David Balding

LDAK-GBAT: Fast and powerful gene-based association testing using summary statistics

Takiy-Eddine Berrandou, David Balding, Doug Speed

Journal article  |  2023  |  AMERICAN JOURNAL OF HUMAN GENETICS

We present LDAK-GBAT, a tool for gene-based association testing using summary statistics from genome-wide association studies that..

Fast and accurate joint inference of coancestry parameters for populations and/or individuals

Tristan M Mary-Huard, David Balding

Journal article  |  2023  |  PLOS GENETICS

We introduce a fast, new algorithm for inferring from allele count data the FST parameters describing genetic distances among a se..

A founder event causing a dominant childhood epilepsy survives 800 years through weak selective pressure

Bronwyn E Grinton, Erandee Robertson, Liam G Fearnley, Ingrid E Scheffer, Anthony G Marson, Terence J O'Brien, W Owen Pickrell, Mark Rees, Sanjay M Sisodiya, David J Balding, Mark F Bennett, Melanie Bahlo, Samuel F Berkovic, Karen L Oliver

Journal article  |  2022  |  AMERICAN JOURNAL OF HUMAN GENETICS

Genetic epilepsy with febrile seizures plus (GEFS+) is an autosomal dominant familial epilepsy syndrome characterized by distincti..

LDAK-GBAT - a Powerful and Efficient Tool for Gene-based Analysis of GWAS Data

Takiy Berrandou, David Balding, Doug Speed

Conference Proceedings  |  2022  |  GENETIC EPIDEMIOLOGY

Including diverse and admixed populations in genetic epidemiology research

Amke Caliebe, Fasil Tekola-Ayele, Burcu F Darst, Xuexia Wang, Yeunjoo E Song, Jiang Gui, Ronnie A Sebro, David J Balding, Mohamad Saad, Marie-Pierre Dube

Journal article  |  2022  |  GENETIC EPIDEMIOLOGY

The inclusion of ancestrally diverse participants in genetic studies can lead to new discoveries and is important to ensure equita..

Disentangling Signatures of Selection Before and After European Colonization in Latin Americans

Javier Mendoza-Revilla, Juan Camilo Chacon-Duque, Macarena Fuentes-Guajardo, Louise Ormond, Ke Wang, Malena Hurtado, Valeria Villegas, Vanessa Granja, Victor Acuna-Alonzo, Claudia Jaramillo, William Arias, Rodrigo Barquera, Jorge Gomez-Valdes, Hugo Villamil-Ramirez, Caio C Silva de Cerqueira, Keyla M Badillo Rivera, Maria A Nieves-Colon, Christopher R Gignoux, Genevieve L Wojcik, Andres Moreno-Estrada, et al.

Journal article  |  2022  |  MOLECULAR BIOLOGY AND EVOLUTION

Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separat..

Interest of the profile and admixed sample for genetic analysis of human facial morphology

Betty Bonfante, Pierre Faux, Nicolas Navarro, Javier Mendoza-Revilla, Morgane Dubied, Charlotte Montillot, Emma Wentworth, Lauriane Poloni, Philip Jones, Ziyi Xiong, Sagnik Palmal, Fan Liu, Seth M Weinberg, John R Shaffer, Evie Stergiakouli, Laurence J Howe, Pirro G Hysi, Timothy D Spector, Rolando Gonzalez-Jose, Lavinia Schuler-Faccini, et al.

Conference Proceedings  |  2022  |  EUROPEAN JOURNAL OF HUMAN GENETICS

SNP-based heritability and selection analyses: Improved models and new results

Doug Speed, Anubhav Kaphle, David J Balding

Journal article  |  2022  |  BIOESSAYS

Complex-trait genetics has advanced dramatically through methods to estimate the heritability tagged by SNPs, both genome-wide and..

Genome-wide association mapping of Hagberg falling number, protein content, test weight, and grain yield in UK wheat

Jon White, Rajiv Sharma, David Balding, James Cockram, Ian J Mackay

Journal article  |  2022  |  CROP SCIENCE

Association mapping using crop cultivars allows identification of genetic loci of direct relevance to breeding. Here, 150 U.K. whe..

Bayesian inference of ancestral recombination graphs

Ali Mahmoudi, Jere Koskela, Jerome Kelleher, Yao-ban Chan, David Balding

Journal article  |  2022  |  PLOS COMPUTATIONAL BIOLOGY

We present a novel algorithm, implemented in the software ARGinfer, for probabilistic inference of the Ancestral Recombination Gra..