Mark Waltham

Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Razan Wafai, Elizabeth D Williams, Emma de Souza, Peter T Simpson, Amy E McCart Reed, Jamie R Kutasovic, Mark Waltham, Cameron E Snell, Tony Blick, Erik W Thompson, Honor J Hugo

Journal article  |  2020  |  BREAST CANCER RESEARCH

BACKGROUND: Breast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integr..

Identifying Therapies to Combat Epithelial Mesenchymal Plasticity-Associated Chemoresistance to Conventional Breast Cancer Therapies Using An shRNA Library Screen

Sugandha Bhatia, Tony Blick, Cletus Pinto, Mark Waltham, James Monkman, Ekaterina Ivanova, Pamela M Pollock, Shivashankar H Nagaraj, Adrian P Wiegmans, Izhak Haviv, Kaylene J Simpson, Erik W Thompson

Journal article  |  2020  |  CANCERS

BACKGROUND: Breast cancer (BC) is a heterogeneous disease for which the commonly used chemotherapeutic agents primarily include th..

Human-specific RNA analysis shows uncoupled epithelial-mesenchymal plasticity in circulating and disseminated tumour cells from human breast cancer xenografts

Anthony Tachtsidis, Anh Viet-Phuong Le, Tony Blick, Devika Gunasinghe, Emma De Sousa, Mark Waltham, Alex Dobrovic, Erik W Thompson

Journal article  |  2019  |  CLINICAL & EXPERIMENTAL METASTASIS

Blood samples, bone marrow, tumours and metastases where possible were collected from SCID mice bearing orthotopic xenografts of t..

Interrogation of Phenotypic Plasticity between Epithelial and Mesenchymal States in Breast Cancer

Sugandha Bhatia, James Monkman, Tony Blick, Cletus Pinto, Mark Waltham, Shivashankar H Nagaraj, Erik W Thompson

Journal article  |  2019  |  JOURNAL OF CLINICAL MEDICINE

Dynamic interconversions between transitional epithelial and mesenchymal states underpin the epithelial mesenchymal plasticity (EM..

Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

HJ Hugo, NPAD Gunasinghe, BG Hollier, T Tanaka, T Blick, A Toh, P Hill, C Gilles, M Waltham, EW Thompson

Journal article  |  2017  |  BREAST CANCER RESEARCH

BACKGROUND: Epithelial-to-mesenchymal transition (EMT) is associated with downregulated E-cadherin and frequently with decreased p..

Mammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive lesions and metastasis

Cecilia W Huo, Mark Waltham, Christine Khoo, Stephen B Fox, Prue Hill, Shou Chen, Grace L Chew, John T Price, Chau H Nguyen, Elizabeth D Williams, Michael Henderson, Erik W Thompson, Kara L Britt

Journal article  |  2016  |  BREAST CANCER RESEARCH

BACKGROUND: High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is asso..

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson

Journal article  |  2015  |  Cell Communication and Signaling

INTRODUCTION: The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastat..

Breast cancer stem cells and epithelial mesenchymal plasticity - Implications for chemoresistance

Cletus A Pinto, Edwin Widodo, Mark Waltham, Erik W Thompson

Journal article  |  2013  |  CANCER LETTERS

Tumour heterogeneity is a key characteristic of cancer and has significant implications relating to tumour response to chemotherap..

Treatment with the vascular disruptive agent OXi4503 induces an immediate and widespread epithelial to mesenchymal transition in the surviving tumor

Theodora Fifis, Linh Nguyen, Cathy Malcontenti-Wilson, Lie Sam Chan, Patricia Luiza Nunes Costa, Jurstine Daruwalla, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Mark Waltham, Erik W Thompson, Christopher Christophi

Journal article  |  2013  |  CANCER MEDICINE

Epithelial to mesenchymal transition (EMT) is considered an important mechanism in tumor resistance to drug treatments; however, i..

Structure of the N-terminal domain of human thioredoxin-interacting protein

Galina Polekhina, David Benjamin Ascher, Shie Foong Kok, Simone Beckham, Matthew Wilce, Mark Waltham

Journal article  |  2013  |  ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY

Thioredoxin-interacting protein (TXNIP) is one of the six known α-arrestins and has recently received considerable attention owing..