Rachel Koldej

Impact of age-, cancer-, and treatment-driven inflammation on T cell function and immunotherapy

Kylie M Quinn, Apriliana ER Kartikasari, Rachel E Cooke, Rachel M Koldej, David S Ritchie, Magdalena Plebanski

Journal article  |  2020  |  Journal of Leukocyte Biology

Many cancers are predominantly diagnosed in older individuals and chronic inflammation has a major impact on the overall health an..

Association between P2X7 Polymorphisms and Post-Transplant Outcomes in Allogeneic Haematopoietic Stem Cell Transplantation

Rachel M Koldej, Travis Perera, Jenny Collins, David S Ritchie

Journal article  |  2020  |  International Journal of Molecular Sciences

Allogeneic stem cell transplantation (alloSCT) is a highly effective treatment method for haematologic malignancies. However, infe..

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma

Thijs WH Flinsenberg, Charnelle C Tromedjo, Nan Hu, Ye Liu, Yin Guo, Kevin YT Thia, Tahereh Noori, Xiaomin Song, Han X Aw Yeang, Daniela G Tantalo, Sasanka Handunnetti, John F Seymour, Andrew W Roberts, David Ritchie, Rachel Koldej, Paul J Neeson, Lai Wang, Joseph A Trapani, Constantine S Tam, Ilia Voskoboinik

Journal article  |  2020  |  Haematologica

Nivolumab induces dynamic alterations in CD8 T-cell function and TIM-3 expression when used to treat relapsed acute myeloid leukemia after allogeneic stem cell transplantation

Eric Wong, Joanne Davis, Rachel Koldej, Jeff Szer, Andrew Grigg, David Ritchie

Journal article  |  2019  |  Leukemia & Lymphoma

Recipient BCL2 inhibition and NK cell ablation form part of a reduced intensity conditioning regime that improves allo-bone marrow transplantation outcomes

Yuhao Jiao, Joanne E Davis, Jai Rautela, Emma M Carrington, Mandy J Ludford-Menting, Wilford Goh, Rebecca B Delconte, Fernando Souza-Fonseca-Guimaraes, Rachel Koldej, Daniel Gray, David Huang, Ben T Kile, Andrew M Lew, David S Ritchie, Nicholas D Huntington

Journal article  |  2019  |  Cell Death & Differentiation

Allogeneic hematopoietic stem cell transplantation (alloSCT) is used to treat over 15,000 patients with acute myeloid leukemia (AM..

Immunotherapeutics in Multiple Myeloma: How Can Translational Mouse Models Help?

Rachel E Cooke, Rachel Koldej, David Ritchie

Journal article  |  2019  |  Journal of Oncology

P2X7 polymorphisms and stem cell mobilisation

Rachel Koldej, Jenny Collins, David Ritchie

Journal article  |  2018  |  Leukemia

Comparison of gene expression and flow cytometry for immune profiling in chronic lymphocytic leukaemia

Chia Sharpe, Joanne Davis, Kylie Mason, Constantine Tam, David Ritchie, Rachel Koldej

Journal article  |  2018  |  Journal of Immunological Methods

More Than a BTK Inhibitor; Ibrutinib Profoundly Impacts the Function of Cell Mediated Immunity

Chia Sharpe, Joanne Davis, Kylie D Mason, Dale I Godfrey, Adam Uldrich, Constantine S Tam, Rachel Koldej, David Ritchie

Conference Proceedings  |  2018  |  Blood

Nivolumab for Relapsed or Residual Haematological Malignancies after Allogeneic Haematopoietic Stem Cell Transplantation (NIVALLO)

Eric Wong, Emily Dawson, Joanne Davis, Rachel Koldej, Mandy Ludford-Menting, Matthew Lansdown, Heather Lambie, Jeffrey Szer, Andrew P Grigg, David Ritchie

Conference Proceedings  |  2018  |  Blood

The Impact of Vitamin D Replacement on Survival, Relapse and GvHD after Allogeneic Stem Cell Transplantation: A Matched Cohort Analysis

Sara Mastaglio, Eric Wong, Travis Perera, Andrew Lim, Kate Mason, Jenny Collins, Jeff Szer, Andrew Grigg, Rachel Koldej, David Ritchie

Conference Proceedings  |  2018  |  BONE MARROW TRANSPLANTATION

Natural killer receptor ligand expression on acute myeloid leukemia impacts survival and relapse after chemotherapy

Sara Mastaglio, Eric Wong, Travis Perera, Jane Ripley, Piers Blombery, Mark J Smyth, Rachel Koldej, David Ritchie

Journal article  |  2018  |  Blood Advances

miRNA expression profiling of cerebrospinal fluid in patients with aneurysmal subarachnoid hemorrhage

Stanley S Stylli, Alexios A Adamides, Rachel M Koldej, Rodney B Luwor, David S Ritchie, James Ziogas, Andrew H Kaye

Journal article  |  2017  |  Journal of Neurosurgery

PREOPERATIVE SERUM microRNA PROFILING AS A DIAGNOSTIC TOOL IN GLIOMA

Andrew Morokoff, Iwan Bennett, Lucy Paradiso, Rod Luwor, Michael Wong, Rachel Koldej, Jason Li, Chenkai Ma, Kate Drummond, Stanley Stylli, Andrew Kaye, Tali Siegal

Conference Proceedings  |  2016  |  NEURO-ONCOLOGY

Spontaneous onset and transplant models of the Vk*MYC mouse show immunological sequelae comparable to human multiple myeloma

Rachel E Cooke, Nicholas A Gherardin, Simon J Harrison, Hang Quach, Dale I Godfrey, Miles Prince, Rachel Koldej, David S Ritchie

Journal article  |  2016  |  JOURNAL OF TRANSLATIONAL MEDICINE

MicroRNA as potential biomarkers in Glioblastoma

Zammam Areeb, Stanley S Stylli, Rachel Koldej, David S Ritchie, Tali Siegal, Andrew P Morokoff, Andrew H Kaye, Rodney B Luwor

Journal article  |  2015  |  JOURNAL OF NEURO-ONCOLOGY

A Radio-Resistant Perforin-Expressing Lymphoid Population Controls Allogeneic T Cell Engraftment, Activation, and Onset of Graft-versus-Host Disease in Mice

Joanne E Davis, Michael Harvey, Nicholas A Gherardin, Rachel Koldej, Nicholas Huntington, Paul Neeson, Joseph A Trapani, David S Ritchie

Journal article  |  2015  |  Biology of Blood and Marrow Transplantation

Preclinical safety and efficacy of an anti-HIV-1 lentiviral vector containing a short hairpin RNA to CCR5 and the C46 fusion inhibitor

O Wolstein, M Boyd, M Millington, H Impey, J Boyer, A Howe, F Delebecque, K Cornetta, M Rothe, C Baum, T Nicolson, R Koldej, J Zhang, N Keech, J Camba Colón, L Breton, J Bartlett, DS An, IS Chen, B Burke, et al.

Journal article  |  2014  |  Molecular Therapy - Methods & Clinical Development

Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors.

Rachel M Koldej, Gael Carney, Matthew M Wielgosz, Sheng Zhou, Jun Zhan, Brian P Sorrentino, Arthur W Nienhuis

Journal article  |  2013  |  Human Gene Therapy Clinical Development

Gene therapy for the treatment of Wiskott-Aldrich syndrome (WAS) presents an alternative to the current use of allogeneic bone mar..

Lentivirus-mediated gene transfer of interleukin 10 to the ovine and human cornea.

Douglas G Parker, Douglas J Coster, Helen M Brereton, Prue H Hart, Rachel Koldej, Donald S Anson, Keryn A Williams

Journal article  |  2010  |  Clinical & Experimental Ophthalmology

BACKGROUND: Gene transfer to a donor cornea ex vivo can modulate corneal graft failure in experimental animal models. We compared ..

Refinement of lentiviral vector for improved RNA processing and reduced rates of self inactivation repair.

Rachel M Koldej, Donald S Anson

Journal article  |  2009  |  BMC Biotechnology

BACKGROUND: Lentiviral gene therapy vectors are now finding clinical application. In order to fully exploit their potential it is ..

Single-dose lentiviral gene transfer for lifetime airway gene expression.

Alice G Stocker, Karlea L Kremer, Rachel Koldej, Darren S Miller, Donald S Anson, David W Parsons

Journal article  |  2009  |  The Journal of Gene Medicine

BACKGROUND: Cystic fibrosis (CF) is caused by a defect in cystic fibrosis transmembrane conductance regulator (CFTR) activity, oft..

Lentiviral-mediated correction of MPS VI cells and gene transfer to joint tissues.

Sharon Byers, Miriam Rothe, Jelena Lalic, Rachel Koldej, Donald S Anson

Journal article  |  2009  |  Molecular Genetics and Metabolism

Joint disease in mucopolysaccharidosis type VI (MPS VI) remains difficult to treat despite the success of enzyme replacement thera..

Lentivirus-mediated gene transfer to the rat, ovine and human cornea

DGA Parker, C Kaufmann, HM Brereton, DS Anson, L Francis-Staite, CF Jessup, K Marshall, C Tan, R Koldej, DJ Coster, KA Williams

Journal article  |  2007  |  Gene Therapy

Lentiviral-mediated gene correction of mucopolysaccharidosis type IIIA

DS Anson, C McIntyre, B Thomas, R Koldej, E Ranieri, A Roberts, PR Clements, K Dunning, S Byers

Journal article  |  2007  |  Genetic Vaccines and Therapy

Optimisation of a multipartite human immunodeficiency virus based vector system; control of virus infectivity and large-scale production.

R Koldej, P Cmielewski, A Stocker, DW Parsons, DS Anson

Journal article  |  2005  |  The Journal of Gene Medicine

BACKGROUND: We have previously described a five-plasmid HIV-1 vector system that utilises a codon-optimised gagpol gene. While thi..