Philippa (Pip) Karoly is a research fellow working to develop an innovative, patient- specific approach to seizure forecasting. Using sophisticated computational techniques, long-term data from brain recordings, environmental, behavioural and physiological factors can be combined and converted into useful seizure likelihood models.
For three years, Pip also worked as a software engineer for the Australian medical technology company, Seer. At Seer she developed a mobile app that provides people with epilepsy insight into their seizure patterns. Now, her research combines this app data with wearable devices and neural implants to generate real-time insights into seizure likelihood. To achieve this goal, Pip maintains close ties with industry partners, providing the optimal balance to translate medical research into innovative clinical solutions
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Displaying the 2 most recent projects by Philippa Karoly.
Displaying the 24 most recent scholarly works by Philippa Karoly.
Ensembling crowdsourced seizure prediction algorithms using long-term human intracranial EEG
Chip Reuben, Philippa Karoly, Dean R Freestone, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothee Proix, Michal Nahlik, Daniel B Grunberg, David B Grayden, Mark J Cook, et al.
Journal article | 2020 | Epilepsia
Seizure prediction is feasible, but greater accuracy is needed to make seizure prediction clinically viable across a large group o..
Computer-assisted EEG diagnostic review for idiopathic generalized epilepsy.
Shannon Clarke, Philippa J Karoly, Ewan Nurse, Udaya Seneviratne, Janelle Taylor, Rory Knight-Sadler, Robert Kerr, Braden Moore, Patrick Hennessy, Dulini Mendis, Claire Lim, Jake Miles, Mark Cook, Dean R Freestone, Wendyl D'Souza
Journal article | 2019 | Epilepsy & Behavior
Epilepsy diagnosis can be costly, time-consuming, and not uncommonly inaccurate. The reference standard diagnostic monitoring is c..
When can we trust responders? Serious concerns when using 50% response rate to assess clinical trials
Philippa J Karoly, Juan Romero, Mark J Cook, Dean R Freestone, Daniel M Goldenholz
Journal article | 2019 | Epilepsia
Individual seizure rates are highly volatile, with large fluctuations from month‐to‐month. Nevertheless, changes in individual mea..
Methods for the Detection of Seizure Bursts in Epilepsy
Udaya Seneviratne, Philippa Karoly, Dean R Freestone, Mark J Cook, Ray C Boston
Journal article | 2019 | Frontiers in Neurology
Background: Seizure clusters and “bursts” are of clinical importance. Clusters are reported to be a marker of antiepileptic drug r..
Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
Wei-Chih Chang, Jan Kudlacek, Jaroslav Hlinka, Jan Chvojka, Michal Hadrava, Vojtech Kumpost, Andrew D Powell, Radek Janca, Matias I Maturana, Philippa J Karoly, Dean R Freestone, Mark J Cook, Milan Palus, Jakub Otahal, John GR Jefferys, Premysl Jiruska
Journal article | 2018 | Nature Neuroscience
Epilepsyecosystem.org: crowd-sourcing reproducible seizure prediction with long-term human intracranial EEG
Levin Kuhlmann, Philippa Karoly, Dean R Freestone, Benjamin H Brinkmann, Andriy Temko, Alexandre Barachant, Feng Li, Gilberto Titericz, Brian W Lang, Daniel Lavery, Kelly Roman, Derek Broadhead, Scott Dobson, Gareth Jones, Qingnan Tang, Irina Ivanenko, Oleg Panichev, Timothee Proix, Michal Nahlik, Daniel B Grunberg, et al.
Journal article | 2018 | Brain
Is seizure frequency variance a predictable quantity?
Daniel M Goldenholz, Shira R Goldenholz, Robert Moss, Jacqueline French, Daniel Lowenstein, Ruben Kuzniecky, Sheryl Haut, Sabrina Cristofaro, Kamil Detyniecki, John Hixson, Philippa Karoly, Mark Cook, Alex Strashny, William H Theodore
Journal article | 2018 | Annals of Clinical and Translational Neurology
Epileptic Seizure Prediction Using Big Data and Deep Learning: Toward a Mobile System
Isabell Kiral-Kornek, Subhrajit Roy, Ewan Nurse, Benjamin Mashford, Philippa Karoly, Thomas Carroll, Daniel Payne, Susmita Saha, Steven Baldassano, Terence O'Brien, David Grayden, Mark Cook, Dean Freestone, Stefan Harrer
Journal article | 2018 | EBioMedicine
Does accounting for seizure frequency variability increase clinical trial power?
Daniel M Goldenholz, Shira R Goldenholz, Robert Moss, Jacqueline French, Daniel Lowenstein, Ruben Kuzniecky, Sheryl Haut, Sabrina Cristofaro, Kamil Detyniecki, John Hixson, Philippa Karoly, Mark Cook, Alex Strashny, William H Theodore, Carl Pieper
Journal article | 2017 | Epilepsy Research
Simulating Clinical Trials With and Without Intracranial EEG Data.
Daniel M Goldenholz, Joseph J Tharayil, Rubin Kuzniecky, Philippa Karoly, William H Theodore, Mark J Cook
Journal article | 2017 | Epilepsia Open
OBJECTIVE: It is currently unknown if knowledge of clinically silent (electrographic) seizures improves the statistical efficiency..
Forecasting Cycles of Seizure Likelihood
Philippa J Karoly, Matias I Maturana, Mark J Cook, Ewan S Nurse, Daniel Payne, Benjamin Brinkmann, David B Grayden, Sonya B Dumanis, Mark P Richardson, Greg Worrell, Andreas Schulze-Bonhage, Levin Kuhlmann, Dean R Freestone
Objective: Seizure unpredictability is rated as one of the most challenging aspects of living with epilepsy. Seizure likelihood ca..
Displaying the 2 most recent news articles by Philippa Karoly.
Research Fellow In Neural Engineering & Epilepsy
Doctor of Philosophy
University of Melbourne
Masters of Engineering
University of Melbourne
Bachelor of Biomedical Engineering
University of Melbourne