Kaushalya Amarasinghe

A Deep Learning Model to Automate Skeletal Muscle Area Measurement on Computed Tomography Images

Kaushalya C Amarasinghe, Jamie Lopes, Julian Beraldo, Nicole Kiss, Nicholas Bucknell, Sarah Everitt, Price Jackson, Cassandra Litchfield, Linda Denehy, Benjamin J Blyth, Shankar Siva, Michael MacManus, David Ball, Jason Li, Nicholas Hardcastle

Journal article  |  2021  |  FRONTIERS IN ONCOLOGY

Background: Muscle wasting (Sarcopenia) is associated with poor outcomes in cancer patients. Early identification of sarcopenia ca..

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

Xiaomeng Zhang, Lie Yang, Pacman Szeto, Gamze Kuser Abali, Youfang Zhang, Aishwarya Kulkarni, Kaushalya Amarasinghe, Jason Li, Ismael A Vergara, Ramyar Molania, Anthony T Papenfuss, Catriona McLean, Mark Shackleton, Kieran F Harvey

Journal article  |  2020  |  ONCOGENE

Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younge..

Therapeutic options for mucinous ovarian carcinoma

Kylie L Gorringe, Dane Cheasley, Matthew J Wakefield, Georgina L Ryland, Prue E Allan, Kathryn Alsop, Kaushalya C Amarasinghe, Sumitra Ananda, David DL Bowtell, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Sian Fereday, C Blake Gilks, Charlie Gourley, Alison M Hadley, Joy Hendley, Sally M Hunter, Scott H Kaufmann, et al.

Journal article  |  2020  |  GYNECOLOGIC ONCOLOGY

OBJECTIVE: Mucinous ovarian carcinoma (MOC) is an uncommon ovarian cancer histotype that responds poorly to conventional chemother..

The molecular origin and taxonomy of mucinous ovarian carcinoma

Dane Cheasley, Matthew J Wakefield, Georgina L Ryland, Prue E Allan, Kathryn Alsop, Kaushalya C Amarasinghe, Sumitra Ananda, Michael S Anglesio, George Au-Yeung, Maret Bohm, David Dl Bowtell, Alison Brand, Georgia Chenevix-Trench, Michael Christie, Yoke-Eng Chiew, Michael Churchman, Anna DeFazio, Renee Demeo, Rhiannon Dudley, Nicole Fairweather, et al.

Journal article  |  2019  |  NATURE COMMUNICATIONS

Mucinous ovarian carcinoma (MOC) is a unique subtype of ovarian cancer with an uncertain etiology, including whether it genuinely ..

Survival Following Chemotherapy in Ovarian Clear Cell Carcinoma Is Not Associated with Pathological Misclassification of Tumor Histotype

Masataka Takenaka, Martin Kobel, Dale W Garsed, Sian Fereday, Ahwan Pandey, Dariush Etemadmoghadam, Joy Hendley, Ayako Kawabata, Daito Noguchi, Nozomu Yanaihara, Hiroyuki Takahashi, Takako Kiyokawa, Masahiro Ikegami, Hirokuni Takano, Seiji Isonishi, Kazuhiko Ochiai, Nadia Traficante, Sreeja Gadipally, Timothy Semple, Dane Vassiliadis, et al.

Journal article  |  2019  |  CLINICAL CANCER RESEARCH

PURPOSE: Although ovarian clear cell carcinomas (OCCC) are commonly resistant to platinum-based chemotherapy, good clinical outcom..

Population-based genetic testing of asymptomatic women for breast and ovarian cancer susceptibility

Simone M Rowley, Lyon Mascarenhas, Lisa Devereux, Na Li, Kaushalya C Amarasinghe, Magnus Zethoven, Jue Er Amanda Lee, Alexandra Lewis, James A Morgan, Sharpe Limb, Mary-Anne Young, Paul A James, Alison H Trainer, Ian G Campbell

Journal article  |  2019  |  GENETICS IN MEDICINE

PURPOSE: The identification of carriers of hereditary breast and ovarian cancer (HBOC) gene variants through family cancer history..

Mutational Landscape of Ovarian Adult Granulosa Cell Tumors from Whole Exome and Targeted TERT Promoter Sequencing

Maria Alexiadis, Simone M Rowley, Simon Chu, Dilys TH Leung, Colin JR Stewart, Kaushalya C Amarasinghe, Ian G Campbell, Peter J Fuller

Journal article  |  2019  |  MOLECULAR CANCER RESEARCH

Adult granulosa cell tumor (aGCT), the most common malignant ovarian sex cord-stromal tumor, is characterized by the forkhead tran..

Mutations in RECQL are not associated with breast cancer risk in an Australian population

Na Li, Simone M Rowley, David L Goode, Kaushalya C Amarasinghe, Simone McInerny, Lisa Devereux, Michelle W Wong-Brown, Richard Lupat, Jue Er Amanda Lee, Siobhan Hughes, Ella R Thompson, Magnus Zethoven, Jason Li, Alison H Trainer, Kylie L Gorringe, Rodney J Scott, Paul A James, Ian G Campbell

Journal article  |  2018  |  NATURE GENETICS

Mutational landscape of adult granulosa cell tumours of the ovary from whole exome sequencing

Peter J Fuller, Maria Alexiadis, Simon Chu, Dilys TH Leung, Simone M Rowley, Jason Li, Kaushalya C Amarasinghe, Ian G Campbell

Conference Proceedings  |  2018  |  CLINICAL ENDOCRINOLOGY

Homologous Recombination DNA Repair Pathway Disruption and Retinoblastoma Protein Loss Are Associated with Exceptional Survival in High-Grade Serous Ovarian Cancer

Dale W Garsed, Kathryn Alsop, Sian Fereday, Catherine Emmanuel, Catherine J Kennedy, Dariush Etemadmoghadam, Bo Gao, Val Gebski, Valerie Gares, Elizabeth L Christie, Maartje CA Wouters, Katy Milne, Joshy George, Ann-Marie Patch, Jason Li, Gisela Mir Arnau, Timothy Semple, Sreeja R Gadipally, Yoke-Eng Chiew, Joy Hendley, et al.

Journal article  |  2018  |  CLINICAL CANCER RESEARCH

Purpose: Women with epithelial ovarian cancer generally have a poor prognosis; however, a subset of patients has an unexpected dra..