Fernando Rossello

gamma delta T Cells in Merkel Cell Carcinomas Have a Proinflammatory Profile Prognostic of Patient Survival

Nicholas A Gherardin, Kelly Waldeck, Alex Caneborg, Luciano G Martelotto, Shiva Balachander, Magnus Zethoven, Pasquale M Petrone, Andrew Pattison, James S Wilmott, Sergio M Quinones-Parra, Fernando Rossello, Atara Posner, Annie Wong, Alison M Weppler, Kerwin F Shannon, Angela Hong, Peter M Ferguson, Valerie Jakrot, Jeanette Raleigh, Athena Hatzimihalis, et al.

Journal article  |  2021  |  CANCER IMMUNOLOGY RESEARCH

Merkel cell carcinomas (MCC) are immunogenic skin cancers associated with viral infection or UV mutagenesis. To study T-cell infil..

Transcriptional signature in microglia associated with A beta plaque phagocytosis

Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John F Ouyang, Guizhi Sun, Nathan P Croft, Fernando J Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa H Vandekolk, Zehra Abay, Yichen Zhou, Xiaodong Liu, Joseph Chen, Michael Larcombe, John M Haynes, Catriona McLean, Sarah Williams, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The role of microglia cells in Alzheimer's disease (AD) is well recognized, however their molecular and functional diversity remai..

FKRP-dependent glycosylation of fibronectin regulates muscle pathology in muscular dystrophy

AJ Wood, CH Lin, M Li, K Nishtala, S Alaei, F Rossello, C Sonntag, L Hersey, LB Miles, C Krisp, S Dudczig, AJ Fulcher, S Gibertini, PJ Conroy, A Siegel, M Mora, P Jusuf, NH Packer, PD Currie

Journal article  |  2021  |  NATURE COMMUNICATIONS

The muscular dystrophies encompass a broad range of pathologies with varied clinical outcomes. In the case of patients carrying de..

Macrophages provide a transient muscle stem cell niche via NAMPT secretion

Dhanushika Ratnayake, Phong D Nguyen, Fernando J Rossello, Verena C Wimmer, Jean L Tan, Laura A Galvis, Ziad Julier, Alasdair J Wood, Thomas Boudier, Abdulsalam I Isiaku, Silke Berger, Viola Oorschot, Carmen Sonntag, Kelly L Rogers, Christophe Marcelle, Graham J Lieschke, Mikael M Martino, Jeroen Bakkers, Peter D Currie

Journal article  |  2021  |  NATURE

Skeletal muscle regenerates through the activation of resident stem cells. Termed satellite cells, these normally quiescent cells ..

TINC-A Method to Dissect Regulatory Complexes at Single-Locus Resolution-Reveals an Extensive Protein Complex at the Nanog Promoter

Anja S Knaupp, Monika Mohenska, Michael R Larcombe, Ethan Ford, Sue Mei Lim, Kayla Wong, Joseph Chen, Jaber Firas, Cheng Huang, Xiaodong Liu, Nguyen Trung, Yu BY Sun, Melissa L Holmes, Pratibha Tripathi, Jahnvi Pflueger, Fernando J Rossello, Jan Schroder, Kathryn C Davidson, Christian M Nefzger, Partha P Das, et al.

Journal article  |  2020  |  STEM CELL REPORTS

Cellular identity is ultimately dictated by the interaction of transcription factors with regulatory elements (REs) to control gen..

Mesenchymal niche-derived Neuregulin-1 drives intestinal stem cell proliferation and regeneration of damaged epithelium

jacqueline Donoghue, Thierry Jarde

Journal article  |  2020  |  Cell Stem Cell

Epidermal growth factor (EGF) maintains intestinal stem cell (ISC) proliferation and is a key component of organoid growth media y..

Reprogramming roadmap reveals route to human induced trophoblast stem cells

Xiaodong Liu, John F Ouyang, Fernando J Rossello, Jia Ping Tan, Kathryn C Davidson, Daniela S Valdes, Jan Schroeder, Yu BY Sun, Joseph Chen, Anja S Knaupp, Guizhi Sun, Hun S Chy, Ziyi Huang, Jahnvi Pflueger, Jaber Firas, Vincent Tano, Sam Buckberry, Jacob M Paynter, Michael R Larcombe, Daniel Poppe, et al.

Journal article  |  2020  |  Nature

The reprogramming of human somatic cells to primed or naive induced pluripotent stem cells recapitulates the stages of early embry..

Epigenetic reprogramming of plasmacytoid dendritic cells drives type I interferon-dependent differentiation of acute myeloid leukemias for therapeutic benefit

Jessica Salmon, Izabela Todorovski, Stephin Vervoort, Kym Stanley, Conor Kearney, Luciano Martelotto, Fernando Rossello, Tim Semple, Gisela Mir-Arnau, Magnus Zethoven, Michael Bots, Eva Vidacs, Kate McArthur, Elise Gressier, Nicky de Weerd, Jens Lichte, Madison Kelly, Leonie Cluse, Simon Hogg, Paul Hertzog, et al.

Journal article  |  2020

Pharmacological inhibition of epigenetic enzymes can have therapeutic benefit, particularly against hematological malignancies. Wh..

Transcriptome analysis of the zebrafish atoh7-/- Mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases.

Giuseppina Covello, Fernando J Rossello, Michele Filosi, Felipe Gajardo, Anne-Laure Duchemin, Beatrice F Tremonti, Michael Eichenlaub, Jose M Polo, David Powell, John Ngai, Miguel L Allende, Enrico Domenici, Mirana Ramialison, Lucia Poggi

Journal article  |  2020  |  FASEB Bioadv

Expression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the d..

Genetic associations with clozapine-induced myocarditis in patients with schizophrenia

Paul Lacaze, Kathlyn J Ronaldson, Eunice J Zhang, Ana Alfirevic, Hardik Shah, Leah Newman, Maya Strahl, Melissa Smith, Chad Bousman, Ben Francis, Andrew P Morris, Trevor Wilson, Fernando Rossello, David Powell, Vivien Vasic, Robert Sebra, John J McNeil, Munir Pirmohamed

Journal article  |  2020  |  TRANSLATIONAL PSYCHIATRY

Clozapine is the most effective antipsychotic drug for schizophrenia, yet it can cause life-threatening adverse drug reactions, in..