Vanessa Bryant

BCL-XL antagonism selectively reduces neutrophil life span within inflamed tissues without causing neutropenia

Emma M Carrington, Cynthia Louis, Tobias Kratina, Manuela Hancock, Christine R Keenan, Nadia Iannarella, Rhys S Allan, Ahmad Z Wardak, Peter E Czabotar, Marco J Herold, Robyn L Schenk, Christine A White, Damian D'Silva, Yuyan Yang, Wesley Wong, Huon Wong, Vanessa L Bryant, Nicholas D Huntington, Jai Rautela, Robyn M Sutherland, et al.

Journal article  |  2021  |  BLOOD ADVANCES

Neutrophils help to clear pathogens and cellular debris, but can also cause collateral damage within inflamed tissues. Prolonged n..

B cells in lung cancer-not just a bystander cell: a literature review

Tracy L Leong, Vanessa L Bryant

Journal article  |  2021  |  TRANSLATIONAL LUNG CANCER RESEARCH

Metastatic lung cancer represents a significant global issue where it is responsible for the most cancer diagnoses and deaths worl..

A single-cell RNA expression atlas of normal, preneoplastic and tumorigenic states in the human breast

Bhupinder Pal, Yunshun Chen, Francois Vaillant, Bianca D Capaldo, Rachel Joyce, Xiaoyu Song, Vanessa L Bryant, Jocelyn S Penington, Leon Di Stefano, Nina Tubau Ribera, Stephen Wilcox, Gregory B Mann, Anthony T Papenfuss, Geoffrey J Lindeman, Gordon K Smyth, Jane E Visvader

Journal article  |  2021  |  EMBO JOURNAL

To examine global changes in breast heterogeneity across different states, we determined the single-cell transcriptomes of > 340,0..

When B cells break bad: development of pathogenic B cells in Sjögren's syndrome.

Joanne H Reed, Gwenny Matthea Verstappen, Maureen Rischmueller, Vanessa L Bryant

Journal article  |  2020  |  Clin Exp Rheumatol

Primary Sjögren's syndrome (pSS) is often considered a B cell-mediated disease, yet the precise role of B cells in the pathogenesi..

IL-17 production by tissue-resident MAIT cells is locally induced in children with pneumonia

Bingtai Lu, Ming Liu, Jun Wang, Huifeng Fan, Diyuan Yang, Li Zhang, Xiaoqiong Gu, Junli Nie, Zhenjun Chen, Alexandra J Corbett, Michael J Zhan, Shengbo Zhang, Vanessa L Bryant, Andrew M Lew, James McCluskey, Hai-bin Luo, Jun Cui, Yuxia Zhang, Yifan Zhan, Gen Lu

Journal article  |  2020  |  MUCOSAL IMMUNOLOGY

Community-acquired pneumonia (CAP) contributes substantially to morbidity and mortality in children under the age of 5 years. In e..

TCF-1 limits the formation of Tc17 cells via repression of the MAF-ROR gamma t axis

Lisa A Mielke, Yang Liao, Ella Bridie Clemens, Matthew A Firth, Brigette Duckworth, Qiutong Huang, Francisca F Almeida, Michael Chopin, Hui-Fern Koay, Carolyn A Bell, Soroor Hediyeh-Zadeh, Simone L Park, Dinesh Raghu, Jarny Choi, Tracy L Putoczki, Philip D Hodgkin, Ashley E Franks, Laura K Mackay, Dale Godfrey, Melissa J Davis, et al.

Journal article  |  2019  |  JOURNAL OF EXPERIMENTAL MEDICINE

Interleukin (IL)-17-producing CD8+ T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and canc..

Fatal Enteroviral Encephalitis in a Patient with Common Variable Immunodeficiency Harbouring a Novel Mutation in NFKB2

Charlotte A Slade, Catriona McLean, Thomas Scerri, Binh Giang Tran, Steven Megaloudis, Alexander Strathmore, Jessica C Tempany, Katherine Nicholls, Colleen D'Arcy, Melanie Bahlo, Philip D Hodgkin, Jo A Douglass, Vanessa L Bryant

Journal article  |  2019  |  JOURNAL OF CLINICAL IMMUNOLOGY

Common variable immunodeficiency is the most prevalent of the primary immunodeficiency diseases, yet its pathogenesis is largely p..

A Demonstration of the Diagnostic and Clinical Utility of Genomic Sequencing in Primary Immunodeficiency Diseases in Australia

Charlotte Slade, Fiona Moghaddas, Sebastian Lunke, Zornitza Stark, Ingrid Winship, Kirsty West, Alison Trainer, Samar Ojaimi, Matthew Hunter, Yael Prawer, Katherine Nicholls, Mittal Patel, Pricilla Auyeung, Kymble Spriggs, Jeremy McComish, Gary Unglik, Joseph De Luca, Samantha Chan, Giulia Valente, Anna Jarmolowicz, et al.

Conference Proceedings  |  2019  |  JOURNAL OF CLINICAL IMMUNOLOGY

Human IFN-gamma immunity to mycobacteria is governed by both IL-12 and IL-23

Ruben Martinez-Barricarte, Janet G Markle, Cindy S Ma, Elissa K Deenick, Noe Ramirez-Alejo, Federico Mele, Daniela Latorre, Seyed Alireza Mandaviani, Caner Aytekin, Davood Mansouri, Vanessa L Bryant, Fabienne Jabot-Hanin, Caroline Deswarte, Alejandro Nieto-Patlan, Laura Surace, Gaspard Kerner, Yuval Itan, Sandra Jovic, Danielle T Avery, Natalie Wong, et al.

Journal article  |  2018  |  SCIENCE IMMUNOLOGY

Hundreds of patients with autosomal recessive, complete IL-12p40 or IL-12Rβ1 deficiency have been diagnosed over the last 20 years..

PITFALLS OF IMMUNOTHERAPY: LESSONS FROM A PATIENT WITH CTLA-4 HAPLOINSUFFICIENCY

Leisa R Watson, Charlotte A Slade, Samar Ojaimi, Sara Barnes, Pasquale Fedele, Prudence Smith, Justine Marum, Sebastian Lunke, Z Stark, Matthew F Hunter, Vanessa L Bryant, Michael SY Low

Conference Proceedings  |  2018  |  INTERNAL MEDICINE JOURNAL