Philippa Karoly

Ensembling crowdsourced seizure prediction algorithms using long-term human intracranial EEG

Chip Reuben, Philippa Karoly, Dean R Freestone, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothee Proix, Michal Nahlik, Daniel B Grunberg, David B Grayden, Mark J Cook, et al.

Journal article  |  2020  |  Epilepsia

Seizure prediction is feasible, but greater accuracy is needed to make seizure prediction clinically viable across a large group o..

Computer-assisted EEG diagnostic review for idiopathic generalized epilepsy.

Shannon Clarke, Philippa J Karoly, Ewan Nurse, Udaya Seneviratne, Janelle Taylor, Rory Knight-Sadler, Robert Kerr, Braden Moore, Patrick Hennessy, Dulini Mendis, Claire Lim, Jake Miles, Mark Cook, Dean R Freestone, Wendyl D'Souza

Journal article  |  2019  |  Epilepsy & Behavior

Epilepsy diagnosis can be costly, time-consuming, and not uncommonly inaccurate. The reference standard diagnostic monitoring is c..

When can we trust responders? Serious concerns when using 50% response rate to assess clinical trials

Philippa J Karoly, Juan Romero, Mark J Cook, Dean R Freestone, Daniel M Goldenholz

Journal article  |  2019  |  Epilepsia

Individual seizure rates are highly volatile, with large fluctuations from month‐to‐month. Nevertheless, changes in individual mea..

Methods for the Detection of Seizure Bursts in Epilepsy

Udaya Seneviratne, Philippa Karoly, Dean R Freestone, Mark J Cook, Ray C Boston

Journal article  |  2019  |  Frontiers in Neurology

Background: Seizure clusters and “bursts” are of clinical importance. Clusters are reported to be a marker of antiepileptic drug r..

Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations

Wei-Chih Chang, Jan Kudlacek, Jaroslav Hlinka, Jan Chvojka, Michal Hadrava, Vojtech Kumpost, Andrew D Powell, Radek Janca, Matias I Maturana, Philippa J Karoly, Dean R Freestone, Mark J Cook, Milan Palus, Jakub Otahal, John GR Jefferys, Premysl Jiruska

Journal article  |  2018  |  Nature Neuroscience

Circadian and circaseptan rhythms in human epilepsy: a retrospective cohort study

Philippa J Karoly, Daniel M Goldenholz, Dean R Freestone, Robert E Moss, David B Grayden, William H Theodore, Mark J Cook

Journal article  |  2018  |  The Lancet Neurology

Seizure pathways: A model-based investigation

Philippa J Karoly, Levin Kuhlmann, Daniel Soudry, David B Grayden, Mark J Cook, Dean R Freestone

Journal article  |  2018  |  PLOS Computational Biology

Epilepsyecosystem.org: crowd-sourcing reproducible seizure prediction with long-term human intracranial EEG

Levin Kuhlmann, Philippa Karoly, Dean R Freestone, Benjamin H Brinkmann, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Scott Dobson, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothee Proix, Michal Nahlik, Daniel B Grunberg, et al.

Journal article  |  2018  |  Brain

Postictal suppression and seizure durations: A patient-specific, long-term iEEG analysis

Daniel E Payne, Philippa J Karoly, Dean R Freestone, Ray Boston, Wendyl D'Souza, Ewan Nurse, Levin Kuhlmann, Mark J Cook, David B Grayden

Journal article  |  2018  |  Epilepsia

Are the days of counting seizures numbered?

Philippa Karoly, Daniel M Goldenholz, Mark Cook

Journal article  |  2018  |  Current Opinion in Neurology

Bifurcation analysis of two coupled Jansen-Rit neural mass models

Saeed Ahmadizadeh, Philippa J Karoly, Dragan Nesic, David B Grayden, Mark J Cook, Daniel Soudry, Dean R Freestone

Journal article  |  2018  |  PLOS ONE

Is seizure frequency variance a predictable quantity?

Daniel M Goldenholz, Shira R Goldenholz, Robert Moss, Jacqueline French, Daniel Lowenstein, Ruben Kuzniecky, Sheryl Haut, Sabrina Cristofaro, Kamil Detyniecki, John Hixson, Philippa Karoly, Mark Cook, Alex Strashny, William H Theodore

Journal article  |  2018  |  Annals of Clinical and Translational Neurology

Epileptic Seizure Prediction Using Big Data and Deep Learning: Toward a Mobile System

Isabell Kiral-Kornek, Subhrajit Roy, Ewan Nurse, Benjamin Mashford, Philippa Karoly, Thomas Carroll, Daniel Payne, Susmita Saha, Steven Baldassano, Terence O'Brien, David Grayden, Mark Cook, Dean Freestone, Stefan Harrer

Journal article  |  2018  |  EBioMedicine

Does accounting for seizure frequency variability increase clinical trial power?

Daniel M Goldenholz, Shira R Goldenholz, Robert Moss, Jacqueline French, Daniel Lowenstein, Ruben Kuzniecky, Sheryl Haut, Sabrina Cristofaro, Kamil Detyniecki, John Hixson, Philippa Karoly, Mark Cook, Alex Strashny, William H Theodore, Carl Pieper

Journal article  |  2017  |  Epilepsy Research

The circadian profile of epilepsy improves seizure forecasting

Philippa J Karoly, Hoameng Ung, David B Grayden, Levin Kuhlmann, Kent Leyde, Mark J Cook, Dean R Freestone

Journal article  |  2017  |  Brain

Simulating Clinical Trials With and Without Intracranial EEG Data.

Daniel M Goldenholz, Joseph J Tharayil, Rubin Kuzniecky, Philippa Karoly, William H Theodore, Mark J Cook

Journal article  |  2017  |  Epilepsia Open

OBJECTIVE: It is currently unknown if knowledge of clinically silent (electrographic) seizures improves the statistical efficiency..

A forward-looking review of seizure prediction

Dean R Freestone, Philippa J Karoly, Mark J Cook

Journal article  |  2017  |  Current Opinion in Neurology

Bursts of seizures in long-term recordings of human focal epilepsy

Philippa J Karoly, Ewan S Nurse, Dean R Freestone, Hoameng Ung, Mark J Cook, Ray Boston

Journal article  |  2017  |  Epilepsia

Interictal spikes and epileptic seizures: their relationship and underlying rhythmicity

Philippa J Karoly, Dean R Freestone, Ray Boston, David B Grayden, David Himes, Kent Leyde, Udaya Seneviratne, Samuel Berkovic, Terence O'Brien, Mark J Cook

Journal article  |  2016  |  Brain

Human focal seizures are characterized by populations of fixed duration and interval

Mark J Cook, Philippa J Karoly, Dean R Freestone, David Himes, Kent Leyde, Samuel Berkovic, Terence O'Brien, David B Grayden, Ray Boston

Journal article  |  2016  |  Epilepsia

Seizure Prediction: Science Fiction or Soon to Become Reality?

Dean R Freestone, Philippa J Karoly, Andre DH Peterson, Levin Kuhlmann, Alan Lai, Farhad Goodarzy, Mark J Cook

Journal article  |  2015  |  Current Neurology and Neuroscience Reports

A Generalizable Brain-Computer Interface (BCI) Using Machine Learning for Feature Discovery

Ewan S Nurse, Philippa J Karoly, David B Grayden, Dean R Freestone

Journal article  |  2015  |  PLOS ONE

Estimation of effective connectivity via data-driven neural modeling

Dean R Freestone, Philippa J Karoly, Dragan Nesic, Parham Aram, Mark J Cook, David B Grayden

Journal article  |  2014  |  Frontiers in Neuroscience

Forecasting Cycles of Seizure Likelihood

Philippa J Karoly, Matias I Maturana, Mark J Cook, Ewan S Nurse, Daniel Payne, Benjamin Brinkmann, David B Grayden, Sonya B Dumanis, Mark P Richardson, Greg Worrell, Andreas Schulze-Bonhage, Levin Kuhlmann, Dean R Freestone

Journal article

Objective: Seizure unpredictability is rated as one of the most challenging aspects of living with epilepsy. Seizure likelihood ca..