Gisela Mir Arnau

TRACEBACK: Testing of Historical Tubo-Ovarian Cancer Patients for Hereditary Risk Genes as a Cancer Prevention Strategy in Family Members

Rachel Delahunty, Linh Nguyen, Stuart Craig, Belinda Creighton, Dinuka Ariyaratne, Dale W Garsed, Elizabeth Christie, Sian Fereday, Lesley Andrews, Alexandra Lewis, Sharne Limb, Ahwan Pandey, Joy Hendley, Nadia Traficante, Natalia Carvajal, Amanda B Spurdle, Bryony Thompson, Michael T Parsons, Victoria Beshay, Mila Volcheck, et al.

Journal article  |  2022  |  JOURNAL OF CLINICAL ONCOLOGY

PURPOSE: Tubo-ovarian cancer (TOC) is a sentinel cancer for BRCA1 and BRCA2 pathogenic variants (PVs). Identification of a PV in t..

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Jessica M Salmon, Izabela Todorovski, Kym L Stanley, Claudia Bruedigam, Conor J Kearney, Luciano G Martelotto, Fernando Rossello, Timothy Semple, Gisela Mir Arnau, Magnus Zethoven, Michael Bots, Stefan Bjelosevic, Leonie A Cluse, Peter J Fraser, Veronique Litalien, Eva Vidacs, Kate McArthur, Antony Y Matthews, Elise Gressier, Nicole A de Weerd, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addit..

732 TUMOR INFILTRATING NEUTROPHILS ARE A POOR PROGNOSTIC MARKER FOR ESOPHAGEAL CANCER PATIENTS RECEIVING NEOADJUVANT CHEMORADIOTHERAPY

Carlos Cabalag, Owen Prall, John Ciciulla, Laurence Galea, Niko Thio, Lynn Chong, Michael W Hii, Paul J Neeson, Gisela Mir Arnau, Wayne A Phillips, Nicholas J Clemons, Cuong P Duong

Conference Proceedings  |  2021  |  Diseases of the Esophagus

Abstract   Significant advances have been made in our understanding of the tum..

Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling

Ismael A Vergara, Christopher P Mintoff, Shahneen Sandhu, Lachlan McIntosh, Richard J Young, Stephen Q Wong, Andrew Colebatch, Daniel L Cameron, Julia Lai Kwon, Rory Wolfe, Angela Peng, Jason Ellul, Xuelin Dou, Clare Fedele, Samantha Boyle, Gisela Mir Arnau, Jeanette Raleigh, Athena Hatzimihalis, Pacman Szeto, Jennifer Mooi, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origi..

Clonal independence of JAK2 and CALR or MPL mutations in comutated myeloproliferative neoplasms demonstrated by single cell DNA sequencing

Ella R Thompson, Tamia Nguyen, Yamuna Kankanige, Paul Yeh, Michael Ingbritsen, Michelle McBean, Timothy Semple, Gisela Mir Arnau, Kate Burbury, Nora Lee, Amit Khot, David Westerman, Piers Blombery

Journal article  |  2021  |  HAEMATOLOGICA

Sex differences in oncogenic mutational processes

Constance H Li, Stephenie D Prokopec, Ren X Sun, Fouad Yousif, Nathaniel Schmitz, Paul C Boutros

Journal article  |  2020  |  NATURE COMMUNICATIONS

Sex differences have been observed in multiple facets of cancer epidemiology, treatment and biology, and in most cancers outside t..

Characterization of the immune profile of oral tongue squamous cell carcinomas with advancing disease

Katie Meehan, Connull Leslie, Michaela Lucas, Angela Jacques, Bob Mirzai, James Lim, Max Bulsara, Yasir Khan, Nicholas C Wong, Benjamin Solomon, Chady Sader, Peter Friedland, Gisela Mir Arnau, Timothy Semple, Annette M Lim

Journal article  |  2020  |  CANCER MEDICINE

We investigated whether a unique immune response was instigated with the development of oral tongue squamous cell carcinomas (OTSC..

Improved next-generation sequencing pre-capture library yields and sequencing parameters using on-bead PCR

Christopher R McEvoy, Timothy Semple, Bhargavi Yellapu, David Y Choong, Huiling Xu, Gisela Mir Arnau, Andrew P Fellowes, Stephen B Fox

Journal article  |  2020  |  BIOTECHNIQUES

Tumor DNA sequencing results can have important clinical implications. However, its use is often limited by low DNA input, owing t..