Mark Waltham

Integrin alpha-2 and beta-1 expression increases through multiple generations of the EDW01 patient-derived xenograft model of breast cancer-insight into their role in epithelial mesenchymal transition in vivo gained from an in vitro model system

Razan Wafai, Elizabeth D Williams, Emma de Souza, Peter T Simpson, Amy E McCart Reed, Jamie R Kutasovic, Mark Waltham, Cameron E Snell, Tony Blick, Erik W Thompson, Honor J Hugo

Journal article  |  2020  |  Breast Cancer Research

BACKGROUND: Breast cancers acquire aggressive capabilities via epithelial to mesenchymal transition (EMT), in which various integr..

Identifying Therapies to Combat Epithelial Mesenchymal Plasticity-Associated Chemoresistance to Conventional Breast Cancer Therapies Using An shRNA Library Screen

Sugandha Bhatia, Tony Blick, Cletus Pinto, Mark Waltham, James Monkman, Ekaterina Ivanova, Pamela M Pollock, Shivashankar H Nagaraj, Adrian P Wiegmans, Izhak Haviv, Kaylene J Simpson, Erik W Thompson

Journal article  |  2020  |  Cancers

BACKGROUND: Breast cancer (BC) is a heterogeneous disease for which the commonly used chemotherapeutic agents primarily include th..

Human-specific RNA analysis shows uncoupled epithelial-mesenchymal plasticity in circulating and disseminated tumour cells from human breast cancer xenografts

Anthony Tachtsidis, Anh Viet-Phuong Le, Tony Blick, Devika Gunasinghe, Emma De Sousa, Mark Waltham, Alex Dobrovic, Erik W Thompson

Journal article  |  2019  |  Clinical & Experimental Metastasis

Interrogation of Phenotypic Plasticity between Epithelial and Mesenchymal States in Breast Cancer

Sugandha Bhatia, James Monkman, Tony Blick, Cletus Pinto, Mark Waltham, Shivashankar H Nagaraj, Erik W Thompson

Journal article  |  2019  |  Journal of Clinical Medicine

Epithelial requirement for in vitro proliferation and xenograft growth and metastasis of MDA-MB-468 human breast cancer cells: oncogenic rather than tumor-suppressive role of E-cadherin

HJ Hugo, NPAD Gunasinghe, BG Hollier, T Tanaka, T Blick, A Toh, P Hill, C Gilles, M Waltham, EW Thompson

Journal article  |  2017  |  Breast Cancer Research

Mammographically dense human breast tissue stimulates MCF10DCIS.com progression to invasive lesions and metastasis

Cecilia W Huo, Mark Waltham, Christine Khoo, Stephen B Fox, Prue Hill, Shou Chen, Grace L Chew, John T Price, Chau H Nguyen, Elizabeth D Williams, Michael Henderson, Erik W Thompson, Kara L Britt

Journal article  |  2016  |  BREAST CANCER RESEARCH

Stimulus-dependent differences in signalling regulate epithelial-mesenchymal plasticity and change the effects of drugs in breast cancer cell lines

J Cursons, KJ Leuchowius, M Waltham, E Tomaskovic-Crook, M Foroutan, CP Bracken, A Redfern, EJ Crampin, I Street, MJ Davis, EW Thompson

Journal article  |  2015  |  Cell Communication and Signaling

Breast cancer stem cells and epithelial mesenchymal plasticity - Implications for chemoresistance

Cletus A Pinto, Edwin Widodo, Mark Waltham, Erik W Thompson

Journal article  |  2013  |  Cancer Letters

Treatment with the vascular disruptive agent OXi4503 induces an immediate and widespread epithelial to mesenchymal transition in the surviving tumor

Theodora Fifis, Linh Nguyen, Cathy Malcontenti-Wilson, Lie Sam Chan, Patricia Luiza Nunes Costa, Jurstine Daruwalla, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Mark Waltham, Erik W Thompson, Christopher Christophi

Journal article  |  2013  |  Cancer Medicine

Structure of the N-terminal domain of human thioredoxin-interacting protein

Galina Polekhina, David Benjamin Ascher, Shie Foong Kok, Simone Beckham, Matthew Wilce, Mark Waltham

Journal article  |  2013  |  Acta Crystallographica Section D, Structural Biology