Karen Day

The impact of indoor residual spraying on Plasmodium falciparum microsatellite variation in an area of high seasonal malaria transmission in Ghana, West Africa

Dionne C Argyropoulos, Shazia Ruybal-Pesantez, Samantha L Deed, Abraham R Oduro, Samuel K Dadzie, Maxwell A Appawu, Victor Asoala, Mercedes Pascual, Kwadwo A Koram, Karen P Day, Kathryn E Tiedje

Journal article  |  2021  |  MOLECULAR ECOLOGY

Here, we report the first population genetic study to examine the impact of indoor residual spraying (IRS) on Plasmodium falciparu..

Frequency-Dependent Competition Between Strains Imparts Persistence to Perturbations in a Model of Plasmodium falciparum Malaria Transmission

Qixin He, Shai Pilosof, Kathryn E Tiedje, Karen P Day, Mercedes Pascual

Journal article  |  2021  |  FRONTIERS IN ECOLOGY AND EVOLUTION

In high-transmission endemic regions, local populations of Plasmodium falciparum exhibit vast diversity of the var genes encoding ..

Clinical malaria incidence following an outbreak in Ecuador was predominantly associated with Plasmodium falciparum with recombinant variant antigen gene repertoires

Shazia Ruybal-Pesántez, Fabian Sáenz, Samantha Deed, Erik Johnson, Daniel Larremore, Claudia Vera-Arias, Kathryn Tiedje, Karen Day

Journal article  |  2021

To better understand the factors underlying the continued incidence of clinical episodes of falciparum malaria in E-2020 countries..

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents

Gerry Tonkin-Hill, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Virginie Rougeron, Michael F Duffy, Sedigheh Zakeri, Tepanata Pumpaibool, Pongchai Harnyuttanakorn, OraLee H Branch, Lastenia Ruiz-Mesia, Thomas S Rask, Franck Prugnolle, Anthony T Papenfuss, Yao-ban Chan, Karen P Day

Journal article  |  2021  |  PLOS GENETICS

Malaria remains a major public health problem in many countries. Unlike influenza and HIV, where diversity in immunodominant surfa..

Histone modifications associated with gene expression and genome accessibility are dynamically enriched at Plasmodium falciparum regulatory sequences

Jingyi Tang, Scott A Chisholm, Lee M Yeoh, Paul R Gilson, Anthony T Papenfuss, Karen P Day, Michaela Petter, Michael F Duffy

Journal article  |  2020  |  EPIGENETICS & CHROMATIN

BACKGROUND: The malaria parasite Plasmodium falciparum has an unusually euchromatic genome with poorly conserved positioning of nu..

Frequency-dependent competition between strains imparts resilience to perturbations in a model ofPlasmodium falciparummalaria transmission

Qixin He, Shai Pilosof, Kathryn Tiedje, Karen Day, Mercedes Pascual

Journal article  |  2020

In high-transmission endemic regions, local populations of Plasmodium falciparum exhibit vast diversity of the var genes encoding ..

Evolution of Antimalarial Drug Resistance Markers in the Reservoir of Plasmodium falciparum Infections in the Upper East Region of Ghana

Charles A Narh, Anita Ghansah, Michael F Duffy, Shazia Ruybal-Pesantez, Christiana O Onwona, Abraham R Oduro, Kwadwo A Koram, Karen P Day, Kathryn E Tiedje

Journal article  |  2020  |  JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: The majority of Plasmodium falciparum infections, constituting the reservoir in all ages, are asymptomatic in high-tra..

Competition for hosts modulates vast antigenic diversity to generate persistent strain structure in Plasmodium falciparum

Shai Pilosof, Qixin He, Kathryn E Tiedje, Shazia Ruybal-Pesantez, Karen P Day, Mercedes Pascual

Journal article  |  2019  |  PLOS BIOLOGY

In their competition for hosts, parasites with antigens that are novel to the host immune system will be at a competitive advantag..

GLOBAL STRUCTURE OF THE VAR GENES ENCODING THE MAJOR VARIANT SURFACE ANTIGEN OF PLASMODIUM FALCIPARUM

Gerry Tonkin-Hill, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Virginie Rougeron, Sedigheh Zakeri, Tepanata Pumpaibool, Pingchai Harnyuttanakorn, OraLee H Branch, Lastenia Ruiz-Mesia, Michael F Duffy, Thomas S Rask, Franck Prugnolle, Yao-Ban Yao-Ban Chan, Anthony T Papenfuss, Karen P Day

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

EVOLUTION OF PLASMODIUM FALCIPARUM AFTER AN OUTBREAK FACILITATES LOW ENDEMICITY MALARIA TRANSMISSION IN ECUADOR

Shazia Ruybal-Pesantez, Fabian E Saenz, Claudia A Vera-Arias, Kathryn E Tiedje, Karen P Day

Conference Proceedings  |  2019  |  AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE