Hyon Xhi Tan

Hemagglutinin Functionalized Liposomal Vaccines Enhance Germinal Center and Follicular Helper T Cell Immunity

Mai N Vu, Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Thomas P Davis, Nghia P Truong, Adam K Wheatley, Stephen J Kent

Journal article  |  2021  |  Advanced Healthcare Materials

Despite remarkable successes of immunization in protecting public health, safe and effective vaccines against a number of life-thr..

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques.

Hyon-Xhi Tan, Jennifer A Juno, Wen Shi Lee, Isaac Barber-Axthelm, Hannah G Kelly, Kathleen M Wragg, Robyn Esterbauer, Thakshila Amarasena, Francesca L Mordant, Kanta Subbarao, Stephen J Kent, Adam K Wheatley

Journal article  |  2021  |  Nature Communications

SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies ag..

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung, et al.

Journal article  |  2021  |  Nature Communications

The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..

Screening and development of monoclonal antibodies for identification of ferret T follicular helper cells

Wenbo Jiang, Julius Wong, Hyon-Xhi Tan, Hannah G Kelly, Paul G Whitney, Ian Barr, Daniel S Layton, Stephen J Kent, Adam K Wheatley, Jennifer A Juno

Journal article  |  2021  |  Scientific Reports

The ferret is a key animal model for investigating the pathogenicity and transmissibility of important human viruses, and for the ..

Adaptive immunity to human coronaviruses is widespread but low in magnitude.

Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Christina Nelson, Robyn Esterbauer, Hannah G Kelly, Thakshila Amarasena, Robert Jones, Graham Starkey, Bao Zhong Wang, Osamu Yoshino, Thomas Tiang, Michael Lindsay Grayson, Helen Opdam, Rohit D'Costa, Angela Vago, undefined Austin Liver Transplant Perfusionist Group, Laura K Mackay, Claire L Gordon, Adam K Wheatley, et al.

Journal article  |  2021  |  Clinical & Translational Immunology

Objectives: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV i..

Aggregation by peptide conjugation rescues poor immunogenicity of the HA stem

Wenbo Jiang, Emily H Pilkington, Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, Stephen J Kent

Journal article  |  2020  |  PLoS One

Influenza virus infection is a global public health threat. Current seasonal influenza vaccines are efficacious only when vaccine ..

Suboptimal SARS-CoV-2-specific CD8( ) T cell response associated with the prominent HLA-A*02:01 phenotype

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen, et al.

Journal article  |  2020  |  Proceedings of the National Academy of Sciences of USA

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Engineered biosynthesis of cyclotides

Thomas NG Handley, Hyon-Xhi Tan, Malcolm T Rutledge, Hans Henning Brewitz, Joel DA Tyndall, Torsten Kleffmann, Margi I Butler, Russell TM Poulter, Sigurd M Wilbanks

Journal article  |  2020  |  New Zealand Journal of Botany

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  Nature Medicine

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive V delta 2( ) T Cell Subset with a MAIT Cell-like Transcriptional Profile

Kathleen M Wragg, Hyon-Xhi Tan, Anne B Kristensen, Catriona Nguyen-Robertson, Anthony D Kelleher, Matthew S Parsons, Adam K Wheatley, Stuart P Berzins, Daniel G Pellicci, Stephen J Kent, Jennifer A Juno

Journal article  |  2020  |  Cell Reports

Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here,..