James Osborne

Maintaining the proliferative cell niche in multicellular models of epithelia

Claire Miller, Edmund Crampin, James M Osborne

Journal article  |  2021  |  JOURNAL OF THEORETICAL BIOLOGY

The maintenance of the proliferative cell niche is critical to epithelial tissue morphology and function. In this paper we investi..

A mathematical model of cell fate selection on a dynamic tissue

Domenic PJ Germano, James M Osborne

Journal article  |  2021  |  JOURNAL OF THEORETICAL BIOLOGY

Multicellular tissues are the building blocks of many biological systems and organs. These tissues are not static, but dynamically..

A modular framework for multiscale, multicellular, spatiotemporal modeling of acute primary viral infection and immune response in epithelial tissues and its application to drug therapy timing and effectiveness

TJ Sego, Josua O Aponte-Serrano, Juliano Ferrari Gianlupi, Samuel R Heaps, Kira Breithaupt, Lutz Brusch, Jessica Crawshaw, James M Osborne, Ellen M Quardokus, Richard K Plemper, James A Glazier

Journal article  |  2020  |  PLOS COMPUTATIONAL BIOLOGY

Simulations of tissue-specific effects of primary acute viral infections like COVID-19 are essential for understanding disease out..

Chaste: Cancer, Heart and Soft Tissue Environment

Fergus Cooper, Ruth Baker, Miguel Bernabeu, Rafel Bordas, Louise Bowler, Alfonso Bueno-Orovio, Helen Byrne, Valentina Carapella, Louie Cardone-Noott, Jonathan Cooper, Sara Dutta, Benjamin Evans, Alexander Fletcher, James Grogan, Wenxian Guo, Daniel Harvey, Maurice Hendrix, David Kay, Jochen Kursawe, Philip Maini, et al.

Journal article  |  2020  |  Journal of Open Source Software

Chaste (Cancer, Heart And Soft Tissue Environment) is an open source simulation package for the numerical solution of mathematical..

Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

Lotte B Romijn, Axel A Almet, Chin Wee Tan, James M Osborne

Journal article  |  2020  |  BMC BIOINFORMATICS

BACKGROUND: Many cancers arise from mutations in cells within epithelial tissues. Mutations manifesting at the subcellular level i..

Addressing Interdisciplinary Difficulties in Developmental Biology/Mathematical Collaborations: A Neural Crest Example

Donald F Newgreen, Kerry A Landman, James M Osborne

Journal article  |  2019  |  NEURAL CREST CELLS

Mathematical modeling can allow insight into the biological processes that can be difficult to access by conventional biological m..

Stochastic clonal expansion of "superstars" enhances the reserve capacity of enteric nervous system precursor cells

Dongcheng Zhang, James M Osborne, Kwaku Dad Abu-Bonsrah, Bevan L Cheeseman, Kerry A Landman, Boaz Jurkowicz, Donald F Newgreen

Journal article  |  2018  |  Developmental Biology

We quantified cell population increase in the quail embryo enteric nervous system (ENS) from E2.5 (about 1500 cells) to E12 (about..

A Fully Discrete Open Source Framework for the Simulation of Vascular Remodelling.

James M Osbotne, Miguel O Bernabeu

Conference Proceedings  |  2018  |  Annu Int Conf IEEE Eng Med Biol Soc

In this paper we present a novel computational framework for the theoretical study of the interaction between haemodynamics and ve..

Cooperation, competition and antibiotic resistance in bacterial colonies

Isabel Frost, William PJ Smith, Sara Mitri, Alvaro San Millan, Yohan Davit, James M Osborne, Joe M Pitt-Francis, R Craig MacLean, Kevin R Foster

Journal article  |  2018  |  ISME JOURNAL

Bacteria commonly live in dense and genetically diverse communities associated with surfaces. In these communities, competition fo..

A Multicellular Model of Intestinal Crypt Buckling and Fission

Axel A Almet, Barry D Hughes, Kerry A Landman, Inke S Nathke, James M Osborne

Journal article  |  2018  |  BULLETIN OF MATHEMATICAL BIOLOGY

Crypt fission is an in vivo tissue deformation process that is involved in both intestinal homeostasis and colorectal tumourigenes..