Toby Mansell

Complex patterns of circulating fatty acid levels in gestational diabetes mellitus subclasses across pregnancy

Ting Zhang, Wen-Rong Jiang, Yin-Yin Xia, Toby Mansell, Richard Saffery, Richard D Cannon, Jamie De Seymour, Zhen Zou, Ge Xu, Ting-Li Han, Hua Zhang, Philip N Baker

Journal article  |  2021  |  CLINICAL NUTRITION

BACKGROUND & AIMS: To investigate the relationship between maternal serum fatty acid levels and gestational diabetes mellitus (GDM..

CHANGES IN PLASMA METABOLITES IN INDIVIDUALS WITH DIABETES ASSOCIATED CHRONIC KIDNEY DISEASE: A CLOSER LOOK AT LIPID PROFILES AND CARDIOVASCULAR RISK

A Lecamwasam, T Mansell, EI Ekinci, R Saffery, KM Dwyer

Conference Proceedings  |  2020  |  NEPHROLOGY

Determinants of placental leptin receptor gene expression and association with measures at birth

Amanda Vlahos, Toby Mansell, David Burgner, Fiona Collier, Boris Novakovic, Richard Saffery

Journal article  |  2020  |  PLACENTA

INTRODUCTION: The leptin signalling pathway is important in metabolic health during pregnancy. However, few studies have investiga..

Sex differences in infant blood metabolite profile in association with weight and adiposity measures

Susan Ellul, Anne-Louise Ponsonby, John B Carlin, Fiona Collier, Toby Mansell, Peter Vuillermin, David Burgner, Richard Saffery

Journal article  |  2020  |  PEDIATRIC RESEARCH

BACKGROUND: Nuclear magnetic resonance (NMR) metabolic profiling quantifies a large number of metabolites. From adolescence, speci..

Prenatal phthalate exposure, oxidative stress-related genetic vulnerability and early life neurodevelopment: A birth cohort study

Anne-Louise Ponsonby, Christos Symeonides, Richard Saffery, Jochen F Mueller, Martin O'Hely, Peter D Sly, Nicole Wardrop, Angela Pezic, Toby Mansell, Fiona Collier, David Burgner, Kristie Thompson, Soumini Vijayasarathy, Eva J Sugeng, Terence Dwyer, Sarath Ranganathan, Peter J Anderson, Vicki Anderson, Peter Vuillermin

Journal article  |  2020  |  NEUROTOXICOLOGY

Prenatal phthalate chemicals may have adverse effects on brain development by various mechanisms including oxidant damage. However..

HIF3Acord blood methylation and systolic blood pressure at 4 years - a population-based cohort study

Toby Mansell, David Burgner, Anne-Louise Ponsonby, Fiona Collier, Angela Pezic, Peter Vuillermin, Markus Juonala, Joanne Ryan, Richard Saffery

Journal article  |  2020  |  EPIGENETICS

Methylation levels at the hypoxia-inducible factor 3α gene (HIF3A) in blood have been linked to body mass index (BMI) in adults. D..

Methylation of the LEP gene promoter in blood at 12 months and BMI at 4 years of age-a population-based cohort study

Toby Mansell, Anne-Louise Ponsonby, Fiona Collier, David Burgner, Angela Pezic, Peter Vuillermin, Joanne Ryan, Richard Saffery

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF OBESITY

Increasing evidence links epigenetic variation to anthropometric and metabolic measures. Leptin signalling regulates appetite and ..

Genetic variation, intrauterine growth, and adverse pregnancy conditions predict leptin gene DNA methylation in blood at birth and 12 months of age

Toby Mansell, Anne-Louise Ponsonby, Fiona Collier, David Burgner, Peter Vuillermin, Katherine Lange, Joanne Ryan, Richard Saffery, John Carlin, Katie Allen, Mimi Tang, Sarath Ranganathan, Terry Dwyer, Kim Jachno, Peter Sly

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF OBESITY

BACKGROUND: Leptin regulates satiety and energy homoeostasis, and plays a key role in placentation in pregnancy. Previous studies ..

Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome

Amanda Vlahos, Toby Mansell, Richard Saffery, Boris Novakovic

Journal article  |  2019  |  PLOS GENETICS

The placenta is the interface between maternal and fetal circulations, integrating maternal and fetal signals to selectively regul..

Early-life determinants of hypoxia-inducible factor 3A gene(HIF3A) methylation: a birth cohort study

Toby Mansell, Anne-Louise Ponsonby, Vania Januar, Boris Novakovic, Fiona Collier, David Burgner, Peter Vuillermin, Joanne Ryan, Richard Saffery, John Carlin, Katie Allen, Mimi Tang, Sarath Ranganathan, Terry Dwyer, Kim Jachno, Peter Sly

Journal article  |  2019  |  CLINICAL EPIGENETICS

BACKGROUND: Methylation of the hypoxia-inducible factor 3α gene (HIF3A) has been linked to pregnancy exposures, infant adiposity a..