Yoshimi Inaba

Novel methylation markers of the dysexecutive-psychiatric phenotype in FMR1 premutation women

Kim M Cornish, Claudine M Kraan, Minh Bui Quang, Mark A Bellgrove, Sylvia A Metcalfe, Julian N Trollor, Darren R Hocking, Howard R Slater, Yoshimi Inaba, Xin Li, Alison D Archibald, Erin Turbitt, Jonathan Cohen, David E Godler

Journal article  |  2015  |  NEUROLOGY

OBJECTIVE: To examine the epigenetic basis of psychiatric symptoms and dysexecutive impairments in FMR1 premutation (PM: 55 to 199..

Early Detection of Fragile X Syndrome: Applications of a Novel Approach for Improved Quantitative Methylation Analysis in Venous Blood and Newborn Blood Spots

Yoshimi Inaba, Charles E Schwartz, Quang M Bui, Xin Li, Cindy Skinner, Michael Field, Tiffany Wotton, Randi J Hagerman, David Francis, David J Amor, John L Hopper, Danuta Z Loesch, Lesley Bretherton, Howard R Slater, David E Godler

Journal article  |  2014  |  CLINICAL CHEMISTRY

BACKGROUND: Standard fragile X syndrome (FXS) diagnostic tests that target methylation of the fragile X mental retardation 1 (FMR1..

Fragile X-related element 2 methylation analysis may provide a suitable option for inclusion of fragile X syndrome and/or sex chromosome aneuploidy into newborn screening: a technical validation study

Yoshimi Inaba, Amy S Herlihy, Charles E Schwartz, Cindy Skinner, Quang M Bui, Joanna Cobb, Elva Z Shi, David Francis, Alison Arvaj, David J Amor, Kate Pope, Tiffany Wotton, Jonathan Cohen, Jacqueline K Hewitt, Randi J Hagerman, Sylvia A Metcalfe, John L Hopper, Danuta Z Loesch, Howard R Slater, David E Godler

Journal article  |  2013  |  GENETICS IN MEDICINE

PURPOSE: We show that a novel fragile X-related epigenetic element 2 FMR1 methylation test can be used along with a test for sex-d..

Normal DNA Methylation Dynamics in DICER1-Deficient Mouse Embryonic Stem Cells

Jonathan Ip, Paul Canham, KH Andy Choo, Yoshimi Inaba, Shelley A Jacobs, Paul Kalitsis, Deidre M Mattiske, Jane Ng, Richard Saffery, Nicholas C Wong, Lee H Wong, Jeffrey R Mann

Journal article  |  2012  |  PLOS GENETICS

Reduced DNA methylation has been reported in DICER1-deficient mouse ES cells. Reductions seen at pericentric satellite repeats hav..

Fragile X Mental Retardation 1 (FMR1) Intron 1 Methylation in Blood Predicts Verbal Cognitive Impairment in Female Carriers of Expanded FMR1 Alleles: Evidence from a Pilot Study

David E Godler, Howard R Slater, Quang M Bui, Elsdon Storey, Michele Y Ono, Freya Gehling, Yoshimi Inaba, David Francis, John L Hopper, Glynda Kinsella, David J Amor, Randi J Hagerman, Danuta Z Loesch

Journal article  |  2012  |  CLINICAL CHEMISTRY

BACKGROUND: Cognitive status in females with mutations in the FMR1 (fragile X mental retardation 1) gene is highly variable. A bio..