Hyon Xhi Tan

Coformulation with Tattoo Ink for Immunological Assessment of Vaccine Immunogenicity in the Draining Lymph Node.

Isaac M Barber-Axthelm, Hannah G Kelly, Robyn Esterbauer, Kathleen M Wragg, Anne M Gibbon, Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Hyon-Xhi Tan, Jennifer A Juno

Journal article  |  2021  |  J Immunol

Characterization of germinal center B and T cell responses yields critical insights into vaccine immunogenicity. Nonhuman primates..

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

Wen Shi Lee, Kevin John Selva, Samantha K Davis, Bruce D Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah G Kelly, Ebene R Haycroft, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, P Mark Hogarth, Deborah Cromer, Miles P Davenport, Amy W Chung, Stephen J Kent

Journal article  |  2021  |  CELL REPORTS MEDICINE

The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectiou..

CD8( ) T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

Thi HO Nguyen, Louise C Rowntree, Jan Petersen, Brendon Y Chua, Luca Hensen, Lukasz Kedzierski, Carolien E van de Sandt, Priyanka Chaurasia, Hyon-Xhi Tan, Jennifer R Habel, Wuji Zhang, Lilith F Allen, Linda Earnest, Kai Yan Mak, Jennifer A Juno, Kathleen Wragg, Francesca L Mordant, Fatima Amanat, Florian Krammer, Nicole A Mifsud, et al.

Journal article  |  2021  |  IMMUNITY

To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19), it is important to examine un..

Systems serology detects functionally distinct coronavirus antibody features in children and elderly

Kevin J Selva, Carolien E van de Sandt, Melissa M Lemke, Christina Y Lee, Suzanne K Shoffner, Brendon Y Chua, Samantha K Davis, Thi HO Nguyen, Louise C Rowntree, Luca Hensen, Marios Koutsakos, Chinn Yi Wong, Francesca Mordant, David C Jackson, Katie L Flanagan, Jane Crowe, Shidan Tosif, Melanie R Neeland, Philip Sutton, Paul Licciardi, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-..

Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity

Mai N Vu, Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Thomas P Davis, Nghia P Truong, Adam K Wheatley, Stephen J Kent

Journal article  |  2021  |  ADVANCED HEALTHCARE MATERIALS

Despite remarkable successes of immunization in protecting public health, safe and effective vaccines against a number of life-thr..

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Tan Hyon-Xhi, Jennifer A Juno, Wen Shi Lee, Isaac Barber-Axthelm, Hannah G Kelly, Kathleen M Wragg, Robyn Esterbauer, Thakshila Amarasena, Francesca L Mordant, Kanta Subbarao, Stephen J Kent, Adam K Wheatley

Journal article  |  2021  |  NATURE COMMUNICATIONS

SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies ag..

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..

Adaptive immunity to human coronaviruses is widespread but low in magnitude

Hyon-Xhi Tan, Wen Shi Lee, Kathleen Wragg, Christina Nelson, Robyn Esterbauer, Hannah Kelly, Thakshila Amarasena, Robert Jones, Graham Starkey, Bao Zhong Wang, Osamu Yoshino, Thomas Tiang, Lindsay Grayson, Helen Opdam, Rohit D’Costa, Angela Vago, Laura Mackay, Claire Gordon, Adam Wheatley, Stephen Kent, et al.

Journal article  |  2021

Endemic human coronaviruses (hCoV) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiqui..

Screening and development of monoclonal antibodies for identification of ferret T follicular helper cells

Wenbo Jiang, Julius Wong, Hyon-Xhi Tan, Hannah G Kelly, Paul G Whitney, Ian Barr, Daniel S Layton, Stephen J Kent, Adam K Wheatley, Jennifer A Juno

Journal article  |  2021  |  SCIENTIFIC REPORTS

The ferret is a key animal model for investigating the pathogenicity and transmissibility of important human viruses, and for the ..

Adaptive immunity to human coronaviruses is widespread but low in magnitude

Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Christina Nelson, Robyn Esterbauer, Hannah G Kelly, Thakshila Amarasena, Robert Jones, Graham Starkey, Bao Zhong Wang, Osamu Yoshino, Thomas Tiang, Michael Lindsay Grayson, Helen Opdam, Rohit D'Costa, Angela Vago, Laura K Mackay, Claire L Gordon, Adam K Wheatley, Stephen J Kent, et al.

Journal article  |  2021  |  CLINICAL & TRANSLATIONAL IMMUNOLOGY

Objectives: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV i..