Ewa Michalak

An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

Marian L Burr, Christina E Sparbier, Kah Lok Chan, Yih-Chih Chan, Ariena Kersbergen, Enid YN Lam, Elizabeth Azidis-Yates, Dane Vassiliadis, Charles C Bell, Omer Gilan, Susan Jackson, Lavinia Tan, Stephen Q Wong, Sebastian Hollizeck, Ewa M Michalak, Hannah Siddle, Michael T McCabe, Rab K Prinjha, Glen R Guerra, Benjamin J Solomon, et al.

Journal article  |  2019  |  Cancer Cell

The roles of DNA, RNA and histone methylation in ageing and cancer

Ewa M Michalak, Marian L Burr, Andrew J Bannister, Mark A Dawson

Journal article  |  2019  |  Nature Reviews Molecular Cell Biology

Chromatin is a macromolecular complex predominantly comprising DNA, histone proteins and RNA. The methylation of chromatin compone..

Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids

Ewa M Michalak, Michael JG Milevskiy, Rachel M Joyce, Johanna F Dekkers, Paul R Jamieson, Bhupinder Pal, Caleb A Dawson, Yifang Hu, Stuart H Orkin, Warren S Alexander, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2018  |  PLOS Biology

Dysregulation of histone methyltransferases in breast cancer - Opportunities for new targeted therapies?

Ewa M Michalak, Jane E Visvader

Journal article  |  2016  |  Molecular Oncology

Caloric restriction modulates Mcl-1 expression and sensitizes lymphomas to BH3 mimetic in mice

Ophelie Meynet, Barbara Zunino, Lina Happo, Ludivine A Pradelli, Johanna Chiche, Marie A Jacquin, Laura Mondragon, Jean-Francois Tanti, Bruno Taillan, Georges Garnier, Julie Reverso-Meinietti, Nicolas Mounier, Jean-Francois Michiels, Ewa M Michalak, Michel Carles, Clare L Scott, Jean-Ehrland Ricci

Journal article  |  2013  |  Blood

p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa

Liz J Valente, Daniel HD Gray, Ewa M Michalak, Josefina Pinon-Hofbauer, Alex Egle, Clare L Scott, Ana Janic, Andreas Strasser

Journal article  |  2013  |  Cell Reports

Transforming Growth Factor-beta Directly Induces p53-up-regulated Modulator of Apoptosis (PUMA) during the Rapid Induction of Apoptosis in Myc-driven B-cell Lymphomas

Lindsay C Spender, Matthew J Carter, Darren I O'Brien, Louise J Clark, Jian Yu, Ewa M Michalak, Lina Happo, Mark S Cragg, Gareth J Inman

Journal article  |  2013  |  Journal of Biological Chemistry

Developmental stage-specific contribution of LGR5( ) cells to basal and luminal epithelial lineages in the postnatal mammary gland

Karin E de Visser, Metamia Ciampricotti, Ewa M Michalak, David Wei-Min Tan, Ewoud N Speksnijder, Cheei-Sing Hau, Hans Clevers, Nick Barker, Jos Jonkers

Journal article  |  2012  |  Journal of Pathology

Studying Therapy Response and Resistance in Mouse Models for BRCA1-Deficient Breast Cancer

Ewa Malgorzata Michalak, Jos Jonkers

Journal article  |  2011  |  Journal of Mammary Gland Biology and Neoplasia

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

Erinna F Lee, Peter E Czabotar, Mark F Van Delft, Ewa M Michalak, Michelle J Boyle, Simon N Willis, Hamsa Puthalakath, Philippe Bouillet, Peter M Colman, David CS Huang, W Douglas Fairlie

Journal article  |  2008  |  Journal of Cell Biology