James Osborne

Modelling realistic 3D deformations of simple epithelia in dynamic homeostasis

Domenic PJ Germano, Stuart T Johnston, Edmund J Crampin, James M Osborne

Journal article  |  2022  |  MATHEMATICAL BIOSCIENCES

The maintenance of tissue and organ structures during dynamic homeostasis is often not well understood. In order for a system to b..

Multiscale modelling of desquamation in the interfollicular epidermis

Claire Miller, Edmund Crampin, James M Osborne

Journal article  |  2022  |  PLOS COMPUTATIONAL BIOLOGY

Maintenance of epidermal thickness is critical to the barrier function of the skin. Decreased tissue thickness, specifically in th..

How quickly does a wound heal? Bayesian calibration of a mathematical model of venous leg ulcer healing

Adriana Zanca, James M Osborne, Sophie G Zaloumis, Carolina D Weller, Jennifer A Flegg

Journal article  |  2022  |  MATHEMATICAL MEDICINE AND BIOLOGY-A JOURNAL OF THE IMA

Chronic wounds, such as venous leg ulcers, are difficult to treat and can reduce the quality of life for patients. Clinical trials..

Traffic Patterns of the Migrating Endothelium: How Force Transmission Regulates Vascular Malformation and Functional Shunting During Angiogenic Remodelling

Lowell T Edgar, Hyojin Park, Jessica R Crawshaw, James M Osborne, Anne Eichmann, Miguel O Bernabeu

Journal article  |  2022  |  FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY

Angiogenesis occurs in distinct phases: initial spouting is followed by remodelling in which endothelial cells (ECs) composing blo..

A simple history-dependent remeshing technique to increase finite element model stability in elastic surface deformations

Jessica R Crawshaw, Jennifer A Flegg, James M Osborne

Journal article  |  2022  |  JOURNAL OF COMPUTATIONAL AND APPLIED MATHEMATICS

In this paper we present and validate a simple adaptive surface remeshing technique to transfer history dependent variables from a..

Push or Pull? Cell Proliferation and Migration During Wound Healing

Adriana Zanca, Jennifer A Flegg, James M Osborne

Journal article  |  2022  |  Frontiers in Systems Biology

Wound healing of the skin is a complex process that is still not well-understood. Wound management is expensive for both individua..

Seven challenges in the multiscale modeling of multicellular tissues

Alexander G Fletcher, James M Osborne

Journal article  |  2022  |  WIRES MECHANISMS OF DISEASE

The growth and dynamics of multicellular tissues involve tightly regulated and coordinated morphogenetic cell behaviors, such as s..

A rigid body framework for multicellular modeling (vol 1, pg 754, 2021)

Phillip J Brown, J Edward F Green, Benjamin J Binder, James M Osborne

Journal article  |  2022  |  NATURE COMPUTATIONAL SCIENCE

In the version of this article initially published, a reference was omitted from the Code availability section. In the text now re..

Modelling Cellular Interactions and Dynamics During Kidney Morphogenesis

Blake Cook, Alex Combes, Melissa Little, James M Osborne

Journal article  |  2022  |  BULLETIN OF MATHEMATICAL BIOLOGY

Kidney disease and renal disorders account for a significant proportion of health complications in mid-late adulthood worldwide. M..

Model Integration in Computational Biology: The Role of Reproducibility, Credibility and Utility.

Jonathan Karr, Rahuman S Malik-Sheriff, James Osborne, Gilberto Gonzalez-Parra, Eric Forgoston, Ruth Bowness, Yaling Liu, Robin Thompson, Winston Garira, Jacob Barhak, John Rice, Marcella Torres, Hana M Dobrovolny, Tingting Tang, William Waites, James A Glazier, James R Faeder, Alexander Kulesza

Journal article  |  2022  |  Front Syst Biol

During the COVID-19 pandemic, mathematical modeling of disease transmission has become a cornerstone of key state decisions. To ad..