Ping Cannon

Placental growth factor is negatively regulated by epidermal growth factor receptor (EGFR) signaling.

Carole-Anne Whigham, Roxanne Hastie, Natalie J Hannan, Fiona Brownfoot, Natasha Pritchard, Ping Cannon, Tuong Vi Nguyen, Manju Kandel, Joshua Masci, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2021  |  Placenta

INTRODUCTION: Preeclampsia is associated with reduced pro-angiogenic Placental Growth Factor (PlGF) and increased levels of anti-a..

Maternal circulating SPINT1 is reduced in small-for-gestational age pregnancies at 26 weeks: Growing up in Singapore towards health outcomes (GUSTO) cohort study

Tu'uhevaha J Kaitu'u-Lino, Stephen Tong, Susan P Walker, Teresa M MacDonald, Ping Cannon, Tuong-Vi Nguyen, Suresh Anand Sadananthan, Mya-Thway Tint, Yi Ying Ong, Loy See Ling, Peter D Gluckman, Yap-Seng Chong, Keith M Godfrey, Shiao-Yng Chan, Kok Hian Tan, Yung Seng Lee, Navin Michael, Johan G Eriksson, Mary E Wlodek

Journal article  |  2021  |  PLACENTA

Fetal growth restriction arising from placental insufficiency is a leading cause of stillbirth. We recently identified low materna..

Circulating Tissue Factor Pathway Inhibitor (TFPI) is increased preceding preeclampsia diagnosis and in established preeclampsia

Teresa M MacDonald, Stephen Tong, Jenny Myers, Ping Cannon, Nguyen Tuong-Vi, Emerson Keenan, Elizabeth Murray, Alesia Harper, Natasha Pritchard, Natalie J Hannan, Kirsten M Dane, Anna L Middleton, Valerie P Kyritsis, Susan P Walker, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2021  |  PLACENTA

INTRODUCTION: Tissue Factor Pathway Inhibitor (TFPI) is a part of the extrinsic coagulation pathway, and highly expressed in the p..

MicroRNAs 363 and 149 are differentially expressed in the maternal circulation preceding a diagnosis of preeclampsia

Carole-Anne Whigham, Teresa M MacDonald, Susan P Walker, Richard Hiscock, Natalie J Hannan, Natasha Pritchard, Ping Cannon, Vi Nguyen Tuong, Manisha Miranda, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2020  |  SCIENTIFIC REPORTS

Preeclampsia is a pregnancy complication associated with angiogenic dysbalance, maternal endothelial dysfunction and end-organ inj..

Esomeprazole and sulfasalazine in combination additively reduce sFlt-1 secretion and diminish endothelial dysfunction: potential for a combination treatment for preeclampsia

Natalie K Binder, Fiona C Brownfoot, Sally Beard, Ping Cannon, Tuong V Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan

Journal article  |  2020  |  PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH

Development and repurposing of therapies that show promise in the prevention or treatment of preeclampsia would be a major advance..

Combining metformin and sulfasalazine additively reduces the secretion of antiangiogenic factors from the placenta: Implications for the treatment of preeclampsia

Fiona C Brownfoot, Roxanne Hastie, Natalie J Hannan, Ping Cannon, Tuong Nguyen, Laura Tuohey, Cathy Cluver, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2020  |  PLACENTA

INTRODUCTION: The antiangiogenic factors soluble fms-like tyrosine kinase-1 (sFlt-1) and soluble endoglin (sENG) are elevated in p..

Circulating SPINT1 is a biomarker of pregnancies with poor placental function and fetal growth restriction

Tu'uhevaha J Kaitu'u-Lino, Teresa M MacDonald, Ping Cannon, Nguyen Tuong-Vi, Richard J Hiscock, Nick Haan, Jenny E Myers, Roxanne Hastie, Kirsten M Dane, Anna L Middleton, Intissar Bittar, Amanda N Sferruzzi-Perri, Natasha Pritchard, Alesia Harper, Natalie J Hannan, Valerie Kyritsis, Nick Crinis, Lisa Hui, Susan P Walker, Stephen Tong

Journal article  |  2020  |  NATURE COMMUNICATIONS

Purpose To investigate the relationship between patient-reported outcome (PRO) questionnaire responses and time to late age-relate..

GDF15 is Increased in Preeclampsia and May be Regulated via Transcription Factors EGR1 and SP1.

Tess Cruickshank, Teresa M MacDonald, Susan P Walker, Natalie J Hannan, Damanpreet Singh, Ping Cannon, Alesia Harper, Murray Elizabeth, Tuong-Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings  |  2020  |  REPRODUCTIVE SCIENCES

Syndecan-1 is Reduced in Fetal Growth Restriction and Cleaved by Matrix Metalloproteinases.

Damanpreet Singh, Teresa M MacDonald, Susan P Walker, Tess Cruickshank, Natalie J Hannan, Ping Cannon, Alesia Harper, Elizabeth Murray, Nguyen Tuong-Vi, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Conference Proceedings  |  2020  |  REPRODUCTIVE SCIENCES

Circulating Delta-like homolog 1 (DLK1) at 36 weeks is correlated with birthweight and is of placental origin

Teresa M MacDonald, Susan P Walker, Richard Hiscock, Ping Cannon, Alesia Harper, Elizabeth Murray, Lisa Hui, Kirsten Dane, Anna Middleton, Valerie Kyritsis, Natasha de Alwis, Natalie J Hannan, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino

Journal article  |  2020  |  PLACENTA

INTRODUCTION: Recently, Delta-like homolog 1 (DLK1) was identified as a potential marker of small-for-gestational-age (SGA; <10th ..