Tom Karagiannis

Investigation of molecular mechanisms of experimental compounds in murine models of chronic allergic airways disease using synchrotron Fourier-transform infrared microspectroscopy.

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Katherine Ververis, Mark J Tobin, Simon G Royce, Chrishan S Samuel, Kenneth J Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  Scientific Reports

The ovalbumin-induced (OVA) chronic allergic airways murine model is a well-established model for investigating pre-clinical thera..

Investigation of potential anti-pneumococcal effects of L-sulforaphane and metabolites: Insights from synchrotron-FTIR microspectroscopy and molecular docking studies

Julia Liang, Anita Mantelos, Zheng Quan Toh, Stephanie M Tortorella, Katherine Ververis, Jitraporn Vongsvivut, Keith R Bambery, Paul Licciardi, Andrew Hung, Tom C Karagiannis

Journal article  |  2020  |  Journal of Molecular Graphics and Modelling

Streptococcus pneumoniae infection can lead to pneumococcal disease, a major cause of mortality in children under the age of five ..

The potential use of L-sulforaphane for the treatment of chronic inflammatory diseases: A review of the clinical evidence

Nadia Mazarakis, Kenneth Snibson, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2020  |  Clinical Nutrition

According to the World Health Organisation, 70% of all deaths globally can be attributed to chronic inflammatory diseases such as ..

Synchrotron-Fourier transform infrared maps of ovalbumin-induced murine chronic allergic airways disease: Correlation with conventional histology.

Nadia Mazarakis, Jitraporn Vongsvivut, Keith R Bambery, Kenneth J Snibson, Simon G Royce, Tom C Karagiannis

Journal article  |  2017  |  Hellenic journal of nuclear medicine

Asthma is a chronic respiratory disease characterised by airway inflammation, remodeling and hyperresponsiveness. The ability to r..

Systems approach to the pharmacological actions of HDAC inhibitors reveals EP300 activities and convergent mechanisms of regulation in diabetes

Haloom Rafehi, Antony Kaspi, Mark Ziemann, Jun Okabe, Tom C Karagiannis, Assam El-Osta

Journal article  |  2017  |  Epigenetics

Pharmacological Histone Deacetylation Distinguishes Transcriptional Regulators

Haloom Rafehi, Tom C Karagiannis, Assam El-Osta

Conference Proceedings  |  2017  |  Current Topics in Medicinal Chemistry

Strand breakage by decay of DNA-bound I-124 provides a basis for combined PET imaging and Auger endoradiotherapy

Pavel Lobachevsky, George R Clark, Patrycja D Pytel, Brenda Leung, Colin Skene, Laura Andrau, Jonathan M White, Tom Karagiannis, Carleen Cullinane, Boon Q Lee, Andrew Stuchbery, Tibor Kibedi, Rodney J Hicks, Roger F Martin

Journal article  |  2016  |  International Journal of Radiation Biology

Qualitative and Quantitative Analysis of Histone Deacetylases in Kidney Tissue Sections

Katherine Ververis, Selly Marzully, Chrishan S Samuel, Tim D Hewitson, Tom C Karagiannis

Book Chapter  |  2016  |  Methods in Molecular Biology

Exploration of mechanisms in nutriepigenomics: Identification of chromatin-modifying compounds from Olea Europaea

Natalie P Bonvino, Nancy B Ray, Vi T Luu, Julia Liang, Andrew Hung, Tom C Karagiannis

Journal article  |  2015  |  Hellenic journal of nuclear medicine

The Implication of Cancer Progenitor Cells and the Role of Epigenetics in the Development of Novel Therapeutic Strategies for Chronic Myeloid Leukemia

Stephanie M Tortorella, Andrew Hung, Tom C Karagiannis

Journal article  |  2015  |  Antioxidants & Redox Signaling

Dietary Sulforaphane in Cancer Chemoprevention: The Role of Epigenetic Regulation and HDAC Inhibition

Stephanie M Tortorella, Simon G Royce, Paul V Licciardi, Tom C Karagiannis

Journal article  |  2015  |  Antioxidants & Redox Signaling

Cellular and Molecular Effects of Bioactive Phenolic Compounds in Olives and Olive Oil

NB Ray, NT Lam, R Luc, NP Bonvino, TC Karagiannis

Book Chapter  |  2015

The Warburg effect: molecular aspects and therapeutic possibilities

Ngo Hanh, Stephanie M Tortorella, Katherine Ververis, Tom C Karagiannis

Journal article  |  2015  |  Molecular Biology Reports

Lactate as an insidious metabolite due to the Warburg effect

Raymond Luc, Stephanie M Tortorella, Katherine Ververis, Tom C Karagiannis

Journal article  |  2015  |  Molecular Biology Reports

Introduction to the molecular basis of cancer metabolism and the Warburg effect

Darleen C Ngo, Katherine Ververis, Stephanie M Tortorella, Tom C Karagiannis

Journal article  |  2015  |  Molecular Biology Reports

RNA sequencing supports distinct reactive oxygen species-mediated pathways of apoptosis by high and low size mass fractions of Bay leaf (Lauris nobilis) in HT-29 cells

Annabelle L Rodd, Katherine Ververis, Dheeshana Sayakkarage, Abdul W Khan, Haloom Rafehi, Mark Ziemann, Shanon J Loveridge, Ross Lazarus, Caroline Kerr, Trevor Lockett, Assam El-Osta, Tom C Karagiannis, Louise E Bennett

Journal article  |  2015  |  Food & Function

The early life origin theory in the development of cardiovascular disease and type 2 diabetes

R Lindblom, K Ververis, S Tortorella, T Karagiannis

Journal article  |  2015  |  Molecular Biology Reports

Derivative of Bardoxolone Methyl, dh404, in an Inverse Dose-Dependent Manner Lessens Diabetes-Associated Atherosclerosis and Improves Diabetic Kidney Disease

Sih Min Tan, Arpeeta Sharma, Nada Stefanovic, Derek YC Yuen, Tom C Karagiannis, Colin Meyer, Keith W Ward, Mark E Cooper, Judy B de Haan

Journal article  |  2014  |  Diabetes

Transferrin Receptor-Mediated Endocytosis: A Useful Target for Cancer Therapy

Stephanie Tortorella, Tom C Karagiannis

Journal article  |  2014  |  The Journal of Membrane Biology

Histone deacetylase inhibitors potentiate photochemotherapy in cutaneous T-cell lymphoma MyLa cells

Jane J Sung, Katherine Ververis, Tom C Karagiannis

Journal article  |  2014  |  Journal of Photochemistry and Photobiology B: Biology

Combination therapy for cancer: Phototherapy and HDAC inhibition

JJ Sung, TC Karagiannis

Book Chapter  |  2014

Nano-based drug delivery modalities for the treatment of cancer: The formulation of tumour-specific and-targeted nanoparticles

LJ Mah, S Tortorella, TC Karagiannis

Book Chapter  |  2014

An overview of epigenetic mechanisms in health and disease

C Westerland, TC Karagiannis

Book Chapter  |  2014

The significance of nanoparticles in medicine and their potential application in asthma

S Tortorella, TC Karagiannis

Book Chapter  |  2014

Molecular mechanisms and physiology of disease: Implications for epigenetics and health

N Maulik, T Karagiannis

Book  |  2014

Dietary antioxidants and chromatin modifying compounds as potential anti-cancer therapies

N Mazarakis, TC Karagiannis

Book Chapter  |  2014

Principles of the warburg effect and cancer cell metabolism

N Molino, K Ververis, TC Karagiannis

Book Chapter  |  2014

Molecular aspects of the warburg effect

E Balding, K Ververis, TC Karagiannis

Book Chapter  |  2014

Anti-inflammatory effects of probiotics and their metabolites: Possible role for epigenetic effects

N Türker, ZQ Toh, TC Karagiannis, PV Licciardi

Book Chapter  |  2014

Preface [Molecular mechanisms and physiology of disease: Implications for Epigenetics and Health]

N Maulik, T Karagiannis

Book Chapter  |  2014

Molecular mechanisms in the development and progression of asthma: The role of epigenetic regulation and the airway epithelium

S Tortorella, SG Royce, TC Karagiannis

Book Chapter  |  2014

Histone deacetylases and their inhibitors: new implications for asthma and chronic respiratory conditions

Simon G Royce, Tom C Karagiannis

Journal article  |  2014  |  Current Opinion in Allergy and Clinical Immunology

The timeless influence of Hippocratic ideas on diet, salicylates and personalized medicine

Tom C Karagiannis

Journal article  |  2014  |  Hellenic Journal of Nuclear Medicine

The Significance of Transferrin Receptors in Oncology: the Development of Functional Nano-based Drug Delivery Systems

Stephanie Tortorella, Tom C Karagiannis

Journal article  |  2014  |  Current Drug Delivery

THE POTENTIAL ROLE OF HDAC INHIBITORS IN DE-SILENCING LATENT HIV VIRUS

K Ververis, TC Karagiannis

Journal article  |  2013  |  Drugs of the Future

The potential role of HDAC inhibitors in de-silencing latent HIV virus

K Ververis, TC Karagiannis

Journal article  |  2013  |  Drugs of the Future

Trefoil Factor-2 Reverses Airway Remodeling Changes in Allergic Airways Disease

Simon G Royce, Clarice Lim, Ruth C Muljadi, Chrishan S Samuel, Katherine Ververis, Tom C Karagiannis, Andrew S Giraud, Mimi LK Tang

Journal article  |  2013  |  American Journal of Respiratory Cell and Molecular Biology

Histone deacetylase inhibitors (HDACIs): multitargeted anticancer agents

Katherine Ververis, Alison Hiong, Tom C Karagiannis, Paul V Licciardi

Journal article  |  2013  |  Biologics: Targets and Therapy

Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers

Haloom Rafehi, Assam El-Osta, Tom C Karagiannis

Journal article  |  2012  |  Journal of Diabetes and its Complications

Influence of Natural and Synthetic Histone Deacetylase Inhibitors on Chromatin

Paul V Licciardi, Faith AA Kwa, Katherine Ververis, Natasha Di Costanzo, Aneta Balcerczyk, Mimi L Tang, Assam El-Osta, Tom C Karagiannis

Journal article  |  2012  |  Antioxidants and Redox Signaling

Factors Influencing Epigenetic Mechanisms and Related Diseases

Tom C Karagiannis, Nilanjana Maulik

Journal article  |  2012  |  Antioxidants and Redox Signaling

Mechanisms of action of phenolic compounds in olive.

Haloom Rafehi, Katherine Ververis, Tom C Karagiannis

Journal article  |  2012  |  Journal of Dietary Supplements

Olive oil, an oil rich in monounsaturated fatty acids (MUFCs) and minor constituents including phenolic compounds, is a major comp..

Histone Deacetylase Inhibitors: Can We Consider Potent Anti-Neoplastic Agents for the Treatment of Asthma?

Simon G Royce, Katherine Ververis, Tom C Karagiannis

Journal article  |  2012  |  Annals of Clinical and Laboratory Science

Controversies surrounding the clinical potential of cinnamon for the management of diabetes

H Rafehi, K Ververis, TC Karagiannis

Journal article  |  2012  |  Diabetes Obesity & Metabolism

Investigation into the biological properties of the olive polyphenol, hydroxytyrosol: mechanistic insights by genome-wide mRNA-Seq analysis

Haloom Rafehi, Andrea J Smith, Aneta Balcerczyk, Mark Ziemann, Jenny Ooi, Shanon J Loveridge, Emma K Baker, Assam El-Osta, Tom C Karagiannis

Journal article  |  2012  |  Genes & Nutrtion

Histone Deacetylases and Their Role in Asthma

Simon G Royce, Tom C Karagiannis

Journal article  |  2012  |  Journal of Asthma (New York)

An atlas of histone deacetylase expression in breast cancer: fluorescence methodology for comparative semi-quantitative analysis

Katherine Ververis, Tom C Karagiannis

Journal article  |  2012  |  American Journal of Translational Research

Safety and efficacy of pralatrexate in the management of relapsed or refractory peripheral T-cell lymphoma.

Annabelle L Rodd, Katherine Ververis, Tom C Karagiannis

Journal article  |  2012  |  Clinical Medicine Insights: Oncology

Peripheral T-cell lymphoma (PTCL) represents a relatively rare group of heterogeneous non-Hodgkin lymphomas, with generally poor p..

Molecular model of naphthalene-induced DNA damage in the murine lung

Tom C Karagiannis, Xuelei Li, Michelle M Tang, Christian Orlowski, Assam El-Osta, Mimi LK Tang, Simon G Royce

Journal article  |  2012  |  Human & Experimental Toxicology: an international journal

Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage

Pavel N Lobachevsky, Raja S Vasireddy, Sam Broadhurst, Carl N Sprung, Tom C Karagiannis, Andrea J Smith, Ian R Radford, Michael J McKay, Roger F Martin

Journal article  |  2011  |  International Journal of Radiation Biology

Trichostatin A accentuates doxorubicin-induced hypertrophy in cardiac myocytes

Tom C Karagiannis, Ann JE Lin, Katherine Ververis, Lisa Chang, Michelle M Tang, Jun Okabe, Assam El-Osta

Journal article  |  2010  |  Aging

gamma H2AX: a sensitive molecular marker of DNA damage and repair

L-J Mah, A El-Osta, TC Karagiannis

Journal article  |  2010  |  Leukemia

Disparity of histone deacetylase inhibition on repair of radiation-induced DNA damage on euchromatin and constitutive heterochromatin compartments

TC Karagiannis, H Kn, A El-Osta

Journal article  |  2007  |  Oncogene

Receptor-mediated DNA-targeted photoimmunotherapy

Tom C Karagiannis, Pavel N Lobachevsky, Brenda KY Leung, Jonathan M White, Roger F Martin

Journal article  |  2006  |  Cancer Research

DNA targeted UVA photo sensitization: Characterization of an extremely photopotent iodinated minor groove binding DNA ligand

Tom C Karagiannis, Pavel N Lobachevsky, Roger F Martin

Journal article  |  2006  |  Journal of Photochemistry and Photobiology B: Biology

Plasmid DNA breakage by decay of DNA-associated auger electron emitters: Approaches to analysis of experimental data

PN Lobachevsky, TC Karagiannis, RF Martin

Journal article  |  2004  |  Radiation Research