Joanne Ryan

Structural brain changes with lifetime trauma and re-experiencing symptoms is 5-HTTLPR genotype-dependent

ML Ancelin, I Carriere, S Artero, JJ Maller, C Meslin, AM Dupuy, K Ritchie, J Ryan, I Chaudieu

Journal article  |  2020  |  European Journal of Psychotraumatology

Randomized placebo-controlled trial of the effects of aspirin on dementia and cognitive decline.

Joanne Ryan, Elsdon Storey, Anne M Murray, Robyn L Woods, Rory Wolfe, Christopher M Reid, Mark R Nelson, Trevor TJ Chong, Jeff D Williamson, Stephanie A Ward, Jessica E Lockery, Suzanne G Orchard, Ruth Trevaks, Brenda Kirpach, Anne B Newman, Michael E Ernst, John J McNeil, Raj C Shah, undefined ASPREE Investigator Group

Journal article  |  2020  |  Neurology

OBJECTIVE: To determine the effect of low-dose aspirin vs placebo on incident all-cause dementia, incident Alzheimer disease (AD),..

Adolescent and young adult mental health problems and infant offspring behavior: Findings from a prospective intergenerational cohort study

Primrose Letcher, Christopher J Greenwood, Helena Romaniuk, Elizabeth Spry, Jacqui A Macdonald, Helena McAnally, Kimberly C Thomson, George Youssef, Delyse Hutchinson, Jennifer McIntosh, Ann Sanson, Joanne Ryan, Ben Edwards, Judith Sligo, Robert J Hancox, George C Patton, Craig A Olsson

Journal article  |  2020  |  Journal of Affective Disorders

BACKGROUND: Parental depression and anxiety have been consistently linked to offspring behavior problems across childhood. However..

HIF3Acord blood methylation and systolic blood pressure at 4 years - a population-based cohort study

Toby Mansell, David Burgner, Anne-Louise Ponsonby, Fiona Collier, Angela Pezic, Peter Vuillermin, Markus Juonala, Joanne Ryan, Richard Saffery

Journal article  |  2020  |  Epigenetics

Methylation levels at the hypoxia-inducible factor 3α gene (HIF3A) in blood have been linked to body mass index (BMI) in adults. D..

The role of glucocorticoid and mineralocorticoid receptor DNA methylation in antenatal depression and infant stress regulation

Megan Galbally, Stuart J Watson, Marinus van IJzendoorn, Richard Saffery, Joanne Ryan, Edo Ronald de Kloet, Tim F Oberlander, Martha Lappas, Andrew J Lewis

Journal article  |  2020  |  Psychoneuroendocrinology

Understanding fetal programming pathways that underpin the relationship between maternal and offspring mental health necessitates ..

Maternal mental health and infant emotional reactivity: a 20-year two-cohort study of preconception and perinatal exposures

Elizabeth Spry, Margarita Moreno-Betancur, Denise Becker, Helena Romaniuk, John B Carlin, Emma Molyneaux, Louise M Howard, Joanne Ryan, Primrose Letcher, Jennifer McIntosh, Jacqui A Macdonald, Christopher J Greenwood, Kimberley C Thomson, Helena McAnally, Robert Hancox, Delyse M Hutchinson, George J Youssef, Craig A Olsson, George C Patton

Journal article  |  2020  |  Psychological Medicine

BACKGROUND: Maternal mental health during pregnancy and postpartum predicts later emotional and behavioural problems in children. ..

A Systematic Review and Meta-analysis of Environmental, Lifestyle, and Health Factors Associated With DNA Methylation Age.

Joanne Ryan, Jo Wrigglesworth, Jun Loong, Peter D Fransquet, Robyn L Woods

Journal article  |  2020  |  The Journals of Gerontology: Series A

DNA methylation (DNAm) algorithms of biological age provide a robust estimate of an individual's chronological age and can predict..

Aromatase (CYP19A1) gene variants, sex steroid levels, and late-life depression.

Marie-Laure Ancelin, Joanna Norton, Marianne Canonico, Pierre-Yves Scarabin, Karen Ritchie, Joanne Ryan

Journal article  |  2020  |  Depression and Anxiety

BACKGROUND: Sex differences in psychiatric disorders are common and could involve sex steroids. Aromatase, the product of the CYP1..

Is Peripheral BDNF Promoter Methylation a Preclinical Biomarker of Dementia?

Peter D Fransquet, Karen Ritchie, Vania Januar, Richard Saffery, Marie-Laure Ancelin, Joanne Ryan

Journal article  |  2020  |  Journal of Alzheimer's Disease

The extent to which childhood adversity and recent stress influence all-cause mortality risk in older adults.

Jade Johnson, Isabelle Chaudieu, Karen Ritchie, Jacqueline Scali, Marie-Laure Ancelin, Joanne Ryan

Journal article  |  2020  |  Psychoneuroendocrinology

BACKGROUND: Psychological stress is recognized as a major risk factor for a range of non-communicable diseases and possibly mortal..