Professor Melissa Little

Professor Melissa Little, BSc PhD GAICD, FAAHMS, FAA is the Theme Director of Cell Biology at the Murdoch Children’s Research Institute in Melbourne, Australia. She is internationally recognised for her work on the systems biology of kidney development.

For more than two decades, her work has investigated the molecular and cellular basis of kidney development and disease. This fundamental research has underpinned her pioneering studies into potential regenerative therapies for kidney disease. As a result, her team have developed approaches for directing the differentiation of human pluripotent stem cells to human kidney organoids. Her group are applying this knowledge to disease modelling, drug screening, cell therapy and tissue engineering. Professor Little is an NHMRC Senior Principal Research Fellow at MCRI, Program Leader of Stem Cells Australia and Professor, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne. Melissa is also President of the Australasian Society for Stem Cell Research, Vice-President of the Board of ISSCR, and immediate past President of ASSCR. A Fellow of the Australian Academy of Science and the Australian Academy of Health and Medical Sciences.

Find out more about Melissa Little's experience

Melissa Little's highlights

FEATURED Journal article

Advances in our understanding of genetic kidney disease using kidney organoids

Melissa Little's selected work

Studying Early Human Kidney Development Using Stem Cells

Research Grant

The future of stem cells: tackling hype versus hope

NEWS ARTICLE

Recreating, expanding and using nephron progenitor populations

Journal article

Pushing The Limits Of Fluroescence Microscopy With Adaptive Optics (NON-ARC Cash)

Research Grant

Organoids: the next revolution in human biology has begun

NEWS ARTICLE

Multivariate patterning of human pluripotent cells under perfusion reveals critical roles ..

Journal article

Projects

Displaying the 10 most recent projects by Melissa Little.

Studying Early Human Kidney Development Using Stem Cells

This project aims to improve our understanding of cell types, lineage relationships, cell-cell interactions and morphogenetic processes in h..

2019 - 2022

Active

Pushing The Limits Of Fluroescence Microscopy With Adaptive Optics (NON-ARC Cash)

This project aims to establish an adaptive optics, super-resolution optical microscopy facility to image cellular events with the highest po..

2018 - 2018

Completed

Pushing The Limits Of Fluroescence Microscopy With Adaptive Optics

This project aims to establish an adaptive optics, super-resolution optical microscopy facility to image cellular events with the highest po..

2018 - 2018

Completed

Super Resolution Confocal Microscopy Facility

This project aims to establish a super-resolution confocal microscopy facility with unrivalled resolution, sensitivity and speed. The widesp..

2016 - 2016

Completed

Understanding Self-Organizing Tissues

This project will discover how an organ can form from a mixture of component cells by 'self-organisation'. Understanding of how this can occ..

2015 - 2016

Completed

Stem Cells Australia (ARC Funding) Using Ipsc-Derived Neuronal Cultures For Drug Discovery In Neurogenetic Epileptic Disorders (2019 Petrou Project - ARC Cash)

Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw ..

2011 - 2019

Completed

Stem Cells Australia (ARC Funding) Sca Legacy Website Ci Munsie

Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw ..

2011 - 2019

Completed

Stem Cells Australia (ARC Funding) Genetic Engineering On Steroids Ci Tanner

Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw ..

2011 - 2019

Completed

Stem Cells Australia

Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw ..

2011 - 2019

Completed

Stem Cells Australia

Despite progress in stem cell research, scientists do not understand how stem cells “decide” what to become. Stem Cells Australia will draw ..

2011 - 2019

Completed

10

Projects

Project Types

Research Grant

Scholarly Works

Displaying the 266 most recent scholarly works by Melissa Little.

Advances in our understanding of genetic kidney disease using kidney organoids

Melissa H Little, Catherine Quinlan

Journal article | 2020 | Pediatric Nephrology

A significant proportion of kidney disease presenting in childhood is likely genetic in origin with a growing number of genes impl..

Recreating, expanding and using nephron progenitor populations

Melissa H Little, Kynan T Lawlor

Journal article | 2020 | Nature Reviews Nephrology

Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development

Nick R Glass, Minoru Takasako, Pei Xuan Er, Drew M Titmarsh, Alejandro Hidalgo, Ernst J Wolvetang, Melissa H Little, Justin J Cooper-White

Journal article | 2020 | Science Advances

Creating complex multicellular kidney organoids from pluripotent stem cells shows great promise. Further improvements in different..

Diving Deep into the Adult Mouse Kidney

Melissa H Little

Journal article | 2019 | Developmental Cell

Kidney organoids: accurate models or fortunate accidents

Melissa H Little, Alexander N Combes

Journal article | 2019 | Genes & Development

A Toolbox to Characterize Human Induced Pluripotent Stem Cell-Derived Kidney Cell Types and Organoids

Jessica M Vanslambrouck, Sean B Wilson, Ker Sin Tan, Joanne Y-C Soo, Michelle Scurr, H Siebe Spijker, Lakshi T Starks, Amber Neilson, Xiaoxia Cui, Sanjay Jain, Melissa Helen Little, Sara E Howden

Journal article | 2019 | Journal of the American Society of Nephrology

BACKGROUND: The generation of reporter lines for cell identity, lineage, and physiologic state has provided a powerful tool in adv..

Recapitulating kidney development: Progress and challenges

Melissa H Little, Santhosh V Kumar, Thomas Forbes

Journal article | 2019 | Seminars in Cell & Developmental Biology

Single cell analysis of the developing mouse kidney provides deeper insight into marker gene expression and ligand-receptor crosstalk

Alexander N Combes, Belinda Phipson, Kynan T Lawlor, Aude Dorison, Ralph Patrick, Luke Zappia, Richard P Harvey, Alicia Oshlack, Melissa H Little

Journal article | 2019 | Development

Direct reprogramming to human nephron progenitor-like cells using inducible piggyBac transposon expression of SNAI2-EYA1-SIX1

Jessica M Vanslambrouck, Lauren E Woodard, Norseha Suhaimi, Felisha M Williams, Sara E Howden, Sean B Wilson, Andrew Lonsdale, Pei X Er, Joan Li, Jovana Maksimovic, Alicia Oshlack, Matthew H Wilson, Melissa H Little

Journal article | 2019 | Kidney International

Vascular bioengineering of scaffolds derived from human discarded transplant kidneys using human pluripotent stem cell-derived endothelium

Danielle G Leuning, Franca MR Witjas, Mehdi Maanaoui, Annemarie MA de Graaf, Ellen Lievers, Thomas Geuens, Christina M Avramut, Loes E Wiersma, Cathelijne W van den Berg, Wendy MPJ Sol, Hetty de Boer, Gangqi Wang, Vanessa LS LaPointe, Johan van der Vlag, Cees van Kooten, Bernard M van den Berg, Melissa H Little, Marten A Engelse, Ton J Rabelink

Journal article | 2019 | American Journal of Transplantation

Reporter-based fate mapping in human kidney organoids confirms nephron lineage relationships and reveals synchronous nephron formation

Sara E Howden, Jessica M Vanslambrouck, Sean B Wilson, Ker Sin Tan, Melissa H Little

Journal article | 2019 | EMBO reports

Kidney micro-organoids in suspension culture as a scalable source of human pluripotent stem cell-derived kidney cells

Santhosh Kumar, Pei X Er, Kynan T Lawlor, Ali Motazedian, Michelle Scurr, Irene Ghobrial, Alexander N Combes, Luke Zappia, Alicia Oshlack, Edouard G Stanley, Melissa H Little

Journal article | 2019 | Development

Nephron progenitor commitment is a stochastic process influenced by cell migration

Kynan T Lawlor, Luke Zappia, James Lefevre, Joo-Seop Park, Nicholas A Hamilton, Alicia Oshlack, Melissa H Little, Alexander N Combes

Journal article | 2019 | eLife

Single-cell analysis reveals congruence between kidney organoids and human fetal kidney

Alexander N Combes, Luke Zappia, Pei Xuan Er, Alicia Oshlack, Melissa H Little

Journal article | 2019 | Genome Medicine

Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

Alena V Yermalovich, Jihan K Osborne, Patricia Sousa, Areum Han, Melissa A Kinney, Michael J Chen, Daisy A Robinton, Helen Montie, Dan S Pearson, Sean B Wilson, Alexander N Combes, Melissa H Little, George Q Daley

Journal article | 2019 | Nature Communications

Generating Kidney from Stem Cells

Melissa H Little, Lorna J Hale, Sara E Howden, Santhosh V Kumar

Journal article | 2019 | Annual Review of Physiology

DNA Methyltransferase 1 Controls Nephron Progenitor Cell Renewal and Differentiation

Nicola Wanner, Julia Vornweg, Alexander Combes, Sean Wilson, Julia Plappert, Gesa Rafflenbeul, Victor G Puelles, Raza-Ur Rahman, Timur Liwinski, Saskia Lindner, Florian Grahammer, Oliver Kretz, Mary E Wlodek, Tania Romano, Karen M Moritz, Melanie Boerries, Hauke Busch, Stefan Bonn, Melissa H Little, Wibke Bechtel-Walz, et al.

Journal article | 2019 | Journal of the American Society of Nephrology

Evaluation of variability in human kidney organoids

Belinda Phipson, Pei X Er, Alexander N Combes, Thomas A Forbes, Sara E Howden, Luke Zappia, Hsan-Jan Yen, Kynan T Lawlor, Lorna J Hale, Jane Sun, Ernst Wolvetang, Minoru Takasato, Alicia Oshlack, Melissa H Little

Journal article | 2019 | Nature Methods

Wnt11 directs nephron progenitor polarity and motile behavior ultimately determining nephron endowment

Lori L O'Brien, Alexander N Combes, Kieran M Short, Nils O Lindstrom, Peter H Whitney, Luise A Cullen-McEwen, Adler Ju, Ahmed Abdelhalim, Odysse Michos, John F Bertram, Ian M Smyth, Melissa H Little, Andrew P McMahon

Journal article | 2018 | eLife

3D organoid-derived human glomeruli for personalised podocyte disease model ling and drug screening

Lorna J Hale, Sara E Howden, Belinda Phipson, Andrew Lonsdale, Pei X Er, Irene Ghobrial, Salman Hosawi, Sean Wilson, Kynan T Lawlor, Shahnaz Khan, Alicia Oshlack, Catherine Quinlan, Rachel Lennon, Melissa H Little

Journal article | 2018 | Nature Communications

Prolonged prenatal hypoxia selectively disrupts collecting duct patterning and postnatal function in male mouse offspring

Sarah L Walton, Reetu R Singh, Melissa H Little, Josephine Bowles, Joan Li, Karen M Moritz

Journal article | 2018 | The Journal of Physiology

Choosing an easier path or following your passion

Melissa Little

Journal article | 2018 | Nature Cell Biology

RAPID TRANSLATION OF NOVEL NEPHROGENETIC AETIOLOGIES FROM FIRST REPORT TO ACCREDITED DIAGNOSTIC OUTCOME

AJ Mallett, C Patel, J Crawford, L Hale, G Ho, K Holman, B Bennetts, M Little, I Smyth, C Simons

Conference Proceedings | 2018 | NEPHROLOGY

Branching morphogenesis in the developing kidney is not impacted by nephron formation or integration

Kieran M Short, Alexander N Combes, Valerie Lisnyak, James G Lefevre, Lynelle K Jones, Melissa H Little, Nicholas A Hamilton, Ian M Smyth

Journal article | 2018 | eLife

Hamartin regulates cessation of mouse nephrogenesis independently of Mtor

Oded Volovelsky, Nguyen Thi, Alison E Jarmas, Alexander N Combes, Sean B Wilson, Melissa H Little, David P Witte, Eric W Brunskill, Raphael Kopan

Journal article | 2018 | Proceedings of the National Academy of Sciences

Bayesian inference of agent-based models: a tool for studying kidney branching morphogenesis

Ben Lambert, Adam L MacLean, Alexander G Fletcher, Alexander N Combes, Melissa H Little, Helen M Byrne

Journal article | 2018 | Journal of Mathematical Biology

Advances in predictive in vitro models of drug-induced nephrotoxicity

Joanne Y-C Soo, Jitske Jansen, Rosalinde Masereeuw, Melissa H Little

Journal article | 2018 | Nature Reviews Nephrology

Shining a Light on Alport Syndrome

Lorna J Hale, Melissa H Little

Journal article | 2018 | Cell Chemical Biology

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

Thomas A Forbes, Sara E Howden, Kynan Lawlor, Belinda Phipson, Jovana Maksimovic, Lorna Hale, Sean Wilson, Catherine Quinlan, Gladys Ho, Katherine Holman, Bruce Bennetts, Joanna Crawford, Peter Trnka, Alicia Oshlack, Chirag Patel, Andrew Mallett, Cas Simons, Melissa H Little

Journal article | 2018 | The American Journal of Human Genetics

Simultaneous reprogramming and gene editing of human fibroblasts

Sara E Howden, James A Thomson, Melissa H Little

Journal article | 2018 | Nature Protocols

EXPANDING CELLULAR THERAPIES THROUGH PROVISION OF A CORD BLOOD-DERIVED IPSC HAPLOBANK

N Elwood, K Abberton, P Tian, A Elefanty, E Stanley, J Youngson, M Diviney, R Holdsworth, K Tiedemann, M Little

Conference Proceedings | 2018 | CYTOTHERAPY

Criml is required for maintenance of the ocular lens epithelium

Oliver H Tam, David Pennisi, Lorine Wilkinson, Melissa H Little, Fatima Wazin, Victor L Wan, Frank J Lovicu

Journal article | 2018 | Experimental Eye Research

Renal Subcapsular Transplantation of PSC-Derived Kidney Organoids Induces Neo-vasculogenesis and Significant Glomerular and Tubular Maturation In Vivo

Cathelijne W van den Berg, Laila Ritsma, M Cristina Avramut, Loes E Wiersma, Bernard M van den Berg, Danielle G Leuning, Ellen Lievers, Marije Koning, Jessica M Vanslambrouck, Abraham J Koster, Sara E Howden, Minoru Takasato, Melissa H Little, Ton J Rabelink

Journal article | 2018 | Stem Cell Reports

Haploinsufficiency for the Six2 gene increases nephron progenitor proliferation promoting branching and nephron number

Alexander N Combes, Sean Wilson, Belinda Phipson, Brandon B Binnie, Adler Ju, Kynan T Lawlor, Cristina Cebrian, Sarah L Walton, Ian M Smyth, Karen M Moritz, Raphael Kopan, Alicia Oshlack, Melissa H Little

Journal article | 2018 | Kidney International

Development of the Human Fetal Kidney from Mid to Late Gestation in Male and Female Infants

Danica Ryan, Megan R Sutherland, Tracey J Flores, Alison L Kent, Jane E Dahlstrom, Victor G Puelles, John F Bertram, Andrew P McMahon, Melissa H Little, Lynette Moore, Mary Jane Black

Journal article | 2018 | EBioMedicine

OPTIMISATION OF KIDNEY ORGANOIDS AS A REPRODUCIBLE AND DEVELOPMENTALLY ACCURATE MODEL OF HUMAN KIDNEY DEVELOPMENT AND DISEASE

Melissa H Little, Pei X Er, Belinda Phipson, Jessica Vanslambrouck, Sara Howden, Lorna Hale, Minoru Takasato, A Oshlack

Conference Proceedings | 2018 | JOURNAL OF GENE MEDICINE

The kids are OK: it is discrimination, not same-sex parents, that harms children

Ken W Knight, Sarah EM Stephenson, Sue West, Martin B Delatycki, Cheryl A Jones, Melissa H Little, George C Patton, Susan M Sawyer, S Rachel Skinner, Michelle M Telfer, Melissa Wake, Kathryn N North, Frank Oberklaid

Journal article | 2017 | The Medical journal of Australia

The kids are OK: It is discrimination, not same-sex parents, that harms children

KW Knight, SEM Stephenson, S West, MB Delatycki, CA Jones, MH Little, GC Patton, SM Sawyer, SR Skinner, MM Telfer, M Wake, KN North, F Oberklaid

Journal article | 2017 | Medical Journal of Australia

The kids are OK: it is discrimination not same-sex parents that harms children

KW Knight, SE Stephenson, S West, MB Delatycki, CA Jones, MH Little, GC Patton, SM Sawyer, SR Skinner, MM Telfer, M Wake, KN North, F Oberklaid

Journal article | 2017 | The Medical journal of Australia

Prenatal hypoxia leads to hypertension, renal renin-angiotensin system activation and exacerbates salt-induced pathology in a sex-specific manner

SL Walton, H Bielefeldt-Ohmann, RR Singh, J Li, TM Paravicini, MH Little, KM Moritz

Journal article | 2017 | Scientific Reports

Mutations in DZIP1L, which encodes a ciliary-transition-zone protein, cause autosomal recessive polycystic kidney disease

Hao Lu, Maria C Rondon Galeano, Elisabeth Ott, Geraldine Kaeslin, P Jaya Kausalya, Carina Kramer, Nadina Ortiz-Bruechle, Nadescha Hilger, Vicki Metzis, Milan Hiersche, Shang Yew Tay, Robert Tunningley, Shubha Vij, Andrew D Courtney, Belinda Whittle, Elke Wuehl, Udo Vester, Bjoern Hartleben, Steffen Neuber, Valeska Frank, et al.

Journal article | 2017 | Nature Genetics

(Re)Building a Kidney

Leif Oxburgh, Thomas J Carroll, Ondine Cleaver, Daniel R Gossett, Deborah K Hoshizaki, Jeffrey A Hubbell, Benjamin D Humphreys, Sanjay Jain, Jan Jensen, David L Kaplan, Carl Kesselman, Christian J Ketchum, Melissa H Little, Andrew P McMahon, Stuart J Shankland, Jason R Spence, M Todd Valerius, Jason A Wertheim, Oliver Wessely, Ying Zheng, et al.

Journal article | 2017 | Journal of the American Society of Nephrology

Organoids: a Special Issue

Melissa H Little

Journal article | 2017 | Development

Self-organisation after embryonic kidney dissociation is driven via selective adhesion of ureteric epithelial cells

James G Lefevre, Han S Chiu, Alexander N Combes, Jessica M Vanslambrouck, Ali Ju, Nicholas A Hamilton, Melissa H Little

Journal article | 2017 | Development

Clinical-Grade Isolated Human Kidney Perivascular Stromal Cells as an Organotypic Cell Source for Kidney Regenerative Medicine

Danielle G Leuning, Marlies EJ Reinders, Joan Li, Anna J Peired, Ellen Lievers, Hetty C de Boer, Willem E Fibbe, Paola Romagnani, Cees van Kooten, Melissa H Little, Marten A Engelse, Ton J Rabelink

Journal article | 2017 | STEM CELLS Translational Medicine

Clinical-Grade Isolated Human Kidney Perivascular Stromal Cells as an Organotypic Cell Source for Kidney Regenerative Medicine.

Daniëlle G Leuning, Marlies EJ Reinders, Joan Li, Anna J Peired, Ellen Lievers, Hetty C de Boer, Willem E Fibbe, Paola Romagnani, Cees van Kooten, Melissa H Little, Marten A Engelse, Ton J Rabelink

Journal article | 2017 | Stem cells translational medicine

Mesenchymal stromal cells (MSCs) are immunomodulatory and tissue homeostatic cells that have shown beneficial effects in kidney di..

Does Renal Repair Recapitulate Kidney Development?

Melissa Helen Little, Pamela Kairath

Journal article | 2017 | Journal of the American Society of Nephrology

Kidney Development in the Mammal

Melissa H Little

Book Chapter | 2017

Regeneration of Kidney From Human Reprogrammed Stem Cells

Melissa H Little, Kenji Osafune

Book Chapter | 2017

Making a Kidney Organoid Using the Directed Differentiation of Human Pluripotent Stem Cells

Minoru Takasato, Melissa H Little

Book Chapter | 2017 | Methods in Molecular Biology

Recapitulating development to generate kidney organoid cultures

MH Little, M Takasato, JYC Soo, TA Forbes

Book Chapter | 2017

A strategy for generating kidney organoids: Recapitulating the development in human pluripotent stem cells

Minoru Takasato, Melissa H Little

Journal article | 2016 | Developmental Biology

Analysed cap mesenchyme track data from live imaging of mouse kidney development

James G Lefevre, Alexander N Combes, Melissa H Little, Nicholas A Hamilton

Journal article | 2016 | Data in Brief

Cap mesenchyme cell swarming during kidney development is influenced by attraction, repulsion, and adhesion to the ureteric tip

Alexander N Combes, James G Lefevre, Sean Wilson, Nicholas A Hamilton, Melissa H Little

Journal article | 2016 | Developmental Biology

Understanding kidney morphogenesis to guide renal tissue regeneration

Melissa H Little, Alexander N Combes, Minoru Takasato

Journal article | 2016 | Nature Reviews Nephrology

A Cas9 Variant for Efficient Generation of Indel-Free Knockin or Gene-Corrected Human Pluripotent Stem Cells

Sara E Howden, Bradley McColl, Astrid Glaser, Jim Vadolas, Steven Petrou, Melissa H Little, Andrew G Elefanty, Edouard G Stanley

Journal article | 2016 | Stem Cell Reports

Generation of kidney organoids from human pluripotent stem cells

Minoru Takasato, Pei X Er, Han S Chiu, Melissa H Little

Journal article | 2016 | Nature Protocols

Regenerative medicine in kidney disease

Melissa H Little, Pamela Kairath

Journal article | 2016 | Kidney International

Growing Kidney Tissue from Stem Cells: How Far from "Party Trick" to Medical Application?

Melissa H Little

Journal article | 2016 | Cell Stem Cell

Neonatal vascularization and oxygen tension regulate appropriate perinatal renal medulla/papilla maturation

Yu Leng Phua, Thierry Gilbert, Alexander Combes, Lorine Wilkinson, Melissa H Little

Journal article | 2016 | The Journal of Pathology

Closing the circle: from organoids back to development

Melissa H Little

Journal article | 2016 | Development

An interview with Melissa Little

Catarina Vicente, Melissa Little

Journal article | 2016 | Development

Crim1 has cell-autonomous and paracrine roles during embryonic heart development

Swati Iyer, Fang Yu Chou, Richard Wang, Han Sheng Chiu, Vinay K Sundar Raju, Melissa H Little, Walter G Thomas, Michael Piper, David J Pennisi

Journal article | 2016 | Scientific Reports

Generating kidney tissue from pluripotent stem cells

MH Little

Journal article | 2016 | Cell Death Discovery

Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

Minoru Takasato, Pei X Er, Han S Chiu, Barbara Maier, Gregory J Baillie, Charles Ferguson, Robert G Parton, Ernst J Wolvetang, Matthias S Roost, Susana M Chuva de Sousa Lopes, Melissa H Little

Journal article | 2015 | Nature

The Life Cycle of the Nephron Progenitor

Melissa H Little

Journal article | 2015 | Developmental Cell

Direct transcriptional reprogramming to nephron progenitors

Jessica M Vanslambrouck, Melissa H Little

Journal article | 2015 | Current Opinion in Genetics & Development

A protocol for the identification and validation of novel genetic causes of kidney disease

Andrew Mallett, Chirag Patel, Barbara Maier, Julie McGaughran, Michael Gabbett, Minoru Takasato, Anne Cameron, Peter Trnka, Stephen I Alexander, Gopala Rangan, Michel C Tchan, Georgina Caruana, George John, Cathy Quinlan, Hugh J McCarthy, Valentine Hyland, Wendy E Hoy, Ernst Wolvetang, Ryan Taft, Cas Simons, et al.

Journal article | 2015 | BMC Nephrology

Multiplexed Microbioreactor Arrays for Rapid Optimisation of Pluripotent Stem Cell Maintenance and Differentiation

D Titmarsh, N Glass, J Hudson, A Hidalgo, E Porrello, M Little, E Wolvetang, J Cooper-White

Conference Proceedings | 2015 | TISSUE ENGINEERING PART A

THE HETEROZYGOUS P.R76W HNF4A VARIANT IS ASSOCIATED WITH ATYPICAL AUTOSOMAL DOMINANT DE TONI-FANCONI-DEBRE SYNDROME AND CAN BE DIAGNOSED UTILISING DIAGNOSTIC CLINICAL EXOMIC ANALYSIS

A Mallett, D Mordaunt, S Crafter, S Mctaggart, A Kark, C Patel, J Crawford, K Holman, E Farnsworth, G Ho, H Healy, S Alexander, B Bennetts, M Little, C Simons

Conference Proceedings | 2015 | NEPHROLOGY

RMND1 MUTATIONS ARE ASSOCIATED WITH AUTOSOMAL RECESSIVE SYNDROMIC NEPHROPATHY

A Mallett, D Mordaunt, R Sonawane, A Walker, J Kausman, H Peters, S White, Z Stark, P Trnka, C Patel, J Crawford, K Holman, E Farnsworth, G Ho, S Alexander, B Bennetts, H Healy, M Little, C Simons, J Yaplito-Lee

Conference Proceedings | 2015 | NEPHROLOGY

THE T616C TRNA(PHE) MUTATION CAUSES MITOCHONDRIALLY INHERITED TUBULOINTERSTITIAL KIDNEY DISEASE

A Mallett, S Hoer, G John, J Burke, C Patel, J Crawford, V Hyland, H Healy, M Little, C Simons, T Connor, P Maxwell

Conference Proceedings | 2015 | NEPHROLOGY

A spatially-averaged mathematical model of kidney branching morphogenesis

VS Zubkov, AN Combes, KM Short, J Lefevre, NA Hamilton, IM Smyth, MH Little, HM Byrne

Journal article | 2015 | Journal of Theoretical Biology

ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation

Elanor N Wainwright, Dagmar Wilhelm, Alexander N Combes, Melissa H Little, Peter Koopman

Journal article | 2015 | Developmental Biology

TRANSCRIPTIONAL REPROGRAMMING AND DIRECTED DIFFENRENTIATION OF PLURIPOTENT STEM CELLS: ALTERNATIVE OPTIONS FOR REGENERATING KIDNEY

MH Little, JM Vanslambrouck, M Takasato, J Li, N Suhaimi, PX Er, H Chiu

Conference Proceedings | 2015 | JOURNAL OF GENE MEDICINE

THE GENERATION OF A TRANSPOSON-MEDIATED SYSTEM FOR DIRECT TRANSCRIPTIONAL REPROGRAMMING TO NEPHRON PROGENITORS

JM Vanslambrouck, LE Woodard, N Suhaimi, MH Wilson, MH Little

Conference Proceedings | 2015 | JOURNAL OF GENE MEDICINE

Evaluation of biomarkers for in vitro prediction of druginduced nephrotoxicity: comparison of HK-2, immortalized human proximal tubule epithelial, and primary cultures of human proximal tubular cells

Johnny X Huang, Geraldine Kaeslin, Max V Ranall, Mark A Blaskovich, Bernd Becker, Mark S Butler, Melissa H Little, Lawrence H Lash, Matthew A Cooper

Journal article | 2015 | Pharmacology Research & Perspectives

Improving our resolution of kidney morphogenesis across time and space

Melissa H Little

Journal article | 2015 | Current Opinion in Genetics & Development

The origin of the mammalian kidney: implications for recreating the kidney in vitro

Minoru Takasato, Melissa H Little

Journal article | 2015 | Development

An illustrated anatomical ontology of the developing mouse lower urogenital tract

Kylie M Georgas, Jane Armstrong, Janet R Keast, Christine E Larkins, Kirk M McHugh, E Michelle Southard-Smith, Martin J Cohn, Ekatherina Batourina, Hanbin Dan, Kerry Schneider, Dennis P Buehler, Carrie B Wiese, Jane Brennan, Jamie A Davies, Simon D Harding, Richard A Baldock, Melissa H Little, Chad M Vezina, Cathy Mendelsohn

Journal article | 2015 | Development

Renal developmental defects resulting from in utero hypoxia are associated with suppression of ureteric beta-catenin signaling

Lorine J Wilkinson, Cailda S Neal, Reetu R Singh, Duncan B Sparrow, Nyoman D Kurniawan, Adler Ju, Stuart M Grieve, Sally L Dunwoodie, Karen M Moritz, Melissa H Little

Journal article | 2015 | Kidney International

Generating a self-organizing kidney from pluripotent cells

Melissa H Little, Minoru Takasato

Journal article | 2015 | Current Opinion in Organ Transplantation

Cell-Cell Interactions Driving Kidney Morphogenesis

Alexander N Combes, Jamie A Davies, Melissa H Little

Book Chapter | 2015 | Current Topics in Developmental Biology

Reprogramming to Kidney

MH Little

Book Chapter | 2015

Kidney development, disease, repair and regeneration

MH Little

Book | 2015

Development. and. Regeneration. Rachel. C. Dodd,. Alan. J. Davidson. Department of Molecular Medicine & Pathology, School of Medi..

Collecting Duct-Derived Cells Display Mesenchymal Stem Cell Properties and Retain Selective In Vitro and In Vivo Epithelial Capacity

Joan Li, Usukhbayar Ariunbold, Norseha Suhaimi, Nana Sunn, Jinjin Guo, Jill A McMahon, Andrew P McMahon, Melissa Little

Journal article | 2015 | Journal of the American Society of Nephrology

An integrated pipeline for the multidimensional analysis of branching morphogenesis

Alexander N Combes, Kieran M Short, James Lefevre, Nicholas A Hamilton, Melissa H Little, Ian M Smyth

Journal article | 2014 | Nature Protocols

The Kidney Research National Dialogue: Gearing Up to Move Forward

Joseph V Bonventre, L Ebony Boulware, Laura M Dember, Barry I Freedman, Susan L Furth, Lawrence B Holzman, Christian J Ketchum, Melissa H Little, Rajnish Mehrotra, Sharon M Moe, Jeff M Sands, John R Sedor, Stefan Somlo, Robert A Star, Krystyna E Rys-Sikora

Journal article | 2014 | Clinical Journal of the American Society of Nephrology

URINE-CONCENTRATING DEFECT ASSOCIATED WITH REDUCED NEPHRON NUMBER AND PROXIMAL AND DISTAL TUBULE ELONGATION IN MALE but not female OFFSPRING EXPOSED TO LATE-GESTATIONAL HYPOXIA

S Walton, R Singh, M Little, K Moritz

Conference Proceedings | 2014 | NEPHROLOGY

Mid-to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner

JSM Cuffe, SL Walton, RR Singh, JG Spiers, H Bielefeldt-Ohmann, L Wilkinson, MH Little, KM Moritz

Journal article | 2014 | The Journal of Physiology

Reprogramming Somatic Cells to a Kidney Fate

Minoru Takasato, Jessica M Vanslambrouck, Melissa H Little

Journal article | 2014 | Seminars in Nephrology

CHRONIC MID-LATE GESTATIONAL HYPOXIA LEADS TO HYPERTENSION IN MALE AND FEMALE MOUSE OFFSPRING

SL Walton, RR Singh, TM Paravicini, L Wilkinson, MH Little, KM Moritz

Conference Proceedings | 2014 | HYPERTENSION

Global Quantification of Tissue Dynamics in the Developing Mouse Kidney

Kieran M Short, Alexander N Combes, James Lefevre, Adler L Ju, Kylie M Georgas, Timothy Lamberton, Oliver Cairncross, Bree A Rumballe, Andrew P McMahon, Nicholas A Hamilton, Ian M Smyth, Melissa H Little

Journal article | 2014 | Developmental Cell

Defining Kidney Biology to Understand Renal Disease

Melissa H Little, Dennis Brown, Benjamin D Humphreys, Andrew P McMahon, Jeffrey H Miner, Jeff M Sands, Ora A Weisz, Chris Mullins, Deborah Hoshizaki

Journal article | 2014 | Clinical Journal of the American Society of Nephrology

Recreating kidney progenitors from pluripotent cells

Minoru Takasato, Barbara Maier, Melissa H Little

Journal article | 2014 | Pediatric Nephrology

Directing human embryonic stem cell differentiation towards a renal lineage generates a self-organizing kidney

M Takasato, PX Er, M Becroft, JM Vanslambrouck, EG Stanley, AG Elefanty, MH Little

Journal article | 2014 | Nature Cell Biology

Nephron Progenitor Cells: Shifting the Balance of Self-Renewal and Differentiation

Raphael Kopan, Shuang Chen, Melissa Little

Book Chapter | 2014 | Current Topics in Developmental Biology

Stromal Protein Ecm1 Regulates Ureteric Bud Patterning and Branching

Suneeta S Paroly, Fengwei Wang, Lee Spraggon, Joseph Merregaert, Ekatherina Batourina, Benjamin Tycko, Kai M Schmidt-Ott, Sean Grimmond, Melissa Little, Cathy Mendelsohn

Journal article | 2013 | PLoS ONE

Modelling cell turnover in a complex tissue during development

J Lefevre, DJ Marshall, AN Combes, AL Ju, MH Little, NA Hamilton

Journal article | 2013 | Journal of Theoretical Biology

Stromal cells in tissue homeostasis: balancing regeneration and fibrosis

Ton J Rabelink, Melissa H Little

Journal article | 2013 | Nature Reviews Nephrology

Luminal Mitosis Drives Epithelial Cell Dispersal within the Branching Ureteric Bud

Adam Packard, Kylie Georgas, Odysse Michos, Paul Riccio, Cristina Cebrian, Alexander N Combes, Adler Ju, Anna Ferrer-Vaquer, Anna-Katerina Hadjantonakis, Hui Zong, Melissa H Little, Frank Costantini

Journal article | 2013 | Developmental Cell

Polarity, cell division, and out-of-equilibrium dynamics control the growth of epithelial structures

Benedetta Cerruti, Alberto Puliafito, Annette M Shewan, Wei Yu, Alexander N Combes, Melissa H Little, Federica Chianale, Luca Primo, Guido Serini, Keith E Mostov, Antonio Celani, Andrea Gamba

Journal article | 2013 | The Journal of Cell Biology

INTRAUTERINE HYPOXIA IMPAIRS KIDNEY DEVELOPMENT VIA DISRUPTION TO B-CATENIN ACTIVITY

L Wilkinson, C Neal, A Ju, R Singh, B Rumballe, J Li, K Moritz, M Little

Conference Proceedings | 2013 | NEPHROLOGY

DIRECTING THE DIFFERENTIATION OF HUMAN ES CELLS TOWARDS A RENAL FATE

M Takasato, M Becroft, P Er, J Vanslambrouck, E Stanley, A Elefanty, M Little

Conference Proceedings | 2013 | NEPHROLOGY

Direct Transcriptional Reprogramming of Adult Cells to Embryonic Nephron Progenitors

Caroline E Hendry, Jessica M Vanslambrouck, Jessica Ineson, Norseha Suhaimi, Minoru Takasato, Fiona Rae, Melissa H Little

Journal article | 2013 | Journal of the American Society of Nephrology

CHRONIC MID-LATE GESTATIONAL HYPOXIA ALTERS RENAL STRUCTURE AND FUNCTION IN ADULT MALE MOUSE OFFSPRING

S Walton, R Singh, L Wilkinson, M Little, K Moritz

Conference Proceedings | 2013 | NEPHROLOGY

MicroRNAs-140-5p/140-3p Modulate Leydig Cell Numbers in the Developing Mouse Testis

Joanna Rakoczy, Selene L Fernandez-Valverde, Evgeny A Glazov, Elanor N Wainwright, Tempei Sato, Shuji Takada, Alexander N Combes, Darren J Korbie, David Miller, Sean M Grimmond, Melissa H Little, Hiroshi Asahara, John S Mattick, Ryan J Taft, Dagmar Wilhelm

Journal article | 2013 | Biology of Reproduction

M2 macrophage polarisation is associated with alveolar formation during postnatal lung development

Christina V Jones, Timothy M Williams, Kenneth A Walker, Hayley Dickinson, Samy Sakkal, Bree A Rumballe, Melissa H Little, Graham Jenkin, Sharon D Ricardo

Journal article | 2013 | Respiratory Research

Distinct sites of renal fibrosis in Crim1 mutant mice arise from multiple cellular origins

Yu Leng Phua, Nick Martel, David J Pennisi, Melissa H Little, Lorine Wilkinson

Journal article | 2013 | The Journal of Pathology

Report on the first AsiaPacific Kidney Development Workshop

Alan J Davidson, Melissa Little

Journal article | 2013 | Nephrology

Epigenetics and developmental programming of adult onset diseases

Lee O'Sullivan, Melissa H Little, Alexander N Combes, Karen M Moritz

Journal article | 2012 | Pediatric Nephrology

Production of a mouse line with a conditional Crim1 mutant allele

Han Sheng Chiu, J Philippe York, Lorine Wilkinson, Pumin Zhang, Melissa H Little, David J Pennisi

Journal article | 2012 | genesis

PODOCYTE SPECIFIC DELETION OF CRIM1 LEADS TO GLOMERULAR FILTRATION BARRIER DEFECTS

LJ Wilkinson, C Neal, S Aroney, DJ Pennisi, MH Little

Conference Proceedings | 2012 | NEPHROLOGY

Association between congenital defects in papillary outgrowth and functional obstruction in Crim1 mutant mice

Lorine Wilkinson, Nyoman D Kurniawan, Yu Leng Phua, Michael J Nguyen, Joan Li, Graham J Galloway, Hikaru Hashitani, Richard J Lang, Melissa H Little

Journal article | 2012 | The Journal of Pathology

Identification of Novel Markers of Mouse Fetal Ovary Development

Huijun Chen, James S Palmer, Rathi D Thiagarajan, Marcel E Dinger, Emmanuelle Lesieur, Hansheng Chiu, Alexandra Schulz, Cassy Spiller, Sean M Grimmond, Melissa H Little, Peter Koopman, Dagmar Wilhelm

Journal article | 2012 | PLoS ONE

Reprogramming the kidney: a novel approach for regeneration

Caroline E Hendry, Melissa H Little

Journal article | 2012 | Kidney International

Identification of molecular compartments and genetic circuitry in the developing mammalian kidney

Jing Yu, M Todd Valerius, Mary Duah, Karl Staser, Jennifer K Hansard, Jin-jin Guo, Jill McMahon, Joe Vaughan, Diane Faria, Kylie Georgas, Bree Rumballe, Qun Ren, A Michaela Krautzberger, Jan P Junker, Rathi D Thiagarajan, Philip Machanick, Paul A Gray, Alexander van Oudenaarden, David H Rowitch, Charles D Stiles, et al.

Journal article | 2012 | Development

Mammalian Kidney Development: Principles, Progress, and Projections

Melissa H Little, Andrew P McMahon

Journal article | 2012 | Cold Spring Harbor Perspectives in Biology

Crim1 has an essential role in glycogen trophoblast cell and sinusoidal-trophoblast giant cell development in the placenta

DJ Pennisi, G Kinna, HS Chiu, DG Simmons, L Wilkinson, MH Little

Journal article | 2012 | Placenta

Proximal tubule overexpression of a locally acting IGF isoform, Igf-1Ea, increases inflammation after ischemic injury

Fiona K Rae, Norseha Suhaimi, Joan Li, Tommaso Nastasi, Esfir Slonimsky, Nadia Rosenthal, Melissa H Little

Journal article | 2012 | Growth Hormone & IGF Research

Dissociation of embryonic kidney followed by re-aggregation as a method for chimeric analysis.

Jamie A Davies, Mathieu Unbekandt, Jessica Ineson, Michael Lusis, Melissa H Little

Journal article | 2012 | Methods in Molecular Biology

This chapter presents three methods for re-constructing mouse foetal kidney tissue from simple suspensions of cells. These techniq..

Erratum to : Access and use of the gudmap database of genitourinary development[Kidney development: Methods and protocols,, methods in molecular biology, (2012), 886,(185) DOI:10.1007/978-1-61779-851-1_36]

JA Davies, MH Little, B Aronow, J Armstrong, J Brennan, S Lloyd-Macgilp, C Armit, S Harding, X Piu, Y Roochun, B Haggarty, D Houghton, D Davidson, R Baldock

Journal article | 2012 | Methods in Molecular Biology

Access and use of the GUDMAP database of genitourinary development.

Jamie A Davies, Melissa H Little, Bruce Aronow, Jane Armstrong, Jane Brennan, Sue Lloyd-MacGilp, Chris Armit, Simon Harding, Xinjun Piu, Yogmatee Roochun, Bernard Haggarty, Derek Houghton, Duncan Davidson, Richard Baldock

Journal article | 2012 | Methods in molecular biology (Clifton, N.J.)

The Genitourinary Development Molecular Atlas Project (GUDMAP) aims to document gene expression across time and space in the devel..

Comprehensive transcriptome and immunophenotype analysis of renal and cardiac MSC-like populations supports strong congruence with bone marrow MSC despite maintenance of distinct identities

Rebecca A Pelekanos, Joan Li, Milena Gongora, Vashe Chandrakanthan, Janelle Scown, Norseha Suhaimi, Gary Brooke, Melinda E Christensen, Tram Doan, Alison M Rice, Geoffrey W Osborne, Sean M Grimmond, Richard P Harvey, Kerry Atkinson, Melissa H Little

Journal article | 2012 | Stem Cell Research

A genome-wide screen to identify transcription factors expressed in pelvic ganglia of the lower urinary tract

Carrie B Wiese, Sara Ireland, Nicole L Fleming, Jing Yu, M Todd Valerius, Kylie Georgas, Han Sheng Chiu, Jane Brennan, Jane Armstrong, Melissa H Little, Andrew P McMahon, E Michelle Southard-Smith

Journal article | 2012 | Frontiers in Neuroscience

Use of in situ hybridization to examine gene expression in the embryonic, neonatal, and adult urogenital system.

Bree A Rumballe, Han Sheng Chiu, Kylie M Georgas, Melissa H Little

Journal article | 2012 | Methods in Molecular Biology

Studies into the molecular basis of morphogenesis frequently begin with investigations into gene expression across time and cell t..

Erratum: Access and use of the GUDMAP database of genitourinary development (Methods in Molecular Biology)

JA Davies, MH Little, B Aronow, J Armstrong, J Brennan, S Lloyd-Macgilp, C Armit, S Harding, X Piu, Y Roochun, B Haggarty, D Houghton, D Davidson, R Baldock

Book | 2012 | Methods in Molecular Biology

The Renal Papilla: An Enigma in Damage and Repair

Jessica Vanslambrouck, Joan Li, Melissa H Little

Journal article | 2011 | Journal of the American Society of Nephrology

Nephron formation adopts a novel spatial topology at cessation of nephrogenesis

Bree A Rumballe, Kylie M Georgas, Alexander N Combes, Adler L Ju, Thierry Gilbert, Melissa H Little

Journal article | 2011 | Developmental Biology

Renal organogenesis What can it tell us about renal repair and regeneration?

Melissa H Little

Journal article | 2011 | Organogenesis

Renal organogenesis: What can it tell us about renal repair and regeneration.

Melissa H Little

Journal article | 2011 | Organogenesis

Increasing prevalence of chronic kidney disease in the absence of new treatment modalities has become a strong driver for innovati..

Defining the Molecular Character of the Developing and Adult Kidney Podocyte

Eric W Brunskill, Kylie Georgas, Bree Rumballe, Melissa H Little, S Steven Potter

Journal article | 2011 | PLoS ONE

Refining transcriptional programs in kidney development by integration of deep RNA-sequencing and array-based spatial profiling

Rathi D Thiagarajan, Nicole Cloonan, Brooke B Gardiner, Tim R Mercer, Gabriel Kolle, Ehsan Nourbakhsh, Shivangi Wani, Dave Tang, Keerthana Krishnan, Kylie M Georgas, Bree A Rumballe, Han S Chiu, Jason A Steen, John S Mattick, Melissa H Little, Sean M Grimmond

Journal article | 2011 | BMC Genomics

Colony-Stimulating Factor-1 Promotes Kidney Growth and Repair via Alteration of Macrophage Responses

Maliha A Alikhan, Christina V Jones, Timothy M Williams, Anthony G Beckhouse, Anne L Fletcher, Michelle M Kett, Samy Sakkal, Chrishan S Samuel, Robert G Ramsay, James A Deane, Christine A Wells, Melissa H Little, David A Hume, Sharon D Ricardo

Journal article | 2011 | American Journal of Pathology

Defining and redefining the nephron progenitor population

Caroline Hendry, Bree Rumballe, Karen Moritz, Melissa H Little

Journal article | 2011 | Pediatric Nephrology

HYPOXIC CONDITIONS DURING KIDNEY DEVELOPMENT DISRUPT NEPHRON FORMATION

LJ Wilkinson, H Chiu, A Ju, B Rumballe, K Georgas, KM Moritz, MH Little

Conference Proceedings | 2011 | NEPHROLOGY

The GUDMAP database - an online resource for genitourinary research

Simon D Harding, Chris Armit, Jane Armstrong, Jane Brennan, Ying Cheng, Bernard Haggarty, Derek Houghton, Sue Lloyd-MacGilp, Xingjun Pi, Yogmatee Roochun, Mehran Sharghi, Christopher Tindal, Andrew P McMahon, Brian Gottesman, Melissa H Little, Kylie Georgas, Bruce J Aronow, S Steven Potter, Eric W Brunskill, E Michelle Southard-Smith, et al.

Journal article | 2011 | Development

Expression of Metanephric Nephron-Patterning Genes in Differentiating Mesonephric Tubules

KM Georgas, HS Chiu, E Lesieur, BA Rumballe, Melissa H Little

Journal article | 2011 | Developmental Dynamics

Identification of Anchor Genes during Kidney Development Defines Ontological Relationships, Molecular Subcompartments and Regulatory Pathways

Rathi D Thiagarajan, Kylie M Georgas, Bree A Rumballe, Emmanuelle Lesieur, Han Sheng Chiu, Darrin Taylor, Dave TP Tang, Sean M Grimmond, Melissa H Little

Journal article | 2011 | PLoS ONE

Potential of the Side Population in Regenerative Nephrology

MH Little, GA Challen

Book Chapter | 2011

Expression and Functional Analysis of Dkk1 during Early Gonadal Development

AN Combes, J Bowles, C-W Feng, HS Chiu, P-L Khoo, A Jackson, MH Little, PPL Tam, P Koopman

Journal article | 2011 | Sexual Development

Subfractionation of Differentiating Human Embryonic Stem Cell Populations Allows the Isolation of a Mesodermal Population Enriched for Intermediate Mesoderm and Putative Renal Progenitors

S Adelia Lin, Gabriel Kolle, Sean M Grimmond, Qi Zhou, Elizabeth Doust, Melissa H Little, Bruce Aronow, Sharon D Ricardo, Martin F Pera, John F Bertram, Andrew L Laslett

Journal article | 2010 | Stem Cells and Development

Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation

Han Sheng Chiu, John C Szucsik, Kylie M Georgas, Julia L Jones, Bree A Rumballe, Dave Tang, Sean M Grimmond, Alfor G Lewis, Bruce J Aronow, James L Lessard, Melissa H Little

Journal article | 2010 | Developmental Biology

Mice null for Crim1 display altered BMP/TGF beta signaling, defects in multiple organ systems and die in utero with severe cardiovascular defects

David J Pennisi, Han S Chiu, KS Vinay, Lorine Wilkinson, Pumin Zhang, Melissa H Little

Journal article | 2010 | Developmental Biology

Isolation of clonogenic, long-term self renewing embryonic renal stem cells

M Lusis, J Li, J Ineson, ME Christensen, A Rice, MH Little

Journal article | 2010 | Stem Cell Research

Molecular anatomy of the kidney: what have we learned from gene expression and functional genomics?

Bree Rumballe, Kylie Georgas, Lorine Wilkinson, Melissa Little

Journal article | 2010 | Pediatric Nephrology

Macrophages in Renal Development, Injury, and Repair

Timothy M Williams, Melissa H Little, Sharon D Ricardo

Journal article | 2010 | Seminars in Nephrology

Redirection of renal mesenchyme to stromal and chondrocytic fates in the presence of TGF-beta 2

Sunder Sims-Lucas, Richard J Young, Gemma Martinez, Darrin Taylor, Sean M Grimmond, Rohan Teasdale, Melissa H Little, John F Bertram, Georgina Caruana

Journal article | 2010 | Differentiation

KIDNEY DEVELOPMENT: TWO TALES OF TUBULOGENESIS

Melissa Little, Kylie Georgas, David Pennisi, Lorine Wilkinson

Book Chapter | 2010 | Current Topics in Developmental Biology

Loss of renal microvascular integrity in postnatal Crim1 hypomorphic transgenic mice

Lorine Wilkinson, Thierry Gilbert, Arnold Sipos, Ildiko Toma, David J Pennisi, Janos Peti-Peterdi, Melissa H Little

Journal article | 2009 | Kidney International

Is There Such a Thing as a Renal Stem Cell?

Melissa H Little, John F Bertram

Journal article | 2009 | Journal of the American Society of Nephrology

Review article: Potential cellular therapies for renal disease: Can we translate results from animal studies to the human condition?

Melissa H Little, Fiona K Rae

Journal article | 2009 | Nephrology

Analysis of early nephron patterning reveals a role for distal RV proliferation in fusion to the ureteric tip via a cap mesenchyme-derived connecting segment

Kylie Georgas, Bree Rumballe, M Todd Valerius, Han Sheng Chiu, Rathi D Thiagarajan, Ernmanuelle Lesieur, Bruce J Aronow, Eric W Brunskill, Alexander N Combes, Dave Tang, Darrin Taylor, Sean M Grimmond, S Steven Potter, Andrew P McMahon, Melissa H Little

Journal article | 2009 | Developmental Biology

GUDMAP - An online genitourinary resource

Simon Harding, Jamie Davies, Jane Armstrong, Jane Brennan, Sue Lloyd-MacGlip, Derek Houghton, Mehran Sharghi, Xingjun Pi, Ying Cheng, Bruce Aronow, Sean Grimmond, Peter Koopman, James Lessard, Melissa Little, Andy McMahon, Cathy Mendelsohn, Steve Potter, Michelle Southard-Smith, Duncan Davidson

Conference Proceedings | 2009 | Mechanisms of Development

Three-Dimensional Visualization of Testis Cord Morphogenesis, a Novel Tubulogenic Mechanism in Development

Alexander N Combes, Emmanuelle Lesieur, Vincent R Harley, Andrew H Sinclair, Melissa H Little, Dagmar Wilhelm, Peter Koopman

Journal article | 2009 | Developmental Dynamics

Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution (vol 15, pg 781, 2008)

Eric W Brunskill, Bruce J Aronow, Kylie Georgas, Bree Rumballe, M Todd Valerius, Jeremy Aronow, Vivek Kaimal, Anil G Jegga, Jing Yu, Sean Grimmond, Andrew P McMahon, Larry T Patterson, Melissa H Little, S Steven Potter

Journal article | 2009 | Developmental Cell

Parietal Epithelial Cells Regenerate Podocytes

Richard Poulsom, Melissa H Little

Journal article | 2009 | Journal of the American Society of Nephrology

Stem cell options for kidney disease

C Hopkins, J Li, F Rae, MH Little

Journal article | 2009 | The Journal of Pathology

Atlas of Gene Expression in the Developing Kidney at Microanatomic Resolution

Eric W Brunskill, Bruce J Aronow, Kylie Georgas, Bree Rumballe, M Todd Valerius, Jeremy Aronow, Vivek Kaimal, Anil G Jegga, Sean Grimmond, Andrew P McMahon, Larry T Patterson, Melissa H Little, S Steven Potter

Journal article | 2008 | Developmental Cell

Use of dual section mRNA in situ hybridisation/immunohistochemistry to clarify gene expression patterns during the early stages of nephron development in the embryo and in the mature nephron of the adult mouse kidney

Kylie Georgas, Bree Rumballe, Lorine Wilkinson, Han Sheng Chiu, Emmanuelle Lesieur, Thierry Gilbert, Melissa H Little

Journal article | 2008 | Histochemistry and Cell Biology

COLONY STIMULATING FACTOR (CSF)-1 IN POSTNATAL NEPHROGENESIS AND ORGAN GROWTH

CV Jones, MH Little, DA Hume, Sharon D Ricardo

Conference Proceedings | 2008 | NEPHROLOGY

High-throughput paraffin section in situ hybridization and dual immunohistochemistry on mouse tissues.

Bree Rumballe, Kylie Georgas, Melissa H Little

Journal article | 2008 | Cold Spring Harbor Protocols

INTRODUCTIONSection in situ hybridization (SISH) is a high-resolution tool used to analyze gene expression patterns. This protocol..

GUDMAP: The Genitourinary Developmental Molecular Anatomy Project

Andrew P McMahon, Bruce J Aronow, Duncan R Davidson, Jamie A Davies, Kevin W Gaido, Sean Grimmond, James L Lessard, Melissa H Little, S Steven Potter, Elizabeth L Wilder, Pumin Zhang

Journal article | 2008 | Journal of the American Society of Nephrology

Tracing the life of the kidney tubule - Re-establishing dogma and redirecting the options

Melissa H Little

Journal article | 2008 | Cell Stem Cell

A high-resolution anatomical ontology of the developing murine genitourinary tract (vol 7, pg 680, 2007)

Melissa H Little, Jane Brennan, Kylie Georgas, Jamie A Davies, Duncan R Davidson, Richard A Baldock, Annemiek Beverdam, John F Bertram, Blanche Capel, Han Sheng Chiu, Dave Clements, Luise Cullen-McEwen, Jean Fleming, Thierry Gilbert, Doris Herzlinger, Derek Houghton, Matt H Kaufman, Elena Kleymenova, Peter A Koopman, Alfor G Lewis, et al.

Journal article | 2007 | Gene Expression Patterns

POSTNATAL KIDNEY DEVELOPMENT IN THE MOUSE: FOCUS ON WHEN AND HOW NEPHRON FORMATION CEASES

T Gilbert, B Gardiner, SM Grimmond, MH Little

Conference Proceedings | 2007 | NEPHROLOGY

COLONY STIMULATING FACTOR (CSF)-1 PROMOTES NEPHROGENESIS AND POSTNATAL GROWTH IN NEWBORN MICE

CV Jones, MH Little, DA Hume, SD Ricardo

Conference Proceedings | 2007 | NEPHROLOGY

COLONY STIMULATING FACTOR REVERSES ESTABLISHED RENAL INJURY IN AN ACUTE ISCHEMIC MOUSE MODEL

SD Ricardo, MA Alikhan, NV Campanale, DA Hume, MH Little

Conference Proceedings | 2007 | NEPHROLOGY

Characterisation and trophic functions of murine embryonic macrophages based upon the use of a Csf1r-EGFP transgene reporter

Fiona Rae, Kyra Woods, Tedjo Sasmono, Naomi Campanale, Darrin Taylor, Dmitry A Ovchinnikov, Sean M Grimmond, David A Hume, Sharon D Ricardo, Melissa H Little

Journal article | 2007 | Developmental Biology

A high-resolution anatomical ontology of the developing murine genitourinary tract

Journal article | 2007 | Gene Expression Patterns

Crim1(KST264/KST264) mice implicate Crim1 in the regulation of vascular endothelial growth factor-A activity during glomerular vascular development

Lorine Wilkinson, Thierry Gilbert, Genevieve Kinna, Leah-Anne Ruta, David Pennisi, Michelle Kett, Melissa H Little

Journal article | 2007 | Journal of the American Society of Nephrology

Crim1(KST264/KST264) mice display a disruption of the Crim1 gene resulting in perinatal lethality with defects in multiple organ systems

David J Pennisi, Lorine Wilkinson, Gabriel Kolle, Michael L Sohaskey, Kevin Gillinder, Michael J Piper, John W McAvoy, Frank J Lovicu, Melissa H Little

Journal article | 2007 | Developmental Dynamics

Delivering on the promise of human stem-cell research - What are the real barriers?

Melissa Little, Wayne Hall, Amy Orlandi

Journal article | 2006 | EMBO reports

Spatial gene expression in the T-stage mouse metanephros

Georgina Caruana, Luise Cullen-McEwen, Amy L Nelson, Xenia Kostoulias, Kyra Woods, Brooke Gardiner, Melissa J Davis, Darrin F Taylor, Rohan D Teasdale, Sean M Grimmond, Melissa H Little, John F Bertram

Journal article | 2006 | Gene Expression Patterns

Regrow or repair: Potential regenerative therapies for the kidney

Melissa H Little

Journal article | 2006 | Journal of the American Society of Nephrology

CELL TRACING STUDIES OF ENDOGENOUS RENAL REPAIR IN A MOUSE MODEL OF REVERSAL OF UNILATERAL URETERAL OBSTRUCTION

MA Alikhan, JA Deane, MH Little, SD Ricardo

Conference Proceedings | 2006 | NEPHROLOGY

Kidney side population reveals multilineage potential and renal functional capacity but also cellular heterogeneity

Grant A Challen, Ivan Bertoncello, James A Deane, Sharon D Ricardo, Melissa H Little

Journal article | 2006 | Journal of the American Society of Nephrology

Differential gene expression in the developing mouse ureter

EKL Mitchell, DF Taylor, K Woods, MJ Davis, AL Nelson, RD Teasdale, SM Grimmond, MH Little, JF Bertram, G Caruana

Journal article | 2006 | Gene Expression Patterns

Definition and spatial annotation of the dynamic secretome during early kidney development

Gemma Martinez, Kylie Georgas, Grant A Challen, Bree Rumhalle, Melissa J Davis, Darrin Taylor, Rohan D Teasdale, Sean M Grimmond, Melissa H Little

Journal article | 2006 | Developmental Dynamics

PAX2 activates WNT4 expression during mammalian kidney development

E Torban, A Dziarmaga, D Iglesias, LL Chu, T Vassilieva, M Little, M Eccles, M Discenza, J Pelletier, P Goodyer

Journal article | 2006 | Journal of Biological Chemistry

Establishment of metanephros transplantation in mice highlights contributions by both nephrectomy and pregnancy to developmental progression

SR Armstrong, GR Campbell, JH Campbell, MH Little

Conference Proceedings | 2006 | CYTOMETRY PART A

Investigating the potential of murine kidney side population cells to act as functional renal stem cells

GA Challen, I Bertoncelllo, SD Ricardo, MH Little

Conference Proceedings | 2006 | CYTOMETRY PART A

Knockdown of zebrafish crim1 results in a bent tail phenotype with defects in somite and vascular development

Genevieve Kinna, Gabriel Kolle, Adrian Carter, Brian Key, Graham J Lieschke, Andrew Perkins, Melissa H Little

Journal article | 2006 | Mechanisms of Development

A side order of stem cells: the SP phenotype.

Grant A Challen, Melissa H Little

Journal article | 2006 | Stem Cells

A defining property of murine hematopoietic stem cells (HSCs) is low fluorescence after staining with Hoechst 33342 and Rhodamine ..

A side order of stem cells: The SP phenotype

GA Challen, MH Little

Journal article | 2006 | STEM CELLS

Angioblast-mesenchyme induction of early kidney development is mediated by Wt1 and Vegfa

XB Gao, X Chen, M Taglienti, B Rumballe, MH Little, JA Kreidberg

Journal article | 2005 | Development

Renal structural and functional repair in a mouse model of reversal of ureteral obstruction

AL Cochrane, MM Kett, CS Samuel, NV Campanale, WP Anderson, DA Hume, MH Little, JF Bertram, SD Ricardo

Journal article | 2005 | Journal of the American Society of Nephrology

Temporal and spatial transcriptional programs in murine kidney development

G Challen, B Gardiner, G Caruana, X Kostoulias, G Martinez, M Crowe, DF Taylor, J Bertram, M Little, SM Grimmond

Journal article | 2005 | Physiological Genomics

Development of the mouse ureter: A histological and global gene expression study

E Mitchell, D Taylor, B Rumballe, K Woods, MJ Davis, AL Nelson, RD Teasdale, SM Grimmond, MH Little, JF Bertram, G Caruana

Conference Proceedings | 2005 | MECHANISMS OF DEVELOPMENT

A hypomorphic mutant of Crim1 reveals a requirement on Crim1 for proper development

D Pennisi, L Wilkinson, G Kolle, K Gillinder, M Little

Conference Proceedings | 2005 | MECHANISMS OF DEVELOPMENT

Investigating the potential of murine kidney side population cells to act as functional renal stem cells

MH Little, GA Challen, SD Ricardo, I Bertoncello

Conference Proceedings | 2005 | MECHANISMS OF DEVELOPMENT