Paul Ekert

Histone H3.3G34-Mutant Intemeuron Progenitors Co-opt PDGFRA for Gliomagenesis

Carol CL Chen, Shriya Deshmukh, Selin Jessa, Djihad Hadjadj, Veronique Lisi, Augusto Faria Andrade, Damien Faury, Wajih Jawhar, Rola Dali, Hiromichi Suzuki, Manav Pathania, A Deli, Frank Dubois, Eleanor Woodward, Steven Hebert, Marie Coutelier, Jason Karamchandani, Steffen Albrecht, Sebastian Brandner, Nicolas De Jay, et al.

Journal article  |  2020  |  Cell

Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specif..

Recurrent SPECC1L-NTRK fusions in pediatric sarcoma and brain tumors

Dong-Anh Khuong-Quang, Lauren M Brown, Marie Wong, Chelsea Mayoh, Alexandra Sexton-Oates, Amit Kumar, Mark Pinese, Sumanth Nagabushan, Loretta Lau, Louise E Ludlow, Andrew J Gifford, Michael Rodriguez, Jayesh Desai, Stephen B Fox, Michelle Haber, David S Ziegler, Jordan R Hansford, Glenn M Marshall, Mark J Cowley, Paul G Ekert

Journal article  |  2020  |  Cold Spring Harbor molecular case studies

The identification of rearrangements driving expression of neurotrophic receptor tyrosine kinase (NTRK) family kinases in tumors h..

PRECISION MEDICINE FOR PAEDIATRIC HIGH-GRADE DIFFUSE MIDLINE GLIOMAS - RESULTS FROM THE ZERO CHILDHOOD CANCER COMPREHENSIVE PRECISION MEDICINE PROGRAM

Khuong-Quang Dong-Anh, Sumanth Nagabushan, Neevika Manoharan, Greg Arndt, Paulette Barahona, Mark J Cowley, Paul G Ekert, Tim Failes, Noemi Fuentes Bolanos, Maely Gauthier, Andrew J Gifford, Michelle Haber, Amit Kumar, Richard B Lock, Glenn M Marshall, Chelsea Mayoh, Emily Mould, Murray D Norris, Anjana Gopalakrishnan, Natacha Omer, et al.

Conference Proceedings  |  2020  |  NEURO-ONCOLOGY

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer

Marie Wong, Chelsea Mayoh, Loretta MS Lau, Dong-Anh Khuong-Quang, Mark Pinese, Amit Kumar, Paulette Barahona, Emilie E Wilkie, Patricia Sullivan, Rachel Bowen-James, Mustafa Syed, Inigo Martincorena, Federico Abascal, Alexandra Sherstyuk, Noemi A Bolanos, Jonathan Baber, Peter Priestley, M Emmy M Dolman, Emmy DG Fleuren, Marie-Emilie Gauthier, et al.

Journal article  |  2020  |  Nature Medicine

The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refract..

A Novel Orthotopic Patient-Derived Xenograft Model of Radiation-Induced Glioma Following Medulloblastoma

Jacqueline P Whitehouse, Meegan Howlett, Hilary Hii, Chelsea Mayoh, Marie Wong, Paulette Barahona, Pamela Ajuyah, Christine L White, Molly K Buntine, Jason M Dyke, Sharon Lee, Santosh Valvi, Jason Stanley, Clara Andradas, Brooke Carline, Mani Kuchibhotla, Paul G Ekert, Mark J Cowley, Nicholas G Gottardo, Raelene Endersby

Journal article  |  2020  |  Cancers

Radiation-induced glioma (RIG) is a highly aggressive brain cancer arising as a consequence of radiation therapy. We report a case..

Molecular targeted therapies and precision medicine for children with neuroblastoma and other refractory malignancies

Michelle Haber, Laura Gamble, Lin Xiao, Ruby Pandher, Klaartje Somers, Jayne Murray, Aaminah Khan, Denise Yu, Laura Franshaw, Mark R Burns, Maria Tsoli, Anahid Ehteda, Anthony Cesare, Aisling O'Connor, Francis Mussai, Carmela de Santo, Paul Cheng, Lioubov Korotchkina, Katerina Gurova, Vanessa Tyrrell, et al.

Conference Proceedings  |  2020  |  CANCER RESEARCH

Zero Childhood Cancer (ZERO): A comprehensive precision medicine platform for children with highrisk cancer

Paulette Barahona, Jamie Fletcher, Noemi Fuentes-Bolanos, Marie-Emilie Gauthier, Michelle Haber, Richard B Lock, Glenn M Marshall, Chelsea Mayoh, Emily Mould, Sumanth Nagabushan, Murray Norris, Tracey O'Brien, Alexandra Sherstyuk, David Thomas, Toby Trahair, Katherine Tucker, Meera Warby, Marie Wong, David S Ziegler, Vanessa J Tyrrell, et al.

Conference Proceedings  |  2020  |  CANCER RESEARCH

Immune profiling of pediatric solid tumors

Rachael L Terry, Deborah Meyran, David S Ziegler, Michelle Haber, Paul G Ekert, Joseph A Trapani, Paul J Neeson

Journal article  |  2020  |  Journal of Clinical Investigation

Pediatric cancers, particularly high-risk solid tumors, urgently need effective and specific therapies. Their outlook has not appr..

Prevalence and spectrum of germline mutations in children with high-risk cancer

Paulette Barahona, Alexandra Sherstyuk, Mark Cowley, Paul Ekert, Judy Kirk, Khuong-Quang Dong-Anh, Amit Kumar, Loretta Lau, Chelsea Mayoh, Glenn Marshall, Emily Moud, Tracey O'Brien, Mark Pinese, David Thomas, Vanessa Tyrell, David Ziegler, Michelle Haber, Katherine Tucker, Noemi Auxiliadora Fuentes-Bolanos, Meera Warby

Conference Proceedings  |  2020  |  CANCER RESEARCH

Cotargeting BCL-2 and MCL-1 in high-risk B-ALL

Donia M Moujalled, Diane T Hanna, Soroor Hediyeh-zadeh, Giovanna Pomilio, Lauren Brown, Veronique Litalien, Ray Bartolo, Shaun Fleming, Maia Chanrion, Sebastien Banquet, Ana-Leticia Maragno, Laurence Kraus-Berthier, Marie Schoumacher, Charles G Mullighan, Angela Georgiou, Christine A White, Guillaume Lessene, David CS Huang, Andrew W Roberts, Olivier Geneste, et al.

Journal article  |  2020  |  BLOOD ADVANCES

Improving survival outcomes in adult B-cell acute lymphoblastic leukemia (B-ALL) remains a clinical challenge. Relapsed disease ha..