Professor Elizabeth Vincan is a Senior Medical Scientist and Researcher at the Doherty Institute for Infection and Immunity, with joint appointments at the University of Melbourne’s Doherty Department and the Victorian Infectious Diseases Reference Laboratory (VIDRL, Melbourne Health). Her role as Medical Scientist is Deputy Section Head of the Molecular Hepatitis Laboratory, a routine diagnostic laboratory at VIDRL.
Elizabeth also heads an independent research lab. Her dual role in diagnostics and research has enabled seamless adoption of research discoveries into a clinical setting. She is internationally recognised in the Wnt signalling field; has published two books and several highly cited reviews on Wnt signalling, and was the convenor of the first international Wnt meeting, and the first EMBO workshop, held in Australia (Cable Beach, Broome, 2014). Elizabeth is an adjunct Professor at the Curtin University, Perth, WA and a founding member of the Australian Living Organoid Alliance (ALOA), a non-profit initiative to establish organoid Biobanks nationally as a research and diagnostic resource.
At the heart of our research projects is the Wnt signal transduction pathway. The Wnt pathway is an ancient form of cell-cell communication that is highly conserved through evolution from simple organisms to man. Wnt proteins bind to Frizzled, their cell surface receptors, to regulate embryonic development, but also homeostasis, repair and regeneration of adult tissues. Deregulated Wnt signaling impacts on many human diseases, including cancer.
In the Vincan lab, we incorporate biochemical, genetic and cell biological approaches to investigate how Wnt and Frizzled regulate these processes. As model systems, we use transgenic mice and three-dimensional organoids (means “organ-like”) established from mouse and human tissues. Tissue-restricted stem cell-derived organoids faithfully recapitulate in a culture dish the architecture, cell composition and function of a tissue. We focus on the gastrointestinal tract - stomach, bowel and liver – as Wnt signalling is critical for normal stem cell function in these tissues and is hyperactive in cancers that arise in these tissues. Using mini-gut and mini-stomach organoids, we identified Frizzled7 as the key Wnt receptor in stem cells that maintain the epithelium lining of the bowel and stomach. Furthermore, we demonstrated that this requirement for Frizzled7-mediated Wnt signalling is hijacked by cancer cells to maintain tumour growth. Blocking Frizzled7 has potent anti-tumour effects. This is now being developed as targeted therapy for gastrointestinal cancers.
More recently, we are using organoids for viral and bacterial infection. Some human pathogens only infect adult human cells, which has hampered the study of natural infection and the investigation of how to prevent or control infection. Organoids established from human tissues support infection and allow the study of natural infection in a tissue culture dish for the first time.
Dr Toby Phesse, Cardiff University, Wales, UK
Professor Nick Barker, Singapore
Professor Hans Clevers, The Netherlands
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Test Biological Mechanisms Of Various Therapeutics Against Respiratory Microbial Agents
Displaying the 7 most recent projects by Elizabeth Vincan.
Displaying the 51 most recent scholarly works by Elizabeth Vincan.
The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling
Manh Tran Bang, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Tran Hoanh, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan
Journal article | 2020 | Cancers
An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection wi..
Targeting Wnt Signaling for the Treatment of Gastric Cancer
Sarah Koushyar, Arfon G Powell, Elizabeth Vincan, Toby J Phesse
Journal article | 2020 | International Journal of Molecular Sciences
The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeosta..
The Function of Lgr5( ) Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo
Dustin Flanagan, Nick Barker, Matthias Ernst, Elizabeth Vincan, Toby Phesse
Journal article | 2019 | Biomedicines
The extreme chemical and mechanical forces endured by the gastrointestinal tract drive a constant renewal of the epithelial lining..
HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models
Joseph Torresi, Manh Tran Bang, Dale Christiansen, Linda Earnest-Silveira, Renate Hilda Marianne Schwab, Elizabeth Vincan
Journal article | 2019 | BMC Cancer
BACKGROUND: Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are ..
Human liver organoids culture as a novel in vitro model of HBV infection
Chuan Kok Lim, Bang M Tran, Byron Shue, Nicholas Eyre, Dustin Flanagan, Elizabeth Vincan, Danni Colledge, Stephen Locarnini, Erin McCartney, Edmund Tse, Andrew Ruszkiewicz, Michael Beard
Conference Proceedings | 2019 | JOURNAL OF HEPATOLOGY
Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations
Dustin J Flanagan, Nick Barker, Natasha S Di Costanzo, Elizabeth A Mason, Austin Gurney, Valerie S Meniel, Sarah Koushyar, Chloe R Austin, Matthias Ernst, Helen B Pearson, Alex Boussioutas, Hans Clevers, Toby J Phesse, Elizabeth Vincan
Journal article | 2019 | Cancer Research
Isolation and Culture of Adult Intestinal, Gastric, and Liver Organoids for Cre-recombinase-Mediated Gene Deletion.
Dustin J Flanagan, Renate HM Schwab, Bang M Tran, Toby J Phesse, Elizabeth Vincan
Journal article | 2019 | Methods in molecular biology (Clifton, N.J.)
The discovery of Lgr5 as a marker of adult stem cells meant that stem cell populations could be purified and studied in isolation...
PI3K activation in neural stem cells drives tumorigenesis which can be suppressed by targeting CREB
Paul Daniel, Gulay Filiz, Daniel Brown, Michael Christie, Paul Waring, Yi Zhang, John Haynes, Colin Pouton, Dustin Flanagan, Elizabeth Vincan, Terrance Johns, Karen Montgomery, Wayne Phillips, Theo Mantamadiotis
Journal article | 2017 | BiorXiv
Hyperactivation of the PI3K signaling is common in human cancers, including gliomas, but the precise role of the pathway in glioma..
Stomach-Specific Activation of Oncogenic KRAS and STAT3-Dependent Inflammation Cooperatively Promote Gastric Tumorigenesis in a Preclinical Model
Stefan Thiem, Moritz F Eissmann, Joachim Elzer, Anna Jonas, Tracy L Putoczki, Ashleigh Poh, Paul Nguyen, Adele Preaudet, Dustin Flanagan, Elizabeth Vincan, Paul Waring, Michael Buchert, Andrew Jarnicki, Matthias Ernst
Journal article | 2016 | Cancer Research
Frizzled7 Functions as a Wnt Receptor in Intestinal Epithelial Lgr5( ) Stem Cells
Dustin J Flanagan, Toby J Phesse, Nick Barker, Renate HM Schwab, Nancy Amin, Jordane Malaterre, Daniel E Stange, Cameron J Nowell, Scott A Currie, Jarel TS Saw, Eva Beuchert, Robert G Ramsay, Owen J Sansom, Matthias Ernst, Hans Clevers, Elizabeth Vincan
Journal article | 2015 | STEM CELL REPORTS
Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-beta-catenin-mediated intestinal tumor growth and regeneration
Toby J Phesse, Michael Buchert, Emma Stuart, Dustin J Flanagan, Maree Faux, Shoukat Afshar-Sterle, Francesca Walker, Hui-Hua Zhang, Cameron J Nowell, Robert Jorissen, Chin Wee Tan, Yumiko Hirokawa, Moritz F Eissmann, Ashleigh R Poh, Jordane Malaterre, Helen B Pearson, David G Kirsch, Paolo Provero, Valeria Poli, Robert G Ramsay, et al.
Journal article | 2014 | Science Signaling
Intestinal epithelial-specific PTEN inactivation results in tumor formation
Do-Sun Byun, Naseem Ahmed, Shannon Nasser, Joongho Shin, Sheren Al-Obaidi, Sanjay Goel, Georgia A Corner, Andrew J Wilson, Dustin J Flanagan, David S Williams, Leonard H Augenlicht, Elizabeth Vincan, John M Mariadason
Journal article | 2011 | American Journal of Physiology - Gastrointestinal and Liver Physiology
PHLDA1 Expression Marks the Putative Epithelial Stem Cells and Contributes to Intestinal Tumorigenesis
Anuratha Sakthianandeswaren, Michael Christie, Carla D'Andreti, Cary Tsui, Robert N Jorissen, Shan Li, Nicholas I Fleming, Peter Gibbs, Lara Lipton, Jordane Malaterre, Robert G Ramsay, Toby J Phesse, Matthias Ernst, Rosemary E Jeffery, Richard Poulsom, Simon J Leedham, Stefania Segditsas, Ian PM Tomlinson, Oliver K Bernhard, Richard J Simpson, et al.
Journal article | 2011 | Cancer Research
Analysis of Wnt/FZD-mediated signalling in a cell line model of colorectal cancer morphogenesis.
Elizabeth Vincan, Robert H Whitehead, Maree C Faux
Journal article | 2008 | Methods in Molecular Biology
Cells in tissues do not exist as isolated entities but are part of the three-dimensional tissue architecture. Consequently, some a..
Enhanced negative chronotropy by inhibitory receptors in transgenic heart overexpressing beta(2)-adrenoceptors.
XJ Du, E Vincan, E Percy, EA Woodcock
Journal article | 2000 | Journal of the Autonomic Nervous System
Transgenic (TG) mice overexpressing beta(2)-adrenoceptors (AR) in the heart have enhanced beta-adrenergic activity. Since the degr..
Sodium butyrate-induced differentiation of human LIM2537 colon cancer cells decreases GSK-3 beta activity and increases levels of both membrane-bound and APC/Axin/GSK-3 beta complex-associated pools of beta-catenin
E Vincan, CSF Leet, NI Reyes, RJ Dilley, RJS Thomas, WA Phillips
Journal article | 2000 | Oncology Research
Microsatellite instability in gastrointestinal tract tumours.
AJ Philp, WA Phillips, SP Rockman, E Vincan, S Baindur-Hudson, W Burns, R Valentine, RJ Thomas
Journal article | 2000 | International journal of surgical investigation
Although a number of studies have documented microsatellite instability (MSI) in gastrointestinal tumours, the clinical significan..
Response to cardiac sympathetic activation in transgenic mice overexpressing beta 2-adrenergic receptor.
XJ Du, E Vincan, DM Woodcock, CA Milano, AM Dart, EA Woodcock
Journal article | 1996 | American Journal of Physiology-Heart and Circulatory Physiology
Transgenic mice have been created with 200-fold overexpression of beta 2-adrenergic receptors specifically in the heart. Cardiac f..
Reduction in Gh protein expression is associated with cytodifferentiation of vascular smooth muscle cells.
E Vincan, CB Neylon, AN Jacobsen, EA Woodcock
Journal article | 1996 | Molecular and Cellular Biochemistry
Gh, a high molecular weight GTP-binding protein that couples alpha 1-adrenoceptors in heart and liver to phosphatidylinositol (Ptd..
Isolation of neonatal cardiomyocytes reduces the expression of the GTP-binding protein, Gh.
E Vincan, CB Neylon, RM Graham, EA Woodcock
Journal article | 1995 | Journal of Molecular and Cellular Cardiology
alpha 1-Adrenoceptors in most tissues couple with the heterotrimeric GTP-binding protein Gq, the alpha subunit of which activates ..
Displaying the 2 most recent news articles by Elizabeth Vincan.
Nhmrc Senior Research Fellow
International Society for Stem Cell Research (ISSCR)
Australian Society for Stem Cell Research (ASSCR)
Aus&NZ Soc Cell Dev Biol (ANZSCDB)
Australian Society for Medical Research (ASMR)
The International EMT Association (TEMTIA)
Doctor of Philosophy
University of Melbourne
Bachelor of Science (Honours)
University of Melbourne