological Agents

Protease-activated receptor 2 (PAR2) is the second member of a new subfamily of G-protein coupled receptors: the protease-activate..

Proteinase-activated receptor-2 and human lung epithelial cells - Disarming by neutrophil serine proteinases

S Dulon, C Cande, NW Bunnett, MD Hollenberg, M Chignard, D Pidard

Journal article  |  2003  |  American Journal of Respiratory Cell and Molecular Biology

Mast cell tryptase and proteinase-activated receptor 2 induce hyperexcitability of guinea-pig submucosal neurons

DE Reed, C Barajas-Lopez, G Cottrell, S Velazquez-Rocha, O Dery, EF Grady, NW Bunnett, SJ Vanner

Journal article  |  2003  |  The Journal of Physiology

Human corneal epithelial cells express functional PAR-1 and PAR-2

R Lang, PI Song, FJ Legat, RM Lavker, B Harten, H Kalden, EF Grady, NW Bunnett, CA Armstrong, JC Ansel

Journal article  |  2003  |  Investigative Opthalmology & Visual Science

Neutral endopeptidase activity is increased in the skin of subjects with diabetic ulcers.

MarcosA Antezana, Stephen R Sullivan, MarciaL Usui, NicoleS Gibran, MichelleL Spenny, JerrieA Larsen, JohnC Ansel, NigelW Bunnett, JohnE Olerud

Journal article  |  2002  |  Journal of Investigative Dermatology

Cutaneous sensory nerves mediate inflammation and wound healing by releasing neuropeptides, such as substance P, which stimulates ..

Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2

N Cenac, AM Coelho, C Nguyen, S Compton, P Andrade-Gordon, WK MacNaughton, JL Wallace, MD Hollenberg, NW Bunnett, R Garcia-Villar, L Bueno, N Vergnolle

Journal article  |  2002  |  The American Journal of Pathology

Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus.

Nicole S Gibran, Young Chul Jang, F Frank Isik, David G Greenhalgh, Lara A Muffley, Robert A Underwood, Marcia L Usui, Jerrie Larsen, Douglas G Smith, Nigel Bunnett, John C Ansel, John E Olerud

Journal article  |  2002  |  Journal of Surgical Research

Background. Patients with diabetic sensory neuropathy have significant risk of chronic ulcers. Insufficient nerve-derived mediator..

Protease-activated receptor 2 mediates eosinophil infiltration and hyperreactivity in allergic inflammation of the airway

F Schmidlin, S Amadesi, K Dabbagh, DE Lewis, P Knott, NW Bunnett, PR Gater, P Geppetti, C Bertrand, ME Stevens

Journal article  |  2002  |  The Journal of Immunology

Differences in receptor binding and stability to enzymatic digestion between CCK-8 and CCK-58.

Joseph R Reeve, Douglas C McVey, Nigel W Bunnett, Travis E Solomon, David A Keire, FJ Ho, Michael T Davis, Terry D Lee, John E Shively, Steven R Vigna

Journal article  |  2002  |  Pancreas

INTRODUCTION AND AIMS: It has been proposed that distinct tertiary structures of the C-terminus of CCK-8 and CCK-58 result in diff..

Neutral endopeptidase inhibition in diabetic wound repair

ML Spenny, P Muangman, SR Sullivan, NW Bunnett, JC Ansel, JE Olerud, NS Gibran

Journal article  |  2002  |  Wound Repair and Regeneration

Recombinant human neutral endopeptidase ameliorates pancreatic elastase-induced lung injury

AM Lightner, TH Jordan, NW Bunnett, EF Grady, KS Kirkwood

Journal article  |  2002  |  Surgery

Heterologous regulation of trafficking and signaling of G protein-coupled receptors: beta-arrestin-dependent interactions between neurokinin receptors

F Schmidlin, O Dery, NW Bunnett, EF Grady

Journal article  |  2002  |  Proceedings of the National Academy of Sciences

Basolateral PAR-2 receptors mediate KCl secretion and inhibition of Na absorption in the mouse distal colon.

John E Cuffe, Marko Bertog, Sara Velázquez-Rocha, Olivier Dery, Nigel Bunnett, Christoph Korbmacher

Journal article  |  2002  |  The Journal of Physiology

Proteinase-activated receptor-2 (PAR-2) may participate in epithelial ion transport regulation. Here we examined the effect of mou..

Expression of protease activated receptor-2 (PAR-2) in central airways of smokers and non-smokers

D Miotto, MD Hollenberg, NW Bunnett, A Papi, F Braccioni, P Boschetto, F Rea, A Zuin, P Geppetti, M Saetta, P Maestrelli, LM Fabbri, CE Mapp

Journal article  |  2002  |  Thorax

Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappa B in human dermal microvascular endothelial cells

VM Shpacovitch, T Brzoska, J Buddenkotte, C Stroh, CP Sommerhoff, JC Ansel, K Schulze-Osthoff, NW Bunnett, TA Luger, M Steinhoff

Journal article  |  2002  |  Journal of Investigative Dermatology

Protease-activated receptors: the role of cell-surface proteolysis in signalling

CS Cottrell, AM Coelho, NW Bunnett

Journal article  |  2002  |  Essays in Biochemistry

Protease-activated receptors: how proteases signal to cells.

F Schmidlin, NW Bunnett

Journal article  |  2001  |  Current Opinion in Pharmacology

Certain proteases from the circulation, mast cells and elsewhere signal directly to cells by cleaving protease-activated receptors..

Agonists of proteinase-activated receptor 2 excite guinea pig ileal myenteric neurons

DR Linden, BP Manning, NW Bunnett, GM Mawe

Journal article  |  2001  |  European Journal of Pharmacology

Pharmacological modulation of skin neuromediators (PAR II).

N Bunnett

Journal article  |  2001  |  Experimental Dermatology

Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle

F Schmidlin, S Amadesi, R Vidil, M Trevisani, N Martinet, G Caughey, M Tognetto, G Cavallesco, C Mapp, P Geppetti, NW Bunnett

Journal article  |  2001  |  American Journal of Respiratory and Critical Care Medicine

Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.

KS Kirkwood, NW Bunnett, J Maa, I Castagliolo, B Liu, N Gerard, J Zacks, C Pothoulakis, EF Grady

Journal article  |  2001  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Toxin A (TxA) of Clostridium difficile induces acute inflammation of the intestine initiated by release of substance P (SP) and ac..

Agonists of proteinase-activated receptor 1 induce plasma extravasation by a neurogenic mechanism

L de Garavilla, N Vergnolle, SH Young, H Ennes, M Steinhoff, VS Ossovskaya, MR D'Andrea, EA Mayer, JL Wallace, MD Hollenberg, P Andrade-Gordon, NW Bunnett

Journal article  |  2001  |  British Journal of Pharmacology

Dynamin and Rab5a-dependent trafficking and signaling of the neurokinin 1 receptor

F Schmidlin, O Dery, KO DeFea, L Slice, S Patierno, C Sternini, EF Grady, NW Bunnett

Journal article  |  2001  |  Journal of Biological Chemistry

Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway

N Vergnolle, NW Bunnett, KA Sharkey, V Brussee, SJ Compton, EF Grady, G Cirino, N Gerard, AI Basbaum, P Andrade-Gordon, MD Hollenberg, JL Wallace

Journal article  |  2001  |  Nature Medicine

Role of peripheral N-methyl-D-aspartate (NMDA) receptors in visceral nociception in rats

JA McRoberts, SV Coutinho, JCG Marvizon, EF Grady, M Tognetto, JN Sengupta, HS Ennes, VV Chaban, S Amadesi, C Creminon, T Lanthorn, P Geppetti, NW Bunnett, EA Mayer

Journal article  |  2001  |  Gastroenterology

Protein kinase C-mediated desensitization of the neurokinin 1 receptor.

O Déry, KA Defea, NW Bunnett

Journal article  |  2001  |  American Journal of Physiology-Cell Physiology

An understanding of the mechanisms that regulate signaling by the substance P (SP) or neurokinin 1 receptor (NK1-R) is of interest..

Protease-activated receptors in inflammation, neuronal signaling and pain

N Vergnolle, JL Wallace, NW Bunnett, MD Hollenberg

Journal article  |  2001  |  Trends in Pharmacological Sciences

Agonist-mediated endocytosis of rat somatostatin receptor subtype 3 involves beta-arrestin and clathrin coated vesicles

OJ Kreuzer, B Krisch, O Dery, NW Bunnett, W Meyerhof

Journal article  |  2001  |  Journal of Neuroendocrinology

Apical and basolateral EGF receptors regulate gastric mucosal paracellular permeability.

MC Chen, J Goliger, N Bunnett, AH Soll

Journal article  |  2001  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Previous studies found that monolayers formed from canine oxyntic epithelial cells in primary culture displayed remarkable resista..

Neutral endopeptidase terminates substance P-induced inflammation in allergic contact dermatitis

TE Scholzen, M Steinhoff, P Bonaccorsi, R Klein, S Amadesi, P Geppetti, B Lu, NP Gerard, JE Olerud, TA Luger, NW Bunnett, EF Grady, CA Armstrong, JC Ansel

Journal article  |  2001  |  The Journal of Immunology

Characterization of an antibody to the human melatonin mt1 receptor

LM Williams, JE Drew, NW Bunnett, E Grady, P Barrett, DR Abramovich, A Morris, D Slater

Journal article  |  2001  |  Journal of Neuroendocrinology

Neural regulation of endothelial cell-mediated inflammation.

KQ Lindsey, SW Caughman, JE Olerud, NW Bunnett, CA Armstrong, JC Ansel

Journal article  |  2000  |  Journal of Investigative Dermatology Symposium Proceedings

There is increasing evidence that the cutaneous neurosensory system can directly modulate inflammatory responses in the skin by th..

Evidence that PAR-1 and PAR-2 mediate prostanoid-dependent contraction in isolated guinea-pig gallbladder.

M Tognetto, M Trevisani, B Maggiore, G Navarra, A Turini, R Guerrini, NW Bunnett, P Geppetti, S Harrison

Journal article  |  2000  |  British Journal of Pharmacology

We have investigated the ability of protease-activated receptor-1 (PAR-1), PAR-2, PAR-3 and PAR-4 agonists to induce contractile r..

Intestinal type 2 proteinase-activated receptors: expression in opioid-sensitive secretomotor neural circuits that mediate epithelial ion transport.

BT Green, NW Bunnett, A Kulkarni-Narla, M Steinhoff, DR Brown

Journal article  |  2000  |  Journal of Pharmacology and Experimental Therapeutics

Trypsin and mast cell tryptase cleave within the extracellular N terminus of proteinase-activated receptor-2 (PAR-2), exposing a t..

NK-1 receptor desensitization and neutral endopeptidase terminate SP-induced pancreatic plasma extravasation.

J Maa, EF Grady, EH Kim, SK Yoshimi, MM Hutter, NW Bunnett, KS Kirkwood

Journal article  |  2000  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Substance P (SP) induces plasma extravasation and neutrophil infiltration by activating the neurokinin-1 receptor (NK1-R). We char..

The proliferative and antiapoptotic effects of substance P are facilitated by formation of a beta -arrestin-dependent scaffolding complex.

KA DeFea, ZD Vaughn, EM O'Bryan, D Nishijima, O Déry, NW Bunnett

Journal article  |  2000  |  Proceedings of the National Academy of Sciences

A requirement for scaffolding complexes containing internalized G protein-coupled receptors and beta-arrestins in the activation a..

Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice.

J Maa, EF Grady, SK Yoshimi, TE Drasin, EH Kim, MM Hutter, NW Bunnett, KS Kirkwood

Journal article  |  2000  |  Surgery

BACKGROUND: The neuropeptide substance P (SP) induces plasma extravasation and neutrophil infiltration by activating the neurokini..

Neurokinin 1 receptor distribution in cholinergic neurons and targets of substance P terminals in the rat nucleus accumbens.

VM Pickel, J Douglas, J Chan, PD Gamp, NW Bunnett

Journal article  |  2000  |  The Journal of Comparative Neurology

Substance P (SP) is the major endogenous ligand for neurokinin 1 (NK1) receptors and, together with acetylcholine, has an importan..

Substance P mediates inflammatory oedema in acute pancreatitis via activation of the neurokinin-1 receptor in rats and mice.

EF Grady, SK Yoshimi, J Maa, D Valeroso, RK Vartanian, S Rahim, EH Kim, C Gerard, N Gerard, NW Bunnett, KS Kirkwood

Journal article  |  2000  |  British Journal of Pharmacology

Pancreatic oedema occurs early in the development of acute pancreatitis, and the overall extent of fluid loss correlates with dise..

Presence and bronchomotor activity of protease-activated receptor-2 in guinea pig airways.

FL Ricciardolo, M Steinhoff, S Amadesi, R Guerrini, M Tognetto, M Trevisani, C Creminon, C Bertrand, NW Bunnett, LM Fabbri, S Salvadori, P Geppetti

Journal article  |  2000  |  American Journal of Respiratory and Critical Care Medicine

The protease activated receptor-2 (PAR-2) belongs to a family of G-protein-coupled receptors that are activated by proteolysis. Tr..

beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.

KA DeFea, J Zalevsky, MS Thoma, O Déry, RD Mullins, NW Bunnett

Journal article  |  2000  |  The Journal of Cell Biology

Recently, a requirement for beta-arrestin-mediated endocytosis in the activation of extracellular signal-regulated kinases 1 and 2..

Substance P induction of murine keratinocyte PAM 212 interleukin 1 production is mediated by the neurokinin 2 receptor (NK-2R).

IS Song, NW Bunnett, JE Olerud, B Harten, M Steinhoff, JR Brown, KJ Sung, CA Armstrong, JC Ansel

Journal article  |  2000  |  Experimental Dermatology

The neurological system plays an important role in modulating some inflammatory skin diseases. Neuro-cutaneous interactions may be..

Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.

M Steinhoff, N Vergnolle, SH Young, M Tognetto, S Amadesi, HS Ennes, M Trevisani, MD Hollenberg, JL Wallace, GH Caughey, SE Mitchell, LM Williams, P Geppetti, EA Mayer, NW Bunnett

Journal article  |  2000  |  Nature Medicine

Trypsin and mast cell tryptase cleave proteinase-activated receptor 2 and, by unknown mechanisms, induce widespread inflammation. ..

Mechanisms of initiation and termination of signalling by neuropeptide receptors: a comparison with the proteinase-activated receptors.

K Defea, F Schmidlin, O Déry, EF Grady, NW Bunnett

Conference Proceedings  |  2000  |  Biochemical Society Transactions

Biological responses to neuropeptides are rapidly attenuated by overlapping mechanisms that include peptide degradation by cell-su..

Substance P activates coincident NF-AT- and NF-kappa B-dependent adhesion molecule gene expression in microvascular endothelial cells through intracellular calcium mobilization.

KL Quinlan, SM Naik, G Cannon, CA Armstrong, NW Bunnett, JC Ansel, SW Caughman

Journal article  |  1999  |  Journal of Immunology

Upon stimulation, cutaneous sensory nerves release neuropeptides such as substance P (SP), which modulate responses in the skin by..

Basolateral proteinase-activated receptor (PAR-2) induces chloride secretion in M-1 mouse renal cortical collecting duct cells.

M Bertog, B Letz, W Kong, M Steinhoff, MA Higgins, A Bielfeld-Ackermann, E Frömter, NW Bunnett, C Korbmacher

Journal article  |  1999  |  The Journal of Physiology

1. Using RT-PCR, Northern blot analysis, and immunocytochemistry, we confirmed renal expression of proteinase-activated receptor (..

Neutral endopeptidase (EC 3.4.24.11) terminates colitis by degrading substance P.

S Sturiale, G Barbara, B Qiu, M Figini, P Geppetti, N Gerard, C Gerard, EF Grady, NW Bunnett, SM Collins

Journal article  |  1999  |  Proceedings of the National Academy of Sciences

Neurogenic inflammation is regulated by sensory nerves and characterized by extravasation of plasma proteins and infiltration of n..

Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.

M Steinhoff, CU Corvera, MS Thoma, W Kong, BE McAlpine, GH Caughey, JC Ansel, NW Bunnett

Journal article  |  1999  |  Experimental Dermatology

Proteinase-activated receptor-2 (PAR-2) is a G-protein coupled receptor. Tryptic proteases cleave PAR-2 exposing a tethered ligand..

Substance P inhibits pancreatic exocrine secretion via a neural mechanism.

KS Kirkwood, EH Kim, XD He, EQ Calaustro, C Domush, SK Yoshimi, EF Grady, J Maa, NW Bunnett, HT Debas

Journal article  |  1999  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

We investigated the effects of the sensory neuropeptide substance P (SP) on amylase and fluid secretion in the isolated vascularly..

Trafficking of proteinase-activated receptor-2 and beta-arrestin-1 tagged with green fluorescent protein. beta-Arrestin-dependent endocytosis of a proteinase receptor.

O Déry, MS Thoma, H Wong, EF Grady, NW Bunnett

Journal article  |  1999  |  Journal of Biological Chemistry

Proteases cleave proteinase-activated receptors (PARs) to expose N-terminal tethered ligands that bind and activate the cleaved re..

Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.

CU Corvera, O Déry, K McConalogue, P Gamp, M Thoma, B Al-Ani, GH Caughey, MD Hollenberg, NW Bunnett

Journal article  |  1999  |  The Journal of Physiology

1. Proteases regulate cells by cleaving proteinase-activated receptors (PARs). Thrombin and trypsin cleave PAR-1 and PAR-2 on neur..

Substance P-induced trafficking of beta-arrestins. The role of beta-arrestins in endocytosis of the neurokinin-1 receptor.

K McConalogue, O Déry, M Lovett, H Wong, JH Walsh, EF Grady, NW Bunnett

Journal article  |  1999  |  Journal of Biological Chemistry

Agonist-induced redistribution of G-protein-coupled receptors (GPCRs) and beta-arrestins determines the subsequent cellular respon..

Neutral endopeptidase expression and distribution in human skin and wounds.

JE Olerud, ML Usui, D Seckin, DS Chiu, CL Haycox, IS Song, JC Ansel, NW Bunnett

Journal article  |  1999  |  Journal of Investigative Dermatology

Cutaneous sensory nerves mediate inflammation and wound healing by the release of neuropeptides such as substance P. Neutral endop..

Activation and internalization of the mu-opioid receptor by the newly discovered endogenous agonists, endomorphin-1 and endomorphin-2.

K McConalogue, EF Grady, J Minnis, B Balestra, M Tonini, NC Brecha, NW Bunnett, C Sternini

Journal article  |  1999  |  Neuroscience

The multiple effects of opiate alkaloids, important therapeutic drugs used for pain control, are mediated by the neuronal miro-opi..

VCAM-1 expression on human dermal microvascular endothelial cells is directly and specifically up-regulated by substance P.

KL Quinlan, IS Song, SM Naik, EL Letran, JE Olerud, NW Bunnett, CA Armstrong, SW Caughman, JC Ansel

Journal article  |  1999  |  Journal of Immunology

Sensory nerves in skin are capable of releasing multiple neuropeptides, which modulate inflammatory responses by activating specif..

Proteinase-activated receptors: a growing family of heptahelical receptors for thrombin, trypsin and tryptase.

O Déry, NW Bunnett

Conference Proceedings  |  1999  |  Biochemical Society Transactions

Neurogenic plasma leakage in mouse airways.

P Baluk, G Thurston, TJ Murphy, NW Bunnett, DM McDonald

Journal article  |  1999  |  British Journal of Pharmacology

1. This study sought to determine whether neurogenic inflammation occurs in the airways by examining the effects of capsaicin or s..

Trypsin activates pancreatic duct epithelial cell ion channels through proteinase-activated receptor-2.

TD Nguyen, MW Moody, M Steinhoff, C Okolo, DS Koh, NW Bunnett

Journal article  |  1999  |  Journal of Clinical Investigation

Proteinase-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved by trypsin within the NH2-terminus, exposi..

Neuropeptide regulation of human dermal microvascular endothelial cell ICAM-1 expression and function.

KL Quinlan, IS Song, NW Bunnett, E Letran, M Steinhoff, B Harten, JE Olerud, CA Armstrong, S Wright Caughman, JC Ansel

Journal article  |  1998  |  American Journal of Physiology-Cell Physiology

There is increasing evidence that sensory nerves may participate in cutaneous inflammatory responses by the release of neuropeptid..

Proteinase-activated receptors: New functions for old enzymes

SK Böhm, K McConalogue, W Kong, NW Bunnett

Journal article  |  1998  |  News in Physiological Sciences

Peptide G protein-coupled receptors meet at Erice.

NW Bunnett, M Bouvier, A De Blasi

Conference Proceedings  |  1998  |  Trends in Pharmacological Sciences

Desensitization of the neurokinin-1 receptor (NK1-R) in neurons: effects of substance P on the distribution of NK1-R, Galphaq/11, G-protein receptor kinase-2/3, and beta-arrestin-1/2.

K McConalogue, CU Corvera, PD Gamp, EF Grady, NW Bunnett

Journal article  |  1998  |  Molecular Biology of the Cell

Observations in reconstituted systems and transfected cells indicate that G-protein receptor kinases (GRKs) and beta-arrestins med..

Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

O Déry, CU Corvera, M Steinhoff, NW Bunnett

Journal article  |  1998  |  American Journal of Physiology-Cell Physiology

Although serine proteases are usually considered to act principally as degradative enzymes, certain proteases are signaling molecu..

Acute ACE inhibition causes plasma extravasation in mice that is mediated by bradykinin and substance P.

C Emanueli, EF Grady, P Madeddu, M Figini, NW Bunnett, D Parisi, D Regoli, P Geppetti

Journal article  |  1998  |  Hypertension

The use of angiotensin-converting enzyme (ACE) has been associated with the occurrence of adverse effects, including cough and ang..

G protein-coupled receptors in gastrointestinal physiology. II. Regulation of neuropeptide receptors in enteric neurons.

K McConalogue, NW Bunnett

Journal article  |  1998  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Neuropeptides exert their diverse biological effects by interacting with G protein-coupled receptors (GPCRs). In this review we ad..

Bradykinin increases intracellular calcium levels in a human bronchial epithelial cell line via the B2 receptor subtype.

FL Ricciardolo, M Lovett, DA Halliday, JA Nadel, T Kaneko, NW Bunnett, P Geppetti

Journal article  |  1998  |  Inflammation Research

OBJECTIVE: To determine which types of kinin receptor are present in human bronchial epithelial cells we studied the capability of..

Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems.

T Scholzen, CA Armstrong, NW Bunnett, TA Luger, JE Olerud, JC Ansel

Journal article  |  1998  |  Experimental Dermatology

The interaction between components of the nervous system and multiple target cells in the cutaneous immune system has been receivi..

Turning off the signal: Mechanisms that attenuate signaling by G protein-coupled receptors

EF Grady, SK Böhm, NW Bunnett

Journal article  |  1997  |  American Journal of Physiology

Characterization of neurokinin-1 receptors in the submucosal plexus of guinea pig ileum

BA Moore, S Vanner, NW Bunnett, KA Sharkey

Journal article  |  1997  |  American Journal of Physiology

Neurokinin 1 receptor internalization in spinal cord slices induced by dorsal root stimulation is mediated by NMDA receptors.

JC Marvizón, V Martínez, EF Grady, NW Bunnett, EA Mayer

Journal article  |  1997  |  The Journal of Neuroscience

The excitability of spinal neurons that transmit pain is modulated by glutamate and substance P (SP). Glutamate is an excitatory n..

Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.

CU Corvera, O Déry, K McConalogue, SK Böhm, LM Khitin, GH Caughey, DG Payan, NW Bunnett

Journal article  |  1997  |  Journal of Clinical Investigation

Proteinase-activated receptor-2 (PAR-2) is a G protein-coupled receptor that is cleaved and activated by trypsin-like enzymes. PAR..

Turning off the signal: mechanisms that attenuate signaling by G protein-coupled receptors.

EF Grady, SK Böhm, NW Bunnett

Journal article  |  1997  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Cellular responses to agonists of G protein-coupled receptors are rapidly attenuated. Mechanisms of signal attenuation include lig..

Characterization of neurokinin-1 receptors in the submucosal plexus of guinea pig ileum.

BA Moore, S Vanner, NW Bunnett, KA Sharkey

Journal article  |  1997  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

This study combined immunohistochemical double-labeling techniques with functional studies to characterize the neurokinin-1 (NK1) ..

Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2.

W Kong, K McConalogue, LM Khitin, MD Hollenberg, DG Payan, SK Böhm, NW Bunnett

Journal article  |  1997  |  Proceedings of the National Academy of Sciences

Proteinase-activated receptor 2 (PAR-2) is a recently characterized G-protein coupled receptor that is cleaved and activated by pa..

Interactions of the skin and nervous system.

JC Ansel, CA Armstrong, I Song, KL Quinlan, JE Olerud, SW Caughman, NW Bunnett

Conference Proceedings  |  1997  |  Journal of Investigative Dermatology Symposium Proceedings

There is increasing experimental evidence that the neurologic system can directly participate in cutaneous inflammation and wound ..

Mechanisms attenuating cellular responses to neuropeptides: extracellular degradation of ligands and desensitization of receptors.

E Grady, S Böhm, K McConalogue, A Garland, J Ansel, J Olerud, N Bunnett

Conference Proceedings  |  1997  |  Journal of Investigative Dermatology Symposium Proceedings

Neuropeptides make up one of the largest and functionally most diverse groups of signaling molecules. They exert their effects by ..

The control of microvascular permeability and blood pressure by neutral endopeptidase.

B Lu, M Figini, C Emanueli, P Geppetti, EF Grady, NP Gerard, J Ansell, DG Payan, C Gerard, N Bunnett

Journal article  |  1997  |  Nature Medicine

Plasma extravasation from postcapillary venules is one of the earliest steps of inflammation. Substance P (SP) and bradykinin (BK)..

G protein-coupled receptor signaling: implications for the digestive system.

ED Jacobson, NW Bunnett

Journal article  |  1997  |  Digestive Diseases

Extracellular signaling molecules regulate intracellular events by way of complex transduction assemblies composed of several prot..

Substance P and bradykinin stimulate plasma extravasation in the mouse gastrointestinal tract and pancreas.

M Figini, C Emanueli, EF Grady, K Kirkwood, DG Payan, J Ansel, C Gerard, P Geppetti, N Bunnett

Journal article  |  1997  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Neurogenic inflammation is mediated by release of tachykinins from sensory nerves, which stimulate plasma extravasation from postc..

Regulatory mechanisms that modulate signalling by G-protein-coupled receptors.

SK Böhm, EF Grady, NW Bunnett

Journal article  |  1997  |  Biochemical Journal

The large and functionally diverse group of G-protein-coupled receptors includes receptors for many different signalling molecules..

Identification of potential tyrosine-containing endocytic motifs in the carboxyl-tail and seventh transmembrane domain of the neurokinin 1 receptor.

SK Böhm, LM Khitin, SP Smeekens, EF Grady, DG Payan, NW Bunnett

Journal article  |  1997  |  Journal of Biological Chemistry

Although agonist-induced endocytosis of G-protein-coupled receptors is critical for receptor desensitization and resensitization, ..

Endocytosis of activated TrkA: evidence that nerve growth factor induces formation of signaling endosomes.

ML Grimes, J Zhou, EC Beattie, EC Yuen, DE Hall, JS Valletta, KS Topp, JH LaVail, NW Bunnett, WC Mobley

Journal article  |  1996  |  The Journal of Neuroscience

The survival, differentiation, and maintenance of responsive neurons are regulated by nerve growth factor (NGF), which is secreted..

Distribution of neurokinin-2 receptors in the guinea-pig gastrointestinal tract

AL Portbury, JB Furness, BR Southwell, H Wong, JH Walsh, NW Bunnett

Journal article  |  1996  |  Cell and Tissue Research

Endocytosis and recycling of neurokinin 1 receptors in enteric neurons.

EF Grady, PD Gamp, E Jones, P Baluk, DM McDonald, DG Payan, NW Bunnett

Journal article  |  1996  |  Neuroscience

Neurotransmission depends on the availability of transmitter and on the presence of functional, high-affinity receptors at the pla..

Detection of naturally expressed receptors for gastrin-releasing peptide and tachykinins using cyanine 3-labelled neuropeptides.

NW Bunnett, DG Payan, EF Grady

Journal article  |  1996  |  The Histochemical Journal

Peptides labelled with the fluorophore cyanine 3 were used to study naturally expressed neuropeptide receptors by confocal microsc..

Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract

EF Grady, P Baluk, S Bohm, PD Gamp, H Wong, DG Payan, J Ansel, AL Portbury, JB Furness, DM McDonald, NW Bunnett

Journal article  |  1996  |  The Journal of Neuroscience

Mechanisms of desensitization and resensitization of proteinase-activated receptor-2.

SK Böhm, LM Khitin, EF Grady, G Aponte, DG Payan, NW Bunnett

Journal article  |  1996  |  Journal of Biological Chemistry

Proteinase-activated receptor-2 (PAR-2) is a G-protein-coupled receptor that is expressed by intestinal epithelial cells, which ar..

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

C Sternini, M Spann, B Anton, DE Keith, NW Bunnett, M von Zastrow, C Evans, NC Brecha

Journal article  |  1996  |  Proceedings of the National Academy of Sciences

Opiate alkaloids are potent analgesics that exert multiple pharmacological effects in the nervous system by activating G protein-c..

Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2.

SK Bohm, W Kong, D Bromme, SP Smeekens, DC Anderson, A Connolly, M Kahn, NA Nelken, SR Coughlin, DG Payan, NW Bunnett

Journal article  |  1996  |  Biochemical Journal

We used PCR to amplify proteinase activated receptor-2 (PAR-2) from human kidney cDNA. The open reading frame comprised 1191 bp an..

Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors.

AM Garland, EF Grady, M Lovett, SR Vigna, MM Frucht, JE Krause, NW Bunnett

Journal article  |  1996  |  Molecular Pharmacology

We compared the desensitization of neurokinin1 and neurokinin2 (NK1 and NK2) receptors expressed in Chinese hamster ovary cells to..

Skin-nervous system interactions.

JC Ansel, AH Kaynard, CA Armstrong, J Olerud, N Bunnett, D Payan

Journal article  |  1996  |  Journal of Investigative Dermatology

Neurogenic inflammation. A model for studying efferent actions of sensory nerves.

DM McDonald, JJ Bowden, P Baluk, NW Bunnett

Journal article  |  1996  |  Advances in Experimental Medicine and Biology

Several lines of evidence suggest that sensory nerves of the carotid body have an efferent function in addition to their afferent ..

A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration.

EC Beattie, J Zhou, ML Grimes, NW Bunnett, CL Howe, WC Mobley

Conference Proceedings  |  1996  |  Cold Spring Harbor Symposia on Quantitative Biology

Purification and characterization of aminopeptidase M from muscle and mucosa of the pig intestine.

H Terashima, NW Bunnett

Journal article  |  1995  |  Journal of Gastroenterology

The aim of this investigation was to purify aminopeptidase M (APM) from the muscle layer of the small intestine, to compare it wit..

Cellular sites of expression of the neurokinin-1 receptor in the rat gastrointestinal tract.

C Sternini, D Su, PD Gamp, NW Bunnett

Journal article  |  1995  |  The Journal of Comparative Neurology

In the digestive system, substance P is an excitatory transmitter to muscle, a putative excitatory neuro-neuronal transmitter, a v..

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.

EF Grady, AM Garland, PD Gamp, M Lovett, DG Payan, NW Bunnett

Journal article  |  1995  |  Molecular Biology of the Cell

Many of the actions of the neuropeptide substance P (SP) that are mediated by the neurokinin 1 receptor (NK1-R) desensitize and re..

T cell gelatinases mediate basement membrane transmigration in vitro.

D Leppert, E Waubant, R Galardy, NW Bunnett, SL Hauser

Journal article  |  1995  |  Journal of Immunology

T cell homing into extravascular sites requires penetration across the subendothelial basal lamina, a specialized nonfibrillar con..

Direct observation of endocytosis of gastrin releasing peptide and its receptor.

EF Grady, LW Slice, WO Brant, JH Walsh, DG Payan, NW Bunnett

Journal article  |  1995  |  Journal of Biological Chemistry

Endocytosis of the gastrin releasing peptide receptor (GRP-R) may regulate cellular responses to GRP. We observed endocytosis in t..

Mechanisms regulating the responsiveness of cells to substance P: Cell-surface degradation of substance P and NK-1 receptor endocytosis

AM Garland, EF Grady, DG Payan, NW Bunnett

Conference Proceedings  |  1995  |  Biomedical Research

Characterization of receptors using cyanine 3-labeled neuropeptides.

NW Bunnett, PF Dazin, DG Payan, EF Grady

Journal article  |  1995  |  Peptides

We labeled substance P (SP), neurokinin A (NKA), and [Lys0]gastrin-releasing peptide-27 (GRP) with cyanine 3.18 (cy3). Cy3-peptide..

Agonist-induced internalization of the substance P (NK1) receptor expressed in epithelial cells.

AM Garland, EF Grady, DG Payan, SR Vigna, NW Bunnett

Journal article  |  1994  |  Biochemical Journal

Internalization of the NK1 receptor (NK1R) and substance P was observed in cells transfected with cDNA encoding the rat NK1R by us..

Direct observation of substance P-induced internalization of neurokinin 1 (NK1) receptors at sites of inflammation.

JJ Bowden, AM Garland, P Baluk, P Lefevre, EF Grady, SR Vigna, NW Bunnett, DM McDonald

Journal article  |  1994  |  Proceedings of the National Academy of Sciences

Substance P (SP) can cause plasma leakage at sites of inflammation by binding to neurokinin type 1 (NK1) receptors on the surface ..

Laminin mediates the restitution of rat gastric mucosa in vitro.

MA Miller, NW Bunnett, HT Debas

Journal article  |  1994  |  Experimental Physiology

Restitution, the rapid re-establishment of mucosal integrity following damage, involves cell migration and can be monitored by mea..

The conserved NPXnY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence.

LW Slice, HC Wong, C Sternini, EF Grady, NW Bunnett, JH Walsh

Journal article  |  1994  |  Journal of Biological Chemistry

Exposure of the gastrin-releasing peptide (GRP) receptor to agonists causes a rapid desensitization of the receptor-stimulated mob..

Interactions between neutral endopeptidase (EC 3.4.24.11) and the substance P (NK1) receptor expressed in mammalian cells.

A Okamoto, M Lovett, DG Payan, NW Bunnett

Journal article  |  1994  |  Biochemical Journal

Interactions between neutral endopeptidase-24.11 (NEP) and the substance P receptor (SPR; NK1) were investigated by examining subs..

Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells.

SR Vigna, JJ Bowden, DM McDonald, J Fisher, A Okamoto, DC McVey, DG Payan, NW Bunnett

Journal article  |  1994  |  The Journal of Neuroscience

Antibodies to neuropeptide receptors can be used to localize and characterize the receptors in tissues and cell lines. Two strateg..

A role for calcitonin gene-related peptide in protection against gastric ulceration.

JL Gray, NW Bunnett, SL Orloff, SJ Mulvihill, HT Debas

Journal article  |  1994  |  Annals of Surgery

OBJECTIVE: The goal of this investigation was to determine the role of calcitonin gene-related peptide (CGRP) in gastric mucosal r..

Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors.

O Huber, C Bertrand, NW Bunnett, CA Pellegrini, JA Nadel, HT Debas, P Geppetti

Journal article  |  1993  |  Gastroenterology

BACKGROUND: The action of tachykinins in the circular muscle of the human esophageal body is not known. The present study aimed to..

Tachykinins mediate contraction of the human lower esophageal sphincter in vitro via activation of NK2 receptors.

O Huber, C Bertrand, NW Bunnett, CA Pellegrini, JA Nadel, P Nakazato, HT Debas, P Geppetti

Journal article  |  1993  |  European Journal of Pharmacology

The contractile response to natural tachykinins and selective peptide agonists for tachykinin receptors was studied in strips of c..

Downregulation of neutral endopeptidase (EC 3.4.24.11) in the inflamed rat intestine.

L Hwang, R Leichter, A Okamoto, D Payan, SM Collins, NW Bunnett

Journal article  |  1993  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Intestinal inflammation induced by the nematode Trichinella spiralis is accompanied by increased intestinal concentrations of subs..

Distribution and abundance of neutral endopeptidase (EC 3.4.24.11) in the alimentary tract of the rat.

NW Bunnett, V Wu, C Sternini, J Klinger, E Shimomaya, D Payan, R Kobayashi, JH Walsh

Journal article  |  1993  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

The distribution of neutral endopeptidase (NEP; EC 3.4.24.11) was examined in the alimentary tract of the rat. Immunoreactive NEP ..

Neutral endopeptidase (EC 3.4.24.11) modulates the contractile effects of neuropeptides on muscle cells from the guinea-pig stomach.

ZF Gu, D Menozzi, A Okamoto, PN Maton, NW Bunnett

Journal article  |  1993  |  Experimental Physiology

The objectives of this investigation were to characterize neuropeptide-degrading enzymes on the surface of gastric muscle cells an..

Antibodies to the rat substance P receptor: production and characterization.

MS Gilbert, NW Bunnett, DG Payan

Journal article  |  1992  |  Cellular and Molecular Neurobiology

1. A protein A-rat substance P receptor (SPR) fusion protein was genetically engineered and used as an immunogen to raise a polycl..

Identification of neuropeptide-degrading enzymes in the pancreas.

H Terashima, A Okamoto, D Menozzi, EJ Goetzl, NW Bunnett

Journal article  |  1992  |  Peptides

Neutral endopeptidase (NEP) and aminopeptidase M (APM) were identified in the pancreas by enzymatic assays and Western blotting. T..

Selective release of somatostatin by calcitonin gene-related peptide and influence on pancreatic secretion.

HT Debas, MT Nelson, NW Bunnett, SJ Mulvihill

Journal article  |  1992  |  Annals of the New York Academy of Sciences

Calcitonin gene-related peptide is a potent inhibitor of stimulated pancreatic exocrine secretion in vivo. The mechanism of this i..

Immunochemical localization of aminopeptidase M in the alimentary tract of the guinea pig and rat.

H Terashima, H Wong, R Kobayashi, NW Bunnett

Journal article  |  1992  |  Gastroenterology

Aminopeptidase M (APM) was localized in the kidney and alimentary tract of guinea pigs and rats by indirect immunohistochemistry. ..

Actions of somatostatins on gastric smooth muscle cells.

ZF Gu, T Pradhan, DH Coy, S Mantey, NW Bunnett, RT Jensen, PN Maton

Journal article  |  1992  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

The effects of somatostatin-28, somatostatin-14, and a synthetic somatostatin octapeptide analogue, D-Phe-Cys-Tyr-D-Trp-Lys-Thr-Cy..

Effects of cholecystokinin and gastrin antagonists on pancreatic exocrine secretion stimulated by gastrin-releasing peptide.

H Terashima, HT Debas, NW Bunnett

Journal article  |  1992  |  Pancreas

The effects of a specific cholecystokinin (CCK) receptor antagonist (L364,718) and a gastrin receptor antagonist (L365,260) on gas..

Isolation of a neuropeptide-degrading carboxypeptidase from the human stomach.

NW Bunnett, SM Goldstein, P Nakazato

Journal article  |  1992  |  Gastroenterology

The aim of this investigation was to isolate and characterize a neuropeptide-degrading carboxypeptidase from the muscular and muco..

Intestinal acid inhibits gastric acid secretion by neural and hormonal mechanisms in rats.

SL Orloff, NW Bunnett, JH Walsh, HT Debas

Journal article  |  1992  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

To determine the relative contributions of neural reflexes and intestinal hormones to the inhibition of gastric acid secretion by ..

Neural and hormonal mechanisms mediate the enterogastric reflex: a study in intestinal transplants in rats.

SL Orloff, NW Bunnett, H Wong, JH Walsh, HT Debas

Journal article  |  1991  |  Gastroenterology

To determine the relative contributions of neural reflexes and intestinal hormones to the inhibition of gastric acid secretion by ..

Inhibition of peptidases potentiates enkephalin-stimulated contraction of gastric muscle cells.

D Menozzi, ZF Gu, PN Maton, NW Bunnett

Journal article  |  1991  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Cell surface peptidases degrade enkephalins and thereby restrict the number of molecules available to activate receptors. The effe..

Human mast cell proteases hydrolyze neurotensin, kinetensin and Leu5-enkephalin.

SM Goldstein, J Leong, NW Bunnett

Journal article  |  1991  |  Peptides

Purified mast cell carboxypeptidase cleaved the C-terminal leucines from Leu5-enkephalin (Leu-ENK), neurotensin (NT), and kinetens..

Catabolism of calcitonin gene-related peptide and substance P by neutral endopeptidase.

M Katayama, JA Nadel, NW Bunnett, GU Di Maria, M Haxhiu, DB Borson

Journal article  |  1991  |  Peptides

Calcitonin gene-related peptide (CGRP) and substance P (SP) are released from sensory nerves upon exposure to irritating stimuli. ..

Calcitonin gene-related peptide inhibits exocrine secretion from the rat pancreas by a neurally mediated mechanism.

NW Bunnett, SJ Mulvihill, HT Debas

Journal article  |  1991  |  Experimental Physiology

The mechanism by which calcitonin gene-related peptide (CGRP) inhibits exocrine secretion from the rat pancreas was examined in th..

Use of small intestine transplantation to study the mechanisms involved in the enterogastric reflex in rats

SL Orloff, NW Bunnett, HT Debas

Journal article  |  1990  |  Surgical Forum

Somatostatin inhibits pancreatic exocrine secretion via a neural mechanism.

SJ Mulvihill, NW Bunnett, Y Goto, HT Debas

Journal article  |  1990  |  Metabolism

The mechanism of inhibition of pancreatic exocrine secretion by somatostatin is unknown. We hypothesized that somatostatin acts in..

CGRP stimulates the release of pro-somatostatin-derived peptides from the gastric fundus.

NW Bunnett, WS Helton, HT Debas, JW Ensinck

Journal article  |  1990  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Calcitonin gene-related peptide (CGRP) stimulates release of peptides derived from pro-somatostatin (Pro-S) into the general circu..

Metabolism of enkephalin in stomach wall of rats.

NW Bunnett, JH Walsh, HT Debas

Journal article  |  1990  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

Peptidases degrade neuropeptides and thereby limit the duration and extent of their influence. This investigation examined the imp..

A role for calcitonin gene-related peptide-containing neurons in gastric cytoprotection

JL Gray, SL Orloff, NW Bunnett, RL Troyer, SJ Mulvihill, HT Debas

Conference Proceedings  |  1989  |  Surgical Forum

Metabolism and inactivation of gastrin releasing peptide by endopeptidase-24.11 in the dog.

NW Bunnett, AJ Turner, HT Debas

Journal article  |  1989  |  Quarterly Journal of Experimental Physiology

The purpose of this investigation was to examine the metabolism and inactivation of gastrin releasing peptide 10 (GRP10) by endope..

Inhibition of gastric and pancreatic secretion in dogs by CGRP: role of somatostatin.

WS Helton, MM Mulholland, NW Bunnett, HT Debas

Journal article  |  1989  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

The coexistence of calcitonin gene-related peptide (CGRP) and somatostatin (SS) within the stomach and pancreas and the potent inh..

Metabolism of gastrin and cholecystokinin by endopeptidase 24.11 from the pig stomach.

NW Bunnett, HT Debas, AJ Turner, R Kobayashi, JH Walsh

Journal article  |  1988  |  American Journal of Physiology-Gastrointestinal and Liver Physiology

The purpose of this investigation is to examine the metabolism and inactivation of human and porcine gastrin 17 (nonsulfated) (G-1..

Isolation of endopeptidase-24.11 (EC 3.4.24.11, "enkephalinase") from the pig stomach. Hydrolysis of substance P, gastrin-releasing peptide 10, [Leu5] enkephalin, and [Met5] enkephalin.

NW Bunnett, AJ Turner, J Hryszko, R Kobayashi, JH Walsh

Journal article  |  1988  |  Gastroenterology

The purpose of this investigation was to isolate the cell-surface enzyme endopeptidase-24.11 from the stomach wall of the pig and ..

The role of neuropeptides in regulating airway function. Postsecretory metabolism of peptides.

NW Bunnett

Journal article  |  1987  |  American Review of Respiratory Disease

Peptide hormones and neurotransmitters play an essential role in regulation of cellular metabolism. Once released from an endocrin..