Paul Ekert

Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL

Teresa Sadras, Fatimah BB Jalud, Hansen JJ Kosasih, Christopher RR Horne, Lauren MM Brown, Sam El-Kamand, Charles EE de Bock, Lachlan McAloney, Ashley PP Ng, Nadia MM Davidson, Louise EA Ludlow, Alicia Oshlack, Mark JJ Cowley, Seong LL Khaw, James MM Murphy, Paul GG Ekert

Journal article  |  2023  |  LEUKEMIA

Description of a novel subtype of acute myeloid leukemia defined by recurrent CBFB insertions.

Georgina L Ryland, Masayuki Umeda, Linda Holmfeldt, Sören Lehmann, Morten Krogh Herlin, Jing Ma, Mahsa Khanlari, Jeffrey E Rubnitz, Rhonda E Ries, Hansen J Kosasih, Paul G Ekert, Hwee Ngee Goh, Ing S Tiong, Sean M Grimmond, Claudia Haferlach, Ryan B Day, Timothy J Ley, Soheil Meshinchi, Xiaotu Ma, Piers Blombery, et al.

Journal article  |  2023  |  Blood

Toblerone: detecting exon deletion events in cancer using RNA-seq

Andrew Lonsdale, Andreas Halman, Lauren Brown, Hansen Kosasih, Paul Ekert, Alicia Oshlack

Journal article  |  2023  |  F1000Research

Cancer is driven by mutations of the genome that can result in the activation of oncogenes or repression of tumour suppressor gene..

Advances in CAR T cell immunotherapy for paediatric brain tumours

Padmashree Rao, Liam Furst, Deborah Meyran, Chelsea Mayoh, Paul J Neeson, Rachael Terry, Dong-Anh Khuong-Quang, Theo Mantamadiotis, Paul G Ekert

Journal article  |  2022  |  FRONTIERS IN ONCOLOGY

Brain tumours are the most common solid tumour in children and the leading cause of cancer related death in children. Current trea..

PRECISION MEDICINE REVEALS A HETEROGENOUS TUMOUR IMMUNE MICROENVIRONMENT IN PAEDIATRIC GLIOMAS

Chelsea Mayoh, Deborah Meyran, Thu Nguyen, Colleen Darcy, David Ziegler, Michelle Haber, Joe Trapani, Paul Ekert, Paul Neeson

Conference Proceedings  |  2022  |  PEDIATRIC BLOOD & CANCER

ALLSorts: an RNA-Seq subtype classifier for B-cell acute lymphoblastic leukemia

Breon Schmidt, Lauren M Brown, Georgina L Ryland, Andrew Lonsdale, Hansen J Kosasih, Louise E Ludlow, Ian J Majewski, Piers Blombery, Paul G Ekert, Nadia M Davidson, Alicia Oshlack

Journal article  |  2022  |  BLOOD ADVANCES

B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Subtypes within B-ALL are distinguished by charac..

Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia

Alexander C Lewis, Victoria S Pope, Melinda N Tea, Manjun Li, Gus O Nwosu, Thao M Nguyen, Craig T Wallington-Beddoe, Paul AB Moretti, Dovile Anderson, Darren J Creek, Maurizio Costabile, Saira R Ali, Chloe AL Thompson-Peach, B Kate Dredge, Andrew G Bert, Gregory J Goodall, Paul G Ekert, Anna L Brown, Richard D'Andrea, Nirmal Robinson, et al.

Journal article  |  2022  |  BLOOD

Inducing cell death by the sphingolipid ceramide is a potential anticancer strategy, but the underlying mechanisms remain poorly d..

Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemia

Shunsuke Kimura, Lindsey Montefiori, Ilaria Iacobucci, Yaqi Zhao, Qingsong Gao, Elisabeth M Paietta, Claudia Haferlach, A Douglas Laird, Paul E Mead, Zhaohui Gu, Wendy Stock, Mark Litzow, Jacob M Rowe, Selina M Luger, Stephen P Hunger, Georgina L Ryland, Breon Schmidt, Paul G Ekert, Alicia Oshlack, Sean M Grimmond, et al.

Journal article  |  2022  |  BLOOD

Transcriptome sequencing has identified multiple subtypes of B-progenitor acute lymphoblastic leukemia (B-ALL) of prognostic signi..

THE CHILDHOOD BRAIN CANCER CELL LINE ATLAS: A RESOURCE FOR BIOMARKER IDENTIFICATION AND THERAPEUTIC DEVELOPMENT

Paul Daniel, Claire Sun, Mateusz Koptyra, Caroline Drinkwater, Nicole Chew, Gabrielle Bradshaw, Melissa Loi, Claire Shi, Motahhareh Tourchi, Sarah Parackal, Wai Chin Chong, Dasun Fernando, Shazia Adjumain, Nguyen Hoang, Dilru Habarakada, Dhanya Sooraj, Duncan Crombie, Nataliya Zhukova, Chris Jones, Jeffrey Rubens, et al.

Conference Proceedings  |  2022  |  NEURO-ONCOLOGY

SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia

Lauren M Brown, Soroor Hediyeh-Zadeh, Teresa Sadras, Hannah Huckstep, Jarrod J Sandow, Ray C Bartolo, Hansen J Kosasih, Nadia M Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky Johnstone, Andrew Webb, Seong L Khaw, Alicia Oshlack, Melissa J Davis, Paul G Ekert

Journal article  |  2022  |  BLOOD ADVANCES

Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL characterized by a gene expres..