Elizabeth Vincan

Frizzled7 Activates β-Catenin-Dependent and β-Catenin-Independent Wnt Signalling Pathways During Developmental Morphogenesis: Implications for Therapeutic Targeting in Colorectal Cancer.

Bang Manh Tran, Dustin James Flanagan, Toby James Phesse, Elizabeth Vincan

Journal article  |  2021  |  Handb Exp Pharmacol

Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways, is highly conserved through evolution f..

Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models

Michelle P Clark, Thao Huynh, Shringar Rao, Liana Mackiewicz, Hugh Mason, Shahla Romal, Michael D Stutz, Sang H Ahn, Linda Earnest, Vitina Sozzi, Margaret Littlejohn, Bang M Tran, Norbert Wiedemann, Elizabeth Vincan, Joseph Torresi, Hans J Netter, Tokameh Mahmoudi, Peter Revill, Marc Pellegrini, Gregor Ebert

Journal article  |  2021  |  CELL DEATH & DISEASE

A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individ..

Investigating virus-host cell interactions: Comparative binding forces between hepatitis C virus-like particles and host cell receptors in 2D and 3D cell culture models

Simon Collett, Joseph Torresi, Linda Earnest Silveira, Vi Khanh Truong, Dale Christiansen, Bang M Tran, Elizabeth Vincan, Paul A Ramsland, Aaron Elbourne

Journal article  |  2021  |  JOURNAL OF COLLOID AND INTERFACE SCIENCE

Cell cultures have been successfully used to study hepatitis C virus (HCV) for many years. However, most work has been done using ..

Captopril, a Renin-Angiotensin System Inhibitor, Attenuates Features of Tumor Invasion and Down-Regulates C-Myc Expression in a Mouse Model of Colorectal Cancer Liver Metastasis

Georgina E Riddiough, Theodora Fifis, Katrina A Walsh, Vijayaragavan Muralidharan, Christopher Christophi, Bang M Tran, Elizabeth Vincan, Marcos V Perini

Journal article  |  2021  |  CANCERS

(1) Background: Recent clinical and experimental data suggests that the liver's regenerative response following partial hepatectom..

Renin-Angiotensin Inhibitor Treatment Attenuates Progression of Colorectal Liver Metastasis

G Riddiough, B Tran, T Fifis, K Walsh, V Muralidharan, E Vincan, C Christophi, M Perini

Journal article  |  2021  |  HPB

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

Manh Tran Bang, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Tran Hoanh, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan

Journal article  |  2020  |  CANCERS

An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection wi..

Targeting Wnt Signaling for the Treatment of Gastric Cancer

Sarah Koushyar, Arfon G Powell, Elizabeth Vincan, Toby J Phesse

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeosta..

Wnt Signaling in Cancer: Not a Binary ON:OFF Switch

Dustin J Flanagan, Elizabeth Vincan, Toby J Phesse

Journal article  |  2019  |  CANCER RESEARCH

In the March 1 issue of Cancer Research, we identified the Wnt receptor Fzd7 as an attractive therapeutic target for the treatment..

The Function of Lgr5( ) Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo

Dustin Flanagan, Nick Barker, Matthias Ernst, Elizabeth Vincan, Toby Phesse

Journal article  |  2019  |  BIOMEDICINES

The extreme chemical and mechanical forces endured by the gastrointestinal tract drive a constant renewal of the epithelial lining..

HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models

Joseph Torresi, Manh Tran Bang, Dale Christiansen, Linda Earnest-Silveira, Renate Hilda Marianne Schwab, Elizabeth Vincan

Journal article  |  2019  |  BMC CANCER

BACKGROUND: Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are ..