Paul Ekert

Immune profiling of pediatric solid tumors.

Rachael L Terry, Deborah Meyran, David S Ziegler, Michelle Haber, Paul G Ekert, Joseph A Trapani, Paul J Neeson

Journal article  |  2020  |  Journal of Clinical Investigation

Pediatric cancers, particularly high-risk solid tumors, urgently need effective and specific therapies. Their outlook has not appr..

Cotargeting BCL-2 and MCL-1 in high-risk B-ALL

Donia M Moujalled, Diane T Hanna, Soroor Hediyeh-zadeh, Giovanna Pomilio, Lauren Brown, Veronique Litalien, Ray Bartolo, Shaun Fleming, Maia Chanrion, Sebastien Banquet, Ana-Leticia Maragno, Laurence Kraus-Berthier, Marie Schoumacher, Charles G Mullighan, Angela Georgiou, Christine A White, Guillaume Lessene, David CS Huang, Andrew W Roberts, Olivier Geneste, et al.

Journal article  |  2020  |  BLOOD ADVANCES

Improving survival outcomes in adult B-cell acute lymphoblastic leukemia (B-ALL) remains a clinical challenge. Relapsed disease ha..

MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data

Marek Cmero, Breon Schmidt, Ian Majewski, Paul Ekert, Alicia Oshlack, Nadia Davidson

Journal article  |  2020

Abstract Genomic rearrangements can modify gene function by altering transcript sequences, and have been shown to be drivers in bo..

The application of RNA sequencing for the diagnosis and genomic classification of pediatric acute lymphoblastic leukemia

Lauren M Brown, Andrew Lonsdale, Andrea Zhu, Nadia M Davidson, Breon Schmidt, Anthony Hawkins, Elise Wallach, Michelle Martin, Francoise M Mechinaud, Seong Lin Khaw, Ray C Bartolo, Louise EA Ludlow, Jackie Challis, Ian Brooks, Vida Petrovic, Nicola C Venn, Rosemary Sutton, Ian J Majewski, Alicia Oshlack, Paul G Ekert

Journal article  |  2020  |  Blood Advances

Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, and implementation of risk-adapted therapy has been in..

Zero Childhood Cancer: A Comprehensive Precision Medicine Platform for Children and Adolescents with High-Risk Cancer

DA Khuong Quang, L Lau, MJ Cowley, PG Ekert, AJ Gifford, M Haber, R Lock, G Marshall, C Mayoh, E Mould, M Norris, T O'Brien, T Trahair, V Tyrrell, DS Ziegler

Conference Proceedings  |  2019  |  PEDIATRIC BLOOD & CANCER

Prevalence and Spectrum of Germline Mutations in Children with High-Risk Cancer

N Fuentes-Bolanos, M Warby, P Barahona, A Sherstyuk, M Cowley, P Ekert, J Kirk, DA Khuong-Quang, K Amit, L Lau, C Mayoh, G Marshall, E Mould, TA O'Brien, M Pinese, D Thomas, V Tyrrell, D Ziegler, M Harber, KM Tucker

Conference Proceedings  |  2019  |  PEDIATRIC BLOOD & CANCER

iPREDICT: Incorporating complex profiling of patients to enrol onto molecularly directed cancer therapeutics. Preliminary results of the adult and paediatric

Kortnye Smith, Sophie O'Haire, Khuong-Quang Dong-Anh, Ben Markman, Hui Gan, Paul G Ekert, Ken O'Byrne, Michael Milward, Ben Solomon, Ben Tran, Clare Scott, Grant McArthur, Damien Kee, Andrew Fellowes, Huiling Xu, Melissa Martyn, Elly Lynch, Paula Lorgelly, Clara Gaff, Stephen Fox, et al.

Conference Proceedings  |  2019  |  ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY

Targeted therapy and disease monitoring in CNTRL-FGFR1-driven leukaemia

Lauren M Brown, Ray C Bartolo, Nadia M Davidson, Breon Schmidt, Ian Brooks, Jackie Challis, Vida Petrovic, Dong-Anh Khuong-Quang, Francoise Mechinaud, Seong L Khaw, Ian J Majewski, Alicia Oshlack, Paul G Ekert

Journal article  |  2019  |  Pediatric Blood & Cancer

We report two patients with leukaemia driven by the rare CNTRL-FGFR1 fusion oncogene. This fusion arises from a t(8;9)(p12;q33) tr..

Human MLL/KMT2A gene exhibits a second breakpoint cluster region for recurrent MLL-USP2 fusions

Claus Meyer, Bruno A Lopes, Aurelie Caye-Eude, Helene Cave, Chloe Arfeuille, Wendy Cuccuini, Rosemary Sutton, Nicola C Venn, Seung Hwan Oh, Grigory Tsaur, Gabriele Escherich, Tobias Feuchtinger, Hansen J Kosasih, Seong L Khaw, Paul G Ekert, Maria S Pombo-de-Oliveira, Audrey Bidet, Bardya Djahanschiri, Ingo Ebersberger, Marketa Zaliova, et al.

Journal article  |  2019  |  Leukemia

Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer

Emily V Mould, Loretta Lau, Greg Arndt, Paulette Barahona, Mark J Cowley, Paul Ekert, Tim Failes, Jamie Fletcher, Andrew Gifford, Dylan Grebert-Wade, Michelle Haber, Alvin Kamili, Amit Kumar, Richard B Lock, Glenn M Marshall, Chelsea Mayoh, Murray Norris, Tracey O'Brien, Dong Anh Khuong Quang, Patrick Strong, et al.

Conference Proceedings  |  2019  |  Clinical Research (Excluding Clinical Trials)

DEVELOPMENT OF NEXT GENERATION CAR'S TARGETING THE LEWIS Y ANTIGEN FOR THE TREATMENT OF CANCER

D Meyran, J Zhu, J Buttler, D Tantalo, M Neeson, P Ekert, M Kershaw, J Trapani, P Darcy, P Neeson

Conference Proceedings  |  2019  |  Cytotherapy

RESULTS OF THE ZERO CHILDHOOD CANCER INTEGRA-TM PRECISION MEDICINE PLATFORM FOR PAEDIATRIC HIGH-RISK BRAIN TUMOURS

Maria Tsoli, Loretta Lau, Paulette Barahona, Chelsea Mayoh, Tim Failes, Marie Wong, Alexandra Sherstyuk, Andrew J Gifford, Amit Kumar, Emily Mould, Caitlin Ung, Ornella Tolhurst, Anjana Gopalakrishnan, Dylan Grebert-Wade, Patrick Strong, Peter Trebilcock, Richard Lock, Vanessa Tyrrell, Toby Trahair, Katherine Tucker, et al.

Conference Proceedings  |  2019  |  NEURO-ONCOLOGY

Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer

Maria Tsoli, Carol Wadham, Mark Pinese, Tim Failes, Swapna Joshi, Emily Mould, Julia X Yin, Velimir Gayevskiy, Amit Kumar, Warren Kaplan, Paul G Ekert, Federica Saletta, Laura Franshaw, Jie Liu, Andrew Gifford, Martin A Weber, Michael Rodriguez, Richard J Cohn, Greg Arndt, Vanessa Tyrrell, et al.

Journal article  |  2018  |  Cancer Biology & Therapy

Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome

Tenzin Gayden, Fernando E Sepulveda, Khuong-Quang Dong-Anh, Jonathan Pratt, Elvis T Valera, Alexandrine Garrigue, Susan Kelso, Frank Sicheri, Leonie G Mikael, Nancy Hamel, Andrea Bajic, Rola Dali, Shriya Deshmukh, Dzana Dervovic, Daniel Schramek, Frederic Guerin, Mikko Taipale, Hamid Nikbakht, Jacek Majewski, Despina Moshous, et al.

Conference Proceedings  |  2018  |  Nature Genetics

Different Classes of ABL1 Fusions Activate Different Downstream Signalling Nodes

Lauren M Brown, Hannah Huckstep, Jarrod Sandow, Ray C Bartolo, Nadia Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky W Johnstone, Alicia Oshlack, Melissa Davis, Paul G Ekert

Conference Proceedings  |  2018  |  Blood

Combined BCL-2 and HDAC Targeting Has Potent and TP53 Independent Activity in AML

Jessica M Salmon, Giovanna Pomilio, Donia M Moujalled, Sarah Macraild, Charis E Teh, Sewa Riajl, Adam Ivey, Tse-Chieh Teh, Paul G Ekert, Laurence Kraus-Berthier, Ioana Kloos, Marie Schoumacher, Daniel Gray, Andrew H Wei

Conference Proceedings  |  2018  |  Blood

Germline TIM-3 Mutations Characterize Sub-Cutaneous Panniculitis T-Cell Lymphomas with Hemophagocytic Lymphohistiocytic Syndrome

Dong-Anh Khuong-Quang, Tenzin Gayden, Fernando Sepulveda, Jonathan Pratt, Elvis Valera, Alexandrine Garrigue, Susan Kelso, Frank Sicheri, Leonie Mikael, Nancy Hamel, Andrea Bajic, Rola Dali, Dzana Dervovic, Daniel Schramek, Frederic Guerin, Mikko Taipale, Hamid Nikbakht, Jacek Majewski, Despina Moshous, Janie Charlebois, et al.

Conference Proceedings  |  2018  |  Blood

Identification of Potent BH3-Mimetic Combinations Targeting Pro-Survival Pathways in Human B-Cell Acute Lymphoblastic Leukemia

Donia M Moujalled, Diane T Hanna, Giovanna Pomilio, Veronique Litalien, Shaun Fleming, Marie Chanrion, Ana-Leticia Maragno, Laurence Kraus-Berthier, Seong Lin Khaw, Guillaume Lessene, David Huang, Andrew W Roberts, Olivier Geneste, Paul G Ekert, Ashley P Ng, Andrew H Wei

Conference Proceedings  |  2018  |  Blood

Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma

David S Ziegler, Marie Wong, Chelsea Mayoh, Amit Kumar, Maria Tsoli, Emily Mould, Vanessa Tyrrell, Dong-Anh Khuong-Quang, Mark Pinese, Velimir Gayevskiy, Richard J Cohn, Loretta MS Lau, Mark Reynolds, Michael C Cox, Andrew Gifford, Michael Rodriguez, Mark J Cowley, Paul G Ekert, Glenn M Marshall, Michelle Haber

Journal article  |  2018  |  British Journal of Cancer

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

Behrouz Hassannia, Bartosz Wiernicki, Irina Ingold, Feng Qu, Simon Van Herck, Yulia Y Tyurina, Hulya Bayir, Behnaz A Abhari, Jose Pedro Friedmann Angeli, Sze Men Choi, Eline Meul, Karen Heyninck, Ken Declerck, Chandra Sekhar Chirumamilla, Maija Lahtela-Kakkonen, Guy Van Camp, Dmitri V Krysko, Paul G Ekert, Simone Fulda, Bruno G De Geest, et al.

Journal article  |  2018  |  Journal of Clinical Investigation

Clinker: visualizing fusion genes detected in RNA-seq data

Breon M Schmidt, Nadia M Davidson, Anthony DK Hawkins, Ray Bartolo, Ian J Majewski, Paul G Ekert, Alicia Oshlack

Journal article  |  2018  |  GigaScience

Zero Childhood Cancer: A comprehensive precision medicine platform for children with high-risk cancer

Emily Mould, Loretta Lau, Greg Arndt, Paulette Barahona, Mark Cowley, Paul Ekert, Tim Failes, Jamie Fletcher, Andrew Gifford, Michelle Haber, Alvin Kamili, Amit Kumar, Richard Lock, Glenn Marshall, Chelsea Mayoh, Scott Mead, Murray Norris, Tracey O'Brien, Mark Pinese, Anh Khuong Quang Dong, et al.

Conference Proceedings  |  2018  |  Clinical Research (Excluding Clinical Trials)

Integrated genomics: drug screening and personalized xenograft development approach to identify precision treatments for aggressive pediatric brain tumors

Maria Tsoli, Carol Wadham, Mark Pinese, Tim Failes, Swapna Joshi, Emily Mould, Julia Yin, Velimir Gayevski, Amit Kumar, Warren Kaplan, Paul Ekert, Laura Franshaw, Andrew Gifford, Martin Weber, Michael Rodriguez, Chelsea Mayoh, Richard Cohn, Greg Arndt, Richard Lock, Vanessa Tyrrell, et al.

Conference Proceedings  |  2018  |  Clinical Research (Excluding Clinical Trials)

MicroRNA-155 expression and function in AML: An evolving paradigm

Nisha Narayan, Cameron P Bracken, Paul G Ekert

Journal article  |  2018  |  Experimental Hematology

POTENT CLINICAL AND RADIOLOGICAL RESPONSE TO LAROTRECTINIB IN FIRST CASE OF TRK FUSION HIGH GRADE GLIOMA

David Ziegler, Maria Tsoli, Vanessa Tyre, Richard Cohn, Loretta Lau, Michael Cox, Mark Cowley, Paul Ekert, Glenn Marshall, Michelle Haber

Conference Proceedings  |  2018  |  NEURO-ONCOLOGY

Role of the beta Common (beta c) Family of Cytokines in Health and Disease

Timothy R Hercus, Winnie LT Kan, Sophie E Broughton, Denis Tvorogov, Hayley S Ramshaw, Jarrod J Sandow, Tracy L Nero, Urmi Dhagat, Emma J Thompson, Karen S Cheung Tung Shing, Duncan R McKenzie, Nicholas J Wilson, Catherine M Owczarek, Gino Vairo, Andrew D Nash, Vinay Tergaonkar, Timothy Hughes, Paul G Ekert, Michael S Samuel, Claudine S Bonder, et al.

Journal article  |  2018  |  Cold Spring Harbor Perspectives in Biology

Enhancing venetoclax activity in acute myeloid leukemia by co-targeting MCL1

T-C Teh, N-Y Nguyen, DM Moujalled, D Segal, G Pomilio, S Rijal, A Jabbour, K Cummins, K Lackovic, P Blombery, E Thompson, PG Ekert, G Lessene, SP Glaser, DCS Huang, AW Roberts, MA Guthridge, AH Wei

Journal article  |  2018  |  Leukemia

Microrna-211-a Novel Oncogene in Acute Myeloid Leukemia

Nisha Narayan, Leah Morenos, Hiu Lam Agnes Yuen, Melissa Chen, Maarten Fornerod, C Michel Zwaan, George Grigoriadis, Paul G Ekert

Conference Proceedings  |  2017  |  BLOOD

Clinker: visualising fusion genes detected in RNA-seq data

Breon Schmidt, Nadia Davidson, Anthony DK Hawkins, Ray Bartolo, Ian Majewski, Paul Ekert, Alicia Oshlack

Journal article  |  2017

ABSTRACT Genomic profiling efforts have revealed a rich diversity of oncogenic fusion genes, and many are emerging as important th..

Chemotherapy-related cardiotoxicity: are Australian practitioners missing the point?

Rachel Conyers, Ben Costello, Andre La Gerche, Anne Tripaydonis, Charlotte Burns, Louise Ludlow, Peter Lange, Paul Ekert, Francoise Mechinaud, Michael Cheung, Michelle Martin, David Elliot

Journal article  |  2017  |  Internal Medicine Journal

Quantitative proteomic analysis of EZH2 inhibition in acute myeloid leukemia reveals the targets and pathways that precede the induction of cell death

Jarrod J Sandow, Giuseppe Infusini, Aliaksei Z Holik, Gabriela Brumatti, Tessa V Averink, Paul G Ekert, Andrew I Webb

Journal article  |  2017  |  PROTEOMICS - Clinical Applications

Dysregulation of BCL-2 family proteins by leukemia fusion genes

Lauren M Brown, Diane T Hanna, Seong L Khaw, Paul G Ekert

Journal article  |  2017  |  Journal of Biological Chemistry

High CD123 levels enhance proliferation in response to IL-3, but reduce chemotaxis by downregulating CXCR4 expression

Nicole L Wittwer, Gabriela Brumatti, Ceilidh Marchant, Jarrod J Sandow, Melanie K Pudney, Mara Dottore, Richard J D'Andrea, Angel F Lopez, Paul G Ekert, Hayley S Ramshaw

Journal article  |  2017  |  Blood Advances

Genetic determinants of anthracycline cardiotoxicity - ready for the clinic?

Lauren A Craig, Paul G Ekert, Rachel Conyers, David A Elliott

Journal article  |  2017  |  British Journal of Clinical Pharmacology

Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia

N Narayan, L Morenos, B Phipson, SN Willis, G Brumatti, S Eggers, N Lalaoui, LM Brown, HJ Kosasih, RC Bartolo, L Zhou, D Catchpoole, R Saffery, A Oshlack, GJ Goodall, PG Ekert

Journal article  |  2017  |  Leukemia

Letting the breaks off MYCN

Giovanni Perini, Giorgio Milazzo, Nisha Narayan, Paul G Ekert

Journal article  |  2016  |  Cell Death & Differentiation

Cycloheximide Can Induce Bax/Bak Dependent Myeloid Cell Death Independently of Multiple BH3-Only Proteins

Katharine J Goodall, Megan L Finch-Edmondson, Joanne van Vuuren, George C Yeoh, Ian E Gentle, James E Vince, Paul G Ekert, David L Vaux, Bernard A Callus

Journal article  |  2016  |  PLOS ONE

A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders

Zornitza Stark, Tiong Y Tan, Belinda Chong, Gemma R Brett, Patrick Yap, Maie Walsh, Alison Yeung, Heidi Peters, Dylan Mordaunt, Shannon Cowie, David J Amor, Ravi Savarirayan, George McGillivray, Lilian Downie, Paul G Ekert, Christiane Theda, Paul A James, Joy Yaplito-Lee, Monique M Ryan, Richard J Leventer, et al.

Journal article  |  2016  |  Genetics in Medicine

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics (vol 29, pg 145, 2016)

Najoua Lalaoui, Kay Hanggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spaii, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia

Gabriela Brumatti, Chunyan Ma, Najoua Lalaoui, Nhu-Y Nguyen, Mario Navarro, Maria C Tanzer, Jennifer Richmond, Margherita Ghisi, Jessica M Salmon, Natasha Silke, Giovanna Pomilio, Stefan P Glaser, Elisha de Valle, Raffi Gugasyan, Mark A Gurthridge, Stephen M Condon, Ricky W Johnstone, Richard Lock, Guy Salvesen, Andrew Wei, et al.

Journal article  |  2016  |  Science Translational Medicine

Targeting p38 or MK2 Enhances the Anti-Leukemic Activity of Smac-Mimetics

Najoua Lalaoui, Kay Haenggi, Gabriela Brumatti, Diep Chau, Nhu-Y N Nguyen, Lazaros Vasilikos, Lisanne M Spilgies, Denise A Heckmann, Chunyan Ma, Margherita Ghisi, Jessica M Salmon, Geoffrey M Matthews, Elisha de Valle, Donia M Moujalled, Manoj B Menon, Sukhdeep Kaur Spall, Stefan P Glaser, Jennifer Richmond, Richard B Lock, Stephen M Condon, et al.

Journal article  |  2016  |  Cancer Cell

Autophagy and AML-food for thought

N Lalaoui, R Johnstone, PG Ekert

Journal article  |  2016  |  Cell Death & Differentiation

The molecular relationships between apoptosis, autophagy and necroptosis

Najoua Lalaoui, Lisa M Lindqvist, Jarrod J Sandow, Paul G Ekert

Journal article  |  2015  |  Seminars in Cell & Developmental Biology

Loss of Prkar1a leads to Bcl-2 family protein induction and cachexia in mice

L Gangoda, M Doerflinger, R Srivastava, N Narayan, LE Edgington, J Orian, C Hawkins, LA O'Reilly, H Gu, M Bogyo, P Ekert, A Strasser, H Puthalakath

Journal article  |  2014  |  Cell Death & Differentiation

Interleukin-3-mediated regulation of beta-catenin in myeloid transformation and acute myeloid leukemia

Teresa Sadras, Michelle Perugini, Chung H Kok, Diana G Iarossi, Susan L Heatley, Gabriela Brumatti, Michael S Samuel, Luen B To, Ian D Lewis, Angel F Lopez, Paul G Ekert, Hayley S Ramshaw, Richard J D'Andrea

Journal article  |  2014  |  Journal of Leukocyte Biology

RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis

James A Rickard, Joanne A O'Donnell, Joseph M Evans, Najoua Lalaoui, Ashleigh R Poh, TeWhiti Rogers, James E Vince, Kate E Lawlor, Robert L Ninnis, Holly Anderton, Cathrine Hall, Sukhdeep K Spall, Toby J Phesse, Helen E Abud, Louise H Cengia, Jason Corbin, Sandra Mifsud, Ladina Di Rago, Donald Metcalf, Matthias Ernst, et al.

Journal article  |  2014  |  Cell

ER stress does not cause upregulation and activation of caspase-2 to initiate apoptosis

JJ Sandow, L Dorstyn, LA O'Reilly, M Tailler, S Kumar, A Strasser, PG Ekert

Journal article  |  2014  |  Cell Death & Differentiation

The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts

Pratiti Bandopadhayay, Anissa M Jabbour, Christopher Riffkin, Marika Salmanidis, Lavinia Gordon, Dean Popovski, Lin Rigby, David M Ashley, David N Watkins, David M Thomas, Elizabeth Algar, Paul G Ekert

Journal article  |  2013  |  BMC Cancer

Role of p53 in cAMP/PKA pathway mediated apoptosis

Ahmad Rahimi, Ying Ying Lee, Hassen Abdella, Marcel Doerflinger, Lahiru Gangoda, Rahul Srivastava, Kun Xiao, Paul G Ekert, Hamsa Puthalakath

Journal article  |  2013  |  APOPTOSIS

Seeking a MCL-1 inhibitor

G Brumatti, PG Ekert

Journal article  |  2013  |  Cell Death & Differentiation

BH3-only protein Noxa contributes to apoptotic control of stress-erythropoiesis

Felix M Wensveen, Christian R Geest, Sten FWM Libregts, Ingrid AM Derks, Paul G Ekert, Verena Labi, Andreas Villunger, Martijn A Nolte, Eric Eldering

Journal article  |  2013  |  Apoptosis

HoxA9 regulated Bcl-2 expression mediates survival of myeloid progenitors and the severity of HoxA9-dependent leukemia

Gabriela Brumatti, Marika Salmanidis, Chung H Kok, Rebecca A Bilardi, Jarrod J Sandow, Natasha Silke, Kylie Mason, Jolanda Visser, Anissa M Jabbour, Stefan P Glaser, Toru Okamoto, Philippe Bouillet, Richard J D'Andrea, Paul G Ekert

Journal article  |  2013  |  Oncotarget

Hoxb8 regulates expression of microRNAs to control cell death and differentiation

M Salmanidis, G Brumatti, N Narayan, BD Green, JA van den Bergen, JJ Sandow, AG Bert, N Silke, R Sladic, H Puthalakath, L Rohrbeck, T Okamoto, P Bouillet, MJ Herold, GJ Goodall, AM Jabbour, PG Ekert

Journal article  |  2013  |  Cell Death & Differentiation

Akt1 is the principal Akt isoform regulating apoptosis in limiting cytokine concentrations

BD Green, AM Jabbour, JJ Sandow, CD Riffkin, D Masouras, CP Daunt, M Salmanidis, G Brumatti, BA Hemmings, MA Guthridge, RB Pearson, PG Ekert

Journal article  |  2013  |  Cell Death & Differentiation

Targeting acute myeloid leukemia by dual inhibition of PI3K signaling and Cdk9-mediated Mcl-1 transcription

Daniel Thomas, Jason A Powell, Francois Vergez, David H Segal, Nhu-Y N Nguyen, Adele Baker, Tse-Chieh Teh, Emma F Barry, Jean-Emmanuel Sarry, Erwin M Lee, Tracy L Nero, Anissa M Jabbour, Giovanna Pomilio, Benjamin D Green, Stephane Manenti, Stefan P Glaser, Michael W Parker, Angel F Lopez, Paul G Ekert, Richard B Lock, et al.

Journal article  |  2013  |  Blood

Exploring the utility of human DNA methylation arrays for profiling mouse genomic DNA

Nicholas C Wong, Jane Ng, Nathan E Hall, Sebastian Lunke, Marika Salmanidis, Gabriela Brumatti, Paul G Ekert, Jeffrey M Craig, Richard Saffery

Journal article  |  2013  |  Genomics

Signalling by the beta c family of cytokines

Timothy R Hercus, Urmi Dhagat, Winnie LT Kan, Sophie E Broughton, Tracy L Nero, Michelle Perugini, Jarrod J Sandow, Richard J D'Andrea, Paul G Ekert, Timothy Hughes, Michael W Parker, Angel F Lopez

Journal article  |  2013  |  Cytokine & Growth Factor Reviews

In vitro differentiation of near-unlimited numbers of functional mouse basophils using conditional Hoxb8

U Gurzeler, T Rabachini, CA Dahinden, M Salmanidis, G Brumatti, PG Ekert, N Echeverry, D Bachmann, HU Simon, T Kaufmann

Journal article  |  2013  |  Allergy

Protein Kinase Activity of Phosphoinositide 3-Kinase Regulates Cytokine-Dependent Cell Survival

Daniel Thomas, Jason A Powell, Benjamin D Green, Emma F Barry, Yuefang Ma, Joanna Woodcock, Stephen Fitter, Andrew CW Zannettino, Stuart M Pitson, Timothy P Hughes, Angel F Lopez, Peter R Shepherd, Andrew H Wei, Paul G Ekert, Mark A Guthridge

Journal article  |  2013  |  PLoS Biology

Cytokine receptor signaling activates an IKK-dependent phosphorylation of PUMA to prevent cell death

JJ Sandow, AM Jabbour, MR Condina, CP Daunt, FC Stomski, BD Green, CD Riffkin, P Hoffmann, MA Guthridge, J Silke, AF Lopez, PG Ekert

Journal article  |  2012  |  Cell Death & Differentiation

The GM-CSF receptor family: Mechanism of activation and implications for disease

Timothy R Hercus, Sophie E Broughton, Paul G Ekert, Hayley S Ramshaw, Michelle Perugini, Michele Grimbaldeston, Joanna M Woodcock, Daniel Thomas, Stuart Pitson, Timothy Hughes, Richard J D'Andrea, Michael W Parker, Angel F Lopez

Journal article  |  2012  |  Growth Factors

p53-Dependent Transcriptional Responses to Interleukin-3 Signaling

Anissa M Jabbour, Lavinia Gordon, Carmel P Daunt, Benjamin D Green, Chung H Kok, Richard D'Andrea, Paul G Ekert

Journal article  |  2012  |  PLoS One

Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia

Christopher N Hahn, Chan-Eng Chong, Catherine L Carmichael, Ella J Wilkins, Peter J Brautigan, Xiao-Chun Li, Milena Babic, Ming Lin, Amandine Carmagnac, Young K Lee, Chung H Kok, Lucia Gagliardi, Kathryn L Friend, Paul G Ekert, Carolyn M Butcher, Anna L Brown, Ian D Lewis, L Bik To, Andrew E Timms, Jan Storek, et al.

Journal article  |  2011  |  Nature Genetics

THE PROTEIN KINASE ACTIVITY OF PHOSPHOINOSITIDE 3-KINASE ALPHA PROMOTES AUTONOMOUS CELL SURVIVAL IN AML STEM/PROGENITOR CELLS

D Thomas, JA Powell, EF Barry, J Woodcock, PG Ekert, BD Green, EM Lee, RB Lock, SK Nilsson, DN Haylock, AF Lopez, MA Guthridge

Conference Proceedings  |  2010  |  EXPERIMENTAL HEMATOLOGY

TARGETING CELL SURVIVAL PATHWAYS IN ACUTE MYELOID LEUKEMIA

JA Powell, D Thomas, EF Barry, CH Kok, LY Ma, LB To, A Brown, ID Lewis, GJ Goodall, TP Speed, J Woodcock, M Osato, PG Ekert, DN Haylock, SK Nilsson, RJ D'Andrea, AF Lopez, MA Guthridge

Conference Proceedings  |  2010  |  EXPERIMENTAL HEMATOLOGY

A NOVEL ROLE FOR HOXA9 IN MYELOID CELLS. REGULATION OF BCL-2 FAMILY MEMBERS, CELL DEATH AND DIFFERENTIATION

G Brumatti, M Salmanidis, N Silke, J van den Bergen, A Jabbour, P Bouillet, P Ekert

Conference Proceedings  |  2010  |  EXPERIMENTAL HEMATOLOGY

IL-3 MEDIATED ACTIVATION OF beta-CATENIN IN ACUTE MYELOID LEUKEMIA

T Sadras, M Perugini, HS Ramshaw, DG Salerno, ID Lewis, AF Lopez, PG Ekert, RJ D'Andrea

Conference Proceedings  |  2010  |  EXPERIMENTAL HEMATOLOGY

Molecular Basis of Cytokine Receptor Activation

Angel F Lopez, Timothy R Hercus, Paul Ekert, Dene R Littler, Mark Guthridge, Daniel Thomas, Hayley S Ramshaw, Frank Stomski, Michelle Perugini, Richard D'Andrea, Michele Grimbaldeston, Michael W Parker

Journal article  |  2010  |  IUBMB Life

Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes

C Oberle, J Huai, T Reinheckel, M Tacke, M Rassner, PG Ekert, J Buellesbach, C Borner

Journal article  |  2010  |  Cell Death & Differentiation

Gene expression analysis reveals HOX gene upregulation in trisomy 8 AML

CH Kok, AL Brown, PG Ekert, RJ D'Andrea

Journal article  |  2010  |  Leukemia

Crossing paths: interactions between the cell death machinery and growth factor survival signals

Gabriela Brumatti, Marika Salmanidis, Paul G Ekert

Journal article  |  2010  |  Cellular and Molecular Life Sciences

Myeloid progenitor cells lacking p53 exhibit delayed up-regulation of Puma and prolonged survival after cytokine deprivation

Anissa M Jabbour, Carmel P Daunt, Benjamin D Green, Sandra Vogel, Lavinia Gordon, Rachel S Lee, Natasha Silke, Richard B Pearson, Cassandra J Vandenberg, Priscilla N Kelly, Stephen L Nutt, Andreas Strasser, Christoph Borner, Paul G Ekert

Journal article  |  2010  |  Blood

Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim

AM Jabbour, JE Heraud, CP Daunt, T Kaufmann, J Sandow, LA O'Reilly, BA Callus, A Lopez, A Strasser, DL Vaux, PG Ekert

Journal article  |  2009  |  Cell Death & Differentiation

Imprinted CDKN1C Is a Tumor Suppressor in Rhabdoid Tumor and Activated by Restoration of SMARCB1 and Histone Deacetylase Inhibitors

Elizabeth M Algar, Andrea Muscat, Vinod Dagar, Christian Rickert, CW Chow, Jaclyn A Biegel, Paul G Ekert, Richard Saffery, Jeff Craig, Ricky W Johnstone, David M Ashley

Journal article  |  2009  |  PLoS One

Imprinted CDKN1C is a tumor suppressor in rhabdoid tumor and activated by restoration of SMARCB1 and histone deacetylase inhibitors

EM Algar, A Muscat, V Dagar, C Rickert, CW Chow, JA Biegel, PG Ekert, R Saffery, J Craig, RW Johnstone, DM Ashley

Journal article  |  2009  |  PLoS ONE

Triggering of Apoptosis by Puma Is Determined by the Threshold Set by Prosurvival Bcl-2 Family Proteins

Bernard A Callus, Donia M Moujallad, John Silke, Robert Gerl, Anissa M Jabbour, Paul G Ekert, David L Vaux

Journal article  |  2008  |  J. Mol. Biol.

Cytoplasmic p53 is not required for PUMA-induced apoptosis

BA Callus, PG Ekert, JE Heraud, AM Jabbour, A Kotevski, JE Vince, J Silke, DL Vaux

Journal article  |  2008  |  Cell Death & Differentiation

Response: Does bid play a role in the DNA damage response?

Thomas Kaufmann, Lin Tai, Paul G Ekert, David CS Huang, Fiona Norris, Ralph K Lindemann, Ricky W Johnstone, Vishva M Dixit, Damien Arnoult, Andreas Strasser

Journal article  |  2007  |  Cell

The BH3-only protein bid is dispensable for DNA darnage- and replicative stress-induced apoptosis or cell-cycle arrest

Thomas Kaufmann, Lin Tai, Paul G Ekert, David CS Huang, Fiona Norris, Ralph K Lindemann, Ricky W Johnstone, Vishva M Dixit, Andreas Strasser

Journal article  |  2007  |  Cell

Programmed anuclear cell death delimits platelet life span

Kylie D Mason, Marina R Carpinelli, Jamie I Fletcher, Janelle E Collinge, Adrienne A Hilton, Sarah Ellis, Priscilla N Kelly, Paul G Ekert, Donald Metcalf, Andrew W Roberts, David CS Huang, Benjamin T Kile

Journal article  |  2007  |  Cell

Identification of mammalian mitochondrial proteins that interact with IAPs via N-terminal IAP binding motifs

AM Verhagen, TK Kratina, CJ Hawkins, J Silke, PG Ekert, DL Vaux

Journal article  |  2007  |  Cell Death & Differentiation

Inhibitor of Apoptosis Proteins and Caspases

J Yu, J Silke, P EKERT

Book Chapter  |  2007

Cell death provoked by loss of interleukin-3 signaling is independent of Bad, Bim, and PI3 kinase, but depends in part on Puma

Paul G Ekert, Anissa M Jabbour, Anand Manoharan, Jacki E Heraud, Jai Yu, Miha Pakusch, Ewa M Michalak, Priscilla N Kelly, Bernard Callus, Thomas Kiefer, Anne Verhagen, John Silke, Andreas Strasser, Christoph Borner, David L Vaux

Journal article  |  2006  |  Blood

Two sisters with IMAGe syndrome: Cytomegalic adrenal histopathology, support for autosomal recessive inheritance and literature review

Tiong Yang Tan, J Larry Jameson, Peter Ellis Campbell, Paul G Ekert, Margaret Zacharin, Ravi Savarirayan

Journal article  |  2006  |  American Journal of Medical Genetics

The mitochondrial protein Bak is pivotal for gliotoxin-induced apoptosis and a critical host factor of Aspergillus fumigatus virulence in mice

Julian Pardo, Christin Urban, Eva M Galvez, Paul G Ekert, Uwe Mueller, June Kwon-Chung, Mario Lobigs, Arno Muellbacher, Reinhard Wallich, Christoph Borner, Markus M Simon

Journal article  |  2006  |  Journal of Cell Biology

Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1

Anissa M Jabbour, Michelle A Puryer, Jai Y Yu, Trevor Lithgow, Christopher D Riffkin, David M Ashley, David L Vaux, Paul G Ekert, Christine J Hawkins

Journal article  |  2006  |  Journal of Cell Science

Spontaneous liver hemorrhage during laparotomy for necrotizing enterocolitis: A potential role for recombinant factor VIIa

PM Filan, JF Miles, TD Clarnette, H Ekert, P Ekert

Journal article  |  2005  |  The Journal of Pediatrics

Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance

J Silke, T Kratina, D Chu, PG Ekert, CL Day, M Pakusch, DCS Huang, DL Vaux

Journal article  |  2005  |  Proceedings of the National Academy of Sciences

Stuck long line syndrome

PM Filan, M Woodward, PG Ekert

Journal article  |  2005  |  Archives of Disease in Childhood

Caspase-8 levels determine signalling pathways used in death ligand-induced glioma cell apoptosis

DM Ashley, CD Riffkin, PG Ekert, MJ Knight, CJ Hawkins

Conference Proceedings  |  2004  |  NEURO-ONCOLOGY

Bcl-2-regulated apoptosis and cytochrome c release can occur independently of both caspase-2 and caspase-9

VS Marsden, PG Ekert, M Van Delft, DL Vaux, JM Adams, A Strasser

Journal article  |  2004  |  J. Cell Biol.

Apaf-1, Caspase-2 and Caspase-9 accelerate apoptosis, but do not determine whether factor-deprived cells die

PG Ekert, S Read, J Silke, VS Marsden, H Kaufmann, CJ Hawkins, R Gerl, S Kumar, DL Vaux

Conference Proceedings  |  2004  |  PEDIATRIC RESEARCH

Modelling apoptosis pathways in yeast

PG Ekert, A Jabbour, J Yu, MA Puyer, PK Ho, CJ Hawkins

Conference Proceedings  |  2004  |  PEDIATRIC RESEARCH

Caspase-8 levels affect necessity for mitochondrial amplification in death ligand-induced glioma cell apoptosis

MJ Knight, CD Riffkin, PG Ekert, DM Ashley, CJ Hawkins

Journal article  |  2004  |  Molecular Carcinogenesis

Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis

J Silke, T Kratina, PG Ekert, M Pakusch, DL Vaux

Journal article  |  2004  |  Journal of Biological Chemistry

Insights into the pathogenesis of cerebral lesions in incontinentia pigmenti

SJ Hennel, PG Ekert, JJ Volpe, TE Inder

Journal article  |  2003  |  Pediatric Neurology

Caspase-9 can be activated in the absence of APAF-1 and bcl-2 provides clonal protection from growth-factor withdrawal induced apoptosis independent of APAF1 and Caspase-9

PG Ekert, S Read, CJ Hawkins, V Marsden, J Silke, S Kumar, DL Vaux

Conference Proceedings  |  2003  |  PEDIATRIC RESEARCH

The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis

AM Jabbour, PG Ekert, EJ Coulson, MJ Knight, DM Ashley, CJ Hawkins

Journal article  |  2002  |  Cell Death & Differentiation

The anti-apoptotic activity of XIAP is retained upon mutation of both the caspase 3-and caspase 9-interacting sites

J Silke, CJ Hawkins, PG Ekert, J Chew, CL Day, M Pakusch, AM Verhagen, DL Vaux

Journal article  |  2002  |  Journal of Cell Biology

The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis

A JABBOUR, PG Ekert, EJ Coulson, MJ Knight, D ASHLEY, C HAWKINS

Journal article  |  2002  |  Cell Death & Differentiation

Analysis of candidate antagonists of IAP-mediated caspase inhibition using yeast reconstituted with the mammalian Apaf-1-activated apoptosis mechanism

CJ Hawkins, J Silke, AM Verhagen, R Foster, PG Ekert, DM Ashley

Journal article  |  2001  |  APOPTOSIS

Till death do us part

PG Ekert, J Silke

Journal article  |  2001  |  Cell Death & Differentiation

DIABLO promotes apoptosis by removing MIHA/XIAP from processed caspase 9

PG Ekert, J Silke, CJ Hawkins, AM Verhagen, DL Vaux

Journal article  |  2001  |  Journal of Cell Biology

Upper cervical spinal cord injury in neonates: The use of magnetic resonance imaging

JF Mills, PA Dargaville, LT Coleman, JV Rosenfeld, PG Ekert

Journal article  |  2001  |  Journal of Pediatrics