Kim Pham

Developing T cells form an immunological synapse for passage through the beta-selection checkpoint

Amr H Allam, Mirren Charnley, Kim Pham, Sarah M Russell

Journal article  |  2021  |  JOURNAL OF CELL BIOLOGY

The β-selection checkpoint of T cell development tests whether the cell has recombined its genomic DNA to produce a functional T c..

A new role for Notch in the control of polarity and asymmetric cell division of developing T cells

Mirren Charnley, Mandy Ludford-Menting, Pham Kim, Sarah M Russell

Journal article  |  2020  |  JOURNAL OF CELL SCIENCE

A fundamental question in biology is how single cells can reliably produce progeny of different cell types. Notch signalling frequ..

Quantifying NK cell growth and survival changes in response to cytokines and regulatory checkpoint blockade helps identify optimal culture and expansion conditions

Robert J Hennessy, Kim Pham, Rebecca Delconte, Jai Rautela, Philip D Hodgkin, Nicholas D Huntington

Journal article  |  2019  |  JOURNAL OF LEUKOCYTE BIOLOGY

NK cells are innate lymphocytes critical for immune surveillance, particularly in eradication of metastatic cancer cells and acute..

Airway Microbiota Dynamics Uncover a Critical Window for Interplay of Pathogenic Bacteria and Allergy in Childhood Respiratory Disease

Shu Mei Teo, Howard HF Tang, Danny Mok, Louise M Judd, Stephen C Watts, Kym Pham, Barbara J Holt, Merci Kusel, Michael Serralha, Niamh Troy, Yury A Bochkov, Kristine Grindle, Robert F Lemanske, Sebastian L Johnston, James E Gern, Peter D Sly, Patrick G Holt, Kathryn E Holt, Michael Inouye

Journal article  |  2018  |  CELL HOST & MICROBE

Repeated cycles of infection-associated lower airway inflammation drive the pathogenesis of persistent wheezing disease in childre..

Converse Smith-Martin cell cycle kinetics by transformed B lymphocytes

K Pham, A Kan, L Whitehead, RJ Hennessy, K Rogers, PD Hodgkin

Journal article  |  2018  |  CELL CYCLE

Recent studies using direct live cell imaging have reported that individual B lymphocytes have correlated transit times between th..

Evaluating the Genomic Yield of a Single Endobronchial Ultrasound-guided Transbronchial Needle Aspiration in Lung Cancer: Meeting the Challenge of Doing More With Less

Tracy L Leong, Michael Christie, Sevastjan Kranz, Kym Pham, Arthur Hsu, Louis B Irving, Marie-Liesse Asselin-Labat, Daniel P Steinfort

Journal article  |  2017  |  CLINICAL LUNG CANCER

BACKGROUND: Minimally invasive techniques, including endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA),..

Cell cycle progression dictates the requirement for BCL2 in natural killer cell survival

Charlotte Viant, Sophie Guia, Robert J Hennessy, Jai Rautela, Kim Pham, Claire Bernat, Wilford Goh, Yuhao Jiao, Rebecca Delconte, Michael Roger, Vanina Simon, Fernando Souza-Fonseca-Guimaraes, Stephanie Grabow, Gabrielle T Belz, Benjamin T Kile, Andreas Strasser, Daniel Gray, Phillip D Hodgkin, Bruce Beutler, Eric Vivier, et al.

Journal article  |  2017  |  JOURNAL OF EXPERIMENTAL MEDICINE

Natural killer (NK) cells are innate lymphoid cells with antitumor functions. Using an N-ethyl-N-nitrosourea (ENU)-induced mutagen..

Global Practices in PDX Programs

GY Ho, CL Scott, K Pham

Book Chapter  |  2017

Patient-derived xenograft (PDX) programs are crucial research tools in providing high-quality preclinical data for successful drug..

Asymmetric Cell Division of T Cells upon Antigen Presentation Uses Multiple Conserved Mechanisms

Jane Oliaro, Vanessa Van Ham, Faruk Sacirbegovic, Anupama Pasam, Ze'ev Bomzon, Kim Pham, Mandy J Ludford-Menting, Nigel J Waterhouse, Michael Bots, Edwin D Hawkins, Sally V Watt, Leonie A Cluse, Chris JP Clarke, David J Izon, John T Chang, Natalie Thompson, Min Gu, Ricky W Johnstone, Mark J Smyth, Patrick O Humbert, et al.

Journal article  |  2010  |  JOURNAL OF IMMUNOLOGY

Asymmetric cell division is a potential means by which cell fate choices during an immune response are orchestrated. Defining the ..

A method for prolonged imaging of motile lymphocytes

Daniel Day, Kim Pham, Mandy J Ludford-Menting, Jane Oliaro, David Izon, Sarah M Russell, Min Gu

Journal article  |  2009  |  IMMUNOLOGY AND CELL BIOLOGY

With new imaging technologies and fluorescent probes, live imaging of cells in vitro has revolutionized many aspects of cell biolo..