David Martino

Genetic determinants of paediatric food allergy: A systematic review

Noor HA Suaini, Yichao Wang, Victoria X Soriano, David J Martino, Katrina J Allen, Justine A Ellis, Jennifer J Koplin

Journal article  |  2019  |  Allergy

BACKGROUND: The genetic determinants of food allergy have not been systematically reviewed. We therefore systematically reviewed t..

B-cell phenotype and function in infants with egg allergy

Melanie R Neeland, David J Martino, Thanh D Dang, Jennifer J Koplin, Rachel L Peters, Alexander Grishin, Shyamali C Dharmage, Mimi L Tang, Hugh A Sampson, Richard Saffery, Katrina J Allen

Journal article  |  2019  |  Allergy

Children with East Asian-Born Parents Have an Increased Risk of Allergy but May Not Have More Asthma in Early Childhood

Noor HA Suaini, Jennifer J Koplin, Rachel L Peters, Mari Sasaki, Justine A Ellis, David J Martino, Adrian J Lowe, Mimi LK Tang, Anne-Louise Ponsonby, Lyle C Gurrin, Shyamali C Dharmage, Katrina J Allen

Journal article  |  2019  |  The Journal of Allergy and Clinical Immunology: In Practice

Egg allergen specific IgE diversity predicts resolution of egg allergy in the population cohort HealthNuts

Thanh D Dang, Rachel L Peters, Jennifer J Koplin, Shyamali C Dharmage, Lyle C Gurrin, Anne-Louise Ponsonby, David J Martino, Melanie Neeland, Mimi LK Tang, Katrina J Allen

Journal article  |  2019  |  Allergy

Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children

Line Hjort, David Martino, Louise Groth Grunnet, Haroon Naeem, Jovana Maksimovic, Anders Henrik Olsson, Cuilin Zhang, Charlotte Ling, Sjurdur Frodi Olsen, Richard Saffery, Allan Arthur Vaag

Journal article  |  2018  |  JCI Insight

Early life innate immune signatures of persistent food allergy

Melanie R Neeland, Jennifer J Koplin, Thanh D Dang, Shyamali C Dharmage, Mimi L Tang, Susan L Prescott, Richard Saffery, David J Martino, Katrina J Allen

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

Epigenetic dysregulation of naive CD4 T-cell activation genes in childhood food allergy

David Martino, Melanie Neeland, Thanh Dang, Joanna Cobb, Justine Ellis, Alice Barnett, Mimi Tang, Peter Vuillermin, Katrina Allen, Richard Saffery

Journal article  |  2018  |  Nature Communications

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry.

Sarah E Ashley, Braydon A Meyer, Justine A Ellis, David J Martino

Journal article  |  2018  |  Journal of Visualized Experiments

Complex diseases are often underpinned by multiple common genetic variants that contribute to disease susceptibility. Here, we des..

Identification and analysis of peanut-specific effector T and regulatory T cells in children allergic and tolerant to peanut

Katherine A Weissler, Marjohn Rasooly, Tom DiMaggio, Hyejeong Bolan, Daly Cantave, David Martino, Melanie R Neeland, Mimi LK Tang, Thanh D Dang, Katrina J Allen, Pamela A Frischmeyer-Guerrerio

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

A Canadian genome-wide association study and meta-analysis confirm HLA as a risk factor for peanut allergy independent of asthma

Yuka Asai, Aida Eslami, C Dorien van Ginkel, Loubna Akhabir, Ming Wan, David Yin, George Ellis, Moshe Ben-Shoshan, Ingo Marenholz, David Martino, Manuel A Ferreira, Katrina Allen, Bruce Mazer, Hans de Groot, Nicolette W de Jong, Roy Gerth van Wijk, Anthony EJ Dubois, Sarah Grosche, Sarah Ashley, Franz Rueschendorf, et al.

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

Genome-wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes C11orf30/EMSY as a genetic risk factor for food allergy

Yuka Asai, Aida Eslami, C Dorien van Ginkel, Loubna Akhabir, Ming Wan, George Ellis, Moshe Ben-Shoshan, David Martino, Manuel A Ferreira, Katrina Allen, Bruce Mazer, Hans de Groot, Nicolette W de Jong, Roy N Gerth van Wijk, Anthony EJ Dubois, Rick Chin, Stephen Cheuk, Joshua Hoffman, Eric Jorgensen, John S Witte, et al.

Journal article  |  2018  |  Journal of Allergy and Clinical Immunology

The DNA methylation landscape of CD4( ) T cells in oligoarticular juvenile idiopathic arthritis

Raul A Chavez-Valencia, Rachel C Chiaroni-Clarke, David J Martino, Jane E Munro, Roger C Allen, Jonathan D Akikusa, Anne-Louise Ponsonby, Jeffrey M Craig, Richard Saffery, Justine A Ellis

Journal article  |  2018  |  Journal of Autoimmunity

The skin barrier function gene SPINK5 is associated with challenge-proven IgE-mediated food allergy in infants

SE Ashley, H-TT Tan, P Vuillermin, SC Dharmage, MLK Tang, J Koplin, LC Gurrin, A Lowe, C Lodge, A-L Ponsonby, J Molloy, P Martin, MC Matheson, R Saffery, KJ Allen, JA Ellis, D Martino

Journal article  |  2017  |  Allergy

Genetic variation at the Th2 immune gene IL13 is associated with IgE-mediated paediatric food allergy

SE Ashley, H-TT Tan, R Peters, KJ Allen, P Vuillermin, SC Dharmage, MLK Tang, J Koplin, A Lowe, A-L Ponsonby, J Molloy, MC Matheson, R Saffery, JA Ellis, D Martino

Journal article  |  2017  |  Clinical & Experimental Allergy

Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA-DRB1

DJ Martino, S Ashley, J Koplin, J Ellis, R Saffery, SC Dharmage, L Gurrin, MC Matheson, B Kalb, I Marenholz, K Beyer, Y-A Lee, X Hong, X Wang, D Vukcevic, A Motyer, S Leslie, KJ Allen, MAR Ferreira

Journal article  |  2017  |  Clinical & Experimental Allergy

Epigenetic modifications: mechanisms of disease and biomarkers of food allergy

David J Martino, Richard Saffery, Katrina J Allen, Susan L Prescott

Journal article  |  2016  |  Current Opinion in Immunology

Polymorphisms affecting vitamin D-binding protein modify the relationship between serum vitamin D (25[OH]D-3) and food allergy

Jennifer J Koplin, Noor HA Suaini, Peter Vuillermin, Justine A Ellis, Mary Panjari, Anne-Louise Ponsonby, Rachel L Peters, Melanie C Matheson, David Martino, Dang Thanh, Nicholas J Osborne, Pamela Martin, Adrian Lowe, Lyle C Gurrin, Mimi LK Tang, Melissa Wake, Terry Dwyer, John Hopper, Shyamali C Dharmage, Katrina J Allen

Journal article  |  2016  |  Journal of Allergy and Clinical Immunology

The role of gene-environment interactions in the development of food allergy

Melanie R Neeland, David J Martino, Katrina J Allen

Journal article  |  2015  |  Expert Review of Gastroenterology & Hepatology

Genome-wide identification of mononuclear cell DNA methylation sites potentially affected by fish oil supplementation in young infants: A pilot study.

MV Lind, D Martino, LBS Harsløf, ZO Kyjovska, M Kristensen, L Lauritzen

Journal article  |  2015  |  Prostaglandins, Leukotrienes and Essential Fatty Acids

Recent evidence suggests that the effects of n-3LCPUFA might be mediated through epigenetic mechanisms, especially DNA-methylation..

Meeting the challenges of measuring human immune regulation

David Martino, Katrina Allen

Journal article  |  2015  |  Journal of Immunological Methods

Food for thought: progress in understanding the causes and mechanisms of food allergy

Sarah Ashley, Dang Thanh, Jennifer Koplin, David Martino, Susan Prescott

Journal article  |  2015  |  Current Opinion in Allergy and Clinical Immunology

Blood DNA methylation biomarkers predict clinical reactivity in food-sensitized infants

David Martino, Thanh Dang, Alexandra Sexton-Oates, Susan Prescott, Mimi LK Tang, Shyamali Dharmage, Lyle Gurrin, Jennifer Koplin, Anne-Louise Ponsonby, Katrina J Allen, Richard Saffery

Journal article  |  2015  |  Journal of Allergy and Clinical Immunology

The ontogeny of naive and regulatory CD4( ) T-cell subsets during the first postnatal year: a cohort study

Fiona M Collier, Mimi Lk Tang, David Martino, Richard Saffery, John Carlin, Kim Jachno, Sarath Ranganathan, David Burgner, Katrina J Allen, Peter Vuillermin, Anne-Louise Ponsonby

Journal article  |  2015  |  Clinical & Translational Immunology

Epigenetic Regulation in Early Childhood: A Miniaturized and Validated Method to Assess Histone Acetylation.

Hani Harb, Manori Amarasekera, Sarah Ashley, Meri K Tulic, Petra Ina Pfefferle, Daniel P Potaczek, David Martino, Dörthe A Kesper, Susan L Prescott, Harald Renz

Journal article  |  2015  |  International Archives of Allergy and Immunology

INTRODUCTION: Chronic inflammatory diseases including allergies and asthma are the result of complex interactions between genes an..

Epigenome-wide analysis of neonatal CD4( ) T-cell DNA methylation sites potentially affected by maternal fish oil supplementation

Manori Amarasekera, Paul Noakes, Deborah Strickland, Richard Saffery, David J Martino, Susan L Prescott

Journal article  |  2014  |  Epigenetics

Methylation of the filaggrin gene promoter does not affect gene expression and allergy

Hern-Tze Tina Tan, Justine A Ellis, Jennifer J Koplin, David Martino, Thanh D Dang, Noor Suaini, Richard Saffery, Katrina J Allen

Journal article  |  2014  |  Pediatric Allergy and Immunology

Environmental and genetic determinants of vitamin D insufficiency in 12-month-old infants

Noor HA Suaini, Jennifer J Koplin, Justine A Ellis, Rachel L Peters, Anne-Louise Ponsonby, Shyamali C Dharmage, Melanie C Matheson, Melissa Wake, Mary Panjari, Hern-Tze Tina Tan, Pamela E Martin, Angela Pezic, Adrian J Lowe, David Martino, Lyle C Gurrin, Peter J Vuillermin, Mimi LK Tang, Katrina J Allen

Journal article  |  2014  |  The Journal of Steroid Biochemistry and Molecular Biology

Epigenetics in immune development and in allergic and autoimmune diseases.

David Martino, Dörthe A Kesper, Manori Amarasekera, Hani Harb, Harald Renz, Susan Prescott

Journal article  |  2014  |  Journal of Reproductive Immunology

Epigenetic mechanisms such as DNA methylation, histone modification, and micro RNA signaling regulate the activity of the genome. ..

Genome-wide DNA methylation profiling identifies a folate-sensitive region of differential methylation upstream of ZFP57-imprinting regulator in humans

Manori Amarasekera, David Martino, Sarah Ashley, Hani Harb, Doerthe Kesper, Deborah Strickland, Richard Saffery, Susan L Prescott

Journal article  |  2014  |  FASEB Journal

Epigenome-wide association study reveals longitudinally stable DNA methylation differences in CD4 T cells from children with IgE-mediated food allergy

David Martino, Jihoon E Joo, Alexandra Sexton-Oates, Thanh Dang, Katrina Allen, Richard Saffery, Susan Prescott

Journal article  |  2014  |  Epigenetics

In vitro exposure of human blood mononuclear cells to active vitamin D does not induce substantial change to DNA methylation on a genome-scale

Raul A Chavez Valencia, David J Martino, Richard Saffery, Justine A Ellis

Journal article  |  2014  |  Journal of Steroid Biochemistry and Molecular Biology

Analysis of epigenetic changes in survivors of preterm birth reveals the effect of gestational age and evidence for a long term legacy

Mark N Cruickshank, Alicia Oshlack, Christiane Theda, Peter G Davis, David Martino, Penelope Sheehan, Yun Dai, Richard Saffery, Lex W Doyle, Jeffrey M Craig

Journal article  |  2013  |  Genome Medicine: medicine in the post-genomic era

Variable promoter methylation contributes to differential expression of key genes in human placenta-derived venous and arterial endothelial cells

Jihoon E Joo, Ursula Hiden, Luciana Lassance, Lavinia Gordon, David J Martino, Gernot Desoye, Richard Saffery

Journal article  |  2013  |  BMC Genomics

Longitudinal, genome-scale analysis of DNA methylation in twins from birth to 18 months of age reveals rapid epigenetic change in early life and pair-specific effects of discordance

David Martino, Yuk Jin Loke, Lavinia Gordon, Miina Ollikainen, Mark N Cruickshank, Richard Saffery, Jeffrey M Craig

Journal article  |  2013  |  Genome Biology

Genome-scale profiling reveals a subset of genes regulated by DNA methylation that program somatic T-cell phenotypes in humans

D Martino, J Maksimovic, J-HE Joo, SL Prescott, R Saffery

Journal article  |  2012  |  Genes and Immunity

T-cell activation genes differentially expressed at birth in CD4 T-cells from children who develop IgE food allergy.

DJ Martino, A Bosco, KL McKenna, E Hollams, D Mok, PG Holt, SL Prescott

Journal article  |  2012  |  Allergy

BACKGROUND: Presymptomatic immaturity in neonatal T-cell function is a consistent antecedent of allergic disease, including reduce..

Epigenetics and prenatal influences on asthma and allergic airways disease.

David Martino, Susan Prescott

Journal article  |  2011  |  Chest

Uterine life is arguably the most critical time in developmental programming, when environmental exposures may have the greatest p..

Silent mysteries: epigenetic paradigms could hold the key to conquering the epidemic of allergy and immune disease.

DJ Martino, Susan L Prescott

Journal article  |  2010  |  Allergy

Epigenetic mechanisms provide new insights into how environmental changes may mediate the increasing propensity for complex immune..

The Role of Dietary Components in the Epidemic of Allergic Disease

SL Prescott, S Jennings, D Martino, H Johanssen

Book Chapter  |  2010

Relationship between early intestinal colonization, mucosal immunoglobulin A production and systemic immune development.

DJ Martino, H Currie, A Taylor, P Conway, SL Prescott

Journal article  |  2008  |  Clinical and Experimental Allergy

BACKGROUND: Variations in early intestinal colonization patterns have been implicated in the predispostion to allergic disease thr..