Daniel Buchanan

Informed choice and attitudes regarding a genomic test to predict risk of colorectal cancer in general practice.

Sibel Saya, Jennifer G McIntosh, Ingrid M Winship, Shakira Milton, Mark Clendenning, Mary Kyriakides, Jasmeen Oberoi, Daniel D Buchanan, Mark A Jenkins, Jon D Emery

Journal article  |  2021  |  Patient Educ Couns

OBJECTIVE: A genomic test to predict personal risk of colorectal cancer (CRC) that targets screening and could be feasibly impleme..

Association Between Smoking and Molecular Subtypes of Colorectal Cancer.

Xiaoliang Wang, Efrat Amitay, Tabitha A Harrison, Barbara L Banbury, Sonja I Berndt, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Yin Cao, Andrew T Chan, Jenny Chang-Claude, Steven J Gallinger, Marios Giannakis, Graham G Giles, Marc J Gunter, John L Hopper, Mark A Jenkins, Yi Lin, Victor Moreno, Reiko Nishihara, et al.

Journal article  |  2021  |  JNCI Cancer Spectr

Background: Smoking is associated with colorectal cancer (CRC) risk. Previous studies suggested this association may be restricted..

Tetranucleotide and Low Microsatellite Instability Are Inversely Associated with the CpG Island Methylator Phenotype in Colorectal Cancer

Sabine Meessen, Nicola Currey, Zeenat Jahan, Hannah W Parker, Mark A Jenkins, Daniel D Buchanan, John L Hopper, Eva Segelov, Jane E Dahlstrom, Maija RJ Kohonen-Corish

Journal article  |  2021  |  CANCERS

MSH3 gene or protein deficiency or loss-of-function in colorectal cancer can cause a DNA mismatch repair defect known as "elevated..

Abstract 816: Genetic variants associated with C-reactive protein and colorectal cancer survival: Sex- and lifestyle factors- specific associations

Yuhan Huang, Xinwei Hua, Julia D Labadie, Tabitha A Harrison, James Dai, Sara Lindstrom, Yi Lin, Sonja I Berndt, Daniel D Buchanan, Peter T Campbell, Graham Casey, Steven J Gallinger, Marc J Gunter, Michael Hoffmeister, Mark A Jenkins, Lori C Sakoda, Robert E Schoen, Brenda Diergaarde, Martha L Slattery, Emily White, et al.

Conference Proceedings  |  2021  |  Epidemiology

Genetic architectures of proximal and distal colorectal cancer are partly distinct

Jeroen R Huyghe, Tabitha A Harrison, Stephanie A Bien, Heather Hampel, Jane C Figueiredo, Stephanie L Schmit, David Conti, Sai Chen, Conghui Qu, Yi Lin, Richard Barfield, John A Baron, Amanda J Cross, Brenda Diergaarde, David Duggan, Sophia Harlid, Liher Imaz, Hyun Min Kang, David M Levine, Vittorio Perduca, et al.

Journal article  |  2021  |  GUT

OBJECTIVE: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision preventi..

Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study

Mark A Jenkins

Journal article  |  2021  |  LANCET ONCOLOGY

BACKGROUND: Existing clinical practice guidelines for carriers of pathogenic variants of DNA mismatch repair genes (Lynch syndrome..

No Difference in Penetrance between Truncating and Missense/Aberrant Splicing Pathogenic Variants in MLH1 and MSH2: A Prospective Lynch Syndrome Database Study

Mev Dominguez-Valentin, John-Paul Plazzer, Julian R Sampson, Christoph Engel, Stefan Aretz, Mark A Jenkins, Lone Sunde, Inge Bernstein, Gabriel Capella, Francesc Balaguer, Finlay Macrae, Ingrid M Winship, Huw Thomas, Dafydd Gareth Evans, John Burn, Marc Greenblatt, Wouter H de Vos Tot Nederveen Cappel, Rolf H Sijmons, Maartje Nielsen, Lucio Bertario, et al.

Journal article  |  2021  |  JOURNAL OF CLINICAL MEDICINE

BACKGROUND: Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mism..

Genetically Predicted Circulating C-Reactive Protein Concentration and Colorectal Cancer Survival: A Mendelian Randomization Consortium Study

Xinwei Hua, James Y Dai, Sara Lindstrom, Tabitha A Harrison, Yi Lin, Steven R Alberts, Elizabeth Alwers, Sonja Berndt, Hermann Brenner, Daniel D Buchanan, Peter T Campbell, Graham Casey, Jenny Chang-Claude, Steven Gallinger, Graham G Giles, Richard M Goldberg, Marc J Gunter, Michael Hoffmeister, Mark A Jenkins, Amit D Joshi, et al.

Journal article  |  2021  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

BACKGROUND: A positive association between circulating C-reactive protein (CRP) and colorectal cancer survival was reported in obs..

Characteristics of Early-Onset vs Late-Onset Colorectal Cancer A Review

Alexandra M Zaborowski, Ahmed Abdile, Michel Adamina, Felix Aigner, Laura d'Allens, Caterina Allmer, Andrea Alvarez, Rocio Anula, Mihailo Andric, Sam Atallah, Simon Bach, Miklosh Bala, Marie Barussaud, Augustinas Bausys, Brendan Bebington, Andrew Beggs, Felipe Bellolio, Melissa-Rose Bennett, Anton Berdinskikh, Vicki Bevan, et al.

Journal article  |  2021  |  JAMA SURGERY

Importance: The incidence of early-onset colorectal cancer (younger than 50 years) is rising globally, the reasons for which are u..

An integrated mass spectrometry imaging and digital pathology workflow for objective detection of colorectal tumours by unique atomic signatures

Bence Paul, Kai Kysenius, James B Hilton, Michael WM Jones, Robert W Hutchinson, Daniel D Buchanan, Christophe Rosty, Fred Fryer, Ashley Bush, Janet M Hergt, Jon D Woodhead, David P Bishop, Philip A Doble, Michelle M Hill, Peter J Crouch, Dominic J Hare

Journal article  |  2021  |  CHEMICAL SCIENCE

Tumours are abnormal growths of cells that reproduce by redirecting essential nutrients and resources from surrounding tissue. Cha..