Shu Wen Wen

Brain-associated innate leukocytes display diverse inflammatory states following experimental stroke.

Brooke J Wanrooy, Shu Wen Wen, Raymond Shim, Jenny L Wilson, Kathryn Prame Kumar, Connie Hy Wong

Journal article  |  2022  |  Immunol Cell Biol

Previous studies investigating innate leukocyte recruitment into the brain after cerebral ischemia have shown conflicting results...

Lung Imaging Reveals Stroke-Induced Impairment in Pulmonary Intravascular Neutrophil Function, a Response Exacerbated with Aging.

Shu Wen Wen, Raymond Shim, Pam Hall, Justin Bedo, Jenny L Wilson, Alyce J Nicholls, Michael J Hickey, Connie HY Wong

Journal article  |  2022  |  J Immunol

In stroke patients, infection is a significant contributor to morbidity and mortality. Moreover, older stroke patients show an inc..

Blood-Derived Extracellular Vesicle-Associated miR-3182 Detects Non-Small Cell Lung Cancer Patients

Kekoolani S Visan, Richard J Lobb, Shu Wen Wen, Justin Bedo, Luize G Lima, Sophie Krumeich, Carlos Palma, Kaltin Ferguson, Ben Green, Colleen Niland, Nicole Cloonan, Peter T Simpson, Amy E McCart Reed, Sarah J Everitt, Michael P MacManus, Gunter Hartel, Carlos Salomon, Sunil R Lakhani, David Fielding, Andreas Moeller

Journal article  |  2022  |  CANCERS

With five-year survival rates as low as 3%, lung cancer is the most common cause of cancer-related mortality worldwide. The severi..

The role of β2 adrenergic receptor on infection development after ischaemic stroke.

Raymond Shim, Jenny L Wilson, Sarah E Phillips, Gavin W Lambert, Shu Wen Wen, Connie HY Wong

Journal article  |  2021  |  Brain Behav Immun Health

Mechanisms underlying post-stroke immune impairments and subsequent development of fatal lung infection have been suggested to inv..

Dynamic roles of neutrophils in post-stroke neuroinflammation.

Brooke J Wanrooy, Shu Wen Wen, Connie Hy Wong

Journal article  |  2021  |  Immunol Cell Biol

Clinical trials involving the blockage of peripheral inflammatory leukocyte recruitment into the brain have puzzlingly led to eith..

Deficiency of Dietary Fiber Modulates Gut Microbiota Composition, Neutrophil Recruitment and Worsens Experimental Colitis.

Sj Shen, Kathryn Prame Kumar, Shu Wen Wen, Raymond Shim, Brooke J Wanrooy, Dragana Stanley, Robert J Moore, Thi Thu Hao Van, Remy Robert, Michael J Hickey, Connie HY Wong

Journal article  |  2021  |  Front Immunol

Ulcerative colitis is an inflammatory disease of the colon that is associated with colonic neutrophil accumulation. Recent evidenc..

Stroke Severity, and Not Cerebral Infarct Location, Increases the Risk of Infection

Raymond Shim, Shu Wen Wen, Brooke J Wanrooy, Michelle Rank, Tharani Thirugnanachandran, Luke Ho, Tara Sepehrizadeh, Michael de Veer, Velandai K Srikanth, Henry Ma, Thanh G Phan, Christopher G Sobey, Connie HY Wong

Journal article  |  2019  |  TRANSLATIONAL STROKE RESEARCH

Infection is a leading cause of death in patients with stroke; however, the impact of cerebral infarct size or location on infecti..

Advanced age promotes colonic dysfunction and gut-derived lung infection after stroke.

Shu Wen Wen, Raymond Shim, Luke Ho, Brooke J Wanrooy, Yogitha N Srikhanta, Kathryn Prame Kumar, Alyce J Nicholls, SJ Shen, Tara Sepehrizadeh, Michael de Veer, Velandai K Srikanth, Henry Ma, Thanh G Phan, Dena Lyras, Connie HY Wong

Journal article  |  2019  |  Aging Cell

Bacterial infection a leading cause of death among patients with stroke, with elderly patients often presenting with more debilita..

Breast Cancer-Derived Exosomes Reflect the Cell-of-Origin Phenotype.

Shu Wen Wen, Luize G Lima, Richard J Lobb, Emma L Norris, Marcus L Hastie, Sophie Krumeich, Andreas Möller

Journal article  |  2019  |  Proteomics

A manner in which cells can communicate with each other is via secreted nanoparticles termed exosomes. These vesicles contain lipi..

Aging- and vascular-related pathologies.

Shu Wen Wen, Connie HY Wong

Journal article  |  2019  |  Microcirculation

Our aging population is set to grow considerably in the coming decades. In fact, the number of individuals older than 65 years wil..