Holly Chinnery

Corneal immune cell morphometry as an indicator of local and systemic pathology: A review.

Holly R Chinnery, Xin Yuan Zhang, Ching Yi Wu, Laura E Downie

Journal article  |  2021  |  Clin Exp Ophthalmol

The corneal epithelium contains a population of resident immune cells commonly referred to as dendritic cells (DCs), or Langerhans..

Identification of presumed corneal neuromas and microneuromas using laser-scanning in vivo confocal microscopy: a systematic review.

Holly Rose Chinnery, Rajni Rajan, Haihan Jiao, Mengliang Wu, Alexis Ceecee Zhang, Manikkuwadura Eranda Harshan De Silva, Eve Makrai, Mary Ann Stepp, Nick Di Girolamo, Laura Elizabeth Downie

Journal article  |  2021  |  Br J Ophthalmol

BACKGROUND/AIMS: This systematic review critically evaluated peer-reviewed publications describing morphological features consiste..

Altered Corneal Epithelial Dendritic Cell Morphology and Phenotype Following Acute Exposure to Hyperosmolar Saline

Kirthana Senthil, Haihan Jiao, Laura E Downie, Holly R Chinnery

Journal article  |  2021  |  Investigative Ophthalmology and Visual Science

Purpose: The purpose of this study was to assess the morphological and phenotypic responses of corneal epithelial dendritic cells ..

Morphometric Changes to Corneal Dendritic Cells in Individuals With Mild Cognitive Impairment

Cirous Dehghani, Shaun Frost, Rajiv Jayasena, Christopher Fowler, Colin L Masters, Yogesan Kanagasingam, Haihan Jiao, Jeremiah KH Lim, Holly R Chinnery, Laura E Downie

Journal article  |  2020  |  FRONTIERS IN NEUROSCIENCE

Purpose: There has been increasing interest in identifying non-invasive, imaging biomarkers for neurodegenerative disorders of the..

The effect of high-fat diet-induced metabolic disturbance on corneal neuroimmune features

Haihan Jiao, Alicia SL Lim, Therese E Fazio Coles, Rachel M McQuade, John B Furness, Holly R Chinnery

Journal article  |  2020  |  EXPERIMENTAL EYE RESEARCH

PURPOSE: The highly innervated cornea is susceptible to nerve loss secondary to systemic diseases such as diabetes and metabolic d..

In vivo immune cell dynamics in the human cornea

Luisa H Colorado, Katie Edwards, Holly R Chinnery, Haydee E Bazan

Journal article  |  2020  |  EXPERIMENTAL EYE RESEARCH

In vivo confocal microscopy (IVCM) allows the evaluation of the living human cornea at the cellular level. The non-invasive nature..

Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer's Disease

Jeremiah KH Lim, Qiao-Xin Li, Zheng He, Algis J Vingrys, Holly R Chinnery, Jamie Mullen, Bang V Bui, Christine TO Nguyen

Journal article  |  2020  |  FRONTIERS IN NEUROSCIENCE

Alzheimer's disease is characterized by the aberrant deposition of protein in the brain and is the leading cause of dementia world..

Corneal Epithelial "Neuromas": A Case of Mistaken Identity?

Mary Ann Stepp, Sonali Pal-Ghosh, Laura E Downie, Alexis Ceecee Zhang, Holly R Chinnery, Joshua Machet, Nick Di Girolamo

Journal article  |  2020  |  CORNEA

Laser scanning in vivo confocal microscopy is a useful clinical tool to assess the corneal nerves in human and laboratory animals...

The neuroregenerative effects of topical decorin on the injured mouse cornea

Mengliang Wu, Laura E Downie, Liam M Grover, Richard JA Moakes, Saaeha Rauz, Ann Logan, Haihan Jiao, Lisa J Hill, Holly R Chinnery

Journal article  |  2020  |  JOURNAL OF NEUROINFLAMMATION

BACKGROUND: The cornea is innervated with a rich supply of sensory nerves that play important roles in ocular surface health. Any ..

Novel alterations in corneal neuroimmune phenotypes in mice with central nervous system tauopathy

Haihan Jiao, Laura E Downie, Xin Huang, Mengliang Wu, Sara Oberrauch, Ryan J Keenan, Laura H Jacobson, Holly R Chinnery

Journal article  |  2020  |  JOURNAL OF NEUROINFLAMMATION

BACKGROUND: Tauopathy in the central nervous system (CNS) is a histopathological hallmark of frontotemporal dementia (FTD) and Alz..