Andrew Keniry

A method for stabilising the XX karyotype in female mESC cultures

Andrew Keniry, Natasha Jansz, Peter F Hickey, Kelsey A Breslin, Megan Iminitoff, Tamara Beck, Quentin Gouil, Matthew E Ritchie, Marnie E Blewitt

Journal article  |  2022  |  DEVELOPMENT

Female mouse embryonic stem cells (mESCs) present differently from male mESCs in several fundamental ways; however, complications ..

Maternal SMCHD1 regulates Hox gene expression and patterning in the mouse embryo.

Natalia Benetti, Quentin Gouil, Andres Tapia Del Fierro, Tamara Beck, Kelsey Breslin, Andrew Keniry, Edwina McGlinn, Marnie E Blewitt

Journal article  |  2022  |  Nat Commun

Parents transmit genetic and epigenetic information to their offspring. Maternal effect genes regulate the offspring epigenome to ..

Maternal SMCHD1 controls both imprinted Xist expression and imprinted X chromosome inactivation

Iromi Wanigasuriya, Sarah A Kinkel, Tamara Beck, Ellise A Roper, Kelsey Breslin, Heather J Lee, Andrew Keniry, Matthew E Ritchie, Marnie E Blewitt, Quentin Gouil

Journal article  |  2022  |  EPIGENETICS & CHROMATIN

Embryonic development is dependent on the maternal supply of proteins through the oocyte, including factors setting up the adequat..

BAF complex-mediated chromatin relaxation is required for establishment of X chromosome inactivation

Andrew Keniry, Natasha Jansz, Linden J Gearing, Iromi Wanigasuriya, Joseph Chen, Christian M Nefzger, Peter F Hickey, Quentin Gouil, Joy Liu, Kelsey A Breslin, Megan Iminitoff, Tamara Beck, Andres Tapia del Fierro, Lachlan Whitehead, Andrew Jarratt, Sarah A Kinkel, Phillippa C Taberlay, Tracy Willson, Miha Pakusch, Matthew E Ritchie, et al.

Journal article  |  2022  |  NATURE COMMUNICATIONS

The process of epigenetic silencing, while fundamentally important, is not yet completely understood. Here we report a replenishab..

Smchd1 is a maternal effect gene required for genomic imprinting

Iromi Wanigasuriya, Quentin Gouil, Sarah A Kinkel, Andres Tapia del Fierro, Tamara Beck, Ellise A Roper, Kelsey Breslin, Jessica Stringer, Karla Hutt, Heather J Lee, Andrew Keniry, Matthew E Ritchie, Marnie E Blewitt

Journal article  |  2020  |  ELIFE

Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific ..

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  Nature Communications

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

Using long-read sequencing to detect imprinted DNA methylation

Scott Gigante, Quentin Gouil, Alexis Lucattini, Andrew Keniry, Tamara Beck, Matthew Tinning, Lavinia Gordon, Chris Woodruff, Terence P Speed, Marnie E Blewitt, Matthew E Ritchie

Journal article  |  2019  |  NUCLEIC ACIDS RESEARCH

Systematic variation in the methylation of cytosines at CpG sites plays a critical role in early development of humans and other m..

Latest techniques to study DNA methylation

Quentin Gouil, Andrew Keniry

Journal article  |  2019  |  DNA METHYLATION

Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has immensely contributed to our understanding..

Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway

Natasha Jansz, Tatyana Nesterova, Andrew Keniry, Megan Iminitoff, Peter F Hickey, Greta Pintacuda, Osamu Masui, Simon Kobelke, Niall Geoghegan, Kelsey A Breslin, Tracy A Willson, Kelly Rogers, Graham F Kay, Archa H Fox, Haruhiko Koseki, Neil Brockdorff, James M Murphy, Marnie E Blewitt

Journal article  |  2018  |  CELL REPORTS

We and others have recently reported that the SMC protein Smchd1 is a regulator of chromosome conformation. Smchd1 is critical for..

Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters

Natasha Jansz, Andrew Keniry, Marie Trussart, Heidi Bildsoe, Tamara Beck, Ian D Tonks, Arne W Mould, Peter Hickey, Kelsey Breslin, Megan Iminitoff, Matthew E Ritchie, Edwina McGlinn, Graham F Kay, James M Murphy, Marnie E Blewitt

Journal article  |  2018  |  NATURE STRUCTURAL & MOLECULAR BIOLOGY

The regulation of higher-order chromatin structure is complex and dynamic, and a full understanding of the suite of mechanisms gov..