Wen Shi Lee

T follicular helper cells in the humoral immune response to SARS-CoV-2 infection and vaccination

Marios Koutsakos, Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Jennifer A Juno

Journal article  |  2021  |  JOURNAL OF LEUKOCYTE BIOLOGY

Vaccination remains the most effective mechanism to reduce the impact of COVID-19. Induction of neutralizing antibodies is a stron..

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domain

Adam K Wheatley, Phillip Pymm, Robyn Esterbauer, Melanie H Dietrich, Wen Shi Lee, Damien Drew, Hannah G Kelly, Li-Jin Chan, Francesca L Mordant, Katrina A Black, Amy Adair, Hyon-Xhi Tan, Jennifer A Juno, Kathleen M Wragg, Thakshila Amarasena, Ester Lopez, Kevin J Selva, Ebene R Haycroft, James P Cooney, Hariprasad Venugopal, et al.

Journal article  |  2021  |  CELL REPORTS

Potent neutralizing monoclonal antibodies are one of the few agents currently available to treat COVID-19. SARS-CoV-2 variants of ..

Simultaneous evaluation of antibodies that inhibit SARS-CoV-2 variants via multiplex assay

Ester Lopez, Ebene R Haycroft, Amy Adair, Francesca L Mordant, Matthew T O'Neill, Phillip Pymm, Samuel J Redmond, Wen Shi Lee, Nicholas A Gherardin, Adam K Wheatley, Jennifer A Juno, Kevin J Selva, Samantha K Davis, Samantha L Grimley, Leigh Harty, Damian FJ Purcell, Kanta Subbarao, Dale Godfrey, Stephen J Kent, Wai-Hong Tham, et al.

Journal article  |  2021  |  JCI INSIGHT

The SARS-CoV-2 receptor binding domain (RBD) is both the principal target of neutralizing antibodies and one of the most rapidly e..

Decay of Fc-dependent antibody functions after mild to moderate COVID-19

Wen Shi Lee, Kevin John Selva, Samantha K Davis, Bruce D Wines, Arnold Reynaldi, Robyn Esterbauer, Hannah G Kelly, Ebene R Haycroft, Hyon-Xhi Tan, Jennifer A Juno, Adam K Wheatley, P Mark Hogarth, Deborah Cromer, Miles P Davenport, Amy W Chung, Stephen J Kent

Journal article  |  2021  |  CELL REPORTS MEDICINE

The capacity of antibodies to engage with immune cells via the Fc region is important in preventing and controlling many infectiou..

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

Sheila K Patel, Jennifer A Juno, Wen Shi Lee, Kathleen M Wragg, P Mark Hogarth, Stephen J Kent, Louise M Burrell

Journal article  |  2021  |  EUROPEAN RESPIRATORY JOURNAL

Immunogenicity of prime-boost protein subunit vaccine strategies against SARS-CoV-2 in mice and macaques

Tan Hyon-Xhi, Jennifer A Juno, Wen Shi Lee, Isaac Barber-Axthelm, Hannah G Kelly, Kathleen M Wragg, Robyn Esterbauer, Thakshila Amarasena, Francesca L Mordant, Kanta Subbarao, Stephen J Kent, Adam K Wheatley

Journal article  |  2021  |  NATURE COMMUNICATIONS

SARS-CoV-2 vaccines are advancing into human clinical trials, with emphasis on eliciting high titres of neutralising antibodies ag..

Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Adam K Wheatley, Jennifer A Juno, Jing J Wang, Kevin J Selva, Arnold Reynaldi, Hyon-Xhi Tan, Wen Shi Lee, Kathleen M Wragg, Hannah G Kelly, Robyn Esterbauer, Samantha K Davis, Helen E Kent, Francesca L Mordant, Timothy E Schlub, David L Gordon, David S Khoury, Kanta Subbarao, Deborah Cromer, Tom P Gordon, Amy W Chung, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The durability of infection-induced SARS-CoV-2 immunity has major implications for reinfection and vaccine development. Here, we s..

Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4( )/CD8( ) T cells and humoral responses in macaques

Z Li, M Khanna, SL Grimley, P Ellenberg, CA Gonelli, Wen Shi Lee, TH Amarasena, AD Kelleher, DFJ Purcell, SJ Kent, C Ranasinghe

Journal article  |  2020  |  SCIENTIFIC REPORTS

Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness of HIV-1 vaccine strategies. Here, we teste..

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Brandon J DeKosky

Journal article  |  2020  |  NATURE MICROBIOLOGY

Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through..

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  NATURE MEDICINE

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..