Fernando Rossello

TINC- A Method to Dissect Regulatory Complexes at Single-Locus Resolution- Reveals an Extensive Protein Complex at the Nanog Promoter.

Anja S Knaupp, Monika Mohenska, Michael R Larcombe, Ethan Ford, Sue Mei Lim, Kayla Wong, Joseph Chen, Jaber Firas, Cheng Huang, Xiaodong Liu, Trung Nguyen, Yu BY Sun, Melissa L Holmes, Pratibha Tripathi, Jahnvi Pflueger, Fernando J Rossello, Jan Schröder, Kathryn C Davidson, Christian M Nefzger, Partha P Das, et al.

Journal article  |  2020  |  Stem Cell Reports

Cellular identity is ultimately dictated by the interaction of transcription factors with regulatory elements (REs) to control gen..

Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

Thierry Jard, Wing Hei Chan, Fernando J Rossello, Tanvir Kaur Kahlon, Mandy Theocharous, Teni Kurian Arackal, Tracey Flores, Megane Giraud, Elizabeth Richards, Eva Chan, Genevieve Kerr, Rebekah M Engel, Mirsada Prasko, Jacqueline F Donoghue, Shin-ichi Abe, Toby J Phesse, Christian M Nefzger, Paul J McMurrick, David R Powell, Roger J Daly, et al.

Journal article  |  2020  |  Cell Stem Cell

Epidermal growth factor (EGF) maintains intestinal stem cell (ISC) proliferation and is a key component of organoid growth media y..

Reprogramming roadmap reveals route to human induced trophoblast stem cells

Xiaodong Liu, John F Ouyang, Fernando J Rossello, Jia Ping Tan, Kathryn C Davidson, Daniela S Valdes, Jan Schroeder, Yu BY Sun, Joseph Chen, Anja S Knaupp, Guizhi Sun, Hun S Chy, Ziyi Huang, Jahnvi Pflueger, Jaber Firas, Vincent Tano, Sam Buckberry, Jacob M Paynter, Michael R Larcombe, Daniel Poppe, et al.

Journal article  |  2020  |  Nature

The reprogramming of human somatic cells to primed or naive induced pluripotent stem cells recapitulates the stages of early embry..

Transcriptome analysis of the zebrafish atoh7-/- Mutant, lakritz, highlights Atoh7-dependent genetic networks with potential implications for human eye diseases.

Giuseppina Covello, Fernando J Rossello, Michele Filosi, Felipe Gajardo, Anne-Laure Duchemin, Beatrice F Tremonti, Michael Eichenlaub, Jose M Polo, David Powell, John Ngai, Miguel L Allende, Enrico Domenici, Mirana Ramialison, Lucia Poggi

Journal article  |  2020  |  FASEB BioAdvances

Expression of the bHLH transcription protein Atoh7 is a crucial factor conferring competence to retinal progenitor cells for the d..

Genetic associations with clozapine-induced myocarditis in patients with schizophrenia

Paul Lacaze, Kathlyn J Ronaldson, Eunice J Zhang, Ana Alfirevic, Hardik Shah, Leah Newman, Maya Strahl, Melissa Smith, Chad Bousman, Ben Francis, Andrew P Morris, Trevor Wilson, Fernando Rossello, David Powell, Vivien Vasic, Robert Sebra, John J McNeil, Munir Pirmohamed

Journal article  |  2020  |  Translational Psychiatry

Clozapine is the most effective antipsychotic drug for schizophrenia, yet it can cause life-threatening adverse drug reactions, in..

DDX5 plays essential transcriptional and post-transcriptional roles in the maintenance and function of spermatogonia

Julien MD Legrand, Ai-Leen Chan, Hue M La, Fernando J Rossello, Minna-Liisa Anko, Frances V Fuller-Pace, Robin M Hobbs

Journal article  |  2019  |  Nature Communications

Mouse and human microglial phenotypes in Alzheimer’s disease are controlled by amyloid plaque phagocytosis through Hif1α

Alexandra Grubman, Xin Yi Choo, Gabriel Chew, John Ouyang, Guizhi Sun, Nathan Croft, Fernando Rossello, Rebecca Simmons, Sam Buckberry, Dulce Vargas Landin, Jahnvi Pflueger, Teresa Vandekolk, Zehra Abay, Xiaodong Liu, John Haynes, Catriona McLean, Sarah Williams, Siew Yeen Chai, Trevor Wilson, Ryan Lister, et al.

Journal article  |  2019

ABSTRACT The important role of microglia, the brain’s resident immune cells, in Alzheimer’s disease (AD) is now well recognized, h..

Deep multi-region whole-genome sequencing reveals heterogeneity and gene-by-environment interactions in treatment-naive, metastatic lung cancer

Tracy L Leong, Velimir Gayevskiy, Daniel P Steinfort, Marc R De Massy, Alvaro Gonzalez-Rajal, Kieren D Marini, Emily Stone, Venessa Chin, Adrian Havryk, Marshall Plit, Louis B Irving, Barton R Jennings, Rachael A McCloy, W Samantha N Jayasekara, Muhammad Alamgeer, Vishal Boolell, Andrew Field, Prudence A Russell, Beena Kumar, Daniel J Gough, et al.

Journal article  |  2019  |  Oncogene

GILZ-dependent modulation of mTORC1 regulates spermatogonial maintenance

Hue M La, Ai-Leen Chan, Julien MD Legrand, Fernando J Rossello, Christina G Gangemi, Antonella Papa, Qiang Cheng, Eric F Morand, Robin M Hobbs

Journal article  |  2018  |  Development

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Kieren D Marini, David R Croucher, Rachael A McCloy, Vijesh Vaghjiani, Alvaro Gonzalez-Rajal, Jordan F Hastings, Venessa Chin, Anette Szczepny, Kaja Kostyrko, Cesar Marquez, W Samantha N Jayasekara, Muhammad Alamgeer, Vishal Boolell, Jeremy ZR Han, Todd Waugh, Hong Ching Lee, Samantha R Oakes, Beena Kumar, Craig A Harrison, Mark P Hedger, et al.

Journal article  |  2018  |  Science Translational Medicine