Fernando Rossello

Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment (vol 13, 6262, 2022)

Magnus Zethoven, Luciano Martelotto, Andrew Pattison, Blake Bowen, Shiva Balachander, Aidan Flynn, Fernando J Rossello, Annette Hogg, Julie A Miller, Zdenek Frysak, Sean Grimmond, Lauren Fishbein, Arthur S Tischler, Anthony J Gill, Rodney J Hicks, Patricia LM Dahia, Roderick Clifton-Bligh, Karel Pacak, Richard W Tothill

Journal article  |  2023  |  NATURE COMMUNICATIONS

The original version of this Article contained an error in Supplementary Data 5, as column A listing the gene names was misaligned..

Single-nuclei and bulk-tissue gene-expression analysis of pheochromocytoma and paraganglioma links disease subtypes with tumor microenvironment

Magnus Zethoven, Luciano Martelotto, Andrew Pattison, Blake Bowen, Shiva Balachander, Aidan Flynn, Fernando J Rossello, Annette Hogg, Julie A Miller, Zdenek Frysak, Sean Grimmond, Lauren Fishbein, Arthur S Tischler, Anthony J Gill, Rodney J Hicks, Patricia LM Dahia, Roderick Clifton-Bligh, Karel Pacak, Richard W Tothill

Journal article  |  2022  |  NATURE COMMUNICATIONS

Pheochromocytomas (PC) and paragangliomas (PG) are rare neuroendocrine tumors associated with autonomic nerves. Here we use single..

ALTEN: A High-Fidelity Primary Tissue-Engineering Platform to Assess Cellular Responses Ex Vivo.

Andrew MK Law, Jiamin Chen, Yolanda Colino-Sanguino, Laura Rodriguez de la Fuente, Guocheng Fang, Susan M Grimes, Hongxu Lu, Robert J Huang, Sarah T Boyle, Jeron Venhuizen, Lesley Castillo, Javad Tavakoli, Joanna N Skhinas, Ewan KA Millar, Julia Beretov, Fernando J Rossello, Joanne L Tipper, Christopher J Ormandy, Michael S Samuel, Thomas R Cox, et al.

Journal article  |  2022  |  Adv Sci (Weinh)

To fully investigate cellular responses to stimuli and perturbations within tissues, it is essential to replicate the complex mole..

Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Christian M Nefzger, Thierry Jarde, Akanksha Srivastava, Jan Schroeder, Fernando J Rossello, Katja Horvay, Mirsada Prasko, Jacob M Paynter, Joseph Chen, Chen-Fang Weng, Yu BY Sun, Xiaodong Liu, Eva Chan, Nikita Deshpande, Xiaoli Chen, Y Jinhua Li, Jahnvi Pflueger, Rebekah M Engel, Anja S Knaupp, Kirill Tsyganov, et al.

Journal article  |  2022  |  NPJ REGENERATIVE MEDICINE

The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigene..

Epigenetic Activation of Plasmacytoid DCs Drives IFNAR-Dependent Therapeutic Differentiation of AML

Jessica M Salmon, Izabela Todorovski, Kym L Stanley, Claudia Bruedigam, Conor J Kearney, Luciano G Martelotto, Fernando Rossello, Timothy Semple, Gisela Mir Arnau, Magnus Zethoven, Michael Bots, Stefan Bjelosevic, Leonie A Cluse, Peter J Fraser, Veronique Litalien, Eva Vidacs, Kate McArthur, Antony Y Matthews, Elise Gressier, Nicole A de Weerd, et al.

Journal article  |  2022  |  CANCER DISCOVERY

UNLABELLED: Pharmacologic inhibition of epigenetic enzymes can have therapeutic benefit against hematologic malignancies. In addit..

Distinctive molecular features of regenerative stem cells in the damaged male germline

Hue M La, Jinyue Liao, Julien MD Legrand, Fernando J Rossello, Ai-Leen Chan, Vijesh Vaghjiani, Jason E Cain, Antonella Papa, Tin Lap Lee, Robin M Hobbs

Journal article  |  2022  |  NATURE COMMUNICATIONS

Maintenance of male fertility requires spermatogonial stem cells (SSCs) that self-renew and generate differentiating germ cells fo..

PTPN2 Regulates the Interferon Signaling and Endoplasmic Reticulum Stress Response in Pancreatic beta-Cells in Autoimmune Diabetes

Bernat Elvira, Valerie Vandenbempt, Julia Bauza-Martinez, Raphael Crutzen, Javier Negueruela, Hazem Ibrahim, Matthew L Winder, Manoja K Brahma, Beata Vekeriotaite, Pieter-Jan Martens, Sumeet Pal Singh, Fernando Rossello, Pascale Lybaert, Timo Otonkoski, Conny Gysemans, Wei Wu, Esteban N Gurzov

Journal article  |  2022  |  DIABETES

Type 1 diabetes (T1D) results from autoimmune destruction of β-cells in the pancreas. Protein tyrosine phosphatases (PTPs) are can..

Breaking constraint of mammalian axial formulae

Gabriel M Hauswirth, Victoria C Garside, Lisa SF Wong, Heidi Bildsoe, Jan Manent, Yi-Cheng Chang, Christian M Nefzger, Jaber Firas, Joseph Chen, Fernando J Rossello, Jose M Polo, Edwina McGlinn

Journal article  |  2022  |  NATURE COMMUNICATIONS

The vertebral column of individual mammalian species often exhibits remarkable robustness in the number and identity of vertebral ..

3D-cardiomics: A spatial transcriptional atlas of the mammalian heart

Monika Mohenska, Nathalia M Tan, Alex Tokolyi, Milena B Furtado, Mauro W Costa, Andrew J Perry, Jessica Hatwell-Humble, Karel van Duijvenboden, Hieu T Nim, Yuan MM Ji, Natalie Charitakis, Denis Bienroth, Francesca Bolk, Celine Vivien, Anja S Knaupp, David R Powell, David A Elliott, Enzo R Porrello, Susan K Nilsson, Gonzalo del Monte-Nieto, et al.

Journal article  |  2021  |  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Understanding the spatial gene expression and regulation in the heart is key to uncovering its developmental and physiological pro..

gamma delta T Cells in Merkel Cell Carcinomas Have a Proinflammatory Profile Prognostic of Patient Survival

Nicholas A Gherardin, Kelly Waldeck, Alex Caneborg, Luciano G Martelotto, Shiva Balachander, Magnus Zethoven, Pasquale M Petrone, Andrew Pattison, James S Wilmott, Sergio M Quinones-Parra, Fernando Rossello, Atara Posner, Annie Wong, Alison M Weppler, Kerwin F Shannon, Angela Hong, Peter M Ferguson, Valerie Jakrot, Jeanette Raleigh, Athena Hatzimihalis, et al.

Journal article  |  2021  |  CANCER IMMUNOLOGY RESEARCH

Merkel cell carcinomas (MCC) are immunogenic skin cancers associated with viral infection or UV mutagenesis. To study T-cell infil..