Wen Shi Lee

Mucosal IL-4R antagonist HIV vaccination with SOSIP-gp140 booster can induce high-quality cytotoxic CD4 /CD8 T cells and humoral responses in macaques.

Z Li, M Khanna, SL Grimley, P Ellenberg, CA Gonelli, Wen Shi Lee, TH Amarasena, AD Kelleher, DFJ Purcell, SJ Kent, C Ranasinghe

Journal article  |  2020  |  Scientific Reports

Inducing humoral, cellular and mucosal immunity is likely to improve the effectiveness of HIV-1 vaccine strategies. Here, we teste..

Plasma ACE2 activity is persistently elevated following SARS-CoV-2 infection: implications for COVID-19 pathogenesis and consequences

Sheila Patel, Jennifer Juno, Wen Shi Lee, Kathleen Wragg, Mark Hogarth, Stephen Kent, Louise Burrell

Journal article  |  2020

COVID-19 causes persistent endothelial inflammation, lung and cardiovascular complications. SARS-CoV-2 utilises the catalytic site..

Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies

Wen Shi Lee, Adam K Wheatley, Stephen J Kent, Brandon J DeKosky

Journal article  |  2020  |  Nature Microbiology

Antibody-based drugs and vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are being expedited through..

Humoral and circulating follicular helper T cell responses in recovered patients with COVID-19

Jennifer A Juno, Hyon-Xhi Tan, Wen Shi Lee, Arnold Reynaldi, Hannah G Kelly, Kathleen Wragg, Robyn Esterbauer, Helen E Kent, C Jane Batten, Francesca L Mordant, Nicholas A Gherardin, Phillip Pymm, Melanie H Dietrich, Nichollas E Scott, Wai-Hong Tham, Dale Godfrey, Kanta Subbarao, Miles P Davenport, Stephen J Kent, Adam K Wheatley

Journal article  |  2020  |  Nature Medicine

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has dramatically expedited global vaccine development ef..

Modulation of the CCR5 Receptor/Ligand Axis by Seminal Plasma and the Utility of In Vitro versus In Vivo Models

Jennifer A Juno, Kathleen M Wragg, Anne B Kristensen, Wen Shi Lee, Kevin J Selva, Renee M van der Sluis, Anthony D Kelleher, Benjamin R Bavinton, Andrew E Grulich, Sharon R Lewin, Stephen J Kent, Matthew S Parsons

Journal article  |  2019  |  JOURNAL OF VIROLOGY

CD4-and Time-Dependent Susceptibility of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity

Wen Shi Lee, Jeremie Prevost, Jonathan Richard, Renee M van der Sluis, Sharon R Lewin, Marzena Pazgier, Andres Finzi, Matthew S Parsons, Stephen J Kent

Journal article  |  2019  |  JOURNAL OF VIROLOGY

Fc-dependent functions are redundant to efficacy of anti-HIV antibody PGT121 in macaques

Matthew S Parsons, Wen Shi Lee, Anne B Kristensen, Thakshila Amarasena, Georges Khoury, Adam K Wheatley, Arnold Reynaldi, Bruce D Wines, P Mark Hogarth, Miles P Davenport, Stephen J Kent

Journal article  |  2019  |  Journal of Clinical Investigation

Anti-HIV-1 antibody-dependent cellular cytotoxicity: is there more to antibodies than neutralization?

Wen Shi Lee, Stephen J Kent

Journal article  |  2018  |  Current Opinion in HIV and AIDS

Impact of alemtuzumab on HIV persistence in an HIV-infected individual on antiretroviral therapy with Sezary syndrome

Thomas A Rasmussen, James McMahon, J Judy Chang, Jori Symons, Michael Roche, Ashanti Dantanarayana, Afam Okoye, Bonnie Hiener, Sarah Palmer, Wen Shi Lee, Stephen J Kent, Carrie Van der Weyden, H Miles Prince, Paul U Cameron, Sharon R Lewin

Journal article  |  2017  |  AIDS

Partial efficacy of a broadly neutralizing antibody against cell-associated SHIV infection

Matthew S Parsons, Sarah B Lloyd, Wen Shi Lee, Anne B Kristensen, Thakshila Amarasena, Rob J Center, Brandon F Keele, Jeffrey D Lifson, Celia C LaBranche, David Montefiori, Bruce D Wines, Mark Hogarth, Kristine M Swiderek, Vanessa Venturi, Miles P Davenport, Stephen J Kent

Journal article  |  2017  |  SCIENCE TRANSLATIONAL MEDICINE