Justin Rubio

Establishing a Longitudinal Opioid Pharmacogenomic Registry for Cancer Patients: Feasibility and Acceptability

Jennifer Philip, Aaron Wong, Leeanne Pasanen, Andrew A Somogyi, Justin Rubio, Pal Klepstad, Anna Collins, Peter Gibbs, Brian Le

Journal article  |  2022  |  JOURNAL OF PALLIATIVE MEDICINE

Purpose: Individual genetic variation can affect both pain expression and opioid response. Large cohort datasets are required to v..

Transcriptomic effects of rs4845604, an IBD and allergy-associated RORC variant, in stimulated ex vivo CD4 T cells

Paul A Wilson, Sara Santos Franco, Liu He, Nicholas W Galwey, Jackie Meakin, Rebecca McIntyre, Simon M McHugh, Michael A Nolan, Sarah L Spain, Thaddeus Carlson, Mercedes Lobera, Justin P Rubio, Bill Davis, Linda C McCarthy

Journal article  |  2021  |  PLOS ONE

RORγt is an isoform of RORC, preferentially expressed in Th17 cells, that functions as a critical regulator of type 3 immunity. As..

Using single cell DNA-seq to decipher disease mechanisms for MS

JP Rubio, A Motyer, S Jackson, DA Markalanda, I Harliwong, C Ye, A Shiu, T Tian, JL Fink, A Harding, M Barnett, SJ Leslie

Conference Proceedings  |  2020  |  MULTIPLE SCLEROSIS JOURNAL

Multiple sclerosis genomic map implicates peripheral immune cells and microglia in susceptibility

Nikolas A Patsopoulos, Sergio E Baranzini, Adams Santaniello, Parisa Shoostari, Chris Cotsapas, Garrett Wong, Ashley H Beecham, Tojo James, Joseph Replogle, Ioannis S Vlachos, Cristin McCabe, Tune H Pers, Aaron Brandes, Charles White, Brendan Keenan, Maria Cimpean, Phoebe Winn, Ioannis-Pavlos Panteliadis, Allison Robbins, Till FM Andlauer, et al.

Journal article  |  2019  |  SCIENCE

We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the gene..

Evidence for the Role of FMR1 Gray Zone Alleles as a Risk Factor for Parkinsonism in Females

Danuta Z Loesch, Flora Tassone, George D Mellick, Malcolm Horne, Justin P Rubio, Minh Q Bui, David Francis, Elsdon Storey

Journal article  |  2018  |  MOVEMENT DISORDERS

Background and Objective There is convincing evidence that small CGG expansion (41-54 repeats): FMR1 "gray zone" alleles (GZ) cont..

Histamine Receptor 3 negatively regulates oligodendrocyte differentiation and remyelination

Yongfeng Chen, Wei Zhen, Tony Guo, Yonggang Zhao, Ailian Liu, Justin P Rubio, David Krull, Jill C Richardson, Hongtao Lu, Ryan Wang

Journal article  |  2017  |  PLOS ONE

BACKGROUND: Agents promoting oligodendrocyte precursor cell differentiation have the potential to restore halted and/or delayed re..

Exome array analysis suggests an increased variant burden in families with schizophrenia

Nina S McCarthy, Phillip E Melton, Sarah V Ward, Spencer M Allan, Milan Dragovic, Melanie L Clark, Bharti Morar, Justin P Rubio, John Blangero, Johanna C Badcock, Veraa Morgan, Eric K Moses, Assen Jablensky

Journal article  |  2017  |  SCHIZOPHRENIA RESEARCH

The exome array assays rare-but-recurrent, likely deleterious, exonic variants and represents an intermediary between single nucle..

Interleukin-2 receptor-alpha proximal promoter hypomethylation is associated with multiple sclerosis

J Field, A Fox, MA Jordan, AG Baxter, T Spelman, M Gresle, H Butzkueven, TJ Kilpatrick, JP Rubio

Journal article  |  2017  |  GENES AND IMMUNITY

Genetic studies have demonstrated association between single-nucleotide polymorphisms within the IL2RA (interleukin-2 receptor α-s..

Estimation of the Antirelapse Efficacy of Tafenoquine, Using Plasmodium vivax Genotyping

Hans-Peter Beck, Rahel Wampfler, Nick Carter, Gavin Koh, Lyda Osorio, Ronnatrai Rueangweerayut, Srivcha Krudsood, Marcus V Lacerda, Alejandro Llanos-Cuentas, Stephan Duparc, Justin P Rubio, Justin A Green

Journal article  |  2016  |  JOURNAL OF INFECTIOUS DISEASES

UNLABELLED: Prevention of relapse of Plasmodium vivax infection is a key treatment goal in malaria. Use of P. vivax genotyping in ..

Tafenoquine treatment of Plasmodium vivax malaria: suggestive evidence that CYP2D6 reduced metabolism is not associated with relapse in the Phase 2b DETECTIVE trial

Pamela L St Jean, Zhengyu Xue, Nick Carter, Gavin CKW Koh, Stephan Duparc, Maxine Taylor, Claire Beaumont, Alejandro Llanos-Cuentas, Ronnatrai Rueangweerayut, Srivicha Krudsood, Justin A Green, Justin P Rubio

Journal article  |  2016  |  MALARIA JOURNAL

BACKGROUND: Tafenoquine (TQ) and primaquine (PQ) are 8-aminoquinolines (8-AQ) with anti-hypnozoite activity against vivax malaria...