Angela Pizzolla

Tissue-resident memory T cells from a metastatic vaginal melanoma patient are tumor-responsive T cells and increase after anti-PD-1 treatment

Angela Pizzolla, Simon Paul Keam, Ismael A Vergara, Franco Caramia, Niko Thio, Minyu Wang, Nikolce Kocovski, Daniela Tantalo, Jafar Jabbari, George Au-Yeung, Shahneen Sandhu, David E Gyorki, Alison Weppler, Maurizio Perdicchio, Grant A McArthur, Anthony T Papenfuss, Paul Joseph Neeson

Journal article  |  2022  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: Vaginal melanoma (VM) is a rare cancer and has a poor response to immune checkpoint blockade (ICB). CD8+Tissue Residen..

Characterization of the treatment-naive immune microenvironment in melanoma with BRAF mutation

Minyu Wang, Soroor Zadeh, Angela Pizzolla, Kevin Thia, David E Gyorki, Grant A McArthur, Richard A Scolyer, Georgina Long, James S Wilmott, Miles C Andrews, George Au-Yeung, Ali Weppler, Shahneen Sandhu, Joseph A Trapani, Melissa J Davis, Paul Joseph Neeson

Journal article  |  2022  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: Patients with BRAF-mutant and wild-type melanoma have different response rates to immune checkpoint blockade therapy. ..

MAIT cells regulate NK cell-mediated tumor immunity

Emma Petley, Hui-Fern Koay, Melissa A Henderson, Kevin Sek, Kirsten L Todd, Simon P Keam, Junyun Lai, Imran G House, Jasmine Li, Magnus Zethoven, Amanda XY Chen, Amanda J Oliver, Jessica Michie, Andrew J Freeman, Lauren Giuffrida, Jack D Chan, Angela Pizzolla, Jeffrey YW Mak, Timothy R McCulloch, Fernando Souza-Fonseca-Guimaraes, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT ce..

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Nicolas Jacquelot, Cyril Seillet, Minyu Wang, Angela Pizzolla, Yang Liao, Soroor Hediyeh-zadeh, Sharon Grisaru-Tal, Cynthia Louis, Qiutong Huang, Jaring Schreuder, Fernando Souza-Fonseca-Guimaraes, Carolyn A de Graaf, Kevin Thia, Sean Macdonald, Mary Camilleri, Kylie Luong, Shengbo Zhang, Michael Chopin, Tristan Molden-Hauer, Stephen L Nutt, et al.

Journal article  |  2021  |  NATURE IMMUNOLOGY

Group 2 innate lymphoid cells (ILC2s) are essential to maintain tissue homeostasis. In cancer, ILC2s can harbor both pro-tumorigen..

Single-Cell Gene Expression, Clonality, and Feature Barcoding of Melanoma Tumor-Infiltrating Lymphocytes

Angela Pizzolla, Simon P Keam, Criselle D'Souza, Timothy Semple, Paul J Neeson

Journal article  |  2021  |  MELANOMA

We describe here a protocol to measure gene expression, T cell receptor (TCR) sequence, and protein expression by single T cells e..

Using Mass Cytometry to Analyze the Tumor-Infiltrating Lymphocytes in Human Melanoma

Daniela Tantalo, Nguyen Thu, Han Xian Aw Yeang, Joe Zhu, Sean Macdonald, Minyu Wang, Harini de Silva, Criselle D'Souza, Angela Pizzolla, Paul J Neeson

Journal article  |  2021  |  MELANOMA

Here we describe the application of mass cytometry to analyze tumor-infiltrating lymphocytes in human melanoma. Mass cytometry is ..

CD8 TISSUE-RESIDENT MEMORY T CELLS ARE TUMOUR REACTIVE AND INCREASE AFTER IMMUNOTHERAPY IN A CASE OF METASTATIC MUCOSAL MELANOMA

Angela Pizzolla, Simon Keam, Ismael Vergara, Franco Caramia, Minyu Wang, Nikolce Kocovski, Nguyen ThuNgoc, Sean Macdonald, Daniela Tantalo, Pasquale Petrone, Han Xian Aw Yeang, David Gyorki, Alison Weppler, George Au-Yeung, Shahneen Sandhu, Maurizio Perdicchio, Grant McArthur, Tony Papenfuss, Paul Neeson

Conference Proceedings  |  2020  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Background Mucosal melanoma is a rare subtype of melanoma originating from mucosal tissues (1), metastases are very aggressive an..

Bystander Activation of Pulmonary Trm Cells Attenuates the Severity of Bacterial Pneumonia by Enhancing Neutrophil Recruitment

Chenghao Ge, Ian R Monk, Angela Pizzolla, Nancy Wang, James G Bedford, Timothy P Stinear, Glen P Westall, Linda M Wakim

Journal article  |  2019  |  CELL REPORTS

Tissue-resident memory T (Trm) cells are described as having a "sensing and alarming" function, meaning they can rapidly release c..

Zymosan by-passes the requirement for pulmonary antigen encounter in lung tissue-resident memory CD8( ) T cell development

Irina Caminschi, Mireille H Lahoud, Angela Pizzolla, Linda M Wakim

Journal article  |  2019  |  MUCOSAL IMMUNOLOGY

Tissue-resident memory T cells (Trm) in the lung provide a frontline defence against respiratory pathogens. Vaccination models tha..

Memory T Cell Dynamics in the Lung during Influenza Virus Infection

Angela Pizzolla, Linda M Wakim

Journal article  |  2019  |  JOURNAL OF IMMUNOLOGY

Influenza A virus is highly contagious, infecting 5-15% of the global population every year. It causes significant morbidity and m..