Dr Annabell Bachem is a research fellow in the Department of Microbiology and Immunology at The University of Melbourne. She received her PhD from the Humboldt University/Robert Koch Institute in Berlin (Germany), where she translated the key finding that CD8+ DC are superior in antigen cross-presentation from mouse to human.
This resulted in the first definition of human cross-presenting DC and the ability to define these cells across different species using the now universally used marker XCR1. In 2014 she became a postdoctoral fellow of the German Research Foundation and joined the group of A/Prof Sammy Bedoui at the Peter Doherty Institute for Infection and Immunity. Supported by an Early Career Research Grant she established the study of the influence of microbiota and microbiota-derived metabolites on CD8+ T cells. In particular she demonstrated that the metabolite butyrate increases CD8+ T cell metabolism and enhances their transition to long-lived memory cells.
Find out more about Annabell Bachem's experience
Annabell Bachem's highlights
Annabell Bachem's selected work
Harnessing Microbiota-Derived Mediators To Improve T Cell-Based Cancer Immunotherapy
Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require..
POSTTRANSLATIONAL MODIFICATION AS A CRITICAL DETERMINANT OF CYTOPLASMIC INNATE IMMUNE RECO..
Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a B..
Displaying the 2 most recent projects by Annabell Bachem.
Internal Research Grant
Displaying the 9 most recent scholarly works by Annabell Bachem.
Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells
Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.
Journal article | 2019 | Immunity
Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..
Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require Infected Dendritic Cells
Paul G Whitney, Christina Makhlouf, Beth MacLeod, Joel Z Ma, Elise Gressier, Marie Greyer, Katharina Hochheiser, Annabell Bachem, Ali Zaid, David Voehringer, William R Heath, Mayura V Wagle, Ian Parish, Tiffany A Russell, Stewart A Smith, David C Tscharke, Thomas Gebhardt, Sammy Bedoui
Journal article | 2018 | Journal of Virology
POSTTRANSLATIONAL MODIFICATION AS A CRITICAL DETERMINANT OF CYTOPLASMIC INNATE IMMUNE RECOGNITION
Paul J Baker, Dominic De Nardo, Fiona Moghaddas, Son Tran Le, Annabell Bachem, Nguyen Tan, Thomas Hayman, Hazel Tye, James E Vince, Sammy Bedoui, Richard L Ferrero, Seth L Masters
Journal article | 2017 | Physiological Reviews
T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming
Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui
Journal article | 2016 | Cell Reports
Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1
Evelyn Hartung, Martina Becker, Annabell Bachem, Nele Reeg, Anika Jaekel, Andreas Hutloff, Harald Weber, Christoph Weise, Claudia Giesecke, Volker Henn, Stephanie Gurka, Konstantinos Anastassiadis, Hans W Mages, Richard A Kroczek
Journal article | 2015 | The Journal of Immunology
Ontogenic, Phenotypic, and Functional Characterization of XCR1( ) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα.
Martina Becker, Steffen Güttler, Annabell Bachem, Evelyn Hartung, Ahmed Mora, Anika Jäkel, Andreas Hutloff, Volker Henn, Hans Werner Mages, Stephanie Gurka, Richard A Kroczek
Journal article | 2014 | Frontiers in Immunology
In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full und..
Expression of XCR1 characterizes the Batf3-dependent lineage of dendritic cells capable of antigen cross-presentation
Annabell Bachem, Evelyn Hartung, Steffen Guettler, Ahmed Mora, Xuefei Zhou, Anika Hegemann, Maud Plantinga, Elisa Mazzini, Patrizia Stoitzner, Stephanie Gurka, Volker Henn, Hans W Mages, Richard A Kroczek
Journal article | 2012 | Frontiers in Immunology
Superior antigen cross-presentation and XCR1 expression define human CD11c( )CD141( ) cells as homologues of mouse CD8( ) dendritic cells
Annabell Bachem, Steffen Guettler, Evelyn Hartung, Frederic Ebstein, Michael Schaefer, Astrid Tannert, Abdulgabar Salama, Kamran Movassaghi, Corinna Opitz, Hans W Mages, Volker Henn, Peter-Michael Kloetzel, Stephanie Gurka, Richard A Kroczek
Journal article | 2010 | The Journal of Experimental Medicine
Honours, Awards and Fellowships
Early Career Researcher Grant from The University of Melbourne
Research Fellowship from the German Research Foundation (DFG)
Microbiology And Immunology
International Cytokine & Interferon Society
Australian and New Zealand Society for Immunology
Doctor rerum naturalium
Humboldt-Universitaet zu Berlin