Fiona Brownfoot

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia.

Natalie K Binder, Fiona C Brownfoot, Sally Beard, Ping Cannon, Tuong V Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2020  |  Pregnancy Hypertension

Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance..

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Tuong Nguyen, Laura Tuohey, Cathy Cluver, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2020  |  Placenta

INTRODUCTION: The antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are elevated in p..

Pravastatin as the statin of choice for reducing pre-eclampsia-associated endothelial dysfunction

Natasha de Alwis, Sally Beard, Yeukai T Mangwiro, Natalie K Binder, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Stephen Tong, Natalie J Hannan

Journal article  |  2020  |  Pregnancy Hypertension

OBJECTIVES: There is avid interest in pravastatin as a therapeutic intervention for pre-eclampsia, however little is known on stat..

Accuracy of clinical suspicion of growth restriction at term despite a normal growth ultrasound: A retrospective cohort study

Brittany Green, Lisa Hui, Roxanne Hastie, Stephen Tong, Fiona C Brownfoot

Journal article  |  2020  |  Australian and New Zealand Journal of Obstetrics and Gynaecology

The incidence of hypertensive disorders of pregnancy following sperm donation in IVF: an Australian state-wide retrospective cohort study

Amber L Kennedy, Cathryn J Stern, Stephen Tong, Roxanne Hastie, Franca Agresta, Susan P Walker, Fiona C Brownfoot, Vivien MacLachlan, Beverley J Vollenhoven, Anthea C Lindquist

Journal article  |  2019  |  Human Reproduction

STUDY QUESTION: Does IVF using donor sperm increase the risk of hypertensive disorders of pregnancy and fetal growth restriction (..

Sulfasalazine decreases soluble fms-like tyrosine kinase-1 secretion potentially via inhibition of upstream placental epidermal growth factor receptor signalling

Roxanne Hastie, Fiona C Brownfoot, Ping Cannon, Nguyen Vi, Laura Tuohey, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2019  |  Placenta

OBJECTIVES: Preeclampsia is a hypertensive disorder of pregnancy with no available medical treatment. We recently reported sulfasa..

Maternal intramuscular dexamethasone versus betamethasone before preterm birth (ASTEROID): a multicentre, double-blind, randomised controlled trial

Caroline A Crowther, Pat Ashwood, Chad C Andersen, Philippa F Middleton, Tran Thach, Lex W Doyle, Jeffrey S Robinson, Jane E Harding, Vincent Ball, Carol Holst, Kaye Robinson, Sasha Zhang, Yee Khong, Andrew McPhee, Katie Groom, Jane Alsweiler, Deb Eaglen, Helga Hauch, Alenna Vallely, Sonia Angus, et al.

Journal article  |  2019  |  The Lancet Child & Adolescent Health

BACKGROUND: Antenatal corticosteroids given to women before preterm birth improve infant survival and health. However, whether dex..

Systematic review of areca (betel nut) use and adverse pregnancy outcomes

Manarangi De Silva, Leeanne Panisi, Fiona C Brownfoot, Anthea Lindquist, Susan P Walker, Stephen Tong, Roxanne Hastie

Journal article  |  2019  |  International Journal of Gynecology & Obstetrics

Growth Trajectory of Preterm Small for Gestational Age Neonates in the Neonatal Intensive Care Unit and Special Care Nursery

C Molony, R Hiscock, F Brownfoot

Conference Proceedings  |  2019  |  AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

Prediction of adverse maternal outcomes in preeclampsia at term

Tarini D Paul, Roxanne Hastie, Stephen Tong, Emerson Keenan, Richard Hiscock, Fiona C Brownfoot

Journal article  |  2019  |  Pregnancy Hypertension

Preeclampsia complicates 5-8% of all pregnancies and is associated with high rates of maternal and perinatal morbidity. The majori..

Predictive Value of the Signs and Symptoms Preceding Eclampsia A Systematic Review

Roxanne Hastie, Fiona C Brownfoot, Catherine A Cluver, Susan P Walker, Susanne Hesselman, Stephen Tong, Lina Bergman

Journal article  |  2019  |  Obstetrics & Gynecology

OBJECTIVE: To estimate the predictive value of signs and symptoms that occur before onset of eclampsia among pregnant women. DATA ..

A double blind, randomised, placebo-controlled trial to evaluate the efficacy of metformin to treat preterm pre-eclampsia (PI2 Trial): study protocol

Catherine Cluver, Susan P Walker, Ben W Mol, David Hall, Richard Hiscock, Fiona C Brownfoot, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article  |  2019  |  BMJ Open

Proton Pump Inhibitors and Preeclampsia Risk Among 157 720 Women A Swedish Population Register-Based Cohort Study

Roxanne Hastie, Lina Bergman, Catherin A Cluver, Anna Wikman, Natalie J Hannan, Susan P Walker, Anna-Karin Wikstrom, Stephen Tong, Susanne Hesselman

Journal article  |  2019  |  Hypertension

Sulfasalazine reduces placental secretion of antiangiogenic factors, up-regulates the secretion of placental growth factor and rescues endothelial dysfunction

Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Nguyen Vi, Roxanne Hastie, Laura J Parry, Sevvandi Senadheera, Laura Tuohey, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2019  |  EBioMedicine

Accuracy of Clinical Suspicion of Growth Restriction at Term Despite a Normal Growth Ultrasound.

Brittany Green, Lisa Hui, Roxanne Hastie, Stephen Tong, Fiona C Brownfoot

Conference Proceedings  |  2019  |  REPRODUCTIVE SCIENCES

Comparing the Ability of Pravastatin, Simvastatin and Rosuvastatin to Quench Markers of Endothelial Dysfunction in Pregnancy.

Natasha de Alwis, Sally Beard, Natalie Binder, Tu'uhevaha Kaitu'u-Lino, Fiona Brownfoot, Stephen Tong, Natalie Hannan

Conference Proceedings  |  2019  |  REPRODUCTIVE SCIENCES

The Diagnostic Accuracy of the Signs and Symptoms Preceding Eclampsia, a Systematic Review.

Roxanne Hastie, Fiona C Brownfoot, Catherine Cluver, Susan P Walker, Susanne Hesselman, Stephen Tong, Lina Bergman

Conference Proceedings  |  2019  |  REPRODUCTIVE SCIENCES

High-dose compared with low-dose oxytocin for induction of labour of nulliparous women at term

Natasha Prichard, Anthea Lindquist, Richard Hiscock, Sophie Ruff, Stephen Tong, Fiona C Brownfoot

Journal article  |  2019  |  The Journal of Maternal-Fetal & Neonatal Medicine

Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury.

Bobbi Fleiss, Flora Wong, Fiona Brownfoot, Isabelle K Shearer, Olivier Baud, David W Walker, Pierre Gressens, Mary Tolcos

Journal article  |  2019  |  Frontiers in Endocrinology

Intrauterine growth restriction (IUGR) is a complex global healthcare issue. Concerted research and clinical efforts have improved..

A Systematic Review of Proton Pump Inhibitors for the Prevention and Treatment of Preeclampsia and Gestational Hypertension

Manarangi De Silva, Fiona Brownfoot, Natalie J Hannan, Susan P Walker, Catherine A Cluver, Anthea Lindquist, Stephen Tong, Roxanne Hastie

Journal article  |  2019  |  Open Journal of Obstetrics and Gynecology

EGFL7 gene expression is regulated by hypoxia in trophoblast and altered in the plasma of patients with early preeclampsia

Clare L Whitehead, Tu'uhevaha J Kaitu'u-Lino, Natalie K Binder, Sally Beard, Natasha De Alwis, Fiona Brownfoot, Stephen Tong, Natalie J Hannan

Journal article  |  2018  |  Pregnancy Hypertension

Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome

Roxanne Hastie, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2018  |  Pregnancy Hypertension

Predicting the Progression of Preeclampsia to Severe Disease at Term

T Paul, S Tong, R Hastie, F Brownfoot

Conference Proceedings  |  2018  |  AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY

TWO PARALLEL PATHWAYS REGULATING SFLT-1 SECRETION FROM PLACENTA

Roxanne Hastie, Fiona C Brownfoot, Natalie J Hannan, Ping Cannon, Nguyen Tuong-Vi, Natasha Pritchard, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings  |  2018  |  PLACENTA

Effect of sildenafil citrate on circulating levels of sFlt-1 in preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Ping Cannon, Nguyen Vi, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2018  |  Pregnancy Hypertension

Re: Pregnancy-associated plasma protein-A is positively correlated with first-trimester skin microvascular reactivity

FC Brownfoot

Journal article  |  2018  |  Ultrasound in Obstetrics & Gynecology

sFlt-1 Transcription and Secretion is Regulated through the Mitochondrial Electron Transport Chain - A New Mechanism to Target for Treating Preeclampsia.

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Nguyen Tuong-Vi, Stephen Tong

Conference Proceedings  |  2018  |  REPRODUCTIVE SCIENCES

Combination Sulfasalazine and Metformin Are Additive in Reducing Placental Anti-Angiogenic Factor Secretion and Up-Regulating Angiogenic Factors.

Fiona C Brownfoot, Stephen Tong, Ping Cannon, Nguyen Vi, Natalie Hannan, Roxanne Hastie, Tu'uhevaha Kaitu'u-Lino

Conference Proceedings  |  2018  |  REPRODUCTIVE SCIENCES

Vinorelbine Potently Induces Placental Cell Death, Does Not Harm Fertility and is a Potential Treatment for Ectopic Pregnancy

Roxanne Hastie, Elgene Lim, Pavel Sluka, Lisa Campbell, Andrew W Horne, Lenore Ellett, Natalie J Hannan, Fiona Brownfoot, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article  |  2018  |  EBioMedicine

Combining metformin and esomeprazole is additive in reducing sFlt-1 secretion and decreasing endothelial dysfunction - implications for treating preeclampsia

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Sally Beard, Ping Cannon, Roxanne Hastie, Tuong V Nguyen, Natalie K Binder, Stephen Tong, Natalie J Hannan

Journal article  |  2018  |  PLOS ONE

Activating Transcription Factor 3 Is Reduced in Preeclamptic Placentas and Negatively Regulates sFlt-1 (Soluble fms-Like Tyrosine Kinase 1), Soluble Endoglin, and Proinflammatory Cytokines in Placenta

Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot, Roxanne Hastie, Ashwini Chand, Ping Cannon, Minh Deo, Laura Tuohey, Clare Whitehead, Natalie J Hannan, Stephen Tong

Journal article  |  2017  |  Hypertension

sFlt-1 and soluble endoglin concentrations in serum vs plasma in preterm preeclampsia: Are they interchangeable for biomarker studies?

Fiona Brownfoot, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Stephen Tong, Natalie Hannan

Journal article  |  2017  |  Pregnancy Hypertension

Epidermal Growth Factor Rescues Endothelial Dysfunction in Primary Human Tissues In Vitro

Roxanne Hastie, Stephen Tong, Natalie J Hannan, Fiona Brownfoot, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2017  |  Reproductive Sciences

Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment

Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Minh Deo, Sally Beard, Tuong V Nguyen, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2017  |  Scientific Reports

Proton Pump Inhibitors Decrease Soluble fms-Like Tyrosine Kinase-1 and Soluble Endoglin Secretion, Decrease Hypertension, and Rescue Endothelial Dysfunction

Kenji Onda, Stephen Tong, Sally Beard, Natalie Binder, Masanaga Muto, Sevvandi N Senadheera, Laura Parry, Mark Dilworth, Lewis Renshall, Fiona Brownfoot, Roxanne Hastie, Laura Tuohey, Kirsten Palmer, Toshihiko Hirano, Masahito Ikawa, Tu'uhevaha Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2017  |  Hypertension

Nuclear factor of activated T-cells (NFAT) regulates soluble fms-like tyrosine kinase-1 secretion (sFlt-1) from human placenta

Louie Ye, Amy Gratton, Natalie J Hannan, Ping Cannon, Minh Deo, Kirsten R Palmer, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Fiona C Brownfoot

Journal article  |  2016  |  PLACENTA

Steroid sulfatase is increased in the placentas and whole blood of women with early-onset preeclampsia

Amy M Gratton, Louie Ye, Fiona C Brownfoot, Natalie J Hannan, Clare Whitehead, Ping Cannon, Minh Deo, Peter J Fuller, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2016  |  Placenta

Effects of simvastatin, rosuvastatin and pravastatin on soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sENG) secretion from human umbilical vein endothelial cells, primary trophoblast cells and placenta

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2016  |  BMC PREGNANCY AND CHILDBIRTH

Loss of Akt increases soluble endoglin release from endothelial cells but not placenta

Tu'uhevaha J Kaitu'u-Lino, Roxanne Hastie, Natalie J Hannan, Fiona Brownfoot, Manarangi De Silva, Ping Cannon, Laura Tuohey, Stephen Tong

Journal article  |  2016  |  Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Jumonji Domain Containing Protein 6 Is Decreased in Human Preeclamptic Placentas and Regulates sFLT-1 Splice Variant Production

Kirsten R Palmer, Stephen Tong, Laura Tuohey, Ping Cannon, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Sebastian E Illanes, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2016  |  Biology of Reproduction

Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Laura Tuohey, Laura J Parry, Sevvandi Senadheera, Sebastian E Illanes, Tu'uhevaha J Kaitu'u-Lino, Stephen Tong

Journal article  |  2016  |  American Journal of Obstetrics and Gynecology

Women's opinions on being weighed at routine antenatal visits

FC Brownfoot, M-A Davey, L Kornman

Journal article  |  2016  |  BJOG: An International Journal of Obstetrics & Gynaecology

Expectant management of severe preterm preeclampsia: a comparison of maternal and fetal indications for delivery

Samantha S Mooney, Rilka M Lee, Stephen Tong, Fiona C Brownfoot

Journal article  |  2016  |  The Journal of Maternal-Fetal & Neonatal Medicine

Routine weighing to reduce excessive antenatal weight gain: a randomised controlled trial

FC Brownfoot, M-A Davey, L Kornman

Journal article  |  2016  |  BJOG: An International Journal of Obstetrics & Gynaecology

Heme Oxygenase-1 Is Not Decreased in Preeclamptic Placenta and Does Not Negatively Regulate Placental Soluble fms-Like Tyrosine Kinase-1 or Soluble Endoglin Secretion

Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Kenji Onda, Sally Beard, Roxanne Hastie, Natalie K Binder, Cathy Cluver, Laura Tuohey, Clare Whitehead, Fiona Brownfoot, Manarangi De Silva, Natalie J Hannan

Journal article  |  2015  |  HYPERTENSION

YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: A possible therapeutic for preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Roxanne Hastie, Ping Cannon, Laura Tuohey, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2015  |  Molecular and Cellular Endocrinology

Effects of Pravastatin on Human Placenta, Endothelium, and Women With Severe Preeclampsia

Fiona C Brownfoot, Stephen Tong, Natalie J Hannan, Natalie K Binder, Susan P Walker, Ping Cannon, Roxanne Hastie, Kenji Onda, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2015  |  HYPERTENSION

Persistent reversed end diastolic flow in the fetal middle cerebral artery: an ominous finding

FC Brownfoot, CA Cluver, SP Walker

Journal article  |  2015  |  Ultrasound

Sofalcone Upregulates the Nuclear Factor (Erythroid-Derived 2)-Like 2/Heme Oxygenase-1 Pathway, Reduces Soluble fms-Like Tyrosine Kinase-1, and Quenches Endothelial Dysfunction Potential Therapeutic for Preeclampsia

Kenji Onda, Stephen Tong, Anzu Nakahara, Mei Kondo, Hideaki Monchusho, Toshihiko Hirano, Tu'uhevaha Kaitu'u-Lino, Sally Beard, Natalie Binder, Laura Tuohey, Fiona Brownfoot, Natalie J Hannan

Journal article  |  2015  |  HYPERTENSION

[261-POS]: Heme oxygenase-1 is not reduced in pre-eclampsia and does not regulate sFlt-1 or soluble endoglin production.

T Kaitu'u-Lino, S Tong, K Onda, F Brownfoot, S Beard, C Whitehead, C Cluver, NJ Hannan

Journal article  |  2015  |  Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

OBJECTIVES: It is now widely accepted that pre-eclampsia is associated with decreased placental heme oxygenase-1 (HO-1; antioxidan..

Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin

Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Sally Beard, Roxanne Hastie, Laura Tuohey, Fiona Brownfoot, Kenji Onda, Natalie J Hannan

Journal article  |  2014  |  Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Complex Atypical Hyperplasia of the Endometrium: Differences in Outcome Following Conservative Management of Pre- and Postmenopausal Women

Fiona C Brownfoot, Martha Hickey, W Catarina Ang, Vivek Arora, Orla McNally

Journal article  |  2014  |  Reproductive Sciences

Peptides do not prevent cleavage of endoglin to produce soluble endoglin

Roxanne Hastie, Stephen Tong, Ping Cannon, Fiona Brownfoot, Natalie J Hannan, Tu'uhevaha Kaitu'u-Lino

Journal article  |  2014  |  Pregnancy Hypertension: An International Journal of Women's Cardiovascular Health

Soluble endoglin production is upregulated by oxysterols but not quenched by pravastatin in primary placental and endothelial cells

FC Brownfoot, N Hannan, K Onda, S Tong, T Kaitu'u-Lino

Journal article  |  2014  |  Placenta

What is the place of hormone replacement therapy in ovarian, endometrial, and breast cancer?

ITA Peters, FC Brownfoot, JB Trimbos, M Hickey

Book Chapter  |  2014

Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth

Fiona C Brownfoot, Daniela I Gagliardi, Emily Bain, Philippa Middleton, Caroline A Crowther

Journal article  |  2013  |  Cochrane Database of Systematic Reviews

Uterine artery embolisation associated with greater need for reintervention than surgical treatment for symptomatic uterine fibroids; quality of life similar though study underpowered.

Martha Hickey, Jennifer L Marino, Fiona C Brownfoot

Journal article  |  2012  |  Evid Based Med

Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth

Fiona C Brownfoot, Caroline A Crowther, Philippa Middleton

Journal article  |  2008  |  Cochrane database of systematic reviews (Online)

Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth

FC Brownfoot, CA Crowther, P Middleton

Journal article  |  2008  |  Cochrane Database of Systematic Reviews

Different corticosteroids and regimens for accelerating fetal lung maturation for women at risk of preterm birth

F Brownfoot, CA Crowther, P Middleton

Journal article  |  2007  |  Cochrane Database of Systematic Reviews