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Dr

Annabell Bachem

Research Fellow
science & technology
life sciences & biomedicine
dendritic cells
animals
mice
humans
subsets
cd8-positive t-lymphocytes
immunology
Annabell Bachem's Profile Picture
Dr

Annabell Bachem

 
Division
Medicine, Dentistry And Health Sciences
Annabell Bachem's Profile Picture
Dr

Annabell Bachem

 

Dr Annabell Bachem is a research fellow in the Department of Microbiology and Immunology at The University of Melbourne. She received her PhD from the Humboldt University/Robert Koch Institute in Berlin (Germany), where she translated the key finding that CD8+ DC are superior in antigen cross-presentation from mouse to human.

This resulted in the first definition of human cross-presenting DC and the ability to define these cells across different species using the now universally used marker XCR1. In 2014 she became a postdoctoral fellow of the German Research Foundation and joined the group of A/Prof Sammy Bedoui at the Peter Doherty Institute for Infection and Immunity. Supported by an Early Career Research Grant she established the study of the influence of microbiota and microbiota-derived metabolites on CD8+ T cells. In particular she demonstrated that the metabolite butyrate increases CD8+ T cell metabolism and enhances their transition to long-lived memory cells.

Projects

Displaying the 2 most recent projects by Annabell Bachem.

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Harnessing Microbiota-Derived Mediators To Improve T Cell-Based Cancer Immunotherapy

2019 - 2022
Active
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How Microbiota Regulates T Cell Immunity

2016 - 2016
Completed

2

Projects

Project Types

1

Internal Research Grant

1

Research Contracts

Scholarly Works

Displaying the 9 most recent scholarly works by Annabell Bachem.

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Microbiota-Derived Short-Chain Fatty Acids Promote the Memory Potential of Antigen-Activated CD8( ) T Cells

Annabel Bachem, Christina Makhlouf, Katrina J Binger, David P de Souza, Deidra Tull, Katharina Hochheiser, Paul G Whitney, Daniel Fernandez-Ruiz, Sabrina Dahling, Wolfgang Kastemuller, Johanna Jonsson, Elise Gressier, Andrew M Lew, Carolina Perdomo, Andreas Kupz, William Figgett, Fabienne Mackay, Moshe Oleshansky, Brendan E Russ, Ian A Parish, et al.

Journal article  |  2019  |  Immunity

Interactions with the microbiota influence many aspects of immunity, including immune cell development, differentiation, and funct..

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Effective Priming of Herpes Simplex Virus-Specific CD8( ) T Cells In Vivo Does Not Require Infected Dendritic Cells

Paul G Whitney, Christina Makhlouf, Beth MacLeod, Joel Z Ma, Elise Gressier, Marie Greyer, Katharina Hochheiser, Annabell Bachem, Ali Zaid, David Voehringer, William R Heath, Mayura V Wagle, Ian Parish, Tiffany A Russell, Stewart A Smith, David C Tscharke, Thomas Gebhardt, Sammy Bedoui

Journal article  |  2018  |  Journal of Virology

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POSTTRANSLATIONAL MODIFICATION AS A CRITICAL DETERMINANT OF CYTOPLASMIC INNATE IMMUNE RECOGNITION

Paul J Baker, Dominic De Nardo, Fiona Moghaddas, Son Tran Le, Annabell Bachem, Nguyen Tan, Thomas Hayman, Hazel Tye, James E Vince, Sammy Bedoui, Richard L Ferrero, Seth L Masters

Journal article  |  2017  |  Physiological Reviews

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Cooperation between Monocyte-Derived Cells and Lymphoid Cells in the Acute Response to a Bacterial Lung Pathogen

Andrew S Brown, Chao Yang, Ka Yee Fung, Annabell Bachem, Dorothee Bourges, Sammy Bedoui, Elizabeth L Hartland, Ian R van Driel

Journal article  |  2016  |  PLOS Pathogens

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T Cell Help Amplifies Innate Signals in CD8( ) DCs for Optimal CD8( ) T Cell Priming

Marie Greyer, Paul G Whitney, Angus T Stock, Gayle M Davey, Christina Tebartz, Annabell Bachem, Justine D Mintern, Richard A Strugnell, Stephen J Turner, Thomas Gebhardt, Meredith O'Keeffe, William R Heath, Sammy Bedoui

Journal article  |  2016  |  Cell Reports

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Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1

Evelyn Hartung, Martina Becker, Annabell Bachem, Nele Reeg, Anika Jaekel, Andreas Hutloff, Harald Weber, Christoph Weise, Claudia Giesecke, Volker Henn, Stephanie Gurka, Konstantinos Anastassiadis, Hans W Mages, Richard A Kroczek

Journal article  |  2015  |  The Journal of Immunology

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Ontogenic, Phenotypic, and Functional Characterization of XCR1( ) Dendritic Cells Leads to a Consistent Classification of Intestinal Dendritic Cells Based on the Expression of XCR1 and SIRPα.

Martina Becker, Steffen Güttler, Annabell Bachem, Evelyn Hartung, Ahmed Mora, Anika Jäkel, Andreas Hutloff, Volker Henn, Hans Werner Mages, Stephanie Gurka, Richard A Kroczek

Journal article  |  2014  |  Frontiers in Immunology

In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full und..

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Expression of XCR1 characterizes the Batf3-dependent lineage of dendritic cells capable of antigen cross-presentation

Annabell Bachem, Evelyn Hartung, Steffen Guettler, Ahmed Mora, Xuefei Zhou, Anika Hegemann, Maud Plantinga, Elisa Mazzini, Patrizia Stoitzner, Stephanie Gurka, Volker Henn, Hans W Mages, Richard A Kroczek

Journal article  |  2012  |  Frontiers in Immunology

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Superior antigen cross-presentation and XCR1 expression define human CD11c( )CD141( ) cells as homologues of mouse CD8( ) dendritic cells

Annabell Bachem, Steffen Guettler, Evelyn Hartung, Frederic Ebstein, Michael Schaefer, Astrid Tannert, Abdulgabar Salama, Kamran Movassaghi, Corinna Opitz, Hans W Mages, Volker Henn, Peter-Michael Kloetzel, Stephanie Gurka, Richard A Kroczek

Journal article  |  2010  |  The Journal of Experimental Medicine

9

Scholarly Works

Keyword Analysis

Clinical Health (organs, Diseases and Abnormal Conditions)
Immunology
Medical Microbiology

Honours, Awards and Fellowships

2016

Early Career Researcher Grant from The University of Melbourne

2014

Research Fellowship from the German Research Foundation (DFG)

2

Awards

Credentials

Positions

Research Fellow

Microbiology And Immunology

Member

International Cytokine & Interferon Society

Member

Australian and New Zealand Society for Immunology

Education

Doctor rerum naturalium

Humboldt-Universitaet zu Berlin

Links