Daniel Buchanan

Intake of Dietary Fruit, Vegetables, and Fiber and Risk of Colorectal Cancer According to Molecular Subtypes: A Pooled Analysis of 9 Studies.

Akihisa Hidaka, Tabitha A Harrison, Yin Cao, Lori C Sakoda, Richard Barfield, Marios Giannakis, Mingyang Song, Amanda I Phipps, Jane C Figueiredo, Syed H Zaidi, Amanda E Toland, Efrat L Amitay, Sonja I Berndt, Ivan Borozan, Andrew T Chan, Steven Gallinger, Marc J Gunter, Mark A Guinter, Sophia Harlid, Heather Hampel, et al.

Journal article  |  2020  |  Cancer Research

Protective associations of fruits, vegetables, and fiber intake with colorectal cancer risk have been shown in many, but not all e..

Genetic variants in the regulatory T cell related pathway and colorectal cancer prognosis.

Sonja Neumeyer, Xinwei Hua, Petra Seibold, Lina Jansen, Axel Benner, Barbara Burwinkel, Niels Halama, Sonja I Berndt, Amanda I Phipps, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Andrew T Chan, Manish Gala, Amit D Joshi, Shuji Ogino, Mingyang Song, Esther Herpel, Hendrik Bläker, Matthias Kloor, et al.

Journal article  |  2020  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better col..

Stochastic Epigenetic Mutations Are Associated with Risk of Breast Cancer, Lung Cancer, and Mature B-cell Neoplasms

Amedeo Gagliardi, Pierre-Antoine Dugue, Therese H Nost, Melissa C Southey, Daniel D Buchanan, Daniel F Schmidt, Enes Makalic, Allison M Hodge, Dallas R English, Nicole W Doo, John L Hopper, Gianluca Severi, Laura Baglietto, Alessio Naccarati, Sonia Tarallo, Luigia Pace, Vittorio Krogh, Domenico Palli, Salvatore Panico, Carlotta Sacerdote, et al.

Journal article  |  2020  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Age-related epigenetic dysregulations are associated with several diseases, including cancer. The number of stochastic..

Genome-wide Modeling of Polygenic Risk Score in Colorectal Cancer Risk

Minta Thomas, Lori C Sakoda, Michael Hoffmeister, Elisabeth A Rosenthal, Jeffrey K Lee, Franzel JB van Duijnhoven, Elizabeth A Platz, Anna H Wu, Christopher H Dampier, Albert de la Chapelle, Alicja Wolk, Amit D Joshi, Andrea Burnett-Hartman, Andrea Gsur, Annika Lindblom, Antoni Castells, Aung Ko Win, Bahram Namjou, Bethany Van Guelpen, Catherine M Tangen, et al.

Journal article  |  2020  |  The American Journal of Human Genetics

Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals at low and high risk of developin..

A Genomic Test for Colorectal Cancer Risk: Is This Acceptable and Feasible in Primary Care?

Sibel Saya, Jennifer G McIntosh, Ingrid M Winship, Mark Clendenning, Shakira Milton, Jasmeen Oberoi, James G Dowty, Daniel D Buchanan, Mark A Jenkins, Jon D Emery

Journal article  |  2020  |  Public Health Genomics

INTRODUCTION: Genomic tests can predict risk and tailor screening recommendations for colorectal cancer (CRC). Primary care could ..

Mendelian randomization analyses suggest a role for cholesterol in the development of endometrial cancer

Pik-Fang Kho, Frederic Amant, Daniela Annibali, Katie Ashton, John Attia, Paul L Auer, Matthias W Beckmann, Amanda Black, Louise Brinton, Daniel D Buchanan, Stephen J Chanock, Chu Chen, Maxine M Chen, Timothy HT Cheng, Linda S Cook, Marta Crous-Bous, Kamila Czene, Immaculata De Vivo, Joe Dennis, Thilo Doerk, et al.

Journal article  |  2020  |  International Journal of Cancer

Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

Syed H Zaidi, Tabitha A Harrison, Amanda Phipps, Robert Steinfelder, Quang M Trinh, Conghui Qu, Barbara L Banbury, Peter Georgeson, Catherine S Grasso, Marios Giannakis, Jeremy B Adams, Elizabeth Alwers, Efrat L Amitay, Richard T Barfield, Sonja Berndt, Ivan Borozan, Hermann Brenner, Stefanie Brezina, Daniel D Buchanan, Yin Cao, et al.

Journal article  |  2020  |  Nature Communications

Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted seque..

TheMLH1polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability

Holly Russell, Katarzyna Kedzierska, Daniel D Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keranen, Graham G Giles, Melissa C Southey, Roger L Milne, Ian Tomlinson, David Church, Amanda B Spurdle, Tracy A O'Mara, Annabelle Lewis

Journal article  |  2020  |  Clinical Epigenetics

Both colorectal (CRC, 15%) and endometrial cancers (EC, 30%) exhibit microsatellite instability (MSI) due to MLH1 hypermethylation..

Medically actionable pathogenic variants in a population of 13,131 healthy elderly individuals

Paul Lacaze, Robert Sebra, Moeen Riaz, Jane Tiller, Jerico Revote, James Phung, Emily J Parker, Suzanne G Orchard, Jessica E Lockery, Rory Wolfe, Maya Strahl, Ying C Wang, Rong Chen, Daniel Sisco, Todd Arnold, Bryony A Thompson, Daniel D Buchanan, Finlay A Macrae, Paul A James, Walter P Abhayaratna, et al.

Journal article  |  2020  |  Genetics in Medicine

PURPOSE: To measure the prevalence of medically actionable pathogenic variants (PVs) among a population of healthy elderly individ..

Association Between Molecular Subtypes of Colorectal Tumors and Patient Survival, Based on Pooled Analysis of 7 International Studies

Amanda Phipps, Elizabeth Alwers, Tabitha Harrison, Barbara Banbury, Hermann Brenner, Peter T Campbell, Jenny Chang-Claude, Daniel Buchanan, Andrew T Chan, Alton B Farris, Jane C Figueiredo, Steven Gallinger, Graham G Giles, Mark Jenkins, Roger L Milne, Polly A Newcomb, Martha L Slattery, Mingyang Song, Shuji Ogino, Syed H Zaidi, et al.

Journal article  |  2020  |  Gastroenterology

BACKGROUND AND AIMS: The heterogeneity among colorectal tumors is probably due to differences in developmental pathways and might ..