Joe Byrne

Using a Bioactive Eremophila-Derived Serrulatane Scaffold to Generate a Unique Carbamate Library for Anti-infective Evaluations

Chen Zhang, Kah Yean Lum, Aya C Taki, Robin B Gasser, Joseph J Byrne, Luis J Montaner, Ian Tietjen, Vicky M Avery, Rohan A Davis

Journal article  |  2023  |  JOURNAL OF NATURAL PRODUCTS

The known Eremophila microtheca-derived diterpenoid 3,7,8-trihydroxyserrulat-14-en-19-oic acid (1) was targeted for large-scale pu..

Using UHPLC-MS profiling for the discovery of new sponge-derived metabolites and anthelmintic screening of the NatureBank bromotyrosine library

Sasha Hayes, Aya C Taki, Kah Yean Lum, Joseph J Byrne, Merrick G Ekins, Robin B Gasser, Rohan A Davis

Journal article  |  2022  |  BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY

In order to further expand the NatureBank open access compound library, chemical investigations of the Australian marine sponge, I..

Thermal proteome profiling reveals Haemonchus orphan protein HCO_011565 as a target of the nematocidal small molecule UMW-868

Aya CC Taki, Tao Wang, Nghi NN Nguyen, Ching-Seng Ang, Michael GG Leeming, Shuai Nie, Joseph JJ Byrne, Neil DD Young, Yuanting Zheng, Guangxu Ma, Pasi KK Korhonen, Anson VV Koehler, Nicholas AA Williamson, Andreas Hofmann, Bill CH Chang, Cecile Haeberli, Jennifer Keiser, Abdul Jabbar, Brad EE Sleebs, Robin BB Gasser

Journal article  |  2022  |  FRONTIERS IN PHARMACOLOGY

Parasitic roundworms (nematodes) cause destructive diseases, and immense suffering in humans and other animals around the world. T..

Identification of Anthelmintic Bishomoscalarane Sesterterpenes from the Australian Marine Sponge Phyllospongia bergquistae and Structure Revision of Phyllolactones A-D

Sasha Hayes, Aya C Taki, Kah Yean Lum, Joseph J Byrne, Jonathan M White, Merrick G Ekins, Robin B Gasser, Rohan A Davis

Journal article  |  2022  |  JOURNAL OF NATURAL PRODUCTS

High-throughput screening of the NatureBank marine extract library (7616 samples) identified an extract derived from the Australia..

A High-Throughput Phenotypic Screen of the 'Pandemic Response Box' Identifies a Quinoline Derivative with Significant Anthelmintic Activity

Harrison T Shanley, Aya C Taki, Joseph J Byrne, Abdul Jabbar, Tim NC Wells, Kirandeep Samby, Peter R Boag, Nghi Nguyen, Brad E Sleebs, Robin B Gasser

Journal article  |  2022  |  PHARMACEUTICALS

Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematode..

Dysidenin from the Marine Sponge Citronia sp. Affects the Motility and Morphology of Haemonchus contortus Larvae In Vitro

Kelsey S Ramage, Aya C Taki, Kah Yean Lum, Sasha Hayes, Joseph J Byrne, Tao Wang, Andreas Hofmann, Merrick G Ekins, Jonathan M White, Abdul Jabbar, Rohan A Davis, Robin B Gasser

Journal article  |  2021  |  MARINE DRUGS

High-throughput screening of the NatureBank marine extract library (n = 7616) using a phenotypic assay for the parasitic nematode ..

High Throughput Screening of the NatureBank 'Marine Collection' in a Haemonchus Bioassay Identifies Anthelmintic Activity in Extracts from a Range of Sponges from Australian Waters

Aya C Taki, Joseph J Byrne, Abdul Jabbar, Kah Yean Lum, Sasha Hayes, Russell S Addison, Kelsey S Ramage, Andreas Hofmann, Merrick G Ekins, Tao Wang, Bill CH Chang, Rohan A Davis, Robin B Gasser

Journal article  |  2021  |  MOLECULES

Widespread resistance in parasitic nematodes to most classes of anthelmintic drugs demands the discovery and development of novel ..

Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold

Chen Zhang, Kah Yean Lum, Aya C Taki, Robin B Gasser, Joseph J Byrne, Tao Wang, Mark AT Blaskovich, Emery T Register, Luis J Montaner, Ian Tietjen, Rohan A Davis

Journal article  |  2021  |  PHYTOCHEMISTRY

Chemical studies of the aerial parts of the Australian desert plant Eremophila microtheca afforded the targeted and known diterpen..

High-Throughput Phenotypic Assay to Screen for Anthelmintic Activity on Haemonchus contortus

Aya C Taki, Joseph J Byrne, Tao Wang, Brad E Sleebs, Nghi Nguyen, Ross S Hall, Pasi K Korhonen, Bill CH Chang, Paul Jackson, Abdul Jabbar, Robin B Gasser

Journal article  |  2021  |  PHARMACEUTICALS

Parasitic worms cause very significant diseases in animals and humans worldwide, and their control is critical to enhance health, ..

Practical High-Throughput Method to Screen Compounds for Anthelmintic Activity against Caenorhabditis elegans

Aya C Taki, Joseph J Byrne, Peter R Boag, Abdul Jabbar, Robin B Gasser

Journal article  |  2021  |  MOLECULES

In the present study, we established a practical and cost-effective high throughput screening assay, which relies on the measureme..