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Rachel Koldej's highlights
FEATURED Journal article
Nivolumab induces dynamic alterations in CD8 T-cell function and TIM-3 expression when used to treat relapsed acute myeloid leukemia after allogeneic stem cell transplantationRead more
Rachel Koldej's selected work
Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioni..
Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK cell effector func..
Displaying the most recent project by Rachel Koldej.
Displaying the 22 most recent scholarly works by Rachel Koldej.
Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes
Yuhao Jiao, Joanne E Davis, Jai Rautela, Emma M Carrington, Mandy J Ludford-Menting, Wilford Goh, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T Kile, Andrew M Lew, David S Ritchie, Nicholas D Huntington
Journal article | 2019 | Cell Death & Differentiation
Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AM..
Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK cell effector function in patients with mantle cell lymphoma.
Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik
Journal article | 2019 | Haematologica
Spontaneous onset and transplant models of the Vk*MYC mouse show immunological sequelae comparable to human multiple myeloma
Rachel E Cooke, Nicholas A Gherardin, Simon J Harrison, Hang Quach, Dale I Godfrey, Miles Prince, Rachel Koldej, David S Ritchie
Journal article | 2016 | Journal of Translational Medicine
A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation, and Onset of Graft-versus-Host Disease in Mice
Joanne E Davis, Michael Harvey, Nicholas A Gherardin, Rachel Koldej, Nicholas Huntington, Paul Neeson, Joseph A Trapani, David S Ritchie
Journal article | 2015 | Biology of Blood and Marrow Transplantation
Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor
O Wolstein, M Boyd, M Millington, H Impey, J Boyer, A Howe, F Delebecque, K Cornetta, M Rothe, C Baum, T Nicolson, R Koldej, J Zhang, N Keech, J Camba Colón, L Breton, J Bartlett, DS An, IS Chen, B Burke, et al.
Journal article | 2014 | Molecular Therapy - Methods & Clinical Development
Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors.
Rachel M Koldej, Gael Carney, Matthew M Wielgosz, Sheng Zhou, Jun Zhan, Brian P Sorrentino, Arthur W Nienhuis
Journal article | 2013 | Human Gene Therapy Clinical Development
Gene therapy for the treatment of Wiskott-Aldrich syndrome (WAS) presents an alternative to the current use of allogeneic bone mar..
Lentivirus-mediated gene transfer of interleukin 10 to the ovine and human cornea.
Douglas G Parker, Douglas J Coster, Helen M Brereton, Prue H Hart, Rachel Koldej, Donald S Anson, Keryn A Williams
Journal article | 2010 | Clinical & Experimental Ophthalmology
BACKGROUND: Gene transfer to a donor cornea ex vivo can modulate corneal graft failure in experimental animal models. We compared ..
Refinement of lentiviral vector for improved RNA processing and reduced rates of self inactivation repair.
Rachel M Koldej, Donald S Anson
Journal article | 2009 | BMC Biotechnology
BACKGROUND: Lentiviral gene therapy vectors are now finding clinical application. In order to fully exploit their potential it is ..
Single-dose lentiviral gene transfer for lifetime airway gene expression.
Alice G Stocker, Karlea L Kremer, Rachel Koldej, Darren S Miller, Donald S Anson, David W Parsons
Journal article | 2009 | The Journal of Gene Medicine
BACKGROUND: Cystic fibrosis (CF) is caused by a defect in cystic fibrosis transmembrane conductance regulator (CFTR) activity, oft..
Lentiviral-mediated correction of MPS VI cells and gene transfer to joint tissues.
Sharon Byers, Miriam Rothe, Jelena Lalic, Rachel Koldej, Donald S Anson
Journal article | 2009 | Molecular Genetics and Metabolism
Joint disease in mucopolysaccharidosis type VI (MPS VI) remains difficult to treat despite the success of enzyme replacement thera..
Optimisation of a multipartite human immunodeficiency virus based vector system; control of virus infectivity and large-scale production.
R Koldej, P Cmielewski, A Stocker, DW Parsons, DS Anson
Journal article | 2005 | The Journal of Gene Medicine
BACKGROUND: We have previously described a five-plasmid HIV-1 vector system that utilises a codon-optimised gagpol gene. While thi..
Medicine - Royal Melbourne Hospital
Medicine - Royal Melbourne Hospital
Bachelor of Biotechnology with honours
Flinders University of South Australia
Doctor of Philosophy