Tom Karagiannis

Interaction of small molecules with the SARS-CoV-2 main protease in silico and in vitro validation of potential lead compounds using an enzyme-linked immunosorbent assay

Eleni Pitsillou, Julia Liang, Chris Karagiannis, Katherine Ververis, Kevion K Darmawan, Ken Ng, Andrew Hung, Tom C Karagiannis

Journal article  |  2020  |  Computational Biology and Chemistry

Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the COVID-19 pandemic is ongoing, with no proven safe ..

Site mapping and small molecule blind docking reveal a possible target site on the SARS-CoV-2 main protease dimer interface

Julia Liang, Chris Karagiannis, Eleni Pitsillou, Kevion K Darmawan, Ken Ng, Andrew Hung, Tom C Karagiannis

Journal article  |  2020  |  Computational Biology and Chemistry

The SARS-CoV-2 virus is causing COVID-19 resulting in an ongoing pandemic with serious health, social, and economic implications. ..

Interaction of the prototypical alpha-ketoamide inhibitor with the SARS-CoV-2 main protease active site in silico: Molecular dynamic simulations highlight the stability of the ligand-protein complex

Julia Liang, Eleni Pitsillou, Chris Karagiannis, Kevion K Darmawan, Ken Ng, Andrew Hung, Tom C Karagiannis

Journal article  |  2020  |  COMPUTATIONAL BIOLOGY AND CHEMISTRY

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) causes an illness known as COVID-19, which has been declared a gl..

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Katherine Ververis, Mark J Tobin, Simon G Royce, Chrishan S Samuel, Kenneth J Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  SCIENTIFIC REPORTS

The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical thera..

Investigation of potential anti-pneumococcal effects of L-sulforaphane and metabolites: Insights from synchrotron-FTIR microspectroscopy and molecular docking studies

Julia Liang, Anita Mantelos, Zheng Quan Toh, Stephanie M Tortorella, Katherine Ververis, Jitraporn Vongsvivut, Keith R Bambery, Paul Licciardi, Andrew Hung, Tom C Karagiannis

Journal article  |  2020  |  JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Streptococcus pneumoniae infection can lead to pneumococcal disease, a major cause of mortality in children under the age of five ..

The potential use of L-sulforaphane for the treatment of chronic inflammatory diseases: A review of the clinical evidence

Nadia Mazarakis, Kenneth Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  CLINICAL NUTRITION

According to the World Health Organisation, 70% of all deaths globally can be attributed to chronic inflammatory diseases such as ..

Synchrotron-Fourier transform infrared maps of ovalbumin-induced murine chronic allergic airways disease: Correlation with conventional histology.

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Kenneth J Snibson, Simon G Royce, Tom C Karagiannis

Journal article  |  2017  |  Hell J Nucl Med

Asthma is a chronic respiratory disease characterised by airway inflammation, remodeling and hyperresponsiveness. The ability to r..

Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes

Haloom Rafehi, Antony Kaspi, Mark Ziemann, Jun Okabe, Tom C Karagiannis, Assam El-Osta

Journal article  |  2017  |  EPIGENETICS

Given the skyrocketing costs to develop new drugs, repositioning of approved drugs, such as histone deacetylase (HDAC) inhibitors,..

Pharmacological Histone Deacetylation Distinguishes Transcriptional Regulators

Haloom Rafehi, Tom C Karagiannis, Assam El-Osta

Conference Proceedings  |  2017  |  CURRENT TOPICS IN MEDICINAL CHEMISTRY

INTRODUCTION: Histone deacetylase (HDAC) enzymes control the acetylation status of transcription factors that regulate chromatin s..

Strand breakage by decay of DNA-bound I-124 provides a basis for combined PET imaging and Auger endoradiotherapy

Pavel Lobachevsky, George R Clark, Patrycja D Pytel, Brenda Leung, Colin Skene, Laura Andrau, Jonathan M White, Tom Karagiannis, Carleen Cullinane, Boon Q Lee, Andrew Stuchbery, Tibor Kibedi, Rodney J Hicks, Roger F Martin

Journal article  |  2016  |  INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Purpose DNA ligands labelled with 125I induce cytotoxic DNA double-strand breaks (DSB), suggesting a potential for Auger endoradio..