Michael Pan

Modular assembly of dynamic models in systems biology

Michael Pan, Peter J Gawthrop, Joseph Cursons, Edmund J Crampin

Journal article  |  2021  |  PLOS COMPUTATIONAL BIOLOGY

It is widely acknowledged that the construction of large-scale dynamic models in systems biology requires complex modelling proble..

Modular dynamic biomolecular modelling with bond graphs: the unification of stoichiometry, thermodynamics, kinetics and data

Peter J Gawthrop, Michael Pan, Edmund J Crampin

Journal article  |  2021  |  JOURNAL OF THE ROYAL SOCIETY INTERFACE

Renewed interest in dynamic simulation models of biomolecular systems has arisen from advances in genome-wide measurement and appl..

Hierarchical semantic composition of biosimulation models using bond graphs

Niloofar Shahidi, Michael Pan, Soroush Safaei, Kenneth Tran, Edmund J Crampin, David P Nickerson

Journal article  |  2021  |  PLOS COMPUTATIONAL BIOLOGY

Simulating complex biological and physiological systems and predicting their behaviours under different conditions remains challen..

Network Thermodynamical Modeling of Bioelectrical Systems: A Bond Graph Approach.

Peter J Gawthrop, Michael Pan

Journal article  |  2021  |  Bioelectricity

Interactions among biomolecules, electrons, and protons are essential to many fundamental processes sustaining life. It is therefo..

The cardiac Na /K ATPase: An updated, thermodynamically consistent model

Michael Pan, Peter J Gawthrop, Joseph Cursons, Kenneth Tran, Edmund J Crampin

Journal article  |  2020  |  Physiome

The Na+/K+ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over ..

The cardiac Na /K ATPase: An updated, thermodynamically consistent model

Michael Pan, Peter J Gawthrop, Joseph Cursons, Kenneth Tran, Edmund J Crampin

Journal article  |  2020  |  Physiome

The Na+/K+ATPase is an essential component of cardiac electrophysiology, maintaining physiological Na+ and K+ concentrations over ..

A thermodynamic framework for modelling membrane transporters

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2019  |  JOURNAL OF THEORETICAL BIOLOGY

Membrane transporters contribute to the regulation of the internal environment of cells by translocating substrates across cell me..

A bond graph approach to integrative biophysical modelling

Michael Pan

Thesis / Dissertation  |  2019

A major goal of systems biology is to develop comprehensive, multi-scale mathematical models of physiological systems that integra..

Bond graph modelling of the cardiac action potential: implications for drift and non-unique steady states

Michael Pan, Peter J Gawthrop, Kenneth Tran, Joseph Cursons, Edmund J Crampin

Journal article  |  2018  |  PROCEEDINGS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES

Mathematical models of cardiac action potentials have become increasingly important in the study of heart disease and pharmacology..

When push comes to shove: Exclusion processes with nonlocal consequences

Axel A Almet, Michael Pan, Barry D Hughes, Kerry A Landman

Journal article  |  2015  |  PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS

Abstract Stochastic agent-based models are useful for modelling collective movement of biological cells. Lattice-based random walk..