Deidre Mattiske

Erectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?

Samuel M Cripps, Deidre M Mattiske, Andrew J Pask

Journal article  |  2021  |  SEXUAL DEVELOPMENT

Erectile dysfunction (ED) is one of the most prevalent chronic conditions affecting men. ED can arise from disruptions during deve..

Oestrogen regulates SOX9 bioavailability by rapidly activating ERK1/2 and stabilising microtubules in a human testis-derived cell line

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2021  |  EXPERIMENTAL CELL RESEARCH

Nuclear SOX9 is essential for Sertoli cell differentiation and the development of a testis. Exposure of Sertoli cells to exogenous..

Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives.

Deidre M Mattiske, Andrew J Pask

Journal article  |  2021  |  Curr Res Toxicol

Hypospadias is a defect in penile urethral closure that occurs in approximately 1/150 live male births in developed nations, makin..

Exogenous Oestrogen Impacts Cell Fate Decision in the Developing Gonads: A Potential Cause of Declining Human Reproductive Health

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The increasing incidence of testicular dysgenesis syndrome-related conditions and overall decline in human fertility has been link..

Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2020  |  BMC MOLECULAR AND CELL BIOLOGY

Background The increasing incidence of reproductive disorders in humans has been attributed to in utero exposure to estrogenic end..

Atrazine induces penis abnormalities including hypospadias in mice

Luke C Govers, Alesia P Harper, Bethany J Finger, Deidre M Mattiske, Andrew J Pask, Mark P Green

Journal article  |  2020  |  JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE

Use of the herbicide atrazine (ATR) is banned in the European Union; yet, it is still widely used in the USA and Australia. ATR is..

A novel long non-coding RNA, Leat1, causes reduced anogenital distance and fertility in female mice

Deidre Mattiske, Richard R Behringer, Paul A Overbeek, Andrew J Pask

Journal article  |  2020  |  DIFFERENTIATION

Defective anorectal and urogenital malformations are some of the most severe congenital anomalies encountered in children. Only a ..

A loss of estrogen signaling in the aromatase deficient mouse penis results in mild hypospadias

Samuel M Cripps, Deidre M Mattiske, Jay R Black, Gail P Risbridger, Luke C Govers, Tiffany R Phillips, Andrew J Pask

Journal article  |  2019  |  DIFFERENTIATION

Hypospadias is the abnormal opening of the urethra on the underside of the penis and occurs in approximately 1/125 live male birth..

A critical role for estrogen signaling in penis development

Luke C Govers, Tiffany R Phillips, Deidre M Mattiske, Nineveh Rashoo, Jay R Black, Adriane Sinclair, Laurence S Baskin, Gail P Risbridger, Andrew J Pask

Journal article  |  2019  |  FASEB JOURNAL

Hypospadias, a developmental defect of the penis, is one of the most common congenital malformations in humans. Its incidence has ..

In utero exposure to both high- and low-dose diethylstilbestrol disrupts mouse genital tubercle development

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2018  |  BIOLOGY OF REPRODUCTION

Exposure to estrogenic endocrine disrupting chemicals (EDCs) during in utero development has been linked to the increasing inciden..