Hyon Xhi Tan

Suboptimal SARS-CoV-2-specific CD8 T cell response associated with the prominent HLA-A*02:01 phenotype.

Jennifer R Habel, Thi HO Nguyen, Carolien E van de Sandt, Jennifer A Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L Flanagan, Denise L Doolan, Joseph Torresi, Weisan Chen, Linda M Wakim, Allen C Cheng, Peter C Doherty, Jan Petersen, et al.

Journal article  |  2020  |  Proceedings of the National Academy of Sciences

An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strate..

Engineered biosynthesis of cyclotides

Thomas NG Handley, Hyon-Xhi Tan, Malcolm T Rutledge, Hans Henning Brewitz, Joel DA Tyndall, Torsten Kleffmann, Margi I Butler, Russell TM Poulter, Sigurd M Wilbanks

Journal article  |  2020  |  New Zealand Journal of Botany

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  Nature Medicine

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..

High CD26 and Low CD94 Expression Identifies an IL-23 Responsive V delta 2( ) T Cell Subset with a MAIT Cell-like Transcriptional Profile

Kathleen M Wragg, Hyon-Xhi Tan, Anne B Kristensen, Catriona Nguyen-Robertson, Anthony D Kelleher, Matthew S Parsons, Adam K Wheatley, Stuart P Berzins, Daniel G Pellicci, Stephen J Kent, Jennifer A Juno

Journal article  |  2020  |  Cell Reports

Vδ2+ T cells play a critical role in immunity to micro-organisms and cancer but exhibit substantial heterogeneity in humans. Here,..

Sequencing B cell receptors from ferrets (Mustela putorius furo)

Julius Wong, Celeste M Tai, Aeron C Hurt, Hyon-Xhi Tan, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  PLoS One

The domestic ferret (Mustela putorius furo) provides a critical animal model to study human respiratory diseases. However immunolo..

Self-assembling influenza nanoparticle vaccines drive extended germinal center activity and memory B cell maturation.

Hannah G Kelly, Hyon-Xhi Tan, Jennifer A Juno, Robyn Esterbauer, Yi Ju, Wenbo Jiang, Verena C Wimmer, Brigette C Duckworth, Joanna R Groom, Frank Caruso, Masaru Kanekiyo, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  JCI Insight

Protein-based, self-assembling nanoparticles elicit superior immunity compared with soluble protein vaccines, but the immune mecha..

Identification of murine antigen-specific T follicular helper cells using an activation-induced marker assay

Wenbo Jiang, Kathleen M Wragg, Hyon-Xhi Tan, Hannah G Kelly, Adam K Wheatley, Stephen J Kent, Jennifer A Juno

Journal article  |  2019  |  Journal of Immunological Methods

Protective antibody (Ab) responses induced by natural infection or vaccination play a central role in defense against invasive pat..

Inducible Bronchus-Associated Lymphoid Tissues (iBALT) Serve as Sites of B Cell Selection and Maturation Following Influenza Infection in Mice

Hyon-Xhi Tan, Robyn Esterbauer, Hillary A Vanderven, Jennifer A Juno, Stephen J Kent, Adam K Wheatley

Journal article  |  2019  |  Frontiers in Immunology

Influenza Virus Infection Enhances Antibody-Mediated NK Cell Functions via Type I Interferon-Dependent Pathways

Sinthujan Jegaskanda, Hillary A Vanderven, Hyon-Xhi Tan, Sheilajen Alcantara, Kathleen M Wragg, Matthew S Parsons, Amy W Chung, Jennifer A Juno, Stephen J Kent

Journal article  |  2019  |  Journal of Virology

Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem

Hyon-Xhi Tan, Sinthujan Jegaskanda, Jennifer A Juno, Robyn Esterbauer, Julius Wong, Hannah G Kelly, Yi Liu, Danielle Tilmanis, Aeron C Hurt, Jonathan W Yewdell, Stephen J Kent, Adam K Wheatley

Journal article  |  2019  |  Journal of Clinical Investigation