Yi Ju

Supramolecular Polyphenol‐DNA Microparticles for In Vivo Adjuvant and Antigen Co‐Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan‐Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez‐Jugo, Francesca Cavalieri, Frank Caruso

Journal article  |  2023  |  Angewandte Chemie

Supramolecular Polyphenol-DNA Microparticles for In Vivo Adjuvant and Antigen Co-Delivery and Immune Stimulation

Yijiao Qu, Robert De Rose, Chan-Jin Kim, Jiajing Zhou, Zhixing Lin, Yi Ju, Sukhvir Kaur Bhangu, Christina Cortez-Jugo, Francesca Cavalieri, Frank Caruso

Journal article  |  2023  |  ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA-based materials have attracted interest due to the tunable structure and encoded biological functionality of nucleic acids. A ..

Impact of anti-PEG antibodies induced by SARS-CoV-2 mRNA vaccines

Yi Ju, Juan Manuel Carreno, Viviana Simon, Kenneth Dawson, Florian Krammer, Stephen J Kent

Journal article  |  2022  |  NATURE REVIEWS IMMUNOLOGY

The successful mRNA vaccines against COVID-19 contain polyethylene glycol (PEG) to stabilize the lipid nanoparticles. Recent data ..

Engineering Poly(ethylene glycol) Nanoparticles for Accelerated Blood Clearance Inhibition and Targeted Drug Delivery

Yuan Tian, Zhiliang Gao, Ning Wang, Ming Hu, Yi Ju, Qiang Li, Frank Caruso, Jingcheng Hao, Jiwei Cui

Journal article  |  2022  |  JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Surface modification with poly(ethylene glycol) (PEGylation) is an effective strategy to improve the colloidal stability of nanopa..

Polyphenol-Functionalized Cubosomes as Thrombolytic Drug Carriers

Haitao Yu, Jason S Palazzolo, Yi Ju, Be'eri Niego, Shuaijun Pan, Christoph E Hagemeyer, Frank Caruso

Journal article  |  2022  |  ADVANCED HEALTHCARE MATERIALS

The safe administration of thrombolytic agents is a challenge for the treatment of acute thrombosis. Lipid-based nanoparticle drug..

Influence of protein corona on the interaction of glycogen-siRNA constructs with ex vivo human blood immune cells

Marcin Wojnilowicz, Petra Laznickova, Yi Ju, Ching-Seng Ang, Federico Tidu, Kamila Bendickova, Giancarlo Forte, Magdalena Plebanski, Frank Caruso, Francesca Cavalieri, Jan Fric

Journal article  |  2022  |  BIOMATERIALS ADVANCES

Glycogen-nucleic acid constructs i.e., glycoplexes are emerging promising platforms for the alteration of gene expression and tran..

Anti-PEG Antibodies Boosted in Humans by SARS-CoV-2 Lipid Nanoparticle mRNA Vaccine

Yi Ju, Wen Shi Lee, Emily H Pilkington, Hannah G Kelly, Shiyao Li, Kevin J Selva, Kathleen M Wragg, Kanta Subbarao, Thi HO Nguyen, Louise C Rowntree, Lilith F Allen, Katherine Bond, Deborah A Williamson, Nghia P Truong, Magdalena Plebanski, Katherine Kedzierska, Siddhartha Mahanty, Amy W Chung, Frank Caruso, Adam K Wheatley, et al.

Journal article  |  2022  |  ACS NANO

Humans commonly have low level antibodies to poly(ethylene) glycol (PEG) due to environmental exposure. Lipid nanoparticle (LNP) m..

Confined microemulsion sono-polymerization of poly(ethylene glycol) nanoparticles for targeted delivery

Zhiliang Gao, Xiaoyu Li, Kaijie Zhao, Huimin Geng, Peiyu Zhang, Yi Ju, Pie Huda, Christopher B Howard, Kristofer J Thurecht, Muthupandian Ashokkumar, Jingcheng Hao, Jiwei Cui

Journal article  |  2022  |  CHEMICAL COMMUNICATIONS

Confined sono-polymerization is developed to prepare poly(ethylene glycol) nanoparticles within water-in-oil microemulsion, follow..

Protein precoating modulates biomolecular coronas and nanocapsule-immune cell interactions in human blood

Shiyao Li, Yi Ju, Jiajing Zhou, Matthew Faria, Ching-Seng Ang, Andrew J Mitchell, Qi-Zhi Zhong, Tian Zheng, Stephen J Kent, Frank Caruso

Journal article  |  2022  |  JOURNAL OF MATERIALS CHEMISTRY B

The biomolecular corona that forms on particles upon contact with blood plays a key role in the fate and utility of nanomedicines...

Template-Assisted Antibody Assembly: A Versatile Approach for Engineering Functional Antibody Nanoparticles

Y Hu, J Li, Y Ju, ZH Houston, NL Fletcher, R De Rose, S Fernandes, CE Hagemeyer, K Alt, KJ Thurecht, C Cortez-Jugo, F Caruso

Journal article  |  2022  |  Chemistry of Materials

The clinical success of monoclonal antibody therapy has inspired research in understanding the fundamental molecular basis of anti..