Melissa Davis

Transcriptomic profiling of cardiac tissues from SARS-CoV-2 patients identifies DNA damage

Arutha Kulasinghe, Ning Liu, Chin Wee Tan, James Monkman, Jane E Sinclair, Dharmesh D Bhuva, David Godbolt, Liuliu Pan, Andy Nam, Habib Sadeghirad, Kei Sato, Gianluigi Li Bassi, Ken O'Byrne, Camila Hartmann, Anna Flavia Ribeiro Dos Santos Miggiolaro, Gustavo Lenci Marques, Lidia Zytynski Moura, Derek Richard, Mark Adams, Lucia de Noronha, et al.

Journal article  |  2022  |  IMMUNOLOGY

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to present with pulmonary and extra-pulmonary organ comp..

TGFb and CIS Inhibition Overcomes NK-cell Suppression to Restore Antitumor Immunity

Fernando Souza-Fonseca-Guimaraes, Gustavo R Rossi, Laura F Dagley, Momeneh Foroutan, Timothy R McCulloch, Jumana Yousef, Hae-Young Park, Jennifer H Gunter, Paul A Beavis, Cheng-Yu Lin, Soroor Hediyeh-Zadeh, Tania Camilleri, Melissa J Davis, Nicholas D Huntington

Journal article  |  2022  |  CANCER IMMUNOLOGY RESEARCH

Antibodies targeting "immune checkpoints" have revolutionized cancer therapy by reactivating tumor-resident cytotoxic lymphocytes,..

MicroRNA-21 is immunosuppressive and pro-metastatic via separate mechanisms

Lap Hing Chi, Ryan SN Cross, Richard P Redvers, Melissa Davis, Soroor Hediyeh-zadeh, Suresh Mathivanan, Monisha Samuel, Erin C Lucas, Kellie Mouchemore, Philip A Gregory, Cameron N Johnstone, Robin L Anderson

Journal article  |  2022  |  ONCOGENESIS

MiR-21 was identified as a gene whose expression correlated with the extent of metastasis of murine mammary tumours. Since miR-21 ..

Functional divergence of the two Elongator subcomplexes during neurodevelopment.

Monika Gaik, Marija Kojic, Megan R Stegeman, Tülay Öncü-Öner, Anna Kościelniak, Alun Jones, Ahmed Mohamed, Pak Yan Stefanie Chau, Sazia Sharmin, Andrzej Chramiec-Głąbik, Paulina Indyka, Michał Rawski, Anna Biela, Dominika Dobosz, Amanda Millar, Vann Chau, Aycan Ünalp, Michael Piper, Mark C Bellingham, Evan E Eichler, et al.

Journal article  |  2022  |  EMBO Mol Med

The highly conserved Elongator complex is a translational regulator that plays a critical role in neurodevelopment, neurological d..

Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures

Arutha Kulasinghe, Chin Wee Tan, Anna Flavia Ribeiro Dos Santos Miggiolaro, James Monkman, Habib SadeghiRad, Dharmesh D Bhuva, Jarbas da Silva Motta Junior, Caroline Busatta Vaz de Paula, Seigo Nagashima, Cristina Pellegrino Baena, Paulo Souza-Fonseca-Guimaraes, Lucia de Noronha, Timothy McCulloch, Gustavo Rodrigues Rossi, Caroline Cooper, Benjamin Tang, Kirsty R Short, Melissa J Davis, Fernando Souza-Fonseca-Guimaraes, Gabrielle T Belz, et al.

Journal article  |  2022  |  EUROPEAN RESPIRATORY JOURNAL

BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) which emerged in late 2019 has spread globally, causi..

Computational Screening of Anti-Cancer Drugs Identifies a New BRCA Independent Gene Expression Signature to Predict Breast Cancer Sensitivity to Cisplatin

Jean Berthelet, Momeneh Foroutan, Dharmesh D Bhuva, Holly J Whitfield, Farrah El-Saafin, Joseph Cursons, Antonin Serrano, Michal Merdas, Elgene Lim, Emmanuelle Charafe-Jauffret, Christophe Ginestier, Matthias Ernst, Frederic Hollande, Robin L Anderson, Bhupinder Pal, Belinda Yeo, Melissa J Davis, Delphine Merino

Journal article  |  2022  |  CANCERS

The development of therapies that target specific disease subtypes has dramatically improved outcomes for patients with breast can..

SFPQ-ABL1 and BCR-ABL1 use different signaling networks to drive B-cell acute lymphoblastic leukemia

Lauren M Brown, Soroor Hediyeh-Zadeh, Teresa Sadras, Hannah Huckstep, Jarrod J Sandow, Ray C Bartolo, Hansen J Kosasih, Nadia M Davidson, Breon Schmidt, Stefan Bjelosevic, Ricky Johnstone, Andrew Webb, Seong L Khaw, Alicia Oshlack, Melissa J Davis, Paul G Ekert

Journal article  |  2022  |  BLOOD ADVANCES

Philadelphia-like (Ph-like) acute lymphoblastic leukemia (ALL) is a high-risk subtype of B-cell ALL characterized by a gene expres..

Characterization of the treatment-naive immune microenvironment in melanoma with BRAF mutation

Minyu Wang, Soroor Zadeh, Angela Pizzolla, Kevin Thia, David E Gyorki, Grant A McArthur, Richard A Scolyer, Georgina Long, James S Wilmott, Miles C Andrews, George Au-Yeung, Ali Weppler, Shahneen Sandhu, Joseph A Trapani, Melissa J Davis, Paul Joseph Neeson

Journal article  |  2022  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: Patients with BRAF-mutant and wild-type melanoma have different response rates to immune checkpoint blockade therapy. ..

Loss of TAF8 causes TFIID dysfunction and p53-mediated apoptotic neuronal cell death

Farrah El-Saafin, Maria Bergamasco, Yunshun Chen, Rose E May, Prabagaran Esakky, Soroor Hediyeh-zadeh, Mathew Dixon, Stephen Wilcox, Melissa J Davis, Andreas Strasser, Gordon K Smyth, Tim Thomas, Anne K Voss

Journal article  |  2022  |  CELL DEATH AND DIFFERENTIATION

Mutations in genes encoding general transcription factors cause neurological disorders. Despite clinical prominence, the consequen..

Large-scale protein-protein post-translational modification extraction with distant supervision and confidence calibrated BioBERT

Aparna Elangovan, Yuan Li, Douglas E Pires, Melissa J Davis, Karin Verspoor

Journal article  |  2022  |  BMC BIOINFORMATICS

MOTIVATION: Protein-protein interactions (PPIs) are critical to normal cellular function and are related to many disease pathways...