David Martino

Epigenomic variability is associated with age-specific naive CD4 T cell response to activation in infants and adolescents

Samira Imran, Melanie R Neeland, David JJ Martino, Stephen Peng, Jennifer Koplin, Shyamali C Dharmage, Mimi LK Tang, Susan Sawyer, Thanh Dang, Vicki McWilliam, Rachel L Peters, Susan Prescott, Kirsten P Perrett, Boris Novakovic, Richard Saffery

Journal article  |  2023  |  IMMUNOLOGY AND CELL BIOLOGY

Childhood is a critical period of immune development. During this time, naïve CD4 (nCD4) T cells undergo programmed cell different..

Association of prenatal alcohol exposure with offspring DNA methylation in mammals: a systematic review of the evidence

Mitchell Bestry, Martyn Symons, Alexander Larcombe, Evelyne Muggli, Jeffrey M Craig, Delyse Hutchinson, Jane Halliday, David Martino

Journal article  |  2022  |  CLINICAL EPIGENETICS

BACKGROUND: Prenatal alcohol exposure (PAE) is associated with a range of adverse offspring neurodevelopmental outcomes. Several s..

Immuno-epigenomic analysis identifies attenuated interferon responses in naive CD4 T cells of adolescents with peanut and multifood allergy

Samira Imran, Melanie R Neeland, Stephen Peng, Amanda Vlahos, David Martino, Shyamali C Dharmage, Mimi LK Tang, Susan Sawyer, Thanh D Dang, Vicki McWilliam, Rachel L Peters, Jennifer J Koplin, Kirsten P Perrett, Boris Novakovic, Richard Saffery

Journal article  |  2022  |  PEDIATRIC ALLERGY AND IMMUNOLOGY

BACKGROUND: IgE-mediated food allergies have been linked to suboptimal naïve CD4 T (nCD4T) cell activation in infancy, underlined ..

Pre-pubertal smoke exposure of fathers and increased risk of offspring asthma: a possible transgenerational effect

Jiacheng Liu, Gayan Bowatte, Jonathan Pham, Jennifer L Perret, John W Holloway, Adrian J Lowe, John A Burgess, Cecilie Svanes, Paul Thomas, Melissa A Russell, Bircan Erbas, Caroline J Lodge, David Martino, Gita D Mishra, Michael J Abramson, Eugene H Walters, Shyamali C Dharmage, Dinh S Bui

Journal article  |  2022  |  EUROPEAN RESPIRATORY JOURNAL

Paternal pre-pubertal tobacco smoking and offspring DNA methylation

N Kitaba, T Knudsen, A Johannessen, F Rezwan, A Malinovschi, A Oudin, B Benediktsdottir, D Martino, F Callejas González, L Gómez, M Holm, O Jõgi, S Shyamali Dharmage, S Skulstad, F Gómez-Real, V Schlünssen, C Svanes, J Holloway

Conference Proceedings  |  2022  |  06.03 - Tobacco, smoking control and health education

Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

Yanshan Zhu, Keng Yih Chew, Melanie Wu, Anjana C Karawita, Georgina McCallum, Lauren E Steele, Ayaho Yamamoto, Larisa I Labzin, Tejasri Yarlagadda, Alexander A Khromykh, Xiaohui Wang, Julian DJ Sng, Claudia J Stocks, Yao Xia, Tobias R Kollmann, David Martino, Merja Joensuu, Frederic A Meunier, Giuseppe Balistreri, Helle Bielefeldt-Ohmann, et al.

Journal article  |  2022  |  PLOS BIOLOGY

Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong..

Parental preconception BMI trajectories from childhood to adolescence and asthma in the future offspring

Gayan Bowatte, Dinh S Bui, Sajith Priyankara, Adrian J Lowe, Jennifer L Perret, Caroline J Lodge, Garun S Hamilton, Bircan Erbas, Paul Thomas, Bruce Thompson, Vivi Schlunssen, David Martino, John W Holloway, Cecilie Svanes, Michael J Abramson, E Haydn Walters, Shyamali C Dharmage

Journal article  |  2022  |  JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

BACKGROUND: Recent evidence suggests that parental exposures before conception can increase the risk of asthma in offspring. OBJEC..

Cohort profile: the multigeneration Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort

Cecilie Svanes, Ane Johannessen, Randi Jacobsen Bertelsen, Shyamali Dharmage, Bryndis Benediktsdottir, Lennart Braback, Thorarinn Gislason, Mathias Holm, Oskar Jogi, Caroline J Lodge, Andrei Malinovschi, Jesus Martinez-Moratalla, Anna Oudin, Jose Luis Sanchez-Ramos, Signe Timm, Christer Janson, Francisco Gomez Real, Vivi Schlunssen

Journal article  |  2022  |  BMJ OPEN

PURPOSE: The Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) cohort was established to (1) investigate how e..

Epigenetic study of COPD-risk lung function trajectories

D Martino, D Bui, C Lodge, J Perret, G Boweatte, A Lowe, R Faner, H Walters, P Thomas, Y Moodley, G Zosky, G Hamilton, J Holloway, C Svanes, M Abramson, S Dharmage

Conference Proceedings  |  2022  |  RESPIROLOGY

Risk Factors for Gut Dysbiosis in Early Life

Kimberley Parkin, Claus T Christophersen, Valerie Verhasselt, Matthew N Cooper, David Martino

Journal article  |  2021  |  MICROORGANISMS

Dysbiosis refers to a reduction in microbial diversity, combined with a loss of beneficial taxa, and an increase in pathogenic mic..