Elizabeth Vincan

Investigating virus-host cell interactions: Comparative binding forces between hepatitis C virus-like particles and host cell receptors in 2D and 3D cell culture models.

Simon Collett, Joseph Torresi, Linda Earnest Silveira, Vi Khanh Truong, Dale Christiansen, Bang M Tran, Elizabeth Vincan, Paul A Ramsland, Aaron Elbourne

Journal article  |  2021  |  Journal of Colloid and Interface Science

Cell cultures have been successfully used to study hepatitis C virus (HCV) for many years. However, most work has been done using ..

The Hepatitis B Virus Pre-Core Protein p22 Activates Wnt Signaling

Manh Tran Bang, Dustin James Flanagan, Gregor Ebert, Nadia Warner, Tran Hoanh, Theodora Fifis, Georgios Kastrappis, Christopher Christophi, Marc Pellegrini, Joseph Torresi, Toby James Phesse, Elizabeth Vincan

Journal article  |  2020  |  Cancers

An emerging theme for Wnt-addicted cancers is that the pathway is regulated at multiple steps via various mechanisms. Infection wi..

Targeting Wnt Signaling for the Treatment of Gastric Cancer

Sarah Koushyar, Arfon G Powell, Elizabeth Vincan, Toby J Phesse

Journal article  |  2020  |  International Journal of Molecular Sciences

The Wnt signaling pathway is evolutionarily conserved, regulating both embryonic development and maintaining adult tissue homeosta..

Wnt Signaling in Cancer: Not a Binary ON:OFF Switch

Dustin J Flanagan, Elizabeth Vincan, Toby J Phesse

Journal article  |  2019  |  Cancer Research

In the March 1 issue of Cancer Research, we identified the Wnt receptor Fzd7 as an attractive therapeutic target for the treatment..

The Function of Lgr5( ) Cells in the Gastric Antrum Does Not Require Fzd7 or Myc In Vivo

Dustin Flanagan, Nick Barker, Matthias Ernst, Elizabeth Vincan, Toby Phesse

Journal article  |  2019  |  Biomedicines

The extreme chemical and mechanical forces endured by the gastrointestinal tract drive a constant renewal of the epithelial lining..

HBV-related hepatocarcinogenesis: the role of signalling pathways and innovative ex vivo research models

Joseph Torresi, Manh Tran Bang, Dale Christiansen, Linda Earnest-Silveira, Renate Hilda Marianne Schwab, Elizabeth Vincan

Journal article  |  2019  |  BMC Cancer

BACKGROUND: Hepatitis B virus (HBV) is the leading cause of liver cancer, but the mechanisms by which HBV causes liver cancer are ..

Pre-clinical evaluation of a quadrivalent HCV VLP vaccine in pigs following microneedle delivery

D Christiansen, L Earnest-Silveira, B Grubor-Bauk, DK Wijesundara, I Boo, PA Ramsland, E Vincan, HE Drummer, EJ Gowans, J Torresi

Journal article  |  2019  |  Scientific Reports

Human liver organoids culture as a novel in vitro model of HBV infection

Chuan Kok Lim, Bang M Tran, Byron Shue, Nicholas Eyre, Dustin Flanagan, Elizabeth Vincan, Danni Colledge, Stephen Locarnini, Erin McCartney, Edmund Tse, Andrew Ruszkiewicz, Michael Beard

Conference Proceedings  |  2019  |  JOURNAL OF HEPATOLOGY

Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations

Dustin J Flanagan, Nick Barker, Natasha S Di Costanzo, Elizabeth A Mason, Austin Gurney, Valerie S Meniel, Sarah Koushyar, Chloe R Austin, Matthias Ernst, Helen B Pearson, Alex Boussioutas, Hans Clevers, Toby J Phesse, Elizabeth Vincan

Journal article  |  2019  |  Cancer Research

Isolation and Culture of Adult Intestinal, Gastric, and Liver Organoids for Cre-recombinase-Mediated Gene Deletion.

Dustin J Flanagan, Renate HM Schwab, Bang M Tran, Toby J Phesse, Elizabeth Vincan

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

The discovery of Lgr5 as a marker of adult stem cells meant that stem cell populations could be purified and studied in isolation...