Sandy Hung

Utility of Self-Destructing CRISPR/Cas Constructs for Targeted Gene Editing in the Retina

Fan Li, Sandy SC Hung, Mohd Khairul Nizam Mohd Khalid, Jiang-Hui Wang, Vicki Chrysostomou, Vickie HY Wong, Vikrant Singh, Kristof Wing, Leilei Tu, James A Bender, Alice Pebay, Anna E King, Anthony L Cook, Raymond CB Wong, Bang Bui, Alex W Hewitt, Guei-Sheung Liu

Conference Proceedings  |  2019  |  Human Gene Therapy

A single-cell transcriptome atlas of the adult human retina

Samuel W Lukowski, Camden Y Lo, Alexei A Sharov, Quan Nguyen, Lyujie Fang, Sandy SC Hung, Ling Zhu, Ting Zhang, Ulrike Grunert, Tu Nguyen, Anne Senabouth, Jafar S Jabbari, Emily Welby, Jane C Sowden, Hayley S Waugh, Adrienne Mackey, Graeme Pollock, Trevor D Lamb, Peng-Yuan Wang, Alex W Hewitt, et al.

Journal article  |  2019  |  The EMBO Journal

Intervention Fidelity Monitoring for the Post Ischaemic Stroke Cardiovascular Exercise Study (PISCES)

Stanley Hung, Sharon Kramer, Emilio Werden, Liam Johnson, Rosalind Hutchings, Laura Bird, Julie Bernhardt, Amy Brodtmann

Conference Proceedings  |  2019  |  INTERNATIONAL JOURNAL OF STROKE

CRISPR/Cas-mediated base editing of the AMD high-risk Y402H complement factor H variant

Alex W Hewitt, Peter Tran, Mohd Khairul Nizam Mohd Khalid, Alice Pebay, Anthony L Cook, Helena Liang, Raymond Wong, Jamie E Craig, Guei-Sheung Liu, Sandy Hung

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Comparison of CRISPR/Cas endonuclease gene editing efficiency of retinal cells in vivo

Fan Li, Kristof Wing, Jiang-Hui Wang, James Bender, Chi D Luu, Jinying Chen, Vivienne Lu, Qi Wang, Qinyi Lu, Peter Tran, Kaylene Young, Anna King, Sandy Hung, Guei-Sheung Liu, Alex W Hewitt

Conference Proceedings  |  2019  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

A Simple Cloning-free Method to Efficiently Induce Gene Expression Using CRISPR/Cas9

Lyujie Fang, Sandy SC Hung, Jennifer Yek, Layal El Wazan, Nguyen Tu, Shahnaz Khan, Shiang Y Lim, Alex W Hewitt, Raymond CB Wong

Journal article  |  2019  |  Molecular Therapy - Nucleic Acids

Potentials of Cellular Reprogramming as a Novel Strategy for Neuroregeneration

Lyujie Fang, Layal El Wazan, Christine Tan, Nguyen Tu, Sandy SC Hung, Alex W Hewitt, Raymond CB Wong

Journal article  |  2018  |  Frontiers in Cellular Neuroscience

Longitudinal expression profiling of CD4 and CD8 cells in patients with active to quiescent giant cell arteritis

Elisabeth De Smit, Samuel W Lukowski, Lisa Anderson, Anne Senabouth, Kaisar Dauyey, Sharon Song, Bruce Wyse, Lawrie Wheeler, Christine Y Chen, Khoa Cao, Amy Wong Ten Yuen, Neil Shuey, Linda Clarke, Isabel Lopez Sanchez, Sandy SC Hung, Alice Pebay, David A Mackey, Matthew A Brown, Alex W Hewitt, Joseph E Powell

Journal article  |  2018  |  BMC Medical Genomics

Using cell reprogramming technology to convert Muller glia into photoreceptors

Raymond Ching Bong Wong, Nguyen Tu, Lucy Lyujie Fang, Camden Lo, Jafar Jabbari, Sandy Hung, Rick Guei-Sheung Liu, Chi D Luu, Mark C Gillies, Alex Hewitt

Conference Proceedings  |  2018  |  INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE

Methods for In Vivo CRISPR/Cas Editing of the Adult Murine Retina

Sandy S Hung, Fan Li, Jiang-Hui Wang, Anna E King, Bang V Bui, Guei-Sheung Liu, Alex W Hewitt

Book Chapter  |  2018  |  Methods in Molecular Biology

Drusen in patient-derived hiPSC-RPE models of macular dystrophies

Chad A Galloway, Sonal Dalvi, Sandy SC Hung, Leslie A MacDonald, Lisa R Latchney, Raymond CB Wong, Robyn H Guymer, David A Mackey, David S Williams, Mina M Chung, David M Gamm, Alice Pebay, Alex W Hewitt, Ruchira Singh

Journal article  |  2017  |  Proceedings of the National Academy of Sciences

Development of a Modular Automated System for Maintenance and Differentiation of Adherent Human Pluripotent Stem Cells

Duncan E Crombie, Maciej Daniszewski, Helena H Liang, Tejal Kulkarni, Fan Li, Grace E Lidgerwood, Alison Conquest, Damian Hernandez, Sandy S Hung, Katherine P Gill, Elisabeth De Smit, Lisa S Kearns, Linda Clarke, Valentin M Sluch, Xitiz Chamling, Donald J Zack, Raymond CB Wong, Alex W Hewitt, Alice Pebay

Journal article  |  2017  |  SLAS DISCOVERY: Advancing the Science of Drug Discovery

Drug discovery using induced pluripotent stem cell models of neurodegenerative and ocular diseases

Sandy SC Hung, Shahnaz Khan, Camden Y Lo, Alex W Hewitt, Raymond CB Wong

Journal article  |  2017  |  Pharmacology & Therapeutics

Generation of a human induced pluripotent stem cell line CERAi001-A-6 using episomal vectors

Raymond CB Wong, Sandy S Hung, Stacey Jackson, Vikrant Singh, Shahnaz Khan, Helena H Liang, Lisa S Kearns, Tu Nguyena, Alison Conquest, Maciej Daniszewski, Alex W Hewitt, Alice Pebay

Journal article  |  2017  |  Stem Cell Research

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Sandy S Hung, Analia Lesmana, Abigail Peck, Rachel Lee, Elly Tchoubrieva, Katherine M Hannan, Jane Lin, Karen E Sheppard, Katarzyna Jastrzebski, Leonie M Quinn, Lawrence I Rothblum, Richard B Pearson, Ross D Hannan, Elaine Sanij

Journal article  |  2017  |  Gene

Mitochondrial replacement in an iPSC model of Leber's hereditary optic neuropathy

Raymond CB Wong, Shiang Y Lim, Sandy SC Hung, Stacey Jackson, Shahnaz Khan, Nicole J Van Bergen, Elisabeth De Smit, Helena H Liang, Lisa S Kearns, Linda Clarke, David A Mackey, Alex W Hewitt, Ian A Trounce, Alice Pebay

Journal article  |  2017  |  Aging

Binary colloidal crystals (BCCs) as a feeder-free system to generate human induced pluripotent stem cells (hiPSCs)

Peng-Yuan Wang, Sandy Shen-Chi Hung, Helmut Thissen, Peter Kingshott, Raymond Ching-Bong Wong

Journal article  |  2016  |  Scientific Reports

LONGITUDINAL EXPRESSION PROFILING OF T LYMPHOCYTES IN PATIENTS WITH ACTIVE TO QUIESCENT GIANT CELL ARTERITIS

Elisabeth De Smit, Linda Clarke, Khoa Ngygen, Neil Shuey, Catherine Hill, Lisa Anderson, David Evans, Matt A Brown, Joseph Powell, Alex W Hewitt

Conference Proceedings  |  2016  |  BMC Medical Genomics

The use of induced pluripotent stem cells for studying and treating optic neuropathies

Shahnaz Khan, Sandy Shen-Chi Hung, Raymond Ching-Bong Wong

Journal article  |  2016  |  Current Opinion in Organ Transplantation

Enriched retinal ganglion cells derived from human embryonic stem cells

Katherine P Gill, Sandy SC Hung, Alexei Sharov, Camden Y Lo, Karina Needham, Grace E Lidgerwood, Stacey Jackson, Duncan E Crombie, Bryony A Nayagam, Anthony L Cook, Alex W Hewitt, Alice Pebay, Raymond CB Wong

Journal article  |  2016  |  Scientific Reports

Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

Jian Kang, Eric P Kusnadi, Allison J Ogden, Rodney J Hicks, Lukas Bammert, Ulrike Kutay, Sandy Hung, Elaine Sanij, Ross D Hannan, Katherine M Hannan, Richard B Pearson

Journal article  |  2016  |  Oncotarget

Genome engineering in ophthalmology: Application of CRISPR/Cas to the treatment of eye disease

Sandy SC Hung, Tristan McCaughey, Olivia Swann, Alice Pebay, Alex W Hewitt

Journal article  |  2016  |  Progress in Retinal and Eye Research

AAV-Mediated CRISPR/Cas Gene Editing of Retinal Cells In Vivo

Sandy SC Hung, Vicki Chrysostomou, Fan Li, Jeremiah KH Lim, Jiang-Hui Wang, Joseph E Powell, Leilei Tu, Maciej Daniszewski, Camden Lo, Raymond C Wong, Jonathan G Crowston, Alice Pebay, Anna E King, Bang V Bui, Guei-Sheung Liu, Alex W Hewitt

Journal article  |  2016  |  Investigative Opthalmology & Visual Science

Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells

Sandy SC Hung, Nicole J Van Bergen, Stacey Jackson, Helena Liang, David A Mackey, Damian Hernandez, Shiang Y Lim, Alex W Hewitt, Ian Trounce, Alice Pebay, Raymond CB Wong

Journal article  |  2016  |  Aging

Electrical Stimulation Promotes Cardiac Differentiation of Human Induced Pluripotent Stem Cells

Damian Hernandez, Rodney Millard, Priyadharshini Sivakumaran, Raymond CB Wong, Duncan E Crombie, Alex W Hewitt, Helena Liang, Sandy SC Hung, Alice Pebay, Robert K Shepherd, Gregory J Dusting, Shiang Y Lim

Journal article  |  2016  |  Stem Cells International

Generation of Integration-free Human Induced Pluripotent Stem Cells Using Hair-derived Keratinocytes

Sandy SC Hung, Alice Pebay, Raymond CB Wong

Journal article  |  2015  |  Journal of Visualized Experiments

Efficient Generation of Integration-Free Human Induced Pluripotent Stem Cells From Keratinocytes by Simple Transfection of Episomal Vectors

Yulan Piao, Sandy Shen-Chi Hung, Shiang Y Lim, Raymond Ching-Bong Wong, Minoru SH Ko

Journal article  |  2014  |  STEM CELLS Translational Medicine

Repression of Global Protein Synthesis by Eif1a-Like Genes That Are Expressed Specifically in the Two-Cell Embryos and the Transient Zscan4-Positive State of Embryonic Stem Cells

Sandy SC Hung, Raymond CB Wong, Alexei A Sharov, Yuhki Nakatake, Hong Yu, Minoru SH Ko

Journal article  |  2013  |  DNA Research

AKT Promotes rRNA Synthesis and Cooperates with c-MYC to Stimulate Ribosome Biogenesis in Cancer

Joanna C Chan, Katherine M Hannan, Kim Riddell, Yee Ng Pui, Abigail Peck, Rachel S Lee, Sandy Hung, Megan V Astle, Megan Bywater, Meaghan Wall, Gretchen Poortinga, Katarzyna Jastrzebski, Karen E Sheppard, Brian A Hemmings, Michael N Hall, Ricky W Johnstone, Grant A McArthur, Ross D Hannan, Richard B Pearson

Journal article  |  2011  |  Science Signaling

A phospho-proteomic screen identifies novel S6K1 and mTORC1 substrates revealing additional complexity in the signaling network regulating cell growth

Katarzyna Jastrzebski, Katherine M Hannan, Colin M House, Sandy S-C Hung, Richard B Pearson, Ross D Hannan

Journal article  |  2011  |  Cellular Signaling

UBF levels determine the number of active ribosomal RNA genes in mammals

Elaine Sanij, Gretchen Poortinga, Kerith Sharkey, Sandy Hung, Timothy P Holloway, Jaclyn Quin, Elysia Robb, Lee H Wong, Walter G Thomas, Victor Stefanovsky, Tom Moss, Lawrence Rothblum, Katherine M Hannan, Grant A McArthur, Richard B Pearson, Ross D Hannan

Journal article  |  2008  |  The Journal of Cell Biology

NF-kappaB-independent induction of endothelial cell apoptosis by the vascular disrupting agent DMXAA.

See-Tarn Woon, Sandy SC Hung, Derek CF Wu, Mary Ann Schooltink, Rachel Sutherland, Bruce C Baguley, Qi Chen, Lawrence W Chamley, Lai-Ming Ching

Journal article  |  2007  |  Anticancer Research

BACKGROUND: DMXAA (5,6-dimethylxanthenone-4-acetic acid; AS1404), a vascular disrupting agent currently in clinical trials, induce..

Antiphospholipid antibodies bind to activated but not resting endothelial cells: is an independent triggering event required to induce antiphospholipid antibody-mediated disease?

Q Chen, PR Stone, S-T Woon, L-M Ching, S Hung, LME McCowan, LW Chamley

Journal article  |  2004  |  Thrombosis Research

INTRODUCTION: Antiphospholipid antibodies (aPL) cause thrombotic disease and recurrent pregnancy loss. Despite their name it is no..