Jonathan Oakhill

SGC-CAMKK2-1: A Chemical Probe for CAMKK2

Carrow Wells, Yi Liang, Thomas L Pulliam, Chenchu Lin, Dominik Awad, Benjamin Eduful, Sean O'Byrne, Mohammad Anwar Hossain, Carolina Moura Costa Catta-Preta, Priscila Zonzini Ramos, Opher Gileadi, Carina Gileadi, Rafael M Counago, Brittany Stork, Christopher G Langendorf, Kevin Nay, Jonathan S Oakhill, Debarati Mukherjee, Luigi Racioppi, Anthony R Means, et al.

Journal article  |  2023  |  CELLS

The serine/threonine protein kinase calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) plays critical roles in a range ..

Blocking AMPK?1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis

Katyayanee Neopane, Natalie Kozlov, Florentina Negoita, Lisa Murray-Segal, Robert Brink, Ashfaqul Hoque, Ashley J Ovens, Gavin Tjin, Luke M McAloon, Dingyi Yu, Naomi XY Ling, Matthew J Sanders, Jonathan S Oakhill, John W Scott, Gregory R Steinberg, Kim Loh, Bruce E Kemp, Kei Sakamoto, Sandra Galic

Journal article  |  2022  |  CELL REPORTS

AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis and a therapeutic target for metabolic di..

A novel small molecule inhibitor of human Drp1.

Ayeshah A Rosdah, Belinda M Abbott, Christopher G Langendorf, Yali Deng, Jia Q Truong, Helen MM Waddell, Naomi XY Ling, William J Smiles, Lea MD Delbridge, Guei-Sheung Liu, Jonathan S Oakhill, Shiang Y Lim, Jessica K Holien

Journal article  |  2022  |  Sci Rep

Mitochondrial dynamin-related protein 1 (Drp1) is a large GTPase regulator of mitochondrial dynamics and is known to play an impor..

Phosphoproteomics of three exercise modalities identifies canonical signaling and C18ORF25 as anAMPK substrate regulating skeletal muscle function

Ronnie Blazev, Christian S Carl, Yaan-Kit Ng, Jeffrey Molendijk, Christian T Voldstedlund, Yuanyuan Zhao, Di Xiao, Andrew J Kueh, Paula M Miotto, Vanessa R Haynes, Justin P Hardee, Jin D Chung, James W McNamara, Hongwei Qian, Paul Gregorevic, Jonathan S Oakhill, Marco J Herold, Thomas E Jensen, Leszek Lisowski, Gordon S Lynch, et al.

Journal article  |  2022  |  CELL METABOLISM

Exercise induces signaling networks to improve muscle function and confer health benefits. To identify divergent and common signal..

Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer

Priyanka Gupta, Keehn Strange, Rahul Telange, Ailan Guo, Heather Hatch, Amin Sobh, Jonathan Elie, Angela M Carter, John Totenhagen, Chunfeng Tan, Yogesh A Sonawane, Jiri Neuzil, Amarnath Natarajan, Ashley J Ovens, Jonathan S Oakhill, Thorsten Wiederhold, Karel Pacak, Hans K Ghayee, Laurent Meijer, Sushanth Reddy, et al.

Journal article  |  2022  |  CELL REPORTS

Metabolic dysfunction mutations can impair energy sensing and cause cancer. Loss of function of the mitochondrial tricarboxylic ac..

Systemic Ablation of Camkk2 Impairs Metastatic Colonization and Improves Insulin Sensitivity in TRAMP Mice: Evidence for Cancer Cell-Extrinsic CAMKK2 Functions in Prostate Cancer

Thomas L Pulliam, Dominik Awad, Jenny J Han, Mollianne M Murray, Jeffrey J Ackroyd, Pavithr Goli, Jonathan S Oakhill, John W Scott, Michael M Ittmann, Daniel E Frigo

Journal article  |  2022  |  CELLS

Despite early studies linking calcium-calmodulin protein kinase kinase 2 (CAMKK2) to prostate cancer cell migration and invasion, ..

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Ashley J Ovens, Yi Sing Gee, Naomi XY Ling, Dingyi Yu, Justin P Hardee, Jin D Chung, Kevin RW Ngoei, Nicholas J Waters, Nolan J Hoffman, John W Scott, Kim Loh, Katrin Spengler, Regine Heller, Michael W Parker, Gordon S Lynch, Fei Huang, Sandra Galic, Bruce E Kemp, Jonathan B Baell, Jonathan S Oakhill, et al.

Journal article  |  2022  |  BIOCHEMICAL JOURNAL

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor and central regulator of energy homeo..

An AMPKa2-specific phospho-switch controls lysosomal targeting for activation

Kaitlin R Morrison, William J Smiles, Naomi XY Ling, Ashfaqul Hoque, Gabrielle Shea, Kevin RW Ngoei, Dingyi Yu, Lisa Murray-Segal, John W Scott, Sandra Galic, Bruce E Kemp, Janni Petersen, Jonathan S Oakhill

Journal article  |  2022  |  CELL REPORTS

AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) are metabolic kinases that co-ordinate ..

Neuropeptide Y1 receptor antagonism protects beta-cells and improves glycemic control in type 2 diabetes

Chieh-Hsin Yang, Danise Ann-Onda, Xuzhu Lin, Stacey Fynch, Shaktypreya Nadarajah, Evan G Pappas, Xin Liu, John W Scott, Jonathan S Oakhill, Sandra Galic, Yanchuan Shi, Alba Moreno-Asso, Cassandra Smith, Thomas Loudovaris, Itamar Levinger, Decio L Eizirik, D Ross Laybutt, Herbert Herzog, Helen E Thomas, Kim Loh

Journal article  |  2021  |  MOLECULAR METABOLISM

OBJECTIVES: Loss of functional β-cell mass is a key factor contributing to poor glycemic control in advanced type 2 diabetes (T2D)..

Personalized phosphoproteomics identifies functional signaling

Elise J Needham, Janne R Hingst, Benjamin L Parker, Kaitlin R Morrison, Guang Yang, Johan Onslev, Jonas M Kristensen, Kurt Hojlund, Naomi XY Ling, Jonathan S Oakhill, Erik A Richter, Bente Kiens, Janni Petersen, Christian Pehmoller, David E James, Jorgen FP Wojtaszewski, Sean J Humphrey

Journal article  |  2021  |  NATURE BIOTECHNOLOGY

Protein phosphorylation dynamically integrates environmental and cellular information to control biological processes. Identifying..