James Osborne

Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

Lotte B Romijn, Axel A Almet, Chin Wee Tan, James M Osborne

Journal article  |  2020  |  BMC Bioinformatics

BACKGROUND: Many cancers arise from mutations in cells within epithelial tissues. Mutations manifesting at the subcellular level i..

Addressing Interdisciplinary Difficulties in Developmental Biology/Mathematical Collaborations: A Neural Crest Example.

Donald F Newgreen, Kerry A Landman, James M Osborne

Journal article  |  2019  |  Methods in molecular biology (Clifton, N.J.)

Mathematical modeling can allow insight into the biological processes that can be difficult to access by conventional biological m..

Stochastic clonal expansion of "superstars" enhances the reserve capacity of enteric nervous system precursor cells

Dongcheng Zhang, James M Osborne, Kwaku Dad Abu-Bonsrah, Bevan L Cheeseman, Kerry A Landman, Boaz Jurkowicz, Donald F Newgreen

Journal article  |  2018  |  Developmental Biology

Cooperation, competition and antibiotic resistance in bacterial colonies

Isabel Frost, William PJ Smith, Sara Mitri, Alvaro San Millan, Yohan Davit, James M Osborne, Joe M Pitt-Francis, R Craig MacLean, Kevin R Foster

Journal article  |  2018  |  The ISME Journal

A Multicellular Model of Intestinal Crypt Buckling and Fission

Axel A Almet, Barry D Hughes, Kerry A Landman, Inke S Nathke, James M Osborne

Journal article  |  2018  |  Bulletin of Mathematical Biology

A mathematical model of antibody-dependent cellular cytotoxicity (ADCC)

F Hoffman, D Gavaghan, J Osborne, IP Barrett, T You, H Ghadially, R Sainson, RW Wilkinson, HM Byrne

Journal article  |  2018  |  Journal of Theoretical Biology

A Fully Discrete Open Source Framework for the Simulation of Vascular Remodelling

J Osborne, Miguel O Bernabeu

Conference Proceedings  |  2018

Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids

Thomas D Carroll, Alistair J Langlands, James M Osborne, Ian P Newton, Paul L Appleton, Inke Nathke

Journal article  |  2017  |  Journal of Cell Science

Enteric nervous system formation: disproportionate stochastic clonal expansion of a few initiating vagal neural crest cells

Donald Newgreen, Dongcheng Zhang, James Osborne, Bevan Cheeseman, Benjamin Binder, Kerry Landman

Conference Proceedings  |  2017  |  Mechanisms of Development

The role of the Hes1 crosstalk hub in Notch-Wnt interactions of the intestinal crypt

Sophie K Kay, Heather A Harrington, Sarah Shepherd, Keith Brennan, Trevor Dale, James M Osborne, David J Gavaghan, Helen M Byrne

Journal article  |  2017  |  PLOS Computational Biology