Elizabeth Vincan

Epigenetic Silencing of RIPK3 in Hepatocytes Prevents MLKL -mediated Necroptosis From Contributing to Liver Pathologies

Simon P Preston, Michael D Stutz, Cody C Allison, Ueli Nachbur, Quentin Gouil, Manh Tran Bang, Valerie Duvivier, Philip Arandjelovic, James P Cooney, Liana Mackiewicz, Yanxiang Meng, Jan Schaefer, Stefanie M Bader, Hongke Peng, Zina Valaydon, Pravin Rajasekaran, Charlie Jennison, Sash Lopaticki, Ann Farrell, Marno Ryan, et al.

Journal article  |  2022  |  GASTROENTEROLOGY

BACKGROUND & AIMS: Necroptosis is a highly inflammatory mode of cell death that has been implicated in causing hepatic injury incl..

Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection

Alexander J McAuley, Petrus Jansen van Vuren, Muzaffar-Ur-Rehman Mohammed, undefined Faheem, Sarah Goldie, Shane Riddell, Nathan J Godde, Ian K Styles, Matthew P Bruce, Simran Chahal, Stephanie Keating, Kim R Blasdell, Mary Tachedjian, Carmel M O'Brien, Nagendrakumar Balasubramanian Singanallur, John Noel Viana, Aditya V Vashi, Carl M Kirkpatrick, Christopher A MacRaild, Rohan M Shah, et al.

Journal article  |  2022  |  VIRUSES-BASEL

The repurposing of licenced drugs for use against COVID-19 is one of the most rapid ways to develop new and alternative therapeuti..

Captopril, a Renin-Angiotensin System Inhibitor, Attenuates Tumour Progression in the Regenerating Liver Following Partial Hepatectomy

Georgina E Riddiough, Katrina A Walsh, Theodora Fifis, Georgios Kastrappis, Bang M Tran, Elizabeth Vincan, Vijayaragavan Muralidharan, Christopher Christophi, Claire L Gordon, Marcos V Perini

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

(1) Liver regeneration following partial hepatectomy for colorectal liver metastasis (CRLM) has been linked to tumour recurrence. ..

Organoid Models of SARS-CoV-2 Infection: What Have We Learned about COVID-19?

Bang M Tran, Georgia Deliyannis, Abderrahman Hachani, Linda Earnest, Joseph Torresi, Elizabeth Vincan

Journal article  |  2022  |  Organoids

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), which was classified as a..

Air-Liquid-Interface Differentiated Human Nose Epithelium: A Robust Primary Tissue Culture Model of SARS-CoV-2 Infection

Bang M Tran, Samantha L Grimley, Julie L McAuley, Abderrahman Hachani, Linda Earnest, Sharon L Wong, Leon Caly, Julian Druce, Damian FJ Purcell, David C Jackson, Mike Catton, Cameron J Nowell, Laura Leonie, Georgia Deliyannis, Shafagh A Waters, Joseph Torresi, Elizabeth Vincan

Journal article  |  2022  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The global urgency to uncover medical countermeasures to combat the COVID-19 pandemic caused by the severe acute respiratory syndr..

Clinical stage drugs targeting inhibitor of apoptosis proteins purge episomal Hepatitis B viral genome in preclinical models

Michelle P Clark, Thao Huynh, Shringar Rao, Liana Mackiewicz, Hugh Mason, Shahla Romal, Michael D Stutz, Sang H Ahn, Linda Earnest, Vitina Sozzi, Margaret Littlejohn, Bang M Tran, Norbert Wiedemann, Elizabeth Vincan, Joseph Torresi, Hans J Netter, Tokameh Mahmoudi, Peter Revill, Marc Pellegrini, Gregor Ebert

Journal article  |  2021  |  CELL DEATH & DISEASE

A major unmet clinical need is a therapeutic capable of removing hepatitis B virus (HBV) genome from the liver of infected individ..

Captopril, a Renin-Angiotensin System Inhibitor, Attenuates Features of Tumor Invasion and Down-Regulates C-Myc Expression in a Mouse Model of Colorectal Cancer Liver Metastasis

Georgina E Riddiough, Theodora Fifis, Katrina A Walsh, Vijayaragavan Muralidharan, Christopher Christophi, Bang M Tran, Elizabeth Vincan, Marcos V Perini

Journal article  |  2021  |  CANCERS

(1) Background: Recent clinical and experimental data suggests that the liver's regenerative response following partial hepatectom..

Investigating virus-host cell interactions: Comparative binding forces between hepatitis C virus-like particles and host cell receptors in 2D and 3D cell culture models

Simon Collett, Joseph Torresi, Linda Earnest Silveira, Vi Khanh Truong, Dale Christiansen, Bang M Tran, Elizabeth Vincan, Paul A Ramsland, Aaron Elbourne

Journal article  |  2021  |  JOURNAL OF COLLOID AND INTERFACE SCIENCE

Cell cultures have been successfully used to study hepatitis C virus (HCV) for many years. However, most work has been done using ..

Frizzled7 Activates β-Catenin-Dependent and β-Catenin-Independent Wnt Signalling Pathways During Developmental Morphogenesis: Implications for Therapeutic Targeting in Colorectal Cancer.

Bang Manh Tran, Dustin James Flanagan, Toby James Phesse, Elizabeth Vincan

Book Chapter  |  2021  |  Handbook of experimental pharmacology

Frizzled7 activates β-catenin-dependent and β-catenin-independent Wnt signalling pathways, is highly conserved through evolution f..

Renin-Angiotensin Inhibitor Treatment Attenuates Progression of Colorectal Liver Metastasis

G Riddiough, B Tran, T Fifis, K Walsh, V Muralidharan, E Vincan, C Christophi, M Perini

Journal article  |  2021  |  HPB