Holly Chinnery

Topographical and Morphological Differences of Corneal Dendritic Cells during Steady State and Inflammation

Haihan Jiao, Cecilia Naranjo Golborne, Samantha J Dando, Paul G McMenamin, Laura E Downie, Holly R Chinnery

Journal article  |  2019  |  Ocular Immunology and Inflammation

Migration rate of presumed immature dendritic cells in the healthy living human cornea as imaged with In vivo corneal confocal microscopy

Luisa H Colorado, Katie Edwards, Holly Rose Chinnery, Haydee EP Bazan

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The role of resident dendritic cells in the maintenance of corneal epithelial sensory nerves

Holly Rose Chinnery, Haihan Jiao, Cecilia Naranjo Golborne

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Novel alterations to the corneal neuroimmune phenotype in mice with central nervous system tauopathy

Haihan Jiao, Laura Elizabeth Downie, Sara Oberrauch, Mengliang Wu, Holly Rose Chinnery, Laura Jacobson

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The Effects of Aging on Corneal and Ocular Surface Homeostasis in Mice

Manikkuwadura Eranda Harshan De Silva, Lisa J Hill, Laura E Downie, Holly R Chinnery

Journal article  |  2019  |  Investigative Opthalmology & Visual Science

Anterior segment optical coherence tomography: its application in clinical practice and experimental models of disease

Haihan Jiao, Lisa J Hill, Laura E Downie, Holly R Chinnery

Journal article  |  2019  |  Clinical and Experimental Optometry

Regional and functional heterogeneity of antigen presenting cells in the mouse brain and meninges

Samantha J Dando, Renee Kazanis, Holly R Chinnery, Paul G McMenamin

Journal article  |  2019  |  Glia

Morphological changes to murine corneal dendritic cells after local and systemic inflammation

Holly Rose Chinnery, Samantha Dando, Paul G McMenamin, Cecilia Naranjo Golborne

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Reversibility of retinal ganglion cell dysfunction due to chronic IOP elevation.

Da Zhao, Vickie Hoi Ying Wong, Zheng He, Christine Tram Oanh Nguyen, Andrew Ian Jobling, Erica Fletcher, Holly Chinnery, Patricia Jusuf, Jeremiah KH Lim, Algis J Vingrys, Bang V Bui

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Retinal vascular reactivity in a mouse model of Alzheimer's disease

Jeremiah KH Lim, Qiao-xin Li, Holly Rose Chinnery, Zheng He, Algis J Vingrys, Bang V Bui, Christine Tram Oanh Nguyen

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Recovery of the sub-basal nerve plexus and superficial nerve terminals after corneal epithelial injury in mice

Laura E Downie, Cecilia Naranjo Golborne, Merry Chen, Ho Ngoc, Hoac Cam, Dasun Liyanapathirana, Carol Luo, Ruo Bing Wu, Holly R Chinnery

Journal article  |  2018  |  Experimental Eye Research

Laser scanning in vivo confocal microscopy (IVCM) for evaluating human corneal sub-basal nerve plexus parameters: protocol for a systematic review

Manikkuwadura Eranda Harshan De Silva, Alexis Ceecee Zhang, Amalia Karahalios, Holly Rose Chinnery, Laura Elizabeth Downie

Journal article  |  2017  |  BMJ Open

Omega-3 supplementation is neuroprotective to corneal nerves in dry eye disease: a pilot study

Holly R Chinnery, Cecilia Naranjo Golborne, Laura E Downie

Journal article  |  2017  |  Ophthalmic and Physiological Optics

Functional characterisation of CD11c-eYFP( ) cells during systemic inflammation reveals that the mouse retina is devoid of antigen presenting cells

Samantha Dando, Renee Kazanis, Holly Rose Chinnery, Claude Charles Bernard, Paul McMenamin

Conference Proceedings  |  2017  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Optical Coherence Tomography Reveals Changes to Corneal Reflectivity and Thickness in Individuals with Tear Hyperosmolarity

Laura Adelaide Deinema, Algis Jonas Vingrys, Holly Rose Chinnery, Laura Elizabeth Downie

Journal article  |  2017  |  Translational Vision Science & Technology

Macrophage physiology in the eye

Holly R Chinnery, Paul G McMenamin, Samantha J Dando

Journal article  |  2017  |  Pflügers Archiv - European Journal of Physiology

A Randomized, Double-Masked, Placebo-Controlled Clinical Trial of Two Forms of Omega-3 Supplements for Treating Dry Eye Disease

Laura A Deinema, Algis J Vingrys, Chinn Yi Wong, David C Jackson, Holly R Chinnery, Laura E Downie

Journal article  |  2017  |  Ophthalmology

Characterization of the Circumlimbal Suture Model of Chronic IOP Elevation in Mice and Assessment of Changes in Gene Expression of Stretch Sensitive Channels.

Da Zhao, Christine TO Nguyen, Vickie HY Wong, Jeremiah KH Lim, Zheng He, Andrew I Jobling, Erica L Fletcher, Holly R Chinnery, Algis J Vingrys, Bang V Bui

Journal article  |  2017  |  Frontiers in Neuroscience

To consider whether a circumlimbal suture can be used to chronically elevate intraocular pressure (IOP) in mice and to assess its ..

Circumlimbal suture chronic intraocular pressure elevation in mice

Bang V Bui, Da Zhao, Tram Oanh Nguyen Christine, Jeremiah KH Lim, Holly Rose Chinnery, Algis I Vingrys, Zheng He

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Amyloid-beta in the rodent retina exhibits a characteristic hyperspectral profile

Christine Tram Oanh Nguyen, Jeremiah KH Lim, Zheng He, Algis J Vingrys, Holly Rose Chinnery, Timothy Marc Ryan, Qiao-Xin Li, Bang V Bui

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

The rd8 mutation in the Crumbs1 gene upregulates activation markers on retinal and brain microglia and CD11c-eYFP( ) cells

Samantha Dando, Cecilia Naranjo-Golborne, Holly Chinnery, Marc Ruitenberg, Paul G McMenamin

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Age-related changes in retinal structure and function in a mouse model of Alzheimer's disease

Jeremiah KH Lim, Zheng He, Algis J Vingrys, Holly Rose Chinnery, Qiao-Xin Li, Bang V Bui, Christine Tram Oanh Nguyen

Conference Proceedings  |  2016  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

A Case of Mistaken Identity: CD11c-eYFP( ) Cells in the Normal Mouse Brain Parenchyma and Neural Retina Display the Phenotype of Microglia, Not Dendritic Cells

Samantha J Dando, Cecilia Naranjo Golborne, Holly R Chinnery, Marc J Ruitenberg, Paul G McMenamin

Journal article  |  2016  |  Glia

Immune privilege in the central nervous system revisited: are there dendritic cells in the brain?

S Dando, H Chinnery, M Ruitenberg, P McMenamin

Conference Proceedings  |  2016  |  EUROPEAN JOURNAL OF IMMUNOLOGY

Longitudinal Changes to Tight Junction Expression and Endothelial Cell Integrity in a Mouse Model of Sterile Corneal Inflammation

Laura E Downie, Janet Choi, Jeremiah KH Lim, Holly R Chinnery

Journal article  |  2016  |  Investigative Opthalmology & Visual Science

Retinal Microglial Activation Following Topical Application of Intracellular Toll-Like Receptor Ligands

Holly R Chinnery, Cecilia Naranjo Golborne, Cheng M Leong, Weisan Chen, John V Forrester, Paul G McMenamin

Journal article  |  2015  |  Investigative Opthalmology & Visual Science

Alterations in tight junction expression and endothelial cell density during a mouse model of sterile corneal inflammation

Holly Rose Chinnery

Conference Proceedings  |  2015  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea

HR Chinnery, CME Leong, W Chen, JV Forrester, PG McMenamin

Journal article  |  2015  |  Journal of leukocyte biology

TLR9 and TLR7/8 activation induces formation of keratic precipitates and giant macrophages in the mouse cornea

Holly R Chinnery, Cheng Mee Leong, Weisan Chen, John V Forrester, Paul G McMenamin

Journal article  |  2015  |  Journal of Leukocyte Biology

Monitoring of Strain-Dependent Responsiveness to TLR Activation in the Mouse Anterior Segment Using SD-OCT

Laura Elizabeth Downie, Matthew James Stainer, Holly Rose Chinnery

Journal article  |  2014  |  Investigative Ophthalmology & Visual Science

A Novel Association Between Resident Tissue Macrophages and Nerves in the Peripheral Stroma of the Murine Cornea

Yashar Seyed-Razavi, Holly R Chinnery, Paul G McMenamin

Journal article  |  2014  |  Investigative Ophthalmology and Visual Science

Effect of vascular endothelial growth factor upregulation on retinal gene expression in the Kimba mouse

Nicolette Binz, Ireni S Ali Rahman, Holly R Chinnery, Richard McKeone, Ken M Simpson, Terence P Speed, Chooi-May Lai, P Elizabeth Rakoczy

Journal article  |  2013  |  Clinical & Experimental Ophthalmology

Interferon γ-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection.

Martin S Zinkernagel, Holly R Chinnery, Monique L Ong, Claire Petitjean, Valentina Voigt, Samuel McLenachan, Paul G McMenamin, Geoffrey R Hill, John V Forrester, Matthew E Wikstrom, Mariapia A Degli-Esposti

Journal article  |  2013  |  The American Journal of Pathology

Microglial cells are the resident macrophages of the central nervous system and participate in both innate and adaptive immune res..

Host defense at the ocular surface.

Eric Pearlman, Yan Sun, Sanhita Roy, Mausita Karmakar, Amy G Hise, Loretta Szczotka-Flynn, Mahmoud Ghannoum, Holly R Chinnery, Paul G McMenamin, Arne Rietsch

Journal article  |  2013  |  International Reviews of Immunology

Microbial infections of the cornea frequently cause painful, blinding and debilitating disease that is often difficult to treat an..

Membrane nanotubes in myeloid cells in the adult mouse cornea represent a novel mode of immune cell interaction.

Yashar Seyed-Razavi, Michael J Hickey, Lucia Kuffová, Paul G McMenamin, Holly R Chinnery

Journal article  |  2013  |  Immunology and Cell Biology

Membrane nanotubes (MNTs) are newly discovered cellular extensions that are either blind-ended or can connect widely separated cel..

Accumulation of murine subretinal macrophages: effects of age, pigmentation and CX(3)CR1

Holly R Chinnery, Samuel McLenachan, Timothy Humphries, Jelena M Kezic, Xiangting Chen, Marc J Ruitenberg, Paul G McMenamin

Journal article  |  2012  |  Neurobiology of Aging

Changes in Murine Hyalocytes Are Valuable Early Indicators of Ocular Disease

Nina N Vagaja, Holly R Chinnery, Nicolette Binz, Jelena M Kezic, Elizabeth P Rakoczy, Paul G McMenamin

Journal article  |  2012  |  Investigative Opthalmology & Visual Science

TLR9 ligand CpG-ODN applied to the injured mouse cornea elicits retinal inflammation.

Holly R Chinnery, Samuel McLenachan, Nicolette Binz, Yan Sun, John V Forrester, Mariapia A Degli-Esposti, Eric Pearlman, Paul G McMenamin

Journal article  |  2012  |  The American Journal of Pathology

During bacterial and viral infections, unmethylated CpG-DNA released by proliferating and dying microbes is recognized by toll-lik..

Bone marrow chimeric mice reveal a role for CX₃CR1 in maintenance of the monocyte-derived cell population in the olfactory neuroepithelium.

Jana Vukovic, Linda V Blomster, Holly R Chinnery, Wolfgang Weninger, Steffen Jung, Paul G McMenamin, Marc J Ruitenberg

Journal article  |  2010  |  Journal of Leukocyte Biology

Macrophages in the olfactory neuroepithelium are thought to play major roles in tissue homeostasis and repair. However, little inf..

Novel characterization of monocyte-derived cell populations in the meninges and choroid plexus and their rates of replenishment in bone marrow chimeric mice.

Holly R Chinnery, Marc J Ruitenberg, Paul G McMenamin

Journal article  |  2010  |  Journal of Neuropathology & Experimental Neurology

The mouse dura mater, pia mater, and choroid plexus contain resident macrophages and dendritic cells (DCs). These cells participat..

In vivo imaging of ocular MCMV infection.

Martin S Zinkernagel, Claire Petitjean, Peter Fleming, Holly R Chinnery, Ian J Constable, Paul G McMenamin, Mariapia A Degli-Esposti

Journal article  |  2010  |  Investigative Opthalmology & Visual Science

PURPOSE: To develop a technique by which murine cytomegalovirus (MCMV) infection can be confirmed and monitored in vivo in various..

Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation.

Holly R Chinnery, Eric C Carlson, Yan Sun, Michelle Lin, Sandra H Burnett, Victor L Perez, Paul G McMenamin, Eric Pearlman

Journal article  |  2009  |  The Journal of Immunology

The mammalian cornea contains an extensive network of resident macrophages and dendritic cells. To determine the role of these cel..

Turnover of bone marrow-derived cells in the irradiated mouse cornea.

Holly R Chinnery, Timothy Humphries, Adam Clare, Ariane E Dixon, Kristen Howes, Caitlin B Moran, Danielle Scott, Marianna Zakrzewski, Eric Pearlman, Paul G McMenamin

Journal article  |  2008  |  Immunology

In light of an increasing awareness of the presence of bone marrow (BM)-derived macrophages in the normal cornea and their uncerta..

Toll-like receptors at the ocular surface.

Eric Pearlman, Angela Johnson, Gautam Adhikary, Yan Sun, Holly R Chinnery, Todd Fox, Mark Kester, Paul G McMenamin

Journal article  |  2008  |  The Ocular Surface

The Toll-like receptor (TLR) family of pathogen recognition molecules has an important role in recognizing microbial pathogens and..

Cutting edge: Membrane nanotubes in vivo: a feature of MHC class II cells in the mouse cornea.

Holly R Chinnery, Eric Pearlman, Paul G McMenamin

Journal article  |  2008  |  The Journal of Immunology

Membrane nanotubes are a recently discovered form of cellular protrusion between two or more cells whose functions include cell co..

Retinal microglia and uveal tract dendritic cells and macrophages are not CX3CR1 dependent in their recruitment and distribution in the young mouse eye.

Jelena Kezic, Heping Xu, Holly R Chinnery, Connor C Murphy, Paul G McMenamin

Journal article  |  2008  |  Investigative Ophthalmology and Visual Science

PURPOSE: The chemokine receptor CX3CR1 is expressed by monocyte-derived dendritic cells (DCs) and macrophages. CX3CR1 mediates leu..

The chemokine receptor CX3CR1 mediates homing of MHC class II-positive cells to the normal mouse corneal epithelium.

Holly R Chinnery, Marc J Ruitenberg, Giles W Plant, Eric Pearlman, Steffen Jung, Paul G McMenamin

Journal article  |  2007  |  Investigative Opthalmology & Visual Science

PURPOSE: Recent investigations have revealed that populations of macrophages and dendritic cells (DCs) are present in the stroma a..

Band-like opacity in the corneas of abattoir-acquired pig eyes.

Holly Chinnery, Jelena Kezic, Season Yeung, Paul G McMenamin

Journal article  |  2005  |  Clinical and Experimental Ophthalmology

In the course of an investigation into the distribution of immune cells in the porcine cornea, a band-like lesion on the cornea of..