Karen Day

Unravelling var complexity: Relationship between DBLα types and var genes in Plasmodium falciparum

Mun Hua Tan, Heejung Shim, Yao-ban Chan, Karen P Day

Journal article  |  2023  |  Frontiers in Parasitology

The enormous diversity and complexity of var genes that diversify rapidly by recombination has led to the exclusion of assembly of..

Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections

Frederic Labbe, Qixin P He, Qi Zhan, Kathryn EE Tiedje, Dionne CS Argyropoulos, Mun Hua E Tan, Anita S Ghansah, Karen PE Day, Mercedes S Pascual

Journal article  |  2023  |  PLOS COMPUTATIONAL BIOLOGY

At a time when effective tools for monitoring malaria control and eradication efforts are crucial, the increasing availability of ..

Age-specific patterns of DBLα var diversity can explain why residents of high malaria transmission areas remain susceptible to Plasmodium falciparum blood stage infection throughout life.

Shazia Ruybal-Pesántez, Kathryn E Tiedje, Shai Pilosof, Gerry Tonkin-Hill, Qixin He, Thomas S Rask, Lucas Amenga-Etego, Abraham R Oduro, Kwadwo A Koram, Mercedes Pascual, Karen P Day

Journal article  |  2022  |  Int J Parasitol

Immunity to Plasmodium falciparum is non-sterilising, thus individuals residing in malaria-endemic areas are at risk of infection ..

Relationship of circulating Plasmodium falciparum lifecycle stage to circulating parasitemia and total parasite biomass

Michael F Duffy, Gerry Q Tonkin-Hill, Leily Trianty, Rintis Noviyanti, Hanh HT Nguyen, Janavi S Rambhatla, Malcolm J McConville, Stephen J Rogerson, Graham V Brown, Ric N Price, Nicholas M Anstey, Karen P Day, Anthony T Papenfuss

Journal article  |  2022  |  NATURE COMMUNICATIONS

Corrigendum: Frequency-dependent competition between strains imparts persistence to perturbations in a model of Plasmodium falciparum malaria transmission(Front. Ecol. Evol., (2021), 9, (633263), 10.3389/fevo.2021.633263)

Q He, S Pilosof, KE Tiedje, KP Day, M Pascual

Journal article  |  2022  |  Frontiers in Ecology and Evolution

In the original article, there was an error in the specific part of the code implementing migration between the global pool and th..

An accurate method for identifying recent recombinants from unaligned sequences

Qian Feng, Kathryn E Tiedje, Shazia Ruybal-Pesantez, Gerry Tonkin-Hill, Michael F Duffy, Karen P Day, Heejung Shim, Yao-Ban Chan

Journal article  |  2022  |  BIOINFORMATICS

MOTIVATION: Recombination is a fundamental process in molecular evolution, and the identification of recombinant sequences is thus..

Indoor residual spraying with a non-pyrethroid insecticide reduces the reservoir of Plasmodium falciparum in a high-transmission area in northern Ghana.

Kathryn E Tiedje, Abraham R Oduro, Oscar Bangre, Lucas Amenga-Etego, Samuel K Dadzie, Maxwell A Appawu, Kwadwo Frempong, Victor Asoala, Shazia Ruybal-Pésantez, Charles A Narh, Samantha L Deed, Dionne C Argyropoulos, Anita Ghansah, Samuel A Agyei, Sylvester Segbaya, Kwame Desewu, Ignatius Williams, Julie A Simpson, Keziah Malm, Mercedes Pascual, et al.

Journal article  |  2022  |  PLOS Glob Public Health

High-malaria burden countries in sub-Saharan Africa are shifting from malaria control towards elimination. Hence, there is need to..

The impact of indoor residual spraying on Plasmodium falciparum microsatellite variation in an area of high seasonal malaria transmission in Ghana, West Africa

Dionne C Argyropoulos, Shazia Ruybal-Pesantez, Samantha L Deed, Abraham R Oduro, Samuel K Dadzie, Maxwell A Appawu, Victor Asoala, Mercedes Pascual, Kwadwo A Koram, Karen P Day, Kathryn E Tiedje

Journal article  |  2021  |  MOLECULAR ECOLOGY

Here, we report the first population genetic study to examine the impact of indoor residual spraying (IRS) on Plasmodium falciparu..

Frequency-Dependent Competition Between Strains Imparts Persistence to Perturbations in a Model of Plasmodium falciparum Malaria Transmission

Qixin He, Shai Pilosof, Kathryn E Tiedje, Karen P Day, Mercedes Pascual

Journal article  |  2021  |  FRONTIERS IN ECOLOGY AND EVOLUTION

In high-transmission endemic regions, local populations of Plasmodium falciparum exhibit vast diversity of the var genes encoding ..

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents

Gerry Tonkin-Hill, Shazia Ruybal-Pesantez, Kathryn E Tiedje, Virginie Rougeron, Michael F Duffy, Sedigheh Zakeri, Tepanata Pumpaibool, Pongchai Harnyuttanakorn, OraLee H Branch, Lastenia Ruiz-Mesia, Thomas S Rask, Franck Prugnolle, Anthony T Papenfuss, Yao-ban Chan, Karen P Day

Journal article  |  2021  |  PLOS GENETICS

Malaria remains a major public health problem in many countries. Unlike influenza and HIV, where diversity in immunodominant surfa..