Ismael Alfonso Vergara Correa

Melanoma brain metastases that progress on BRAF-MEK inhibitors demonstrate resistance to ipilimumab-nivolumab that is associated with the Innate PD-1 Resistance Signature (IPRES)

Peter Kar Han Lau, Breon Feran, Lorey Smith, Arian Lasocki, Ramyar Molania, Kortnye Smith, Alison Weppler, Christopher Angel, Damien Kee, Prachi Bhave, Belinda Lee, Richard J Young, Amir Iravani, Hanxian Aw Yeang, Ismael A Vergara, David Kok, Kate Drummond, Paul Joseph Neeson, Karen E Sheppard, Tony Papenfuss, et al.

Journal article  |  2021  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

BACKGROUND: Melanoma brain metastases (MBMs) are a challenging clinical problem with high morbidity and mortality. Although first-..

Evolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling

Ismael A Vergara, Christopher P Mintoff, Shahneen Sandhu, Lachlan McIntosh, Richard J Young, Stephen Q Wong, Andrew Colebatch, Daniel L Cameron, Julia Lai Kwon, Rory Wolfe, Angela Peng, Jason Ellul, Xuelin Dou, Clare Fedele, Samantha Boyle, Gisela Mir Arnau, Jeanette Raleigh, Athena Hatzimihalis, Pacman Szeto, Jennifer Mooi, et al.

Journal article  |  2021  |  NATURE COMMUNICATIONS

Although melanoma is initiated by acquisition of point mutations and limited focal copy number alterations in melanocytes-of-origi..

CD8 TISSUE-RESIDENT MEMORY T CELLS ARE TUMOUR REACTIVE AND INCREASE AFTER IMMUNOTHERAPY IN A CASE OF METASTATIC MUCOSAL MELANOMA

Angela Pizzolla, Simon Keam, Ismael Vergara, Franco Caramia, Minyu Wang, Nikolce Kocovski, Nguyen ThuNgoc, Sean Macdonald, Daniela Tantalo, Pasquale Petrone, Han Xian Aw Yeang, David Gyorki, Alison Weppler, George Au-Yeung, Shahneen Sandhu, Maurizio Perdicchio, Grant McArthur, Tony Papenfuss, Paul Neeson

Conference Proceedings  |  2020  |  JOURNAL FOR IMMUNOTHERAPY OF CANCER

Background Mucosal melanoma is a rare subtype of melanoma originating from mucosal tissues (1), metastases are very aggressive an..

The Hippo pathway in melanoma.

Xiaomeng Zhang, Lie Yang, Ismael Vergara, Pacman Szeto, Youfang Zhang, Anthony Papenfuss, Mark Shackleton, Kieran Harvey

Conference Proceedings  |  2020  |  MOLECULAR CANCER RESEARCH

The Hippo pathway oncoprotein YAP promotes melanoma cell invasion and spontaneous metastasis

Xiaomeng Zhang, Lie Yang, Pacman Szeto, Gamze Kuser Abali, Youfang Zhang, Aishwarya Kulkarni, Kaushalya Amarasinghe, Jason Li, Ismael A Vergara, Ramyar Molania, Anthony T Papenfuss, Catriona McLean, Mark Shackleton, Kieran F Harvey

Journal article  |  2020  |  ONCOGENE

Melanoma is a deadly form of skin cancer that accounts for a disproportionally large proportion of cancer-related deaths in younge..

The Hippo pathway in melanoma

Xiaomeng Zhang, Lie Yang, Ismael Vergara, Pacman Szeto, Youfang Zhang, Anthony Papenfuss, Mark Shackleton, Kieran Harvey

Conference Proceedings  |  2020  |  CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Abstract Melanoma is usually driven by mutations in BRAF or NRAS that trigger hyperactivation of mitogen-activated ..

Adaptive Evolution of Geobacter sulfurreducens in Coculture with Pseudomonas aeruginosa

Lucie Semenec, Ismael A Vergara, Andrew E Lalock, Steve Petrovski, Philip L Bond, Ashley E Franks

Journal article  |  2020  |  MBIO

Interactions between microorganisms in mixed communities are highly complex, being either syntrophic, neutral, predatory, or compe..

Regulation of PRMT5-MDM4 axis is critical in the response to CDK4/6 inhibitors in melanoma

Shatha AbuHammad, Carleen Cullinane, Claire Martin, Zoe Bacolas, Teresa Ward, Huiqin Chen, Alison Slater, Kerry Ardley, Laura Kirby, Keefe T Chan, Natalie Brajanovski, Lorey K Smith, Aparna D Rao, Emily J Lelliott, Margarete Kleinschmidt, Ismael A Vergara, Anthony T Papenfuss, Peter Lau, Prerana Ghosh, Sue Haupt, et al.

Journal article  |  2019  |  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are c..

Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma

Xiaomeng Zhang, Jian Zhong Tang, Ismael A Vergara, Youfang Zhang, Pacman Szeto, Lie Yang, Christopher Mintoff, Andrew Colebatch, Lachlan McIntosh, Katrina A Mitchell, Evangeline Shaw, Helen Rizos, Georgina Long, Nicholas Hayward, Grant A McArthur, Anthony T Papenfuss, Kieran F Harvey, Mark Shackleton

Journal article  |  2019  |  MOLECULAR CANCER RESEARCH

Melanoma is usually driven by mutations in BRAF or NRAS, which trigger hyperactivation of MAPK signaling. However, MAPK-targeted t..

Bioinformatics analysis of sequence data

AT Papenfuss, D Cameron, J Schroeder, I Vergara

Book Chapter  |  2017

Bioinformatics is the application of mathematics, statistics and computer science to biological data. In this chapter, we introduc..