Joanne Ryan

Aromatase (CYP19A1) gene variants, sex steroid levels, and late-life depression.

Marie-Laure Ancelin, Joanna Norton, Marianne Canonico, Pierre-Yves Scarabin, Karen Ritchie, Joanne Ryan

Journal article  |  2019  |  Depression and Anxiety

BACKGROUND: Sex differences in psychiatric disorders are common and could involve sex steroids. Aromatase, the product of the CYP1..

The current status of blood epigenetic biomarkers for dementia

Peter D Fransquet, Joanne Ryan

Journal article  |  2019  |  Critical Reviews in Clinical Laboratory Sciences

Mental health trajectories among women in Australia as they age

Tran Thach, Karin Hammarberg, Joanne Ryan, Judy Lowthian, Rosanne Freak-Poli, Alice Owen, Maggie Kirkman, Andrea Curtis, Heather Rowe, Helen Brown, Stephanie Ward, Carlene Britt, Jane Fisher

Journal article  |  2019  |  Aging & Mental Health

Early-life determinants of hypoxia-inducible factor 3A gene(HIF3A) methylation: a birth cohort study

Toby Mansell, Anne-Louise Ponsonby, Vania Januar, Boris Novakovic, Fiona Collier, David Burgner, Peter Vuillermin, Joanne Ryan, Richard Saffery, John Carlin, Katie Allen, Mimi Tang, Sarath Ranganathan, Terry Dwyer, Kim Jachno, Peter Sly

Journal article  |  2019  |  Clinical Epigenetics

Genetic and Epigenetic Regulation of the Serotonin Transporter Gene in Late-Life Depression.

Joanne Ryan, Marie-Laure Ancelin

Journal article  |  2019  |  Journal of Geriatric Psychiatry and Neurology

Prenatal alcohol exposure and infant gross motor development: a prospective cohort study

Delyse Hutchinson, George J Youssef, Clare McCormack, Judy Wilson, Steve Allsop, Jake Najman, Elizabeth Elliott, Lucinda Burns, Sue Jacobs, Ingrid Honan, Larissa Rossen, Hannah Fiedler, Samantha Teague, Joanne Ryan, Craig A Olsson, Richard P Mattick

Journal article  |  2019  |  BMC Pediatrics

Normative performance of healthy older individuals on the Modified Mini-Mental State (3MS) examination according to ethno-racial group, gender, age, and education level.

Joanne Ryan, Robyn L Woods, Carlene Britt, Anne M Murray, Raj C Shah, Christopher M Reid, Brenda Kirpach, Rory S Wolfe, Mark R Nelson, Jessica E Lockery, Suzanne G Orchard, Ruth E Trevaks, John J McNeil, Elsdon Storey, undefined ASPREE Investigator Group

Journal article  |  2019  |  The Clinical Neuropsychologist

OBJECTIVE: To present normative performance data on the Modified Mini-Mental State (3MS) examination for healthy community-dwellin..

The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis

Peter D Fransquet, Jo Wrigglesworth, Robyn L Woods, Michael E Ernst, Joanne Ryan

Journal article  |  2019  |  Clinical Epigenetics

Brain-derived neurotrophic factor DNA methylation mediates the association between neighborhood disadvantage and adolescent brain structure

Jo Wrigglesworth, Joanne Ryan, Nandita Vijayakumar, Sarah Whittle

Journal article  |  2019  |  Psychiatry Research: Neuroimaging

Lifetime major depression and grey-matter volume

Marie-Laure Ancelin, Isabelle Carrière, Sylvaine Artero, Jerome Maller, Chantal Meslin, Karen Ritchie, Joanne Ryan, Isabelle Chaudieu

Journal article  |  2019  |  Journal of Psychiatry & Neuroscience

Background: There is evidence of structural brain alterations in major depressive disorder (MDD), but little is known about how th..

Association between DNA methylation of the KITLG gene and cortisol levels under stress: a replication study.

Jo Wrigglesworth, Marie-Laure Ancelin, Karen Ritchie, Joanne Ryan

Journal article  |  2019  |  Stress

A recent study reported for the first time, that DNA methylation of the KITLG gene mediates the association between childhood trau..

5-HTTLPR × stress hypothesis: is the debate over?

M-L Ancelin, J Ryan

Journal article  |  2018  |  Molecular Psychiatry

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

JJ McNeil, MR Nelson, RL Woods, JE Lockery, R Wolfe, CM Reid, B Kirpach, RC Shah, DG Ives, E Storey, J Ryan, AM Tonkin, AB Newman, JD Williamson, KL Margolis, ME Ernst, WP Abhayaratna, N Stocks, SM Fitzgerald, SG Orchard, et al.

Journal article  |  2018  |  New England Journal of Medicine

Effect of Aspirin on Disability-free Survival in the Healthy Elderly

JJ McNeil, RL Woods, MR Nelson, CM Reid, B Kirpach, R Wolfe, E Storey, RC Shah, JE Lockery, AM Tonkin, AB Newman, JD Williamson, KL Margolis, ME Ernst, WP Abhayaratna, N Stocks, SM Fitzgerald, SG Orchard, RE Trevaks, LJ Beilin, et al.

Journal article  |  2018  |  New England Journal of Medicine

Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly

JJ McNeil, R Wolfe, RL Woods, AM Tonkin, GA Donnan, MR Nelson, CM Reid, JE Lockery, B Kirpach, E Storey, RC Shah, JD Williamson, KL Margolis, ME Ernst, WP Abhayaratna, N Stocks, SM Fitzgerald, SG Orchard, RE Trevaks, LJ Beilin, et al.

Journal article  |  2018  |  New England Journal of Medicine

Genotype-dependent associations between serotonin transporter gene (SLC6A4) DNA methylation and late-life depression

Dilys Lam, Marie-Laure Ancelin, Karen Ritchie, Rosanne Freak-Poli, Richard Saffery, Joanne Ryan

Journal article  |  2018  |  BMC Psychiatry

Micro RNA as a potential blood-based epigenetic biomarker for Alzheimer's disease

Peter D Fransquet, Joanne Ryan

Journal article  |  2018  |  Clinical Biochemistry

Time- and sex-dependent associations between prenatal alcohol exposure

Yuk Jing Loke, Evelyne Muggli, Linh Nguyen, Joanne Ryan, Richard Saffery, Elizabeth J Elliott, Jane Halliday, Jeffrey M Craig

Journal article  |  2018  |  Epigenomics

The role of oxytocin receptor gene (OXTR) DNA methylation (DNAm) in human social and emotional functioning: a systematic narrative review

Catherine Maud, Joanne Ryan, Jennifer E McIntosh, Craig A Olsson

Journal article  |  2018  |  BMC Psychiatry

Maternal depression, antidepressant use and placental oxytocin receptor DNA methylation: Findings from the MPEWS study

Megan Galbally, Joanne Ryan, Marinus van IJzendoorn, Stuart J Watson, Olav Spigset, Martha Lappas, Richard Saffery, Ron de Kloet, Andrew James Lewis

Journal article  |  2018  |  Psychoneuroendocrinology

Cohort Profile: The Triple B Pregnancy Cohort Study: A longitudinal study of the relationship between alcohol, tobacco and other substance use during pregnancy and the health and well-being of Australian children and families

Delyse Hutchinson, Judy Wilson, Steve Allsop, Elizabeth Elliott, Jake Najman, Lucinda Burns, Anne Bartu, Sue Jacobs, Ingrid Honan, Clare McCormack, Larissa Rossen, Hannah Fiedler, Chiara Stone, Sarah Khor, Joanne Ryan, George J Youssef, Craig A Olsson, Richard P Mattick

Journal article  |  2018  |  International Journal Of Epidemiology

DNA methylation and genetic variation of the angiotensin converting enzyme (ACE) in depression

Dilys Lam, Marie-Laure Ancelin, Karen Ritchie, Richard Saffery, Joanne Ryan

Journal article  |  2018  |  Psychoneuroendocrinology

Blood DNA methylation as a potential biomarker of dementia: A systematic review

Peter D Fransquet, Paul Lacaze, Richard Saffery, John McNeil, Robyn Woods, Joanne Ryan

Journal article  |  2018  |  Alzheimer's & Dementia

Cognitive Impairment, Sexual Activity and Physical Tenderness in Community-Dwelling Older Adults: A Cross-Sectional Exploration.

Rosanne Freak-Poli, Silvan Licher, Joanne Ryan, M Arfan Ikram, Henning Tiemeier

Journal article  |  2018  |  Gerontology

BACKGROUND: The ability to engage in sexual activity and better cognitive functioning are both associated with better health. Howe..

Epigenetics: a missing link in understanding psychiatric disorders?

Joanne Ryan, Richard Saffery, George Patton

Journal article  |  2018  |  The Lancet Psychiatry

The effect of an adverse psychological environment on salivary cortisol levels in the elderly differs by 5-HTTLPR genotype

Marie-Laure Ancelin, Jacqueline Scali, Joanna Norton, Karen Ritchie, Anne-Marie Dupuy, Isabelle Chaudieu, Joanne Ryan

Journal article  |  2017  |  Neurobiology of Stress

Mercy Pregnancy and Emotional Well-being Study (MPEWS): Understanding maternal mental health, fetal programming and child development. Study design and cohort profile

Megan Galbally, Marinus van IJzendoorn, Michael Permezel, Richard Saffery, Martha Lappas, Joanne Ryan, Elisabeth van Rossum, Andrew R Johnson, Douglas Teti, Andrew J Lewis

Journal article  |  2017  |  International Journal of Methods in Psychiatric Research

The impact of psychological distress during pregnancy on the developing fetus: biological mechanisms and the potential benefits of mindfulness interventions

Monica Isgut, Alicia K Smith, Eduardo Schuch Reimann, Omer Kucuk, Joanne Ryan

Journal article  |  2017  |  Journal of Perinatal Medicine

The Dangers of Direct-to-Consumer Genetic Testing for Alzheimer's Disease : Comment on "Personal Genomic Testing, Genetic Inheritance, and Uncertainty".

Paul Lacaze, Jane Tiller, Joanne Ryan

Journal article  |  2017  |  Journal of Bioethical Inquiry

The overarching issue with this case study is poor regulation and quality control over direct-to-consumer genetic testing, deliver..

Investigating the epigenetic profile of the inflammatory gene IL-6 in late-life depression

Joanne Ryan, Lauren Pilkington, Katharina Neuhaus, Karen Ritchie, Marie-Laure Ancelin, Richard Saffery

Journal article  |  2017  |  BMC Psychiatry

Pathogenic variants in the healthy elderly: unique ethical and practical challenges

Paul Lacaze, Joanne Ryan, Robyn Woods, Ingrid Winship, John McNeil

Journal article  |  2017  |  Journal of Medical Ethics

Relationships Between Self-Reported and Observed Parenting Behaviour, Adolescent Disordered Eating Attitudes and Behaviours, and the 5-HTTLPR Polymorphism: Data From the Australian Temperament Project

Vanja Rozenblat, Joanne Ryan, Eleanor Wertheim, Ross King, Craig A Olsson, Primrose Letcher, Isabel Krug

Journal article  |  2017  |  European Eating Disorders Review

Investigating Direct Links between Depression, Emotional Control, and Physical Punishment with Adolescent Drive for Thinness and Bulimic Behaviors, Including Possible Moderation by the Serotonin Transporter 5-HTTLPR Polymorphism

Vanja Rozenblat, Joanne Ryan, Eleanor H Wertheim, Ross King, Craig A Olsson, Isabel Krug

Journal article  |  2017  |  Frontiers in Psychology

Chronic and remitting trajectories of depressive symptoms in the elderly. Characterisation and risk factors.

I Carrière, A Farré, C Proust-Lima, J Ryan, ML Ancelin, K Ritchie

Journal article  |  2017  |  Epidemiology and Psychiatric Sciences

BACKGROUND: In elderly general population sub-syndromal clinically significant levels of depressive symptoms are highly prevalent ..

Does maternal mental well-being in pregnancy impact the early human epigenome?

Joanne Ryan, Toby Mansell, Peter Fransquet, Richard Saffery

Journal article  |  2017  |  Epigenomics

Heterogeneity in HPA axis dysregulation and serotonergic vulnerability to depression

Marie-Laure Ancelin, Jacqueline Scali, Joanna Norton, Karen Ritchie, Anne-Marie Dupuy, Isabelle Chaudieu, Joanne Ryan

Journal article  |  2017  |  Psychoneuroendocrinology

Preliminary evidence for a role of the adrenergic nervous system in generalized anxiety disorder

Xiaobin Zhang, Joanna Norton, Isabelle Carriere, Karen Ritchie, Isabelle Chaudieu, Joanne Ryan, Marie-Laure Ancelin

Journal article  |  2017  |  Scientific Reports

Genetic association of rs1344706 in ZNF804A with bipolar disorder and schizophrenia susceptibility in Chinese populations

Shuquan Rao, Yao Yao, Joanne Ryan, Chunhui Jin, Yong Xu, Xinhe Huang, Jianxiu Guo, Yueqiang Wen, Canquan Mao, David Meyre, Fuquan Zhang

Journal article  |  2017  |  Scientific Reports

Cannabis use by women during pregnancy does not influence infant DNA methylation of the dopamine receptor DRD4

Peter D Fransquet, Delyse Hutchinson, Craig A Olsson, Steve Allsop, Elizabeth J Elliott, Lucinda Burns, Richard Mattick, Richard Saffery, Joanne Ryan

Journal article  |  2017  |  The American Journal of Drug and Alcohol Abuse

Preliminary indications of the effect of a brief yoga intervention on markers of inflammation and DNA methylation in chronically stressed women.

KN Harkess, J Ryan, PH Delfabbro, S Cohen-Woods

Journal article  |  2016  |  Translational Psychiatry

Yoga is associated with reduced stress and increased well-being, although the molecular basis for these benefits is not clear. Mou..

Maternal mental well-being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonate

Toby Mansell, Peter Vuillermin, Anne-Louise Ponsonby, Fiona Collier, Richard Saffery, Joanne Ryan

Journal article  |  2016  |  Development and Psychopathology

Biological underpinnings of trauma and post-traumatic stress disorder: focusing on genetics and epigenetics

Joanne Ryan, Isabelle Chaudieu, Marie-Laure Ancelin, Richard Saffery

Journal article  |  2016  |  Epigenomics

Common variants in FKBP5 gene and major depressive disorder (MDD) susceptibility: a comprehensive meta-analysis

Shuquan Rao, Yao Yao, Joanne Ryan, Tao Li, Duan Wang, Chuan Zheng, Yong Xu, Qi Xu

Journal article  |  2016  |  Scientific Reports

Common variants in CACNA1C and MDD susceptibility: A comprehensive meta-analysis

Shuquan Rao, Yao Yao, Chuan Zheng, Joanne Ryan, Canquan Mao, Fuquan Zhang, David Meyre, Qi Xu

Journal article  |  2016  |  American Journal of Medical Genetics Part B: Neuropsychiatric Genetics

The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood

T Mansell, B Novakovic, B Meyer, P Rzehak, P Vuillermin, A-L Ponsonby, F Collier, D Burgner, R Saffery, J Ryan

Journal article  |  2016  |  Translational Psychiatry

Meta-analysis indicates that SNP rs9939609 within FTO is not associated with major depressive disorder (MDD) in Asian population

Yao Yao, Yueqiang Wen, Tingfu Du, Ning Sun, Hong Deng, Joanne Ryan, Shuquan Rao

Journal article  |  2016  |  Journal of Affective Disorders

GWAS-identified risk variants for major depressive disorder: Preliminary support for an association with late-life depressive symptoms and brain structural alterations

Joanne Ryan, Sylvaine Artero, Isabelle Carriere, Jerome J Maller, Chantal Meslin, Karen Ritchie, Marie-Laure Ancelin

Journal article  |  2016  |  European Neuropsychopharmacology

BDNF promoter methylation and genetic variation in late-life depression

V Januar, M-L Ancelin, K Ritchie, R Saffery, J Ryan

Journal article  |  2015  |  Translational Psychiatry

Epigenetics and depressive disorders: a review of current progress and future directions

Vania Januar, Richard Saffery, Joanne Ryan

Journal article  |  2015  |  International Journal of Epidemiology

Involvement of GPR50 polymorphisms in depression: independent replication in a prospective elderly cohort

Joanne Ryan, Isabelle Carriere, Karen Ritchie, Marie-Laure Ancelin

Journal article  |  2015  |  Brain and Behavior

C-reactive protein gene variants: independent association with late-life depression and circulating protein levels

M-L Ancelin, A Farre, I Carriere, K Ritchie, I Chaudieu, J Ryan

Journal article  |  2015  |  Translational Psychiatry

Impact of a premature menopause on cognitive function in later life.

J Ryan, J Scali, I Carrière, H Amieva, O Rouaud, C Berr, K Ritchie, M-L Ancelin

Journal article  |  2014  |  BJOG: An International Journal of Obstetrics & Gynaecology

OBJECTIVE: To determine whether premature menopause (≤40 years) can have long-lasting effects on later-life cognition and investig..

Postnatal stability, tissue, and timing specific effects of AHRR methylation change in response to maternal smoking in pregnancy

Boris Novakovic, Joanne Ryan, Natalie Pereira, Berin Boughton, Jeffrey M Craig, Richard Saffery

Journal article  |  2014  |  Epigenetics

Crucial timing in schizophrenia: role of DNA methylation in early neurodevelopment

Joanne Ryan, Richard Saffery

Journal article  |  2014  |  Genome Biology

Estrogen receptor polymorphisms and incident dementia: The prospective 3C study

Joanne Ryan, Isabelle Carriere, Laure Carcaillon, Jean-Francois Dartigues, Sophie Auriacombe, Olivier Rouaud, Claudine Berr, Karen Ritchie, Pierre-Yves Scarabin, Marie-Laure Ancelin

Journal article  |  2014  |  Alzheimer's & Dementia

Prospective analysis of the association between estrogen receptor gene variants and the risk of cognitive decline in elderly women

Joanne Ryan, Isabelle Corriere, Helene Amieva, Olivier Rouaud, Claudine Berr, Karen Ritchie, Pierre-Yves Scarabin, Marie-Lau Re Ancelin

Journal article  |  2013  |  European Neuropsychopharmacology

Lifetime endogenous reproductive factors and severe depressive symptoms in postmenopausal women: findings from the E3N cohort

Florence Perquier, Joanne Ryan, Marie-Laure Ancelin, Sylvie Mesrine, Francoise Clavel-Chapelon

Journal article  |  2013  |  Menopause

Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression

M-L Ancelin, I Carriere, J Scali, K Ritchie, I Chaudieu, J Ryan

Journal article  |  2013  |  Translational Psychiatry

Anxiety and mortality risk in community-dwelling elderly people

Isabelle Carriere, Joanne Ryan, Joanna Norton, Jacqueline Scali, Robert Stewart, Karen Ritchie, Marie Laure Ancelin

Journal article  |  2013  |  British Journal of Psychiatry

Lifelong estrogen exposure and memory in older postmenopausal women.

Mary C Tierney, Joanne Ryan, Marie-Laure Ancelin, Rahim Moineddin, Stephanie Rankin, Christie Yao, Neil J MacLusky

Journal article  |  2013  |  Journal of Alzheimer's Disease

Menopausal changes in endogenous estrogen have been associated with memory decline. However, because earlier findings regarding th..

Endogenous oestradiol as a positive correlate of plasma fibrinogen among older postmenopausal women: a population-based study (the Three-City cohort study).

Marianne Canonico, Sylvie Brailly-Tabard, Pascale Gaussem, Julie Setiao, Olivier Rouaud, Joanne Ryan, Laure Carcaillon, Anne Guiochon-Mantel, Pierre-Yves Scarabin

Journal article  |  2012  |  Clinical Endocrinology

BACKGROUND: Plasma fibrinogen is a strong predictor of ischaemic arterial disease in women. Sex steroid hormones including hormone..

Polymorphisms of estrogen receptors and risk of depression: therapeutic implications.

Joanne Ryan, Marie-Laure Ancelin

Journal article  |  2012  |  Drugs

Accumulating evidence suggests the involvement of estrogen in depression. Estrogen can modulate neurotransmitter turnover, enhanci..

Low plasma testosterone and elevated carotid intima-media thickness: importance of low-grade inflammation in elderly men.

Véronique Soisson, Sylvie Brailly-Tabard, Jean-Philippe Empana, Catherine Féart, Joanne Ryan, Marion Bertrand, Anne Guiochon-Mantel, Pierre-Yves Scarabin

Journal article  |  2012  |  Atherosclerosis

CONTEXT AND OBJECTIVE: An inverse correlation between plasma testosterone levels and carotid intima-media thickness (IMT) has been..

High Level of Plasma Estradiol as a New Predictor of Ischemic Arterial Disease in Older Postmenopausal Women: The Three‐City Cohort Study

Valérie Scarabin‐Carré, Marianne Canonico, Sylvie Brailly‐Tabard, Séverine Trabado, Pierre Ducimetière, Maurice Giroud, Joanne Ryan, Catherine Helmer, Geneviève Plu‐Bureau, Anne Guiochon‐Mantel, Pierre Yves Scarabin

Journal article  |  2012  |  Journal of the American Heart Association

Estrogen receptor alpha gene variants and major depressive episodes.

Joanne Ryan, Jacqueline Scali, Isabelle Carrière, Karine Peres, Olivier Rouaud, Pierre-Yves Scarabin, Karen Ritchie, Marie-Laure Ancelin

Journal article  |  2012  |  Journal of Affective Disorders

BACKGROUND: Despite evidence of estrogen's mood-enhancing effects, the association between estrogen receptor (ER) gene variants an..

Hormone treatment, estrogen receptor polymorphisms and mortality: a prospective cohort study.

Joanne Ryan, Marianne Canonico, Laure Carcaillon, Isabelle Carrière, Jacqueline Scali, Jean-Francois Dartigues, Carole Dufouil, Karen Ritchie, Pierre-Yves Scarabin, Marie-Laure Ancelin

Journal article  |  2012  |  PLoS One

BACKGROUND: The association between hormone treatment (HT) and mortality remains controversial. This study aimed to determine whet..

Estrogen receptor gene variants are associated with anxiety disorders in older women.

Joanne Ryan, Jacqueline Scali, Isabelle Carrière, Pierre-Yves Scarabin, Karen Ritchie, Marie-Laure Ancelin

Journal article  |  2011  |  Psychoneuroendocrinology

BACKGROUND: Estrogen is thought to play a key role in anxiety, but it remains unknown whether genetic variants in the estrogen rec..

Oestrogen receptor polymorphisms and late-life depression.

Joanne Ryan, Jacqueline Scali, Isabelle Carrière, Karine Peres, Olivier Rouaud, Pierre-Yves Scarabin, Karen Ritchie, Marie-Laure Ancelin

Journal article  |  2011  |  British Journal of Psychiatry

BACKGROUND: Evidence suggests a role for oestrogen in depression but the involvement of oestrogen receptor polymorphisms remains u..

A prospective study of hormone therapy and depression in community-dwelling elderly women: the Three City Study.

Jacqueline Scali, Joanne Ryan, Isabelle Carrière, Jean-François Dartigues, Béatrice Tavernier, Karen Ritchie, Marie-Laure Ancelin

Journal article  |  2010  |  Journal of Clinical Psychiatry

BACKGROUND: The potential benefits of hormone therapy (HT) in treating depressed postmenopausal women are controversial, and data ..

Characteristics of hormone therapy, cognitive function, and dementia The prospective 3C Study

J Ryan, I Carriere, J Scali, JF Dartigues, C Tzourio, M Poncet, K Ritchie, ML Ancelin

Journal article  |  2009  |  Neurology

The Wnt Target Jagged-1 Mediates the Activation of Notch Signaling by Progastrin in Human Colorectal Cancer Cells

Julie Pannequin, Caroline Bonnans, Nathalie Delaunay, Joanne Ryan, Jean-Francois Bourgaux, Dominique Joubert, Frederic Hollande

Journal article  |  2009  |  Cancer Research

A prospective study of hormonal treatment and anxiety disorders in community-dwelling elderly women (the Esprit Study).

Jacqueline Scali, Joanne Ryan, Isabelle Carrière, Karen Ritchie, Marie-Laure Ancelin

Journal article  |  2009  |  Journal of Affective Disorders

BACKGROUND: The impact of hormone therapy use on late-life anxiety disorder in elderly women has not been evaluated. METHODS: Anxi..

Lifetime hormonal factors may predict late-life depression in women.

Joanne Ryan, Isabelle Carrière, Jacqueline Scali, Karen Ritchie, Marie-Laure Ancelin

Journal article  |  2008  |  International Psychogeriatrics

BACKGROUND: Fluctuating hormone levels are known to influence a woman's mood and well-being. This study aimed to determine whether..

New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations.

Aline Moulin, Luc Demange, Joanne Ryan, Delphine Mousseaux, Pierre Sanchez, Gilbert Bergé, Didier Gagne, Daniel Perrissoud, Vittorio Locatelli, Antonio Torsello, Jean-Claude Galleyrand, Jean-Alain Fehrentz, Jean Martinez

Journal article  |  2008  |  Journal of Medicinal Chemistry

Ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure were synthesized and evaluated for their in vitro bindin..

Hormonal treatment, mild cognitive impairment and Alzheimer's disease.

Joanne Ryan, Jaqueline Scali, Isabelle Carriere, Karen Ritchie, Marie-Laure Ancelin

Conference Proceedings  |  2008  |  Conference on MCI in the Elderly and Populations at Risk

A plethora of in vitro and in vivo studies have supported the neuroprotective role of estrogens and their impact on the neurotrans..

Late-life depression and mortality: influence of gender and antidepressant use.

Joanne Ryan, Isabelle Carriere, Karen Ritchie, Robert Stewart, Gwladys Toulemonde, Jean-François Dartigues, Christophe Tzourio, Marie-Laure Ancelin

Journal article  |  2008  |  British Journal of Psychiatry

BACKGROUND: Depression may increase the risk of mortality among certain subgroups of older people, but the part played by antidepr..

Trisubstituted 1,2,4-triazoles as ligands for the ghrelin receptor: on the significance of the orientation and substitution at position 3.

Aline Moulin, Luc Demange, Joanne Ryan, Céline M'Kadmi, Jean-Claude Galleyrand, Jean Martinez, Jean-Alain Fehrentz

Journal article  |  2008  |  Bioorganic and Medicinal Chemistry Letters

The synthesis and structure-activity relationships concerning 3,4,5-trisubstituted 1,2,4-triazoles as ghrelin receptor ligands are..

Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations.

Aline Moulin, Luc Demange, Gilbert Bergé, Didier Gagne, Joanne Ryan, Delphine Mousseaux, Annie Heitz, Daniel Perrissoud, Vittorio Locatelli, Antonio Torsello, Jean-Claude Galleyrand, Jean-Alain Fehrentz, Jean Martinez

Journal article  |  2007  |  Journal of Medicinal Chemistry

A series of ghrelin receptor ligands based on the trisubstituted 1,2,4-triazole structure were synthesized and evaluated for their..

Recent developments in ghrelin receptor ligands.

Aline Moulin, Joanne Ryan, Jean Martinez, Jean-Alain Fehrentz

Journal article  |  2007  |  ChemMedChem

The 28-amino acid peptide ghrelin is a neuroendocrine hormone synthesized primarily in the stomach. It stimulates growth hormone s..

Synthesis and pharmacological in vitro and in vivo evaluations of novel triazole derivatives as ligands of the ghrelin receptor. 1.

Luc Demange, Damien Boeglin, Aline Moulin, Delphine Mousseaux, Joanne Ryan, Gilbert Bergé, Didier Gagne, Annie Heitz, Daniel Perrissoud, Vittorio Locatelli, Antonio Torsello, Jean-Claude Galleyrand, Jean-Alain Fehrentz, Jean Martinez

Journal article  |  2007  |  Journal of Medicinal Chemistry

A new series of growth hormone secretagogue (GHS) analogues based on the 1,2,4-triazole structure were synthesized and evaluated f..

DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma

Stephanie Boireau, Michael Buchert, Michael S Samuel, Julie Pannequin, Joanne L Ryan, Armelle Choquet, Heliette Chapuis, Xavier Rebillard, Christophe Avances, Matthias Ernst, Dominique Joubert, Nicolas Mottet, Frederic Hollande

Journal article  |  2007  |  Carcinogenesis

beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors

J Pannequin, N Delaunay, M Buchert, F Surrel, JF Bourgaux, J Ryan, S Boireau, J Coelho, A Pelegrin, P Singh, AA Shulkes, ME Yim, G Baldwin, C Pignodel, G Lambeau, P Jay, D Joubert, F Hollande

Journal article  |  2007  |  Gastroenterology

Regulation of ERK1/2 activity by ghrelin-activated growth hormone secretagogue receptor 1A involves a PLC/PKCvarepsilon pathway.

Delphine Mousseaux, Lionel Le Gallic, Joanne Ryan, Catherine Oiry, Didier Gagne, Jean-Alain Fehrentz, Jean-Claude Galleyrand, Jean Martinez

Journal article  |  2006  |  British Journal of Pharmacology

1. The growth hormone secretagogue receptor 1a (GHSR-1a) is a G-protein coupled receptor, involved in the biological actions of gh..