Paul Ekert

Precision medicine and phosphoproteomics for the identification of novel targeted therapeutic avenues in sarcomas

Ashleigh M Fordham, Paul G Ekert, Emmy DG Fleuren

Journal article  |  2021  |  BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Rapid advances in genomic technologies have enabled in-depth interrogation of cancer genomes, revealing novel and unexpected thera..

Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis

Neevika Manoharan, Pamela Ajuyah, Akanksha Senapati, Marie Wong, Anna Mullins, Michael Rodriguez, Helen Doyle, Geoff McCowage, Loretta MS Lau, Paul G Ekert, David S Ziegler

Journal article  |  2021  |  ACTA NEUROPATHOLOGICA COMMUNICATIONS

Diffuse leptomeningeal glioneuronal tumours (DLGNT) represent rare enigmatic CNS tumours of childhood. Most patients with this dis..

Chimeric Antigen Receptor T cell Therapy and the Immunosuppressive Tumor Microenvironment in Pediatric Sarcoma

Rachael L Terry, Deborah Meyran, Emmy DG Fleuren, Chelsea Mayoh, Joe Zhu, Natacha Omer, David S Ziegler, Michelle Haber, Phillip K Darcy, Joseph A Trapani, Paul J Neeson, Paul G Ekert

Journal article  |  2021  |  CANCERS

Sarcomas are a diverse group of bone and soft tissue tumors that account for over 10% of childhood cancers. Outcomes are particula..

Whole-genome sequencing facilitates patient-specific quantitative PCR-based minimal residual disease monitoring in acute lymphoblastic leukaemia, neuroblastoma and Ewing sarcoma

Vinod Vijay Subhash, Libby Huang, Alvin Kamili, Marie Wong, Dan Chen, Nicola C Venn, Caroline Atkinson, Chelsea Mayoh, Pooja Venkat, Vanessa Tyrrell, Glenn M Marshall, Mark J Cowley, Paul G Ekert, Murray D Norris, Michelle Haber, Michelle J Henderson, Rosemary Sutton, Jamie Fletcher, Toby N Trahair

Journal article  |  2021  |  BRITISH JOURNAL OF CANCER

BACKGROUND: Minimal residual disease (MRD) measurement is a cornerstone of contemporary acute lymphoblastic leukaemia (ALL) treatm..

Early-phenotype CAR-T cells for the treatment of pediatric cancers.

D Meyran, RL Terry, JJ Zhu, M Haber, DS Ziegler, PG Ekert, JA Trapani, PK Darcy, PJ Neeson

Journal article  |  2021  |  Ann Oncol

Chimeric antigen receptor (CAR)-T-cell therapy is a promising approach for the treatment of childhood cancers, particularly high-r..

Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance

Mohamed Fareh, Wei Zhao, Wenxin Hu, Joshua ML Casan, Amit Kumar, Jori Symons, Jennifer M Zerbato, Danielle Fong, Ilia Voskoboinik, Paul G Ekert, Rajeev Rudraraju, Damian FJ Purcell, Sharon R Lewin, Joseph A Trapani

Journal article  |  2021  |  NATURE COMMUNICATIONS

The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approa..

Abstract 639: Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR

Vinod Vijay Subhash, Alvin Kamili, Marie-Wong Erasmus, Dan Chen, Libby Huang, Vanessa Tyrell, Caroline Atkinson, Nicola Venn, Mark Cowley, Glenn Marshall, Paul Ekert, Michelle Henderson, Rosemary Sutton, Murray Norris, Michelle Haber, Jamie Fletcher, Toby Trahair

Conference Proceedings  |  2021  |  Clinical Research (Excluding Clinical Trials)

Analysis of DNA minimal residual disease markers in pediatric solid cancers using quantitative real time PCR and droplet digital PCR.

Vinod Vijay Subhash, Alvin Kamili, Marie-Wong Erasmus, Dan Chen, Libby Huang, Vanessa Tyrell, Caroline Atkinson, Nicola Venn, Mark Cowley, Glenn Marshall, Paul Ekert, Michelle Henderson, Rosemary Sutton, Murray Norris, Michelle Haber, Jamie Fletcher, Toby Trahair

Conference Proceedings  |  2021  |  CANCER RESEARCH

Matching target to therapy in childhood cancers

Paul Ekert

Conference Proceedings  |  2021  |  Pathology

Abstract 3044: The unexplored immune landscape of high-risk pediatric cancers

Chelsea Mayoh, Rachael L Terry, Marie Wong, Loretta M Lau, Dong Anh Khuong-Quang, Marion K Mateos, Vanessa Tyrrell, Michelle Haber, David S Ziegler, Mark J Cowley, Joseph A Trapani, Paul J Neeson, Paul G Ekert

Conference Proceedings  |  2021  |  Tumor Biology