Andrew Keniry

Smchd1 is a maternal effect gene required for genomic imprinting

Iromi Wanigasuriya, Quentin Gouil, Sarah A Kinkel, Andres Tapia del Fierro, Tamara Beck, Ellise A Roper, Kelsey Breslin, Jessica Stringer, Karla Hutt, Heather J Lee, Andrew Keniry, Matthew E Ritchie, Marnie E Blewitt

Journal article  |  2020  |  eLife

Genomic imprinting establishes parental allele-biased expression of a suite of mammalian genes based on parent-of-origin specific ..

Unique properties of a subset of human pluripotent stem cells with high capacity for self-renewal

Kevin X Lau, Elizabeth A Mason, Joshua Kie, David P De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J McConville, Andrew Keniry, Tamara Beck, Marnie E Blewitt, Matthew E Ritchie, Shalin H Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L Baker, Tracy C McGarr, Christine A Wells, et al.

Journal article  |  2020  |  Nature Communications

Archetypal human pluripotent stem cells (hPSC) are widely considered to be equivalent in developmental status to mouse epiblast st..

Using long-read sequencing to detect imprinted DNA methylation

Scott Gigante, Quentin Gouil, Alexis Lucattini, Andrew Keniry, Tamara Beck, Matthew Tinning, Lavinia Gordon, Chris Woodruff, Terence P Speed, Marnie E Blewitt, Matthew E Ritchie

Journal article  |  2019  |  Nucleic Acids Research

Systematic variation in the methylation of cytosines at CpG sites plays a critical role in early development of humans and other m..

Latest techniques to study DNA methylation

Quentin Gouil, Andrew Keniry

Journal article  |  2019  |  Essays in Biochemistry

Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has immensely contributed to our understanding..

Smchd1 Targeting to the Inactive X Is Dependent on the Xist-HnrnpK-PRC1 Pathway

Natasha Jansz, Tatyana Nesterova, Andrew Keniry, Megan Iminitoff, Peter F Hickey, Greta Pintacuda, Osamu Masui, Simon Kobelke, Niall Geoghegan, Kelsey A Breslin, Tracy A Willson, Kelly Rogers, Graham F Kay, Archa H Fox, Haruhiko Koseki, Neil Brockdorff, James M Murphy, Marnie E Blewitt

Journal article  |  2018  |  Cell Reports

We and others have recently reported that the SMC protein Smchd1 is a regulator of chromosome conformation. Smchd1 is critical for..

Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters

Natasha Jansz, Andrew Keniry, Marie Trussart, Heidi Bildsoe, Tamara Beck, Ian D Tonks, Arne W Mould, Peter Hickey, Kelsey Breslin, Megan Iminitoff, Matthew E Ritchie, Edwina McGlinn, Graham F Kay, James M Murphy, Marnie E Blewitt

Journal article  |  2018  |  Nature Structural & Molecular Biology

The regulation of higher-order chromatin structure is complex and dynamic, and a full understanding of the suite of mechanisms gov..

Studying X chromosome inactivation in the single-cell genomic era

Andrew Keniry, Marnie E Blewitt

Journal article  |  2018  |  Biochemical Society Transactions

Single-cell genomics is set to revolutionise our understanding of how epigenetic silencing works; by studying specific epigenetic ..

Analysis of Histone Modifications in Acute Myeloid Leukaemia Using Chromatin Immunoprecipitation

Benjamin J Shields, Andrew Keniry, Marnie E Blewitt, Matthew P McCormack

Journal article  |  2018  |  Methods in molecular biology (Clifton, N.J.)

Chromatin Immunoprecipitation (ChIP) using antibodies specific for histone modifications is a powerful technique for assessing the..

High concordance between Illumina HiSeq2500 and NextSeq500 for reduced representation bisulfite sequencing (RRBS)

Danqing Yin, Matthew E Ritchie, Jafar S Jabbari, Tamara Beck, Marnie E Blewitt, Andrew Keniry

Journal article  |  2016  |  Genomics Data

Reduced representation bisulfite sequencing (RRBS) provides an efficient method for measuring DNA methylation at single base resol..

Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing

Andrew Keniry, Linden J Gearing, Natasha Jansz, Joy Liu, Aliaksei Z Holik, Peter F Hickey, Sarah A Kinkel, Darcy L Moore, Kelsey Breslin, Kelan Chen, Ruijie Liu, Catherine Phillips, Miha Pakusch, Christine Biben, Julie M Sheridan, Benjamin T Kile, Catherine Carmichael, Matthew E Ritchie, Douglas J Hilton, Marnie E Blewitt

Journal article  |  2016  |  Epigenetics and Chromatin

BACKGROUND: The presence of histone 3 lysine 9 (H3K9) methylation on the mouse inactive X chromosome has been controversial over t..