Deidre Mattiske

Exposure to an environmentally relevant concentration of 17α-ethinylestradiol disrupts craniofacial development of juvenile zebrafish.

Melanie K Stewart, Luca Hoehne, Stefanie Dudczig, Deidre M Mattiske, Andrew J Pask, Patricia R Jusuf

Journal article  |  2023  |  Ecotoxicol Environ Saf

Endocrine disrupting chemicals (EDCs) can interact with native hormone receptors to interfere with and disrupt hormone signalling ..

Oestrogen Activates the MAP3K1 Cascade and beta-Catenin to Promote Granulosa-like Cell Fate in a Human Testis-Derived Cell Line

Melanie K Stewart, Pascal Bernard, Ching-Seng Ang, Deidre M Mattiske, Andrew J Pask

Journal article  |  2021  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sex determination triggers the differentiation of the bi-potential gonad into either an ovary or testis. In non-mammalian vertebra..

Erectile Dysfunction in Men on the Rise: Is There a Link with Endocrine Disrupting Chemicals?

Samuel M Cripps, Deidre M Mattiske, Andrew J Pask

Journal article  |  2021  |  SEXUAL DEVELOPMENT

Erectile dysfunction (ED) is one of the most prevalent chronic conditions affecting men. ED can arise from disruptions during deve..

Endocrine disrupting chemicals in the pathogenesis of hypospadias; developmental and toxicological perspectives

Deidre M Mattiske, Andrew J Pask

Journal article  |  2021  |  CURRENT RESEARCH IN TOXICOLOGY

Hypospadias is a defect in penile urethral closure that occurs in approximately 1/150 live male births in developed nations, makin..

Oestrogen regulates SOX9 bioavailability by rapidly activating ERK1/2 and stabilising microtubules in a human testis-derived cell line

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2021  |  EXPERIMENTAL CELL RESEARCH

Nuclear SOX9 is essential for Sertoli cell differentiation and the development of a testis. Exposure of Sertoli cells to exogenous..

Exogenous Oestrogen Impacts Cell Fate Decision in the Developing Gonads: A Potential Cause of Declining Human Reproductive Health

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2020  |  INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The increasing incidence of testicular dysgenesis syndrome-related conditions and overall decline in human fertility has been link..

Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line

Melanie K Stewart, Deidre M Mattiske, Andrew J Pask

Journal article  |  2020  |  BMC MOLECULAR AND CELL BIOLOGY

Background The increasing incidence of reproductive disorders in humans has been attributed to in utero exposure to estrogenic end..

Atrazine induces penis abnormalities including hypospadias in mice

Luke C Govers, Alesia P Harper, Bethany J Finger, Deidre M Mattiske, Andrew J Pask, Mark P Green

Journal article  |  2020  |  JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE

Use of the herbicide atrazine (ATR) is banned in the European Union; yet, it is still widely used in the USA and Australia. ATR is..

A novel long non-coding RNA, Leat1, causes reduced anogenital distance and fertility in female mice

Deidre Mattiske, Richard R Behringer, Paul A Overbeek, Andrew J Pask

Journal article  |  2020  |  DIFFERENTIATION

Defective anorectal and urogenital malformations are some of the most severe congenital anomalies encountered in children. Only a ..

A loss of estrogen signaling in the aromatase deficient mouse penis results in mild hypospadias

Samuel M Cripps, Deidre M Mattiske, Jay R Black, Gail P Risbridger, Luke C Govers, Tiffany R Phillips, Andrew J Pask

Journal article  |  2019  |  DIFFERENTIATION

Hypospadias is the abnormal opening of the urethra on the underside of the penis and occurs in approximately 1/125 live male birth..