Daniel Buchanan

The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability (vol 12, 102, 2020)

Holly Russell, Katarzyna Kedzierska, Daniel D Buchanan, Rachael Thomas, Emma Tham, Miriam Mints, Anne Keranen, Graham G Giles, Melissa C Southey, Roger L Milne, Ian Tomlinson, David Church, Amanda B Spurdle, Tracy A O'Mara, Annabelle Lewis

Journal article  |  2021  |  Clinical Epigenetics

Germline and Tumor Sequencing as a Diagnostic Tool To Resolve Suspected Lynch Syndrome.

Bernard J Pope, Mark Clendenning, Christophe Rosty, Khalid Mahmood, Peter Georgeson, Jihoon E Joo, Romy Walker, Ryan A Hutchinson, Harindra Jayasekara, Sharelle Joseland, Julia Como, Susan Preston, Amanda B Spurdle, Finlay A Macrae, Aung K Win, John L Hopper, Mark A Jenkins, Ingrid M Winship, Daniel D Buchanan

Journal article  |  2021  |  Journal of Molecular Diagnostics

Patients in whom mismatch repair (MMR)-deficient cancer develops in the absence of pathogenic variants of germline MMR genes or so..

A Combined Proteomics and Mendelian Randomization Approach to Investigate the Effects of Aspirin-Targeted Proteins on Colorectal Cancer

Aayah Nounu, Alexander Greenhough, Kate J Heesom, Rebecca C Richmond, Jie Zheng, Stephanie J Weinstein, Demetrius Albanes, John A Baron, John L Hopper, Jane C Figueiredo, Polly A Newcomb, Noralane M Lindor, Graham Casey, Elizabeth A Platz, Loic Le Marchand, Cornelia M Ulrich, Christopher Li, Franzel JB van Duijnhoven, Andrea Gsur, Peter T Campbell, et al.

Journal article  |  2021  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Evidence for aspirin's chemopreventative properties on colorectal cancer (CRC) is substantial, but its mechanism of ac..

Genetic architectures of proximal and distal colorectal cancer are partly distinct.

Jeroen R Huyghe, Tabitha A Harrison, Stephanie A Bien, Heather Hampel, Jane C Figueiredo, Stephanie L Schmit, David V Conti, Sai Chen, Conghui Qu, Yi Lin, Richard Barfield, John A Baron, Amanda J Cross, Brenda Diergaarde, David Duggan, Sophia Harlid, Liher Imaz, Hyun Min Kang, David M Levine, Vittorio Perduca, et al.

Journal article  |  2021  |  Gut

OBJECTIVE: An understanding of the etiologic heterogeneity of colorectal cancer (CRC) is critical for improving precision preventi..

Rare variants in the DNA repair pathway and the risk of colorectal cancer.

Marco Matejcic, Hiba A Shaban, Melanie W Quintana, Fredrick R Schumacher, Christopher K Edlund, Leah A Naghi, Rish K Pai, Robert W Haile, A Joan Levine, Daniel D Buchanan, Mark A Jenkins, Jane C Figueiredo, Gad Rennert, Stephen B Gruber, Li Li, Graham Casey, David V Conti, Stephanie L Schmit

Journal article  |  2021  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Inherited susceptibility is an important contributor to colorectal cancer (CRC) risk and rare variants in key genes or..

Evaluating the utility of tumour mutational signatures for identifying hereditary colorectal cancer and polyposis syndrome carriers.

Peter Georgeson, Bernard J Pope, Christophe Rosty, Mark Clendenning, Khalid Mahmood, Jihoon E Joo, Romy Walker, Ryan A Hutchinson, Susan Preston, Julia Como, Sharelle Joseland, Aung Ko Win, Finlay A Macrae, John L Hopper, Dmitri Mouradov, Peter Gibbs, Oliver M Sieber, Dylan E O'Sullivan, Darren R Brenner, Steve Gallinger, et al.

Journal article  |  2021  |  Gut

OBJECTIVE: Germline pathogenic variants (PVs) in the DNA mismatch repair (MMR) genes and in the base excision repair gene MUTYH un..

Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers

Dylan M Glubb, Deborah J Thompson, Katja KH Aben, Ahmad Alsulimani, Frederic Amant, Daniela Annibali, John Attia, Aurelio Barricarte, Matthias W Beckmann, Andrew Berchuck, Marina Bermisheva, Marcus Q Bernardini, Katharina Bischof, Line Bjorge, Clara Bodelon, Alison H Brand, James D Brenton, Louise A Brinton, Fiona Bruinsma, Daniel D Buchanan, et al.

Journal article  |  2021  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide a..

Adiposity, metabolites, and colorectal cancer risk: Mendelian randomization study

Caroline J Bull, Joshua A Bell, Neil Murphy, Eleanor Sanderson, George Davey Smith, Nicholas J Timpson, Barbara L Banbury, Demetrius Albanes, Sonja I Berndt, Stephane Bezieau, D Timothy Bishop, Hermann Brenner, Daniel D Buchanan, Andrea Burnett-Hartman, Graham Casey, Sergi Castellvi-Bel, Andrew T Chan, Jenny Chang-Claude, Amanda J Cross, Albert de la Chapelle, et al.

Journal article  |  2020  |  BMC Medicine

BACKGROUND: Higher adiposity increases the risk of colorectal cancer (CRC), but whether this relationship varies by anatomical sub..

Monoallelic NTHL1 Loss-of-Function Variants and Risk of Polyposis and Colorectal Cancer

Fadwa A Elsayed, Judith E Grolleman, Abiramy Ragunathan, Daniel D Buchanan, Tom van Wezel, Richarda M de Voer

Journal article  |  2020  |  Gastroenterology

Genetic Variants in the Regulatory T cell-Related Pathway and Colorectal Cancer Prognosis

Sonja Neumeyer, Xinwei Hua, Petra Seibold, Lina Jansen, Axel Benner, Barbara Burwinkel, Niels Halama, Sonja I Berndt, Amanda I Phipps, Lori C Sakoda, Robert E Schoen, Martha L Slattery, Andrew T Chan, Manish Gala, Amit D Joshi, Shuji Ogino, Mingyang Song, Esther Herpel, Hendrik Blaker, Matthias Kloor, et al.

Journal article  |  2020  |  Cancer Epidemiology Biomarkers & Prevention

BACKGROUND: High numbers of lymphocytes in tumor tissue, including T regulatory cells (Treg), have been associated with better col..